clinical-research funding
108 open opportunities tagged clinical-research, across federal agencies and private foundations. Sorted by deadline.
NIH, CDC and FDA Small Business Innovation Research Grant (Parent SBIR [R43/R44] Clinical Trial Optional)
S. technology development and commercialization.
6 review criteria on fileSBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)
S. technology development and commercialization.
7 review criteria on fileNIH Small Business Technology Transfer Grant (Parent STTR [R41/R42] Clinical Trial Optional)
S. technology development and commercialization.
6 review criteria on fileNIH Small Business Innovation Research (SBIR) Phase IIB Strategic Breakthrough Award (Parent [R44] Clinical Trial Optional)
S. technology development and commercialization.
7 review criteria on fileAcademic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)
The purpose of this Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions is to support small scale research grants at institutions that do not receive substantial funding from the NIH, with an emphasis on providing biomedical research experiences primarily for undergraduate students and enhancing the research…
6 review criteria on fileAlcohol Treatment, Pharmacotherapy, and Recovery Research (R01 Clinical Trial Required)
The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R01 Clinical Trial Required mechanism focusing on alcohol treatment and recovery research.
3 review criteria on fileAlcohol Treatment, Pharmacotherapy, and Recovery Research (R34 Clinical Trial required)
The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R34 Clinical Trial Optional mechanism focusing on alcohol health services.
3 review criteria on fileARMY ARM26BX03-NP006 — xTech|Inversion Competition
S.S.
3 review criteria on fileNCI Community Oncology Research Program (NCORP) Research Bases (UG1 Clinical Trial Required)
This Notice of Funding Opportunity (NOFO) is one of three NOFOs for the National Cancer Institute (NCI) Community Oncology Research Program (NCORP). NCORP is designed to enhance generalizability and dissemination of clinical trial and other human research study results through accrual in a variety of community settings.
7 review criteria on fileNAVY DON26BZ05-NV068 — Intelligent Tools for Naval Aircrew Performance and Readiness
Research, develop, and demonstrate innovative methods for designing intelligent human performance systems to enhance Naval Aircrew readiness. These systems will track, predict, and mitigate cognitive, physical, and psychological vulnerabilities, serving as prehabilitation and protection tools.
3 review criteria on fileDARPA DPA26BZ05-DV020 — Universal Cell Culture Platform for Rapid Establishment of Species-Agnostic Cell Lines and Autonomous Culture Operations
Develop and demonstrate a universal, species-agnostic cell culture platform that (1) enables rapid establishment of viable, reproducible cell lines - including induced pluripotent stem cells (iPSCs) where feasible - from diverse non-model species (vertebrate and invertebrate); (2) leverages autonomous, closed-loop culture automation to…
3 review criteria on fileNAVY DON26BZ05-DV087 — DIRECT TO PHASE II: Edge-Deployed Explainable Digital-Twin Condition Based Maintenance CBM+ Platforms for Carrier-Based Systems
Develop Digital Twin modeling and simulation, leveraging existing and new sensors to detect faults and predict possible failures in Aircraft Launch and Recovery Equipment (ALRE) to provide advance notice and prepare “maintainers” performing Condition Based Maintenance (CBM).
3 review criteria on fileAtopic Dermatitis Research Network (ADRN) (U19 Clinical Trial Optional)
Research Objectives Atopic Dermatitis (AD) is a chronic inflammatory pruritic skin disease that affects approximately 11% of children and up to 9% of adults in the United States.
13 review criteria on fileCancer Center Support Grants (CCSGs) for NCI-designated Cancer Centers (P30 Clinical Trial Optional)
Purpose This Notice of Funding Opportunity (NOFO) invites applications for P30 Cancer Center Support Grants (CCSGs) to support NCI-Designated Cancer Centers. NCI-Designated Cancer Centers serve as major sources of discovery into the nature of cancer and of the development of more effective approaches to prevention, diagnosis, and therapy.
11 review criteria on fileSpecialized Programs of Research Excellence (SPOREs) in Human Cancers for Years 2024, 2025, and 2026 (P50 Clinical Trial Required)
Through this funding opportunity announcement (FOA), the National Cancer Institute (NCI) invites applications for P50 Research Center Grants for Specialized Programs of Research Excellence (SPORE).
5 review criteria on fileIn Vivo High-Resolution Imaging for Inner Ear Visualization (R01 Clinical Trial optional)
This funding opportunity aims to support the development of in vivo high-resolution structural and functional imaging technologies for the living human inner ear.
3 review criteria on fileCooperative Agreement for In Vivo High-Resolution Imaging for Inner Ear Visualization (U01 Clinical Trial Required)
This funding opportunity aims to support high risk clinical trials for the development of in vivo high-resolution structural and functional imaging technologies for the living human inner ear.
4 review criteria on fileLimited Competition: Intellectual and Developmental Disabilities Research Centers 2027 (P50 Clinical Trial Optional)
Purpose This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III.
17 review criteria on fileData Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative U24 Clinical Trial Required)
NOFO Research Objectives This NOFO supports applications to develop and conduct a Data Coordinating Center (DCC) for investigator-initiated multi-site clinical trials submitted to the collaborating Clinical Coordinating Center NOFO ( PAR-27-012 ).
8 review criteria on fileSingle-Site Investigator-Initiated Clinical Trials (R61/R33 Clinical Trial Required)
NOFO Research Objectives This NOFO supports applications to develop and conduct investigator-initiated single-site clinical trials. Clinical trials supported by this NOFO include Phase II and above clinical trials.
3 review criteria on fileNHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R61/R33 Clinical Trial Required)
The objective of this Notice of Funding Opportunity (NOFO) is to support investigator-initiated, Phase I clinical trials for diagnostic and therapeutic interventions for heart, lung, blood, and sleep (HLBS) disorders in adults and children.
3 review criteria on fileClinical Coordinating Center for Multi-Site Investigator-Initiated Clinical Trials (Collaborative UG3/UH3 Clinical Trial Required)
NOFO Research Objectives This NOFO supports applications to develop and conduct a Clinical Coordinating Center (CCC) for investigator-initiated multi-site clinical trials. Clinical trials supported by this NOFO include Phase II and above clinical trials that will enroll participants from two or more recruitment sites.
3 review criteria on fileEffectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)
NIMH seeks applications for research projects to evaluate the effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions affecting youth, adults, and older adults.
3 review criteria on fileScreening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities (R01, Clinical Trial Required)
The Office of Disease Prevention (ODP) and participating National Institutes of Health (NIH) Institutes, Centers, and Offices (ICOs) are issuing this notice of funding opportunity (NOFO) seeking applications to test innovative approaches to implementing SBIRT/P for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult…
3 review criteria on fileInterventions to expand cancer screening and preventive services to ADVANCE health in populations that experience health disparities (R01, Clinical Trial Required)
The Office of Disease Prevention (ODP) and participating National Institutes of Health (NIH) Institutes, Centers, and Offices (ICs) are issuing this R01 to solicit applications to address barriers and facilitators that impede use or uptake of cancer screening and preventive services in populations that experience health disparities.
3 review criteria on fileClinical Characterization of Cancer Therapy-induced Adverse Sequelae and Mechanism-based Interventional Strategies (R01 Clinical Trial Optional)
The purpose of this Funding Opportunity Announcement (FOA) is to support collaborative research projects designed to address adverse sequelae of cancer therapies that persist and become chronic comorbidities or develop as delayed posttreatment effects.
3 review criteria on filePilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)
, consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden., comparative effectiveness study, practical trial) designed to definitely test the effectiveness of interventions to improve post-acute outcomes.
3 review criteria on fileLaboratories to Optimize Digital Health (R01 Clinical Trial Required)
NIMH seeks applications for innovative research projects to test strategies to increase the reach, efficiency, effectiveness, and quality of digital mental health interventions which may impact mental health outcomes, including suicide behaviors and serious mental illness.
3 review criteria on fileDoW Peer Reviewed Cancer, Clinical Trial Award
Summary: The fiscal year 2026 (FY26) Peer Reviewed Cancer Research Program (PRCRP) Clinical Trial Award (CTA) supports the rapid implementation of clinical trials with the potential to have a significant impact on the treatment or management of cancer within at least one of the FY26 PRCRP Topic Areas.
Review criteria on fileNIAID Clinical Trial Implementation Cooperative Agreement (U01 Clinical Trial Required)
Background Clinical trials are one strategy NIAID uses to improve prevention, diagnosis, and treatment of infectious, immunologic, and allergic diseases in addition to understanding the mechanisms of these diseases.
3 review criteria on fileNIH Research Project Grant (Parent R01 Clinical Trial Required)
The NIH Research Project Grant supports a discrete, specified, circumscribed project in areas representing the specific interests and competencies of the investigator(s). This Parent Notice of Funding Opportunity requires that at least 1 clinical trial be proposed.
3 review criteria on fileNavigator Emergency Department Diversion Models for Non-Urgent Mental Health Concerns (R01 Clinical Trial Required)
The purpose of this notice of funding opportunity (NOFO) is to encourage research applications that test the effectiveness, implementation, and optimization of patient navigation Emergency Department (ED) diversion models for non-urgent youth mental health problems.
3 review criteria on fileCancer Prevention and Control Clinical Trials Grant Program (R01 Clinical Trial Required)
Through this notice of funding opportunity (NOFO), the National Cancer Institute (NCI) invites applications for support of investigator-initiated clinical trials that have the potential to reduce the burden of cancer through improvements in early detection, screening, prevention and interception, healthcare delivery, quality of life,…
3 review criteria on fileNational Cancer Institute's Investigator-Initiated Early Phase Clinical Trials for Cancer Treatment and Diagnosis (R01 Clinical Trial Required)
Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) is soliciting research projects that implement early phase (Phase 0, I, and II) investigator-initiated clinical trials focused on cancer-targeted diagnostic and therapeutic interventions of direct relevance to the research mission of DCTD and OHAM.
4 review criteria on fileBioengineering Research Grants (BRG) (R01 Clinical Trial Optional)
Purpose The goal for a bioengineering research grant (BRG) is to foster the development of an innovative technology, model, technique, design, or method that has the potential for a significant impact on biomedical research by infusing principles and concepts from the quantitative sciences.
3 review criteria on fileAlzheimer's Drug-Development Program (U01 Clinical Trial Optional)
The goal of this Notice of Funding Opportunity (NOFO) is to provide funding support for the pre-clinical and early stage clinical (Phase I) development of novel small-molecule and biologic drug candidates that prevent Alzheimer's disease (AD), slow its progression, or treat its cognitive and behavioral symptoms.
5 review criteria on fileAcademic-Industrial Partnerships for Translation of Technologies for Diagnosis and Treatment (R01 - Clinical Trial Optional)
The purpose of this Notice of Funding Opportunity (NOFO) Announcement is to stimulate efforts to translate scientific discoveries and engineering developments into methods or tools that address problems in basic research to understand disease, or in applied research to assess risk, detect, prevent, diagnose, treat, and/or manage disease.
3 review criteria on fileMind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)
, mindfulness meditation, yoga, acupuncture, massage, and other brain and/or body based interventions) impact mechanisms of emotional well-being (EWB) and their associations with whole person health (WPH), consistent with the NIH priority to address the health needs of the American people and improve their well-being.
3 review criteria on fileNIDCR Drug, Biologic, Device and/or Procedure Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
This Notice of Funding Opportunity (NOFO) will support UG3/UH3 phased, cooperative agreement research applications to plan and implement clinical trials within the mission of the National Institute of Dental and Craniofacial Research (NIDCR).
6 review criteria on fileNIDCR Behavioral and Social Intervention Clinical Trial Planning and Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)
The purpose of this Notice of Funding Opportunity (NOFO) is to encourage UG3/UH3 phased cooperative agreement research applications to plan and implement behavioral and social intervention clinical trials.
3 review criteria on fileNIDCD Research Career Enhancement Award for Established Investigators (K18 Clinical Trial Required)
The purpose of the NIDCD Research Career Enhancement Award for Established Investigators (K18) program is to enable established, proven investigators to augment or redirect their research programs through the acquisition of new research skills to answer questions relevant to the hearing, balance, smell, taste, voice, speech and language…
8 review criteria on fileOptimal Treatment Strategies for use of Anti-Obesity Medications (AOMs) in Children and Adolescents Clinical Centers (U01 Clinical Trial Required)
Purpose This Notice of Funding Opportunity (NOFO) invites applications from clinical centers to participate in a consortium to test anti-obesity medication (AOM) treatment strategies for youth with obesity that maximize benefits and minimize risks of AOM use.), and quality of life and be feasible to implement in clinical care settings.
3 review criteria on fileEngineering Research Initiation
The NSF Directorate for Engineering (ENG) seeks to build engineering research capacity across the nation by investing in new academic investigators who have yet to receive sufficient research funding from Federal Agencies.
2 review criteria on file · agency frameworkAddressing Methodological Challenges with Clinical Trials of Rapid-Acting Psychotropic Interventional Drugs (RAPIDs) (R01 Clinical Trial Required)
Background Rapid-acting psychotropic interventional drugs (RAPIDs) are a class of psychoactive drugs that produce intense subjective effects and include 5-HT2A agonists such as psilocybin and lysergic acid diethylamide (LSD), dissociative anesthetics such as ketamine, and entactogens such as 3,4-methylenedioxymethamphetamine (MDMA).
3 review criteria on fileIndependent Scientist Award (Parent K02 - Independent Clinical Trial Required)
The purpose of the NIH Independent Scientist Award (K02) is to foster the development of outstanding scientists and enable them to expand their potential to make significant contributions to their field of research.
5 review criteria on fileNHLBI Career Transition Award for Intramural Postdoctoral Fellows and Research Trainees (K22 Clinical Trial Required)
The purpose of the NHLBI Career Transition Award (K22) program is to provide highly qualified postdoctoral fellows in the NHLBI Division of Intramural Research the opportunity to transition their research programs as new investigators to extramural institutions.
8 review criteria on fileCareer Transition Award for NINDS Intramural Clinician-Scientists (K22 Clinical Trial Required)
The objective of the NIH Career Transition Award (K22) is to provide support to outstanding basic or clinical investigators to develop their independent research skills through a two phase program: an initial period involving an intramural appointment at the NIH and a final period of support at an extramural institution.
6 review criteria on fileNIH Pathway to Independence Award (Parent K99/R00 Independent Clinical Trial Required)
The purpose of the NIH Pathway to Independence Award (K99/R00) program is to increase and maintain a strong cohort of new and talented, NIH-supported, independent investigators.
4 review criteria on fileMentored Research Scientist Development Award (Parent K01 - Independent Clinical Trial Required)
The purpose of the NIH Mentored Research Scientist Development Award (K01) is to provide support and protected time (three to five years) for an intensive, supervised career development experience in the biomedical, behavioral, or clinical sciences leading to research independence.
4 review criteria on fileMentored Patient-Oriented Research Career Development Award (Parent K23 Independent Clinical Trial Required)
The purpose of the NIH Mentored Patient-Oriented Research Career Development Award (K23) is to support the career development of individuals with a clinical doctoral degree who have made a commitment to focus their research endeavors on patient-oriented research.
4 review criteria on fileMentored Clinical Scientist Research Career Development Award (Parent K08 Independent Clinical Trial Required)
The primary purpose of the NIH Mentored Clinical Scientist Research Career Development Awards (K08) program is to prepare qualified individuals for careers that have a significant impact on the health-related research needs of the Nation.
4 review criteria on fileMentored Quantitative Research Development Award (Parent K25 Independent Clinical Trial Required)
The purpose of the Mentored Quantitative Research Career Development Award (K25) is to attract to NIH-relevant research those investigators whose quantitative science and engineering research has thus far not been focused primarily on questions of health and disease.
4 review criteria on fileMidcareer Investigator Award in Patient-Oriented Research (Parent K24 Independent Clinical Trial Required)
The purpose of the NIH Midcareer Investigator Award in Patient-Oriented Research (K24) is to provide support to mid-career health-professional doctorates for protected time to devote to patient-oriented research (POR) and to act as research mentors primarily for clinical residents, clinical fellows and/or junior clinical faculty.
4 review criteria on fileNCI Pathway to Independence Award (K99/R00 Clinical Trial Required)
The purpose of the NCI Pathway to Independence Award (K99/R00) program is to facilitate a timely transition of talented postdoctoral researchers with a research and/or clinical doctorate degree from mentored, postdoctoral research positions to independent, tenure-track or equivalent faculty positions.
9 review criteria on fileNIDCD Mentored Career Development Award for Postdoctorate Au.D./Ph.D. Audiologists (K01 Clinical Trial Required)
D.D.
8 review criteria on fileNCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00 - Independent Clinical Trial Required)
The purpose of the NCI Pathway to Independence Award for Early-Stage Postdoctoral Researchers (K99/R00) program is to increase and maintain a strong cohort of new and talented, NCI-supported, independent investigators.
Review criteria on fileINCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)
The INCLUDE Transformative Research Award Program supports collaborative investigative teams or individual scientists who propose unusually innovative research projects, which, if successful, would have a major impact in understanding the biology of Down syndrome or related co-occurring conditions, or development of new treatments for…
3 review criteria on fileFull-Scale Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 - Clinical Trial Required)
Clinical Trials to Test the Effectiveness of Treatment, Preventive, and Services Interventions (R01 Clinical Trial Required). This NOFO is a key element of NIMHs set of NOFOs to support clinical trials research across the intervention development and testing pipeline.
3 review criteria on fileAdvancing Research on Empirically-Supported Interventions for Older Adults Living with Serious Mental Illness (SMI) (R01 Clinical Trial Optional)
Key Definitions for this NOFO: Older adult: For the purposes of this announcement, "older adult" is defined as individuals with SMI who are 50 years of age and older.
3 review criteria on fileEarly Stage Testing of Pharmacologic or Neuromodulatory Device-based Interventions for the Treatment of Mental Disorders (R33- Clinical Trial Required)
NIMH solicits clinical trial applications through a series of notice of funding opportunities (NOFOs) that cover the intervention development pipeline, from first-in-human, early testing of new interventions, confirmatory efficacy trials, through to effectiveness trials.
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