This four-year doctoral position in the Department of Clinical Neuroscience at Karolinska Institute focuses on how activated autophagy affects protein degradation in Alzheimer's disease models. The student will join Pontus Plavén-Sigray's research group, which conducts translational research on ageing and Alzheimer's disease with a focus on drugs that modulate autophagy and mTOR signalling.
The project has three integrated components: examining mechanisms in human neuronal cell cultures, testing findings in mouse Alzheimer's disease models, and analyzing proteomics data from human cerebrospinal fluid samples. Work includes cell culture, rodent drug-treatment studies, tissue analysis, immunohistochemistry, microscopy, and bioinformatic analysis.
Candidates should hold a master's degree and have documented hands-on laboratory experience with rodents and cell culture techniques, with particular emphasis on experience with mTOR inhibitors, Alzheimer's disease models, and CSF sampling procedures.
Text as published by the employer. Always confirm details on the employer's site.