Principal Scientist, Process Development (Expression Systems)
Moderna · Norwood, Massachusetts, United States
About the role
Moderna is hiring a Principal Scientist to own the strategy for E. coli host strain, vector, and expression-system development for recombinant enzymes used in DNA template manufacturing supporting the mRNA medicines platform. Responsibilities include designing screening cascades, optimizing small-scale expression workflows, engineering strains to improve production performance, establishing selection criteria, executing high-throughput screening, and translating findings into scalable manufacturing processes with process development and analytics teams. Requires a PhD with 5+ years (or MS with 10+ years, or BS with 12+ years) of relevant industry experience, E. coli strain engineering expertise, hands-on screening workflow development, and demonstrated project leadership in biotechnology settings.
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