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643 companies · SBIR/STTR awards, last two years

All recently funded science companies in California

Every company in California that closed a federal SBIR/STTR award in the last two years: those with open roles on our board first, then newest award first. Back to the California page

Inversion Space Company

74 open roles on the board

Los Angeles, CA61 employeesDepartment of DefensePhase IIcompany site

“Modular Payload Container for Earth Re-Entry”

$3.6M2 awards

Muon Space Inc

49 open roles on the board

Mountain View, CA240 employeesDepartment of DefensePhase I/IIcompany site

“Adapting Existing Multispectral Scanning Payload for Missile Warning / Missile Track”

$5.1M3 awards

Divergent Technologies Inc

40 open roles on the board

Torrance, CA447 employeesDepartment of DefensePhase I/IIcompany site

“Adaptive Manufacturing to Scale Production and Integration of Third-Party Innovations across the Defense Industrial Base”

$3.6M3 awards

Scout AI Inc.

18 open roles on the board

Sunnyvale, CA21 employeesDepartment of DefensePhase IIcompany site

“Scout AI - Mission Complete Unmanned Ground Vehicle Systems”

$2M

Snorkel AI Inc

16 open roles on the board

Redwood City, CA98 employeesDepartment of DefensePhase IIcompany site

“Revolutionizing Aircraft Survivability Analysis with AI-Driven Data Extraction”

$1.2M

Epirus, Inc

11 open roles on the board

Torrance, CA182 employeesDepartment of DefensePhase Icompany site

“DC Power Controller (DCPC) for Tactical Microgrid”

$250k

Vannevar Labs Inc

9 open roles on the board

Palo Alto, CA207 employeesDepartment of DefensePhase IIcompany site

“NASIC GXK STRATFI Proposal - OCR enabled intelligence”

$4.3M

Arize AI, Inc

7 open roles on the board

Mill Valley, CA90 employeesDepartment of DefensePhase IIcompany site

“Advanced LLM Evaluation and Development Tooling for Strategic USAF AI Integration - AFRL NIPRGPT”

$1.2M

Pulse Biosciences, Inc.

6 open roles on the board

Hayward, CA51 employeesDepartment of Health and Human ServicesPhase Icompany site

“Minimally invasive pancreatic cancer treatment combining nanosecond electric pulses and immune system stimulants”

$303k

Samara Aerospace, Inc.

6 open roles on the board

San Francisco, CA9 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Active Spacecraft Jitter Cancellation Using Deployable Panels”

$150k

Anello Photonics Inc

6 open roles on the board

Santa Clara, CA23 employeesDepartment of DefensePhase IIcompany site

“NAVAIR Open Topic for Logistics in a Contested Environment”

$988k

Momentus Space LLC

6 open roles on the board

San Jose, CA81 employeesDepartment of DefensePhase IIcompany site

“Low Cost Multispectral RPO Sensor Suite”

$1.9M

Elroy Air Inc

5 open roles on the board

Byron, CA60 employeesDepartment of DefensePhase IIcompany site

“Chaparral Airdrop Capability Development”

$1.9M

Virtualitics Inc

4 open roles on the board

Pasadena, CA85 employeesDepartment of DefensePhase IIcompany site

“Generating Optimized RSP Loading Plans using modern AI-based Constraint Solvers”

$3.6M2 awards

Swift Solar Inc

3 open roles on the board

San Carlos, CA38 employeesDepartment of DefensePhase IIcompany site

“Precursor Impurity Control for Stable Perovskite Tandem Photovoltaic Modules”

$1.4M

Noctrix Health

2 open roles on the board

Pleasanton, CA72 employeesDepartment of Health and Human ServicesPhase II

“Developing closed-loop tonic motor activation therapy for treatment of refractory restless legs syndrome”

$516k

Oblate Optics Inc

San Diego, CA2 employeesDepartment of DefensePhase I/II

“Inverse-designed lightweight, planar focus lenses for Vis to LWIR hyperspectral imaging”

$2.0M2 awards

Intellisense Systems Inc

Torrance, CA140 employeesDepartment of Defense, Department of Homeland Security, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Tethered Robot for Coating Application and Inspection”

$28.8M51 awards

Aimdyn, Inc.

Santa Barbara, CA22 employeesDepartment of DefensePhase IIwoman-ownedcompany site

“Koopman Operator-Based Rapid Adjudication of Federated COA's (KOBRA)”

$1.8M

Spectral Labs Incorporated

San Diego, CA25 employeesDepartment of Defense, Department of Health and Human ServicesPhase I/IIcompany site

“Advanced Wearable Integration and Synchronization Hub (AWISH)”

$1.1M2 awards

Toyon Research Corporation

Goleta, CA275 employeesDepartment of Defense, Department of Homeland SecurityPhase I/IIcompany site

“Advanced Modeling and Evaluation of Air Combat Autonomy”

$21.8M32 awards

Lineaje Inc.

Saratoga, CA30 employeesDepartment of DefensePhase I/IIcompany site

“Trusted OSS Analysis and TTP Automation for Secure Software Enclaves”

$1.9M2 awards

Machina Cognita Technologies, Inc.

Carlsbad, CA23 employeesDepartment of DefensePhase I/IIcompany site

“Natural-language Ontologies for battlespace Visualizations and Analytics (NOVA)”

$2.4M6 awards

Thoughtforge Inc.

Berkeley, CA5 employeesDepartment of DefensePhase IIcompany site

“SLITHER: Snake-Like Inspection Technology for Hazardous and Enclosed Regions”

$1.2M

Perceptronics Solutions, Inc

Sherman Oaks, CA35 employeesDepartment of DefensePhase I/IIcompany site

“Automated Intelligence Preparation of the Battlespace from Open-Source Information (AutoIPB)”

$5.9M5 awards

Datashapes, Inc.

San Rafael, CA3 employeesDepartment of DefensePhase Icompany site

“Modular, Optimized Real-time Processing Harness for Edge-Unit Schedulers (MORPHEUS)”

$140k

Inferlink Corp

El Segundo, CA24 employeesDepartment of DefensePhase I/IIcompany site

“GENESIS: Generative AI for Educational Systems and Instructional Support”

$2.1M5 awards

Fenix Research Corporation

Palo Alto, CA6 employeesDepartment of DefensePhase I

“Off-Axis Laser Detector”

$140k

Atac

Santa Clara, CA63 employeesDepartment of DefensePhase Icompany site

“High-Resolution Environmental Forecasting Through Advanced ML Downscaling Techniques”

$140k

Alphastar Technology Solutions

Irvine, CA12 employeesDepartment of DefensePhase Iwoman-ownedcompany site

“A Hybrid Digital Twin Framework for Modeling Machine Process Parameters for Automated Fiber Placement-based Manufacturing of Composite Struc”

$140k

Stottler Henke Associates, Inc

San Mateo, CA60 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Text-and-Image-Conditioned content GENeration (TICGEN)”

$6.4M9 awards

Lucidean, Inc

Goleta, CA8 employeesDepartment of DefensePhase I/II

“Fiber-optic Avionic Low-SWaP-C Coherent Optical Network (FALCON)”

$1.4M2 awards

Fantastic Data LLC

San Francisco, CA2 employeesDepartment of DefensePhase I

“Intelligent Radio Access Network for Beyond 5G Resilient Tactical Networks”

$240k

American Lithium Energy Corp.

Vista, CA70 employeesDepartment of DefensePhase I/IIcompany site

“Development of Safe, Robust, Sodium-Ion Battery for Naval Aviation Using Domestically Made Inexpensive Raw Materials”

$8.2M3 awards

Systems Technology, Inc

Hawthorne, CA26 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase Icompany site

“State and Trajectory Optimization for Real-time Range Extension (STORRE)”

$810k5 awards

Nextgen Aeronautics, Inc.

Torrance, CA18 employeesDepartment of DefensePhase I/IIcompany site

“Optimized Novel Multifunctional Composite Sandwich Structures”

$2.0M2 awards

Dstar Communications

Woodland Hills, CA2 employeesDepartment of DefensePhase Icompany site

“Multimode Bragg Grating Multiplexer (MBG MUX)”

$240k

M4 Engineering, Inc.

Long Beach, CA35 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Hypersonic Computational Fluid Dynamics Heat Flux Sub-Models”

$1.4M4 awards

Apsidal LLC

Riverside, CA6 employeesDepartment of DefensePhase IIcompany site

“Low-Dispersion Ultrahigh-Bandwidth Microstructured Photonic Fibers for Avionics Networks and Sensors”

$5.2M3 awards

Abram Scientific Inc

South San Francisco, CA4 employeesDepartment of DefensePhase II

“CoagCare: Novel Miniaturized Handheld Thromboelastographic Platform for Rapid Assessment of Coagulopathy and Resuscitation Management of War”

$2.0M

TopoLight, Inc.

Berkeley, CA2 employeesNational Science FoundationPhase Icompany site

“SBIR Phase I: High-Power, Surface-Emitting, Single-Mode Laser Chips with Photonics Crystal Cavity Design”

$305k

Highri Optics, Inc.

Oakland, CA5 employeesDepartment of Commerce, National Aeronautics and Space AdministrationPhase I/IIwoman-ownedcompany site

“BINARY PSEUDO RANDOM ARRAY (BPRA) FOR THE ENHANCEMENT OF OPTICAL IMAGERS”

$549k2 awards

Coolaimate, Inc

Pasadena, CA2 employeesNational Science FoundationPhase Icompany site

“SBIR Phase I: Silicon photonics tunable laser for analyzing energy content of natural gas”

$305k

Cosine Corp.

Stanford, CA1 employeeNational Science FoundationPhase I

“SBIR Phase I: Electrified Thermochemical Biogas Reforming for Hydrocarbon Fuel Production”

$305k

PeraWatt Energy Inc.

Richmond, CA2 employeesNational Science FoundationPhase I

“STTR Phase I: Scalable Soft Magnetic Composite for High-Frequency Power Electronics”

$305k

Krokos Bio Inc

Davis, CA0 employeesNational Science FoundationPhase I

“SBIR Phase I: A Method for Domestic Production of Saffron, Utilizing Novel Plant Cell Culture Techniques for Cell Adhesion and Immobilizatio”

$305k

Yolo Immune Inc

San Carlos, CA4 employeesNational Science FoundationPhase I

“SBIR Phase I: Novel Immuno-therapy for Specific Depletion of IgG4 Subtype of Autoantibodies”

$305k

Sensate Robotics Inc.

Los Angeles, CA3 employeesNational Aeronautics and Space Administration, National Science FoundationPhase Icompany site

“SBIR Phase I: Tactile-enabled Robotic Quality Control Cell”

$461k2 awards

Sorcerer Corporation

San Francisco, CA3 employeesNational Science FoundationPhase I

“SBIR Phase I: Constellation of Small, High-Altitude Balloons for Atmospheric Data Collection”

$305k

Vellex Computing Inc

San Luis Obispo, CA6 employeesNational Science FoundationPhase Icompany site

“SBIR Phase I: An Analog Hardware Accelerator for Power Systems Feasibility Studies”

$305k

Objectsecurity LLC

San Diego, CA12 employeesDepartment of Commerce, Department of DefensePhase I/IIcompany site

“Operational Technology Artificial Intelligence - NIST Compliance Tool (OTAI-NCT)”

$2.4M3 awards

Toro Bio, inc.

Redwood city, CA1 employeeNational Science FoundationPhase Icompany site

“SBIR Phase I: Automated System for Point of Care Manufacture of Tumor Infiltrating Lymphocytes Cell Therapies”

$305k

Infinion Technology, Inc.

Stanford, CA2 employeesNational Science FoundationPhase I

“STTR Phase I: Improving the reliability of the United States' energy grid by predicting transformer failures”

$305k

Yona Care

San Francisco, CA1 employeeDepartment of Health and Human Services, National Science FoundationPhase Iwoman-ownedcompany site

“SBIR Phase I: Novel Gynecological Speculum Instrument for Decreased Patient Pain and Enhanced Provider Functionality”

$575k2 awards

Folde' Inc.

Pleasanton, CA11 employeesNational Science FoundationPhase I

“SBIR Phase I: A Novel Device for Difficult Urethral Catheterization”

$303k

Electroflow Technologies, Inc.

Burlingame, CA8 employeesNational Science FoundationPhase Icompany site

“SBIR Phase I: Assessing and Improving Membrane Stability to Enable Sustainable Lithium Chemical Production”

$305k

Recon RF, Inc.

San Diego, CA15 employeesDepartment of Defense, Department of EnergyPhase IIcompany site

“Advanced Semiconductor Production of Next-Gen X-Band SSPAs for USAF Radar, EW, & Comms”

$4.0M3 awards

Ata Engineering, Inc.

San Diego, CA232 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“A Machine Learning-Accelerated Framework for Lethality Assessment of Directed Energy Engagements of Hypersonic Threats”

$4.9M5 awards

Seacoast Science, Inc.

Carlsbad, CA9 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Auto-calibrating, Air Quality Monitoring System”

$542k

Vector Atomic Inc

Pleasanton, CA69 employeesDepartment of DefensePhase IIcompany site

“Iodine Clock with Acceleration- and Radiation-tolerance for Use in Space (ICARUS)”

$12.6M5 awards

Chromologic LLC

Monrovia, CA35 employeesDepartment of Defense, Department of Health and Human ServicesPhase I/IIcompany site

“Wearable Heat Related Injury Risk Analysis (WHERA) system Resubmission”

$4.4M5 awards

Umbra Lab, Inc

Santa Barbara, CA135 employeesDepartment of DefensePhase IIcompany site

“CRAZY TRAIN”

$65.1M5 awards

Molecular Instruments, Inc.

Los Angeles, CA35 employeesDepartment of Health and Human ServicesPhase Icompany site

“Advancing Probe Technology for Ultrasensitive RNA Imaging via Hybridization Chain Reaction”

$307k

Xr Navigation Inc

Gilroy, CA4 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Developing and Evaluating Visual, Auditory, and Tactile and Text Digital Thematic Map Viewer to Provide Blind and Low Vision Individuals Ful”

$1.0M

Kouros Sariri

Huntington Beach, CA34 employeesNational Aeronautics and Space AdministrationPhase I

“-200°C Rad hard Cold Capable Thermally multiplexed controller”

$150k

Metrolaser, Incorporated

Laguna Hills, CA14 employeesDepartment of Defense, Department of Energy, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Stand-off Detection of Xenon Spin Polarization by Radar REMPI”

$5.6M6 awards

Cyan Systems, Inc.

Santa Barbara, CA10 employeesDepartment of DefensePhase IIcompany site

“High Dynamic Range Broadband Adaptive Sensor System”

$1.8M

NeoVascularX, Inc.

Palo Alto, CA1 employeeDepartment of Health and Human ServicesPhase I

“Topical Ophthalmic Treatment for Neovascular Age-related Macular Degeneration (nAMD)”

$305k

Atombeam Technologies Inc.

Moraga, CA7 employeesDepartment of DefensePhase IIcompany site

“Effective Compaction of Satellite Transmission to Maximize Bandwidth and Data Security”

$2.0M

Interlink Electronics, Inc

Irvine, CA82 employeesDepartment of Health and Human Services, National Aeronautics and Space AdministrationPhase Icompany site

“Innovative Amperometric Gas Sensors for Monitoring Post-Harvest Food Quality and Safety”

$631k3 awards

Opto-Knowledge Systems Inc

Torrance, CA66 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Optical probe for static pressure measurements in vitiated flows for ground test facilities”

$10.6M9 awards

Symplectic Engineering Corp

Berkeley, CA1 employeeDepartment of DefensePhase IIcompany site

“High Temperature Fracture”

$2M

Thinkom Solutions, Inc.

Hawthorne, CA178 employeesDepartment of DefensePhase IIcompany site

“Transportable, Flexible, Digital Array Ground Station”

$1.9M

T3W Business Solutions, Inc.

San Diego, CA140 employeesDepartment of DefensePhase IIwoman-ownedcompany site

“MedScribe Defense - Generative Artificial Intelligence (GenAI) Ambient Medical Scribe Supporting Air Force Medical Readiness Exams and Scree”

$1.2M

Opal AI Inc

Los Angeles, CA8 employeesDepartment of Transportation, National Aeronautics and Space AdministrationPhase I/IIcompany site

“FireVision: An AI-Powered Decision-Support Platform Leveraging NASA Earth Science Data for Wildfire Risk, Mitigation, and Response”

$1.3M3 awards

Contextual AI, Inc.

Mountain View, CA32 employeesDepartment of DefensePhase I

“RAG 2.0: Gen AI in Advanced Supply Chain Analytics”

$191k

Radiabeam Systems, LLC

Santa Monica, CA12 employeesDepartment of EnergyPhase Icompany site

“Multi-beam accelerator system for mobile food irradiation applications”

$400k2 awards

Eysz, Inc.

Berkeley, CA1 employeeDepartment of Health and Human ServicesPhase Iwoman-owned

“Detecting Absence Seizures Using Hyperventilation In a Home Environment”

$545k

Wavefront Technology, Inc

Paramount, CA35 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Diamond Turning High Aspect Ratio Mandrels for X-ray Mirror Manufacturing”

$150k

Der Security Corp

Scotts Valley, CA9 employeesDepartment of EnergyPhase Icompany site

“UNsupervised Learning for DER (UNDER): Detecting Power System Attacks Using Machine Learning and Digital Twins”

$200k

Phase Iii Physics LLC

Los Angeles, CA6 employeesDepartment of Energy, National Aeronautics and Space AdministrationPhase I/IIcompany site

“A Spiking Neuromorphic Analytics Platform (SNAP) for Photomultiplier Signal Processing”

$1.9M5 awards

Trex Enterprises Corporation

El Cajon, CA19 employeesDepartment of DefensePhase IIcompany site

“Metalens Solar Compass (MLSC)”

$2.0M

Syntr Health Technologies, Inc

Irvine, CA3 employeesDepartment of Health and Human ServicesPhase I/IIcompany site

“Device Automation of an FDA-cleared CD-Microfluidic Platform for Rapid Tissue Microsizing”

$1.8M3 awards

Rangeview Inc.

El Segundo, CA8 employeesDepartment of DefensePhase IIcompany site

“Advanced Digital Investment Casting Technology for High-Precision, Low-Cost Turbine Components”

$1.4M

Opterro, Inc.

Milpitas, CA10 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Robust Highly-Multiplexed Fiber Optic Sensor Array for Cryogenic Fluid Management”

$156k

Karagozian & Case, Inc.

Glendale, CA47 employeesDepartment of DefensePhase Icompany site

“BDAM: A Blast Dose Accumulation Methodology for Heavy Weapon Firing in Actual Combat Scenarios”

$400k2 awards

AnySignal, Inc.

El Segundo, CA8 employeesDepartment of DefensePhase IIcompany site

“RAIDEN: A Resilient, Agile, and Interference-Defiant Network for Secure MILSATCOM”

$1.9M

Open Sesame Media, Inc

Marina Del Rey, CA12 employeesDepartment of DefensePhase IIcompany site

“SyncPath - Ultra low-latency resilient multipath communication protocol in contested environments over MILSATCOM only and hybrid SATCOM arch”

$1.9M

Cambridge Terahertz Inc

Santa Clara, CA8 employeesDepartment of Defense, National Science FoundationPhase II

“Sub-THz Reflectarrays: An Alternative Architecture for Enhanced Array Scaling with 3D Heterogeneous Integration for DoD ELGAR Use Cases”

$2.7M2 awards

Eitr Biologics, Inc.

San Diego, CA2 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Multidimensional antibody engineering to enhance the potency and breadth of a betacoronavirus medical countermeasure”

$1M

Pyka Inc.

Alameda, CA69 employeesDepartment of DefensePhase II

“Airdrop-Capable Hybrid Group 4 UAS for Contested Logistics: Enabling ACE for the DAF”

$1.2M

Firestorm Labs, Inc.

San Diego, CA112 employeesDepartment of DefensePhase I/IIcompany site

“FIRESTORM EXPEDITIONAIRY MANUFACTURING CELL (xCell) AND MANUFACTURED HARDWARE”

$2.4M3 awards

Shasqi, Inc.

San Francisco, CA4 employeesDepartment of Health and Human ServicesPhase II

“CEACAM5-targeted activation of potent chemotherapeutics via bioorthogonal click chemistry”

$1.1M

Mainsquare Co

San Francisco, CA2 employeesDepartment of Health and Human ServicesPhase IIwoman-owned

“Engagement and clinical impact of the Teleo virtual therapy platform in clinical settings”

$1.2M

Vena Vitals Inc

Irvine, CA2 employeesDepartment of Health and Human ServicesPhase Iwoman-owned

“Continuous Non-Invasive Blood Pressure during Sleep as a Cardiovascular Biomarker”

$307k

Mapp Biopharmaceutical, Inc.

San Diego, CA70 employeesDepartment of Health and Human ServicesPhase I/IIcompany site

“Development of highly potent human monoclonal for RSV immunoprophylaxis”

$1.3M2 awards

Metrosage LLC

Volcano, CA2 employeesDepartment of DefensePhase IIcompany site

“Enabling Digital Metrology and Manufacturing Through the Model-Based Enterprise”

$1.2M

Antares Nuclear, Inc.

Torrance, CA100 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/II

“High Temperature Radiator Coating”

$1.4M2 awards

Hop Aero, Inc.

Orange, CA6 employeesDepartment of DefensePhase II

“ROOK: Rapid Operations Over Kilometers”

$1.2M

Paramita Therapeutics, Inc.

San Diego, CA5 employeesDepartment of Health and Human ServicesPhase Icompany site

“Novel multivalent PSMA-targeted taxane-conjugates for bone metastases in prostate cancer”

$353k

Mimyr, LLC

Torrance, CA8 employeesDepartment of DefensePhase I/IIcompany site

“Briefing and Onboard Data Enhancement for Pilot Vehicle Interface (BODENPVI)”

$2.0M2 awards

Orpro Therapeutics Inc

San Diego, CA3 employeesDepartment of Health and Human ServicesPhase I

“Engineered Monothiol Thioredoxin for Treatment of Radiation Induced Lung Injury”

$509k

Neonc Technologies Inc

Los Angeles, CA3 employeesDepartment of Health and Human ServicesPhase I/IIcompany site

“Developing a Clinically Relevant Radiosensitizer for Temozolomide-resistant Gliomas”

$1.4M2 awards

Dynovas Inc

Poway, CA51 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Dynovas Advanced Pressure Resin Transfer Molding (DAP-RTM) for Large Three Dimensional Woven Preforms”

$6.0M10 awards

Arris Composites, Inc.

Berkeley, CA40 employeesDepartment of DefensePhase IIcompany site

“Continuous-Fiber & Long-Fiber Thermoplastic Composite Molding for Aerospace Structures”

$1.1M

Exploration Technology Group Corp

San Francisco, CA4 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“High-Test Peroxide Generation System for Scalable In-Situ Monopropellant Production from Lunar Water and Oxygen”

$149k

Arinna, Inc

South San Francisco, CA8 employeesNational Aeronautics and Space Administration, National Science FoundationPhase Icompany site

“Extremely power-dense solar for the extremes of space”

$455k2 awards

Opto-Atomics Corp

San Pedro, CA4 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Sodium Excitation Laser for Mesospheric Analysis”

$2.1M4 awards

Viridian Space Corporation

El Segundo, CA8 employeesDepartment of DefensePhase I/IIcompany site

“Resilient VLEO Operations with an Air Scooping Electric Thruster”

$3.0M3 awards

Cosmic Robotics, Inc.

San Francisco, CA8 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Cosmic-XT, A Truss-Traversing General-Purpose Outfitting Robot”

$150k

Exquadrum Inc

Victorville, CA73 employeesDepartment of DefensePhase I/IIcompany site

“ULTRA-VK Exoatmospheric Flight Test”

$5.2M3 awards

Rarefied Biosciences, Inc.

Santa Monica, CA1 employeeDepartment of Health and Human ServicesPhase I

“Testing MALT1 inhibitors as a treatment for the rare pediatric inborn error of immunity CARD11 gain of function”

$313k

Empowerx, Inc.

Del Mar, CA10 employeesDepartment of Health and Human ServicesPhase Iwoman-owned

“PEP/PrEP via Pharmacist-Prescribing Implementation (PEPPI)”

$243k

Saaz Micro, Inc.

Camarillo, CA45 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“UNHIDES - Uncover Nimble Hypersonic objects by Imaging in Dual-band Event-based Sensing”

$7.1M6 awards

Novomedix LLC

San Diego, CA5 employeesDepartment of Health and Human ServicesPhase I/IIwoman-ownedcompany site

“Arthrofibrosis control using small molecule inhibitors of interleukin-11”

$3.3M2 awards

Amira Health Inc.

South San Francisco, CA4 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“Validating Terra, a device for closed-loop hot-flash cooling relief and sleep improvement”

$277k

Sinopia Biosciences Inc

San Diego, CA4 employeesDepartment of Health and Human ServicesPhase Icompany site

“Development of a metabolomics enabled AI/ML platform for discovery of new treatments to enhance drug sensitivity in cancer”

$636k2 awards

Trl11 Inc

Irvine, CA20 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“MoonCast: Space-Rated Codec for Ultra-Low Delay, True Color Capture Lunar Broadcasting T8.08 Lunar Imagery”

$2.8M4 awards

Intelligent Fiber Optic Systems Corp

Fremont, CA22 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Photonically Sensorized Robotic Subsurface Sampling System”

$4.4M6 awards

Nest Health Tech Inc.

Albany, CA9 employeesDepartment of Health and Human ServicesPhase I/IIcompany site

“CARDIAC CASCADE: Cardiomyopathy and Arrhythmia Risk Dissemination through Innovative Family Sharing”

$1.4M2 awards

Translucence Biosystems, Inc.

Irvine, CA10 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Brain-Wide Quantification of Blood-Brain Barrier Penetrating Antibody Therapeutics”

$1.4M

Panorama Research Incorporated

Sunnyvale, CA15 employeesDepartment of Health and Human ServicesPhase I

“Novel Therapy for Sarcopenia”

$354k

Storii, Inc.

San Mateo, CA14 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Strengthening Bonds: A Telephone Reminiscence Intervention to Reduce Social Isolation and Improve Mental Health in Rural Older Adults”

$818k

Jaan Biotherapeutics LLC

San Diego, CA1 employeeDepartment of Health and Human ServicesPhase IIwoman-owned

“Heart Muscle Regeneration”

$1.3M

One Health Studio LLC

San Francisco, CA0 employeesDepartment of Health and Human ServicesPhase I

“Flourish All: Women's Integrated Stress Reduction for Alzheimer's Risk Prevention Using Digital Tools and Biomarker Monitoring”

$474k

Hido Technologies, Inc

El Dorado Hills, CA5 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Behavioral Shifts in Dementia Patients Using Novel Pharmacy Home Robotics: A Cost-Effective Approach to Aging in Place”

$1.2M

Dabble Health

Newark, CA1 employeeDepartment of Health and Human ServicesPhase I

“Ecological Cognitive Monitoring through AI-Enhanced Personal Photo Activities”

$500k

Aivocode, Inc.

San Diego, CA3 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Single domain antibody development for improving vascular dysfunction in Alzheimer’s disease”

$1.2M

Cellsight Technologies, Inc.

San Francisco, CA5 employeesDepartment of Health and Human ServicesPhase IIwoman-ownedcompany site

“Imaging intracerebral and systemic T cell immunity in patients with Alzheimer's disease using 18F-F-AraG”

$871k

Friendi.fi Corporation

Millbrae, CA0 employeesDepartment of Health and Human ServicesPhase II

“Implementing and Scaling the STEADI Fall Prevention Algorithm Using a Conversational Relational Agent for Community-Dwelling Older Adults wi”

$916k

Active Motif, Inc.

Carlsbad, CA62 employeesDepartment of Health and Human ServicesPhase Icompany site

“A Novel Epigenetic Editing Platform”

$306k

Photozig Inc

Campbell, CA8 employeesDepartment of Health and Human ServicesPhase Icompany site

“CaringGPT: Empowering Dementia Caregivers with Personalized and Accessible Resources to Match Their Needs, Enhance Cope with Caregiving, and”

$500k

S-3 Research LLC

San Diego, CA8 employeesDepartment of Health and Human ServicesPhase Icompany site

“Co-designing a mobile tool to improve diversity and inclusivity in AD/ADRD trial participation”

$500k

Posit Science Corp

San Francisco, CA32 employeesDepartment of Health and Human ServicesPhase II

“Improving Neurological Health with Acetylcholine via Neuroplasticity-based Computerized Exercise in Mild Cognitive Impairment (INHANCE-MCI)”

$1.0M

Reelin Therapeutics, Inc.

San Diego, CA3 employeesDepartment of Health and Human ServicesPhase I

“Identification of next generation gamma-secretase modulators for Alzheimer's disease”

$258k

Intelligent Optical Systems, Inc.

Gardena, CA17 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Laser Ultrasonic Testing for In-Space Welding Environments”

$313k2 awards

Glycyx Mor, Inc.

San Francisco, CA3 employeesDepartment of Health and Human ServicesPhase IIcompany site

“A Phase 2 Trial of Axelopran Plus Pembrolizumab for the First-Line Treatment of Recurrent/Metastatic HNSCC That Is PD-L1 Positive (PD-L1CPS ”

$1.2M

Makel Engineering, Inc.

Chico, CA17 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“High Pressure, In-Situ Hydrogen Sensor For Space Based Regenerative Fuel Cell Systems”

$150k

Savage Medical Inc.

Belmont, CA4 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Safety and Efficacy Trial of the ColoSeal ICD System for the Treatment of Diverticular Disease Patients”

$1.2M

Ep Analytics, Inc..

San Diego, CA2 employeesDepartment of DefensePhase Iwoman-ownedcompany site

“EP-SOA: A Framework to Enable Transition of High-Fidelity Codes to Heterogeneous Computing Environments”

$200k

L'garde, Inc.

Tustin, CA19 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Bolt-On Capture Detumble Deorbit Device”

$150k

FleX Orthopaedics, Inc.

Agoura Hills, CA5 employeesDepartment of Health and Human ServicesPhase I

“A Compliant Intramedullary Stem to Increase Longevity of Revision Total Knee Arthroplasty”

$307k

AeroCytek, Inc

San Diego, CA4 employeesDepartment of Health and Human ServicesPhase Icompany site

“Point-of-care autologous CAR-T cell manufacturing”

$400k

Ultramet

Pacoima, CA57 employeesDepartment of Defense, Department of Energy, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Thin, Flexible Oxidation-Resistant Coatings for 3D-Woven Carbon Fabric TPS Materials”

$4.2M8 awards

Torrey Pines Logic, Inc.

San Diego, CA24 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Long Range LiDAR (LR-LiDAR)”

$2.2M3 awards

Phase Four, Inc.

Hawthorne, CA30 employeesDepartment of DefensePhase IIcompany site

“Flight Development of an ASCENT Propellant Decomposition Chamber”

$1.8M

Navega Therapeutics, Inc.

San Diego, CA5 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“Reformulating NT-Z001 and its delivery route to treat rheumatoid arthritis”

$297k

Astrileux Corporation

Carlsbad, CA1 employeeNational Aeronautics and Space AdministrationPhase Iwoman-owned

“The Blueprint for Generative AI chips manufactured on the ISS”

$150k

Malama Health, Inc.

Stanford, CA3 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“A Specialized Risk-Stratification Platform and Tailored Diabetes Prevention Program for Post-Partum to Reduce Progression to Type 2 Diabetes”

$314k

Orbotic Systems Inc

Thousand Oaks, CA6 employeesNational Aeronautics and Space AdministrationPhase IIcompany site

“RIDDANCE: Removal of Irregular Debris using Double Assisted Nets with Controlled Enhancement”

$900k

Neuralthread Inc

San Francisco, CA6 employeesDepartment of Health and Human ServicesPhase IIcompany site

“TulleKit: Integrated Deep Brain Neural Recording System for Non-Human Primate Models”

$981k

Orbitswarm Inc.

San Francisco, CA3 employeesDepartment of DefensePhase I

“Spatial-Temporal Reservoir Inference with Knowledge-based Enhancements (STRIKE)”

$250k

Behzadi LLC

Stevenson Ranch, CA2 employeesNational Aeronautics and Space AdministrationPhase Iwoman-ownedcompany site

“High Dynamic Range Force Torque Sensor”

$142k

Arete Associates

Northridge, CA464 employeesDepartment of DefensePhase I/IIcompany site

“Acoustic Training Data”

$16.5M20 awards

Zero Cognitive Systems, Inc.

Campbell, CA27 employeesDepartment of DefensePhase Icompany site

“HerculesAI: Fast, Reliable, and Secure AI-powered Data Solutions to Automate DoD Workflows”

$149k

Integrated Medical Sensors

Irvine, CA5 employeesDepartment of Health and Human ServicesPhase Icompany site

“A Miniaturized and Flexible Continuous Glucose Monitoring Platform”

$560k2 awards

Health Tequity LLC

Oakland, CA4 employeesDepartment of Health and Human ServicesPhase Iwoman-owned

“ACTIVATE: An AI-Enabled Multilingual Platform for Connected and Accessible Care Coordination and Remote Monitoring.”

$385k

ANTA Biotechnologies Corporation

San Diego, CA3 employeesNational Aeronautics and Space Administration, National Science FoundationPhase I/IIwoman-owned

“Automated DNA Extraction in Space”

$1.4M2 awards

Angstrom Designs Inc

Santa Barbara, CA6 employeesDepartment of DefensePhase IIcompany site

“Photovoltaic Thermal Runaway Test Capability for Advanced Space Solar Cells”

$1.2M

Vaxiion Therapeutics Inc

San Diego, CADepartment of Health and Human ServicesPhase I

“Preclinical development of VAX024 - a novel targeted combination STING agonist/oncolytic agent”

$306k

Eclipse Regenesis, Inc.

Mountain View, CA3 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Outcomes study for the XL1 distraction enterogenesis device to improve nutrient absorption in short bowel syndrome patients”

$857k

EpiTune

San Diego, CA1 employeeDepartment of Health and Human ServicesPhase I

“Novel imaging-based platform for cell quality and identity control”

$350k

Milanowski & Associates, Inc.

San Diego, CA3 employeesDepartment of DefensePhase IIcompany site

“Radiation-Induced Upset Circumvention & Recovery in Modern Electronics Systems”

$1.2M

Eivie

Watsonville, CA9 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“The Annular-Wing VTOL Aircraft”

$150k

Advanced Brain Monitoring, Inc.

Carlsbad, CA44 employeesDepartment of Health and Human ServicesPhase Icompany site

“Characterizing neurocognitive deficits in post-acute sequelae of COVID-19”

$326k

Telemetrak Inc

Oakland, CA3 employeesDepartment of DefensePhase I/IIcompany site

“New Integrated MilSpec ATC Predictive Tool Replacement Toolbox Running Off Central Computer”

$5.0M4 awards

Novoron Bioscience Inc

San Diego, CA11 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Human iPSC neural spheroids to screen for compounds that block tau propagation”

$1.3M

Satlyt

Sunnyvale, CA3 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Autonomous QoS Optimization for Delay-Tolerant Mobile Edge Cloud and Content Delivery”

$150k

Rybodyn, Inc.

San Diego, CA7 employeesDepartment of Health and Human ServicesPhase Icompany site

“A novel spatial biology platform for protein profiling which is cost effective and scalable”

$307k

Outpost Technologies Corp

Los Angeles, CA30 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Autonomous Paragliders for Martian Landings”

$19.9M4 awards

Claria Medical, Inc

Mountain View, CA7 employeesDepartment of Health and Human ServicesPhase IIcompany site

“A Safe, Fast, and Cost-Effective System for Tissue Removal in Laparoscopic Hysterectomy and Other Minimally Invasive Surgery”

$2.1M

Blue Marble Rehab Inc

Altadena, CA10 employeesDepartment of Health and Human ServicesPhase IIwoman-ownedcompany site

“BREATHE-BRinging Exercise, Asthma Assessments, TeacHing to Everyone”

$1.1M

Ecotune, Inc.

Irvine, CA1 employeeNational Science FoundationPhase IIwoman-owned

“SBIR Phase II: Scalable Development of Fully Bio-Based and High-Performance Bio-Inspired Materials”

$1.2M

Navigateio Inc.

Santa Rosa, CA5 employeesNational Aeronautics and Space AdministrationPhase I

“Secure Wireless Data Collection for First Responders Using Uncrewed Aircraft Systems”

$156k

Predictive Science Incorporated

San Diego, CA16 employeesNational Aeronautics and Space AdministrationPhase I/IIcompany site

“Improved Probabilistic Forecasts of Solar Energetic Particles with MagPy”

$999k2 awards

American Gnc Corp

Simi Valley, CA6 employeesNational Aeronautics and Space AdministrationPhase Iwoman-ownedcompany site

“Robust System Fault Classification & Detection System (RobustDetect)”

$150k

Ceiba Bio Inc.

San Diego, CA2 employeesDepartment of Health and Human ServicesPhase Iwoman-owned

“Development of Platelet-Derived Exercise Mimetics as a Treatment for Alzheimer's Disease and Alzhimer's Disease Related Dementias”

$506k

Immunowork LLC

Monrovia, CA2 employeesDepartment of Health and Human ServicesPhase Iwoman-owned

“Quantifying peripheral blood antigen-specific memory B cells as a new biomarker in patients with PLA2R-associated membranous nephropathy”

$305k

Maguro Surgical Inc

Redwood City, CA6 employeesDepartment of Health and Human ServicesPhase Iwoman-owned

“Developing a magnetic system for endoscopic retrieval of kidney stones”

$305k

Takeoff41, Inc.

Portola Valley, CA3 employeesDepartment of Health and Human ServicesPhase IIcompany site

“An AI-driven total parenteral nutrition platform for cost-effective and scientifically personalized nutrition for premature newborns”

$1.1M

Livivos Inc.

San Diego, CA1 employeeDepartment of Health and Human ServicesPhase IIcompany site

“Accurate Point of Care Liver Disease Diagnostics, Phase II”

$947k

PHusis Therapeutics Inc

San Diego, CA4 employeesDepartment of Health and Human ServicesPhase IIwoman-owned

“Clinical evaluation of a novel AKT/PDK1 inhibitor, PHT-427, for the treatment of multi-field actinitc keratoses”

$2.1M

Gigamune, Inc.

San Francisco, CA3 employeesDepartment of Health and Human ServicesPhase Icompany site

“A Novel Lentivector for Enhanced In Vivo Delivery of T Cell Receptors for Cell Therapy for Stage IV Melanoma”

$400k

Berendo Scientific LLC

Los Angeles, CA1 employeeDepartment of Health and Human ServicesPhase I

“SleepFlex head and neck exercise program for the treatment of mild to moderate obstructive sleep apnea”

$584k

Biosettia Inc

San Diego, CA6 employeesDepartment of Health and Human ServicesPhase I

“Targeting endogenous retrovirus Gag genes for biomarker development in type 1 diabetes”

$292k

Snj Pharma Inc.

Torrance, CA2 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“Novel Plasmin-independent Thrombolytic Agent for Pulmonary Embolism”

$500k

Ampa Inc.

San Diego, CA4 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Validation of next-generation TMS system optimizing for widely scalable, personalized treatment of depression”

$1.2M

Aust Development, LLC

Mountain View, CA0 employeesDepartment of Health and Human ServicesPhase I

“Precision Lead Delivery for Advanced Conduction System Pacing”

$313k

Redwood Neuro Inc

Irvine, CA3 employeesDepartment of Health and Human ServicesPhase Icompany site

“Democratizing Early Detection and Longitudinal Monitoring of Alzheimer's Disease: An Ultra-Sensitive Blood-Based Assay”

$506k

Vis Viva Space LLC

Ventura, CA2 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Campaign Modeling with Data-Oriented Modeling Architectures”

$149k

Evoloh, Inc.

Palo Alto, CA8 employeesNational Science FoundationPhase II

“SBIR Phase II: Advanced Anodes for Anion Exchange Membrane Water Electrolyzers”

$1.2M

Unstructured Technologies, Inc

Loomis, CA60 employeesDepartment of DefensePhase I/IIcompany site

“Unlocking the Power of Unstructured Data: Delivering the RAG-Ready Data Layer for DoD Generative AI Applications”

$3.1M3 awards

Cogni Trax

Santa Clara, CA0 employeesNational Science FoundationPhase II

“SBIR Phase II: High Efficiency, Low Cost Catadioptric Waveguide and Display Optical Engine for Augmented Reality Smart Glasses using Spatial”

$1.2M

Shoonya Digital, Inc

Goleta, CA4 employeesDepartment of EducationPhase Iwoman-ownedcompany site

“Building Math Literacy Confidence for Early Multilingual Learners: An Inclusive EdTech Solution”

$250k

Illuminant Surgical Inc

Palo Alto, CA7 employeesDepartment of Health and Human Services, National Science FoundationPhase II

“Scanner Agnostic Image-Guided Biopsy Platform Employing Advanced Computer Vision and Computer Graphics to Enable Non-Invasive Registration a”

$2.4M2 awards

Perlara PBC

Alameda, CA4 employeesDepartment of Health and Human ServicesPhase IIcompany site

“REMIT (Rescue Mitochondrial Therapeutics): Unlocking Broad-Spectrum Mitochondrial Rescuers”

$1.0M

Sesh Incorporated

San Diego, CA2 employeesDepartment of Health and Human ServicesPhase Icompany site

“HLA LOH Detection via Liquid Biopsy: A Blood-Based Predictive Biomarker Assay for Precision Immuno-Oncology”

$407k

Quartus Engineering Incorporated

San Diego, CA165 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Robust LiDAR-Stereo Fusion for Lunar Autonomy”

$149k

The Calsoyas Group, LLC

Oakland, CA3 employeesDepartment of EducationPhase IIcompany site

“The Mentor Selection Tool: Empowering Districts to Make Data-Driven Student Teacher Placements”

$1M

Cislune Inc

Rosemead, CA7 employeesNational Aeronautics and Space AdministrationPhase I/IIcompany site

“Terrain Regolith Evaluation And Degradation (TREAD)”

$1.0M2 awards

iTherapy, LLC

Vallejo, CA4 employeesDepartment of EducationPhase Iwoman-owned

“Automated Compliance and Communication System for IEP Management Using Blockchain and Conversational AI”

$250k

Zenobia Therapeutics, Inc.

San Diego, CA3 employeesDepartment of EducationPhase Iwoman-ownedcompany site

“Sci-Quest: An Interactive Guided Hero's Journey through the Scientific Method to teach Core Scientific Concepts and Hands-on Skills to Under”

$250k

Epigen Biosciences Inc

San Diego, CA4 employeesDepartment of Health and Human ServicesPhase Icompany site

“Novel Methods for Nicotinic Receptor Modulation in the Treatment of Post-Operative Pain”

$350k

Algae Research And Supply, Inc

Carlsbad, CA4 employeesDepartment of EducationPhase Icompany site

“Accessible Microbiology: Algae Bioprospecting as a Gateway to STEM”

$250k

Project Wayfinder

Berkeley, CA64 employeesDepartment of EducationPhase Icompany site

“Wayfinder IES SBIR Phase 1B 2025”

$250k

Future Engineers LLC

Pasadena, CA9 employeesDepartment of EducationPhase Iwoman-ownedcompany site

“SeaQ for STEM Education”

$250k

Riboscience LLC

Palo Alto, CA3 employeesDepartment of Health and Human ServicesPhase I

“Inhibitors of ENPP1 for the treatment of hepatocellular carcinoma”

$307k

Wecoso, Inc.

Huntington Beach, CA36 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Miniature 30K Cryocooler”

$3.6M4 awards

MiResource, Inc.

Woodside, CA5 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“Improving longitudinal mental health monitoring to generate personalized guides and timely referrals”

$314k

Vivid BioInnovations, PBC

San Francisco, CA10 employeesDepartment of Health and Human ServicesPhase Icompany site

“FIND-seq: A Novel Cell Sorting Technology to Enable Investigation of Rare Cells in Primary Human Tissues”

$1.2M3 awards

Dropzone Robotics

Santa Clarita, CA1 employeeDepartment of DefensePhase II

“A Rugged Tactical Perception System for AI-Driven Casualty Registration and Medical Scene Awareness”

$1.3M

Exoanalytic Solutions Inc

El Toro, CA133 employeesDepartment of DefensePhase I/IIcompany site

“FATES Phase II”

$3.9M5 awards

Keywise, Inc.

San Diego, CA5 employeesDepartment of Health and Human ServicesPhase I

“Passive cognitive assessment across the menopausal transition”

$400k

Cordance Medical Inc

Mountain View, CA7 employeesDepartment of Health and Human ServicesPhase IIcompany site

“NeuroAccess: a Focused Ultrasound System for SonoBiopsy of the Brain”

$999k

Neuro42 Inc

San Francisco, CA6 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Portable Intraoperative MRI for Neurosurgery”

$1.4M

Nanos, Inc.

Loma Linda, CA2 employeesDepartment of Health and Human ServicesPhase I

“Topical nitrite reverses nitroglycerin tolerance.”

$307k

Rerx Therapeutics, Inc

Berkeley, CA1 employeeDepartment of Health and Human ServicesPhase IIcompany site

“Evaluation of novel small molecule targeting lipid and energy homeostasis for treating obesity”

$752k

Amydis Diagnostics Inc.

San Diego, CA5 employeesDepartment of Health and Human ServicesPhase IIwoman-owned

“Development of a topical tracer to detect TDP43 in ALS, LATE and FTD retinas for AI-powered disease insights”

$1.4M

Artery Therapeutics Inc

San Ramon, CA3 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Manufacturing of ABCA1 agonist small molecule peptide CS6253 to support chronic toxicology studies in Wistar rats and Cynomolgus monkeys”

$2.5M

Glytr Therapeutics, Inc.

Irvine, CA1 employeeDepartment of Health and Human ServicesPhase Icompany site

“Maximizing GlyTR pan-cancer immunotherapy by enhancing target density”

$464k

Radiabeam Technologies, LLC

Santa Monica, CA48 employeesDepartment of Defense, Department of Energy, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Lightweight High-Energy X-ray Source for In-Space Nondestructive Evaluation”

$6.9M9 awards

QuSpectra, Inc

San Diego, CA2 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“High-sensitivity Quantum Spectrometer for Autonomous Biological Analysis”

$156k

Armida Labs, Inc.

San Diego, CA2 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Targeting pancreatic cancer metastases with Targefrin”

$1.2M

Actiox LLC

Thousand Oaks, CA6 employeesDepartment of Health and Human ServicesPhase I

“Real-Time Continuous Troponin Monitoring: A Breakthrough in Personalized Cardiovascular Risk Assessment and Management”

$350k

Dynamofl, Inc.

San Francisco, CA45 employeesDepartment of DefensePhase II

“Comprehensive Controls for Security, Privacy, and Compliance in AI Systems for Army Applications”

$1.9M

Flight Works, Inc.

Irvine, CA43 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“Helium Refueling Demonstration for On-Orbit Servicing Applications using Efficient High-Pressure-Ratio Compressor”

$2.2M3 awards

Credo AI

Palo Alto, CA55 employeesDepartment of DefensePhase IIwoman-ownedcompany site

“AI Governance, Risk Management & Compliance for the AI-Powered Army”

$2M

Trethera Corporation

Sherman Oaks, CA1 employeeDepartment of Health and Human ServicesPhase I/II

“Development of a novel, targeted small molecule inhibitor of the nucleoside salvage pathway through murine studies to enable further clinica”

$3.5M4 awards

Examinart, LLC

Mountain View, CA3 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Lunar Materials Analyzer (LuMA)”

$149k

Castelion Corporation

Torrance, CA90 employeesDepartment of DefensePhase IIcompany site

“Compact Hypersonic Missile/Effector Reactive Material (CHyMERA) Warhead Prototype & Demonstration”

$5.2M3 awards

Drive Medical, Inc

Claremont, CA0 employeesDepartment of Health and Human ServicesPhase I

“A robotic enteroscope for safe and effective access to the small bowel”

$316k

Aleutian Therapeutics, Inc

Los Angeles, CA0 employeesDepartment of Health and Human ServicesPhase I

“Development of an immune evasive stem cell line for Type 1 diabetes regenerative therapy”

$985k3 awards

Polysentry Inc

Mill Valley, CA6 employeesDepartment of DefensePhase IIcompany site

“NeoMode: AI/ML Scaffolding and AI Assurance”

$1.1M

Vivere Oncotherapies, Inc.

Oakland, CA8 employeesDepartment of Health and Human ServicesPhase I

“Translation of Evolved Oncolytic Virotherapy Product for Colorectal Cancer Treatment”

$307k

Safetraces, Inc

Pleasanton, CA11 employeesDepartment of DefensePhase IIcompany site

“Rapid Pathogen Intelligence: Field-Deployable, Environmental Biosensing for Military Readiness”

$1.3M

Altamar Technologies Inc

Del Mar, CA1 employeeDepartment of DefensePhase IIcompany site

“Maritime Communications transformed through AI”

$1.2M

Holochip Corporation

Torrance, CA15 employeesDepartment of Defense, Environmental Protection AgencyPhase I/IIcompany site

“Prescription Optical Visor for the M50 Air Purifying Respirator”

$1.9M3 awards

Motiv Space Systems, Inc.

Pasadena, CA37 employeesNational Aeronautics and Space AdministrationPhase I/IIcompany site

“Rad-tolerant Avionics & Mechanisms for the Modern Space Economy- RAMMSE”

$2.0M4 awards

Innotech Systems LLC

La Crescenta, CA5 employeesDepartment of TransportationPhase IIcompany site

“Enhanced Decentralized V2V Communications Leveraging the Potential of Automotive RADAR”

$1.5M

Advanced Rotorcraft Technology, Inc.

Fremont, CA21 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Automated Airfoil Table Generation for VTOL Aircraft”

$150k

PHNX Materials

San Leandro, CA4 employeesDepartment of DefensePhase Icompany site

“Gallium Acquisition from Landfilled Legacy Ash Novel Technology (GALLANT)”

$100k

Cts Cement Manufacturing Corp

Garden Grove, CA250 employeesDepartment of DefensePhase I/IIcompany site

“An Integral Materials and Logistical Approach to Increasing the Shelf Life of Rapid Setting Cements”

$1.9M2 awards

Quinstar Technology, Incorporated

Torrance, CA130 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase Icompany site

“Radiation-Hardened Compact W-band Transceiver”

$440k3 awards

Akua, Inc.

Woodside, CA6 employeesDepartment of DefensePhase Icompany site

“Innovative Approach for Conductive Material Seals Tamper Detection Confidence Factor Analytics Utilizing Real World Conductive Seal Test Dat”

$100k

Volcano Platforms Inc

Palo Alto, CA5 employeesNational Aeronautics and Space AdministrationPhase I/IIcompany site

“Accurate Airframe Noise Predictions Using Large Eddy Simulations”

$990k2 awards

Advanced Scientific Concepts, LLC

Goleta, CA33 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“On-orbit Reconfigurable LiDAR for Mapping and Hazard Detection”

$150k

AstraQua Inc

Santa Monica, CA8 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“AstraSense: AI-Driven Health Predictions for Sustainable Aviation”

$156k

Auxilium Biotechnologies Inc.

San Diego, CA1 employeeNational Aeronautics and Space AdministrationPhase I

“Auxilium Microfabrication Platform Cartridge Modification”

$147k

Integra Technologies, Inc.

El Segundo, CA77 employeesDepartment of DefensePhase IIcompany site

“Advanced 150V GaN Solid State Power Amplifier Topologies for High Power Microwave Applications”

$998k

Space Environment Technologies, LLC

Pacific Palisades, CA25 employeesNational Aeronautics and Space AdministrationPhase I/IIcompany site

“Producing a Benchmark HASDM Forecast Density Database”

$1000k2 awards

Softsonics LLC

La Jolla, CA7 employeesNational Aeronautics and Space AdministrationPhase I

“Wearable cardiac ultrasound imager”

$150k

Bayspec, Inc.

San Jose, CA25 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Miniaturized Ion Trap Mass Spectrometer for In Situ Lunar and Planetary Analysis”

$150k

Myogene Bio LLC

San Diego, CA3 employeesDepartment of Health and Human ServicesPhase IIwoman-ownedcompany site

“Advancing manufacturing and release testing of a gene editing therapy for Duchenne muscular dystrophy”

$1.8M2 awards

Healcisio Inc

San Diego, CA5 employeesDepartment of Health and Human ServicesPhase Icompany site

“Automating Quality to Accelerate Transformational Improvements in Care (AQUATIC)”

$411k

The Aird

Pleasanton, CA3 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“Commercialization of Optical Coherence Tomography with Advanced Optical Design and Adaptive Optics for Rodent Eye”

$305k

Newomics Inc.

Berkeley, CA6 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Multispray Technology for Studying Biomolecular Interactions”

$1M

Cellfe, Inc

Alameda, CA14 employeesDepartment of Health and Human ServicesPhase I

“Accelerated, scalable same-day microfluidic sequential gene editing for allogeneic cell therapy”

$314k

Rebound Health Inc

San Francisco, CA4 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“Development and Validation of a Scalable, Self-Guided Trauma Wellness App to Expand Access to Trauma-Focused Mental Health Care”

$366k

Khemia Metals Inc

San Carlos, CA0 employeesNational Science FoundationPhase II

“SBIR Phase II: Metal Foils for High Energy Density, Low-cost, Lithium-ion Batteries”

$1.2M

Evanesc Therapeutics, Inc.

Encino, CA3 employeesDepartment of Health and Human ServicesPhase Icompany site

“Non-invasive Medical Device to Permeabilize the Blood-Brain Barrier Using Low Power Radio Frequency Evanescent Waves”

$350k

Magnetic Tides Inc

El Cerrito, CA4 employeesDepartment of Health and Human ServicesPhase I/IIcompany site

“A novel method of non-invasive brain stimulation to enhance motor function in chronic stroke patients”

$3.1M3 awards

Eye-Predict LLC

Los Angeles, CA5 employeesDepartment of Health and Human ServicesPhase Icompany site

“Complete Mental Counts for Patients Recovering from Brain Injury”

$497k

Million Marker Wellness Inc

El Cerrito, CA10 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“Reducing rural health disparities by empowering people to minimize PFAS exposure and improve cardiovascular health”

$614k2 awards

Lutris, Inc.

Berkeley, CA3 employeesNational Science FoundationPhase IIcompany site

“SBIR Phase II: Massively Parallel Protocols for Software-based Wireless Instrumentation”

$1.2M

NUCB1 Holdings LLC

San Francisco, CA1 employeeDepartment of Health and Human ServicesPhase I

“Development of amyloid conformer-targeting technologies in type 2 diabetes mellitus”

$325k

Avery Digital Data, Inc.

La Jolla, CA3 employeesDepartment of Health and Human ServicesPhase II

“Integrated Circuit Electrical DNA Assembly”

$895k

Synvect, Inc

San Diego, CA6 employeesDepartment of Health and Human ServicesPhase I

“NextGenSIT: An Off-the-Shelf and On-Demand Product for Biological Control of Aedes aegypti Mosquitoes”

$303k

Dogpatch Medical LLC

San Francisco, CA2 employeesDepartment of Health and Human ServicesPhase Iwoman-owned

“MAGNETIC (MRI-Assisted Guidance via NeuroInterventional Targeted Imaging Catheters)”

$306k

Aveera Medical Inc.

San Clemente, CA10 employeesDepartment of Health and Human ServicesPhase II

“Preventing major amputations and preserving functional limbs in no option critical limb-threating ischemia patients”

$1.0M

Auricle Inc

San Francisco, CA2 employeesDepartment of Health and Human ServicesPhase I

“A Novel Technology to Treat the Underlying Cause of Tinnitus”

$306k

Eye C Better

La Quinta, CA1 employeeDepartment of Health and Human ServicesPhase I

“New, Non-Invasive (No-Puff, No-Touch), Tonometry Method: Remote photonic IOP biomonitoring using the damping factor of transitional oscilla”

$316k

Picogrid, Inc.

El Segundo, CA55 employeesDepartment of DefensePhase IIcompany site

“Low-Altitude Passive Integrated Sensors (LAPIS)”

$8.1M5 awards

Skyfront Corp

Redwood City, CA9 employeesDepartment of DefensePhase IIcompany site

“UAV Hybrid Power System for Frontline Resupply and Loitering Munition Delivery”

$1.7M

Graymatter Robotics Inc.

Carson, CA78 employeesDepartment of DefensePhase I/IIcompany site

“Smart Robotic Canopy Sanding”

$2.9M4 awards

Yurts Technologies, Inc.

San Rafael, CA6 employeesDepartment of DefensePhase IIcompany site

“Yurts Platform for Intelligence Analysis and COAs”

$1.1M

Inhance Digital Corporation

Los Angeles, CA15 employeesDepartment of Commerce, Department of DefensePhase I/IIcompany site

“Mixed Reality Platform for Aircraft Maintenance (MRMX)”

$2.1M3 awards

Workera Corp.

Palo Alto, CA55 employeesDepartment of DefensePhase IIcompany site

“Benchmarking Data Analytics, AI and Operations Research Skills to World-Class Standards and Customizing Source-Agnostic Learning Paths”

$2.0M

Aeluma, Inc.

Goleta, CA18 employeesDepartment of Defense, Department of Energy, National Aeronautics and Space AdministrationPhase I/IIcompany site

“SHIPS: Scalable Heterogeneous Integration for Photon-entanglement Sources”

$1.5M4 awards

Navi AI, Inc.

San Franicsco, CA4 employeesDepartment of DefensePhase I/IIcompany site

“Project WingMan”

$1.3M2 awards

Swift Engineering Inc.

San Clemente, CA56 employeesNational Aeronautics and Space AdministrationPhase IIcompany site

“Swift Ultra Long Endurance (SULE) High-Altitude Platform Systems (HAPS) Capability Demonstration”

$849k

Grid Raster Inc

Mountain View, CA17 employeesDepartment of DefensePhase I/IIcompany site

“Multimodal Dynamic Spatial Tracking for Enhanced Automatic Manufacturing – Extended Reality (STEAM-XR)”

$3.3M4 awards

Paratus AI, Inc

San Francisco, CA5 employeesDepartment of DefensePhase Icompany site

“Generative AI Platform for Automating Personnel Readiness”

$121k

Saraniasat Inc.

Tujunga, CA3 employeesDepartment of DefensePhase Icompany site

“Generative AI for Automatic Target Recognition via Sparse, Multimodal Sensing”

$150k

Microsurgeonbot Inc

Sylmar, CA5 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase I/IIcompany site

“OrbitGuard: From Data Deluge to Decision Dominance”

$1.3M2 awards

Pytho AI

San Bruno, CA2 employeesDepartment of DefensePhase Icompany site

“Autonomous COA Engine for Multi-Domain Operations”

$536k3 awards

Prewitt Ridge Inc

Los Angeles, CA11 employeesDepartment of DefensePhase Icompany site

“State Machine to SysML v2 State Machine via Graph Recognition”

$150k

Fireflower AI Inc

Cardiff, CA3 employeesDepartment of DefensePhase Icompany site

“Fireflower Ignite Secure GenAI Platform for Federal”

$150k

Spectrum Scientific Incorporated

Irvine, CA20 employeesNational Aeronautics and Space AdministrationPhase IIwoman-ownedcompany site

“Creating Blazed Gratings for Freeform Mirror Surfaces”

$899k

RED RIVER RESOURCES LLC (dba Navaide)

San Diego, CA94 employeesDepartment of DefensePhase Iwoman-ownedcompany site

“Navaideĺs AI-Driven Decision Support Framework”

$149k

Advanced Onion Inc

Monterey, CA74 employeesDepartment of DefensePhase Icompany site

“Enhancing Supply Chain Management with LLMs: A Next Generation Chat Assistant Framework for Natural Language Queries”

$149k

Flosonics Medical LLC

Mountain View, CA52 employeesDepartment of DefensePhase IIcompany site

“FloPredict - DOPPLER INTELLIGENCE: ADVANCING AI-POWERED HEMODYNAMIC MONITORING FOR EARLY DETECTION OF CLINICAL DETERIORATION”

$1.2M

Heliospace Corporation

Berkeley, CA44 employeesNational Aeronautics and Space AdministrationPhase I/IIcompany site

“Deployable Baffle by SABER System (DeBSS)”

$1.8M3 awards

Aosense, Inc.

Fremont, CA36 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Advanced Narrow-linewidth Tunable Laser for Rydberg Sensors (ANTLRS)”

$150k

Odys Aviation, Inc.

Long Beach, CA47 employeesDepartment of DefensePhase I/II

“High Efficiency Turbogenerator for Group III UAV”

$4.0M4 awards

Matregenix Inc

Mission Viejo, CA6 employeesDepartment of Defense, Department of Health and Human ServicesPhase I/IIcompany site

“Streamlined Synthetic Amniotic Membrane for Ocular Penetrating Injuries and Burns: Simplified Logistics, No Special Storage, Extended Shelf ”

$3.5M4 awards

Faraday Labs Inc

Santa Monica, CA5 employeesDepartment of DefensePhase I/II

“T B D”

$1.9M2 awards

Tg Sky

San Diego, CA12 employeesDepartment of DefensePhase I/II

“Next-Gen Wireless Asset Tracking: A Permanent Solution for Department of the Air Force IT Logistics”

$1.3M2 awards

Intelligenic, Inc

San Jose, CA6 employeesDepartment of DefensePhase Icompany site

“Intelligenic Proposal for OSD254-P001”

$150k

Arith Inc

Palo Alto, CA1 employeeDepartment of DefensePhase I/II

“MIGHTYFP™ - A SWAPC2-OPTIMIZED AI ACCELERATOR FOR DEFENSE AND AEROSPACE APPLICATIONS”

$1.9M2 awards

DeepNight Inc.

San Francisco, CA10 employeesDepartment of DefensePhase I/IIcompany site

“Night Vision Reconnaissance Augmentation System (NRAS)”

$4.1M4 awards

Gambit Defense, Inc.

Valley Village, CA8 employeesDepartment of DefensePhase I/II

“Spectrum Supremacy Utilizing a Mesh Network: NEURON”

$3.1M4 awards

Cicero Technologies INC

Pacifica, CA50 employeesDepartment of DefensePhase II

“ACR: Augmented Contract Review Application”

$1.2M

ImmPORT Therapeutics Inc dba Antigen Discovery Inc

Irvine, CA15 employeesDepartment of Health and Human ServicesPhase Icompany site

“A sensitive and specific serology test for evaluating potency of whole cell Pertussis vaccines”

$600k2 awards

Alare Technologies, LLC

Moorpark, CA19 employeesDepartment of DefensePhase IIcompany site

“Mobile Target Tracking”

$1.8M

Monde Wireless Inc

Goleta, CA9 employeesDepartment of DefensePhase II

“Removing Heat from Next Generation Wireless Systems”

$1.2M

Rix Industries

Benicia, CA178 employeesDepartment of TransportationPhase Icompany site

“Autonomous Dynamic Load Adjusted Central Tire Inflation System (ADLACTIS)”

$205k

Ethos Space Corp.

Los Angeles, CA9 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Lunar In-Situ Thermal Wadis”

$148k

Planette Analytics Inc

Fremont, CA4 employeesNational Aeronautics and Space Administration, National Science FoundationPhase Iwoman-ownedcompany site

“QubitCast: A Quantum-Inspired Environmental Forecasting System”

$455k2 awards

Pacific Microchip Corp.

Culver City, CA7 employeesNational Aeronautics and Space AdministrationPhase I/IIcompany site

“A Low-Power 14GHz Spectrometer ASIC”

$1.2M3 awards

General Lasertronics Corporation

Fremont, CA5 employeesDepartment of DefensePhase IIcompany site

“Portable Laser Removal Tool, Phase II”

$2.0M

Parabilis Space Technologies, Inc.

San Marcos, CA16 employeesNational Aeronautics and Space AdministrationPhase I/IIcompany site

“Green Propellant Rapid Orbital Mobility Bus”

$999k2 awards

Programs Management Analytics & Technologies, Inc.

San Diego, CA37 employeesDepartment of DefensePhase IIcompany site

“Dynamic Rerouting Optimization for Platforms and Sensors (DROPS)”

$1.7M2 awards

Peregrine Falcon Corporation

Pleasanton, CA8 employeesDepartment of DefensePhase IIcompany site

“OSD233-003 Specialized Crystal Growth and Material Characterization”

$963k

EarthTraq Corporation

San Carlos, CA3 employeesNational Aeronautics and Space AdministrationPhase I

“Multi-Spacecraft On-orbit Space Computing Testbed”

$138k

Bright Apps LLC

Walnut Creek, CA30 employeesDepartment of DefensePhase Icompany site

“BrightArc: A Generative AI Framework for Automating Video Analysis and Enhancing Efficiency in Government Operations”

$289k2 awards

Stell Engineering, Inc.

Marina Del Rey, CA12 employeesDepartment of DefensePhase IIwoman-ownedcompany site

“Requirements Operating System for Integrated Engineering (ROSIE) AI”

$1.0M

Rebel Space Technologies Inc

Long Beach, CA10 employeesDepartment of DefensePhase IIcompany site

“Muse: Accelerating Test & Evaluation with Generative AI for Next-Generation Defense Systems”

$1.2M

Obsidian Sensors Inc

San Diego, CA16 employeesDepartment of DefensePhase I/IIcompany site

“Highly Scalable Readout Integrated Circuit (ROIC) with Thermal Image Processor Chip to Support the 12um SXGA Microbolometer on Glass Develop”

$4.2M3 awards

Fitoto Technologies Inc.

Oakland, CA2 employeesNational Science FoundationPhase I/II

“SBIR Fast-Track: Providing Timely, Inexpensive, and Comfortable Earmolds (EMs) for Hearing Loss (HL) Patients using Computed Axial Lithograp”

$1.6M2 awards

Rubato, Inc.

Pacific Palisades, CA5 employeesDepartment of Health and Human ServicesPhase Icompany site

“Novel AI-driven music-based intervention to reduce behavioral and psychological symptoms for people living with dementia”

$251k

Organos, Inc.

Berkeley, CADepartment of Health and Human ServicesPhase II

“Microheart muscle based discovery and development of inotropic compounds”

$1.0M

Toi Labs, Inc.

San Francisco, CA5 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Use of a Novel Toilet Seat to Passively Collect Digital Biomarkers in Assisted Living Settings”

$1.2M

Immunomatics, Inc.

San Marcos, CA1 employeeDepartment of Health and Human ServicesPhase I

“Eliminating Donor Availability Disparities in Hematopoietic Stem Cell Transplantation with AI-based Prediction of Permissive HLA Mismatches ”

$208k

Modalai Inc

San Diego, CA45 employeesDepartment of DefensePhase I/IIcompany site

“VOXL 3 - Maximizing Image Processing per Gram”

$2.2M2 awards

Realseq Biosciences, Inc.

Santa Cruz, CA4 employeesDepartment of Health and Human ServicesPhase II

“Preparation of sequencing libraries for multi-analyte analysis of RNAs”

$1.0M

Revel Pharmaceuticals Inc.

San Francisco, CA8 employeesDepartment of Health and Human ServicesPhase I/IIcompany site

“Development of enzymatic tools for rapid measurement of Advanced Glycation and Lipoxidation End Product-protein adducts”

$1.7M2 awards

Alida Biosciences Inc.

San Diego, CA15 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Pseudouridine detection with single-base resolution in a multiplexed epitranscriptomics assay”

$1.1M

Visionary Tech & Event Solutions LLC

Santa Clara, CA1 employeeDepartment of DefensePhase I

“VOCAL: Voice Originality Cloning Across Languages”

$150k

Oak Therapeutics Inc

Westlake Village, CA4 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Oral Dissolvable Strips (ODS) as new pediatric and adult delivery mode of therapy for latent tuberculosis”

$893k

Senseeker Corp

Santa Barbara, CA39 employeesDepartment of DefensePhase I/IIcompany site

“Optimized Multi-Spectral Digital Pixel Readout IC”

$2.3M3 awards

Origami Therapeutics, Inc.

San Diego, CA2 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“Uncovering the molecular target(s) of ORI-113, a potential brain-penetrant small molecule therapeutic for Huntington's disease.”

$500k

Flexlynqs LLC

Fremont, CA7 employeesDepartment of TransportationPhase Icompany site

“FleetLynq: AI-driven Decision Support Solution for Transit Fleet”

$206k

Tendel Therapies Inc

Kensington, CA5 employeesDepartment of Health and Human ServicesPhase II

“Optimizing SIV reservoir depletion by Tendel bsAb-98”

$1000k

Advanced Systems & Technologies Inc

Irvine, CA5 employeesDepartment of DefensePhase IIcompany site

“Sensor-Array Broadband Express-Rate Wavefront Sensor (SABER_WFS)”

$1.8M

Tiami Networks

Elk Grove, CA12 employeesDepartment of DefensePhase I/II

“Diffusion-based spectrum monitoring and awareness in real time”

$2.0M2 awards

Nabla Zero Labs

South Pasadena, CA3 employeesNational Aeronautics and Space AdministrationPhase IIcompany site

“Missfit: Statistical Multi-Event Missed-Thrust Optimization for Low-Thrust Trajectories”

$850k

ZabBio, Inc.

San Diego, CA2 employeesDepartment of Health and Human ServicesPhase Icompany site

“Development of a monoclonal therapy for neonatal herpes”

$249k

Protabit, LLC

Pasadena, CA5 employeesDepartment of Health and Human ServicesPhase I

“High-Throughput Engineering of Bispecific Antibodies”

$305k

Parallel Flight Technologies, Inc.

Watsonville, CA8 employeesDepartment of DefensePhase IIcompany site

“Modifications to Firefly to make maritime compatible”

$3.7M

Tyfast Energy Corp

San Diego, CA10 employeesDepartment of DefensePhase I

“Domestically Sourced and Globally Superior LVO Battery Technology for Directed Energy Weapons”

$140k

Leiden Measurement Technology LLC

Sunnyvale, CA4 employeesNational Aeronautics and Space AdministrationPhase IIcompany site

“CHESS: Compact High-Entendue Spectrometer for Space”

$850k

Biospherical Instruments, Inc.

San Diego, CA41 employeesNational Aeronautics and Space AdministrationPhase IIcompany site

“Hyperspectral Optical Profiling System with Advanced Dynamic Vertical Sampling Resolution (Hy-OPS ADVSR)”

$846k

Siolta Therapeutics, Inc.

San Carlos, CA9 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Development of a multispecies live biotherapeutic product for the prevention of recurrent bacterial vaginosis”

$529k

Endure Biotherapeutics, Inc.

Carlsbad, CA3 employeesDepartment of Health and Human ServicesPhase I

“Development of Novel Engineered Native Bacteria (ENB) for the Treatment of Familial Adenomatous Polyposis”

$393k

Onc.AI, Inc.

San Carlos, CA17 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Deep Learning Serial Radiomics for Improved Cancer Therapy Response Assessment.”

$1.7M

Tega Therapeutics Inc

San Diego, CA7 employeesDepartment of Health and Human ServicesPhase Icompany site

“Title: New Clinical Biomarkers for GM1 Gamgliosidosis”

$500k

Zephyr Computing Systems, Inc.

Oakland, CA8 employeesDepartment of DefensePhase IIcompany site

“Peregrine Falcon - Modular Multi-Mission Processing for Spacecraft”

$1.9M

Spectral Therapeutics, INC.

San Marcos, CA4 employeesDepartment of Health and Human ServicesPhase Icompany site

“Production of Stimulated Emission-Encoded Beads for Large Molecular Library Generation”

$322k

Nanoelectronic Imaging, Inc.

Riverside, CA4 employeesDepartment of CommercePhase Icompany site

“Thermal NanoImaging of Semiconductor Devices”

$100k

Space Information Laboratories, LLC

Santa Maria, CA23 employeesDepartment of DefensePhase IIwoman-ownedcompany site

“VBIRS Space Based Range”

$2.0M

Topaz Biosciences, Inc.

Emeryville, CA7 employeesDepartment of Health and Human ServicesPhase IIwoman-owned

“Development of novel endolysins targeting Cutibacterium acnes to treat acne vulgaris”

$1.5M

Ometa Labs LLC

Oceanside, CA6 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Bioinformatics platform for large scale untargeted metabolomics analysis”

$676k

Autonomous Healthcare Inc.

Santa Clara, CA8 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Noncontact Monitoring for the Detection of Opioid-Induced Respiratory Depression”

$1.2M

SmartAirway LLC

Venice, CA2 employeesDepartment of Health and Human ServicesPhase I

“A Novel Articulating Stylet for Improving First-Pass Intubation Success”

$313k

Cisterna Biologics, Inc.

Oceanside, CA1 employeeDepartment of Health and Human ServicesPhase I

“A Novel Approach to Eliminate Length Impurities for High-Quality mRNA Production”

$700k2 awards

Spikegadgets, Inc.

San Francisco, CA10 employeesDepartment of Health and Human ServicesPhase IIcompany site

“A Commercial Platform for High-Volume Behavior and Electrophysiology Research”

$1.3M

Imvaria Inc

Berkeley, CA3 employeesDepartment of Health and Human ServicesPhase Icompany site

“A fully automated tool for more accurate malignancy assessment in pulmonary nodules from chest CT”

$399k

Capienda Biotech, LLC

San Diego, CA3 employeesDepartment of Health and Human ServicesPhase Icompany site

“High-throughput kinetic system for small-molecule drug discovery”

$329k

Engage Biologics Inc

San Carlos, CA5 employeesDepartment of Health and Human ServicesPhase II

“Tethosomes: a non-viral DNA platform for durable expression of therapeutic transgenes in specific target cells”

$865k

Oxylo, Inc.

San Diego, CA3 employeesDepartment of Health and Human ServicesPhase I

“Oxygen reducing microcapsules for in vitro control of hypoxia”

$229k

Vibo Health Inc

Los Angeles, CA2 employeesDepartment of CommercePhase I

“Phantoms for Mobile MRS Calibration and Testing”

$100k

Calis Books Inc

Los Angeles, CA10 employeesDepartment of Health and Human Services, National Science FoundationPhase I/IIwoman-ownedcompany site

“Introducing Young Children to Biomedical Science with a Screenless Interactive Device (infinibook)”

$1.4M2 awards

Silicon Kidney LLC

San Francisco, CA5 employeesDepartment of Health and Human ServicesPhase II

“An intravascular Bioartificial Pancreas (iBAP)”

$1M

Celestial Therapeutics Inc

Irvine, CA2 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Development of a dry powder inhalation product against Respiratory Syncytial Virus based on an endogenous anionic pulmonary surfactant lipid”

$1M

Proteris Biotech, Inc.

Glendale, CA3 employeesDepartment of Health and Human ServicesPhase I

“Clusterin Targeting Epitheliopathy for Dry Eye”

$322k

Verisim Life, Inc

San Francisco, CA9 employeesDepartment of Health and Human ServicesPhase IIwoman-ownedcompany site

“Development of therapeutic candidates for stimulant use disorder using AI-driven platform for focused drug discovery and accelerated develop”

$812k

Novoglia, Inc.

Irvine, CA4 employeesDepartment of Health and Human ServicesPhase II

“Engineered microglia for the treatment of Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia (ALSP)”

$1.5M

Cytorum, Inc.

Santa Clara, CA2 employeesDepartment of Health and Human ServicesPhase II

“Xbeads: A Platform for Flow Cytometry Sample QC and Harmonization”

$1.2M

ViVita Technologies, Inc.

Woodland, CA1 employeeDepartment of Health and Human ServicesPhase Icompany site

“Unfixed, xenogeneic extracellular matrix for crimp damage-resistant and regenerative transcatheter heart valve prostheses”

$496k

Pumpkinseed Technologies Inc

Palo Alto, CA3 employeesDepartment of Health and Human Services, National Science FoundationPhase I/IIcompany site

“SBIR Phase II: High-throughput De-novo Peptide Sequencing with Metasurface Optics”

$1.6M2 awards

Tangram Robotics, Inc.

Burlingame, CA6 employeesNational Aeronautics and Space AdministrationPhase IIcompany site

“A low-power, high-dynamic range sensor system for long-term autonomy, navigation, and mapping on the lunar surface”

$850k

Autonomous Defense Technologies Corp.

Oxnard, CA10 employeesDepartment of DefensePhase I/IIcompany site

“Autonomous Collaborative Platform (ACP) Low-Cost, High-Volume Manufacturing”

$1.4M2 awards

Cobra Scientific, LLC

Anaheim, CA5 employeesDepartment of DefensePhase IIcompany site

“Cobra AF251-D003”

$1.3M

Protonex LLC

Windsor, CA20 employeesDepartment of DefensePhase I/IIcompany site

“PNI Sensor Enhanced Pilot Locator Beacon for GPS Denied Environments”

$1.4M2 awards

Squid3 Space, Inc.

Irvine, CA5 employeesDepartment of DefensePhase Icompany site

“Operationally Responsive Textile Manufacturing using Collaborative Robots”

$249k

United Semiconductors, LLC

Los Alamitos, CA5 employeesNational Aeronautics and Space AdministrationPhase IIwoman-ownedcompany site

“Physical vapor deposition reactor design and validation for in-space manufacturing of aluminum nitride single crystals”

$840k

Onenav, Inc

Sunnyvale, CA33 employeesDepartment of DefensePhase IIcompany site

“TBD”

$2.5M2 awards

Avatar Partners Inc

Irvine, CA25 employeesDepartment of DefensePhase Iwoman-ownedcompany site

“EOD_XR Dual Mode Immersive Training”

$250k

Northstar Photonics, Inc.

San Jose, CA19 employeesDepartment of DefensePhase IIcompany site

“Reduced Half-Wave Voltage in Integrated Optical Circuits for Interferometric Fiber Optic Gyroscopes”

$1.8M2 awards

Real-Time Innovations, Inc.

Sunnyvale, CA267 employeesDepartment of DefensePhase Icompany site

“APIARY: Aegis Platform Integration of Aerial Robotic sYstems”

$600k4 awards

Spark Thermionics, Inc.

Berkeley, CA4 employeesDepartment of DefensePhase I

“Affordable Integrated Surface Modification of Ceramic and Refractory Substructures with UHTCs for High Temperature Resilient Thermal Protect”

$350k2 awards

Chaos 1, Inc.

Hawthorne, CA230 employeesDepartment of DefensePhase IIcompany site

“GRIFFIN - Passive, Expeditionary Air Defense Radar”

$1.2M

Atmo, Inc.

San Francisco, CA10 employeesDepartment of DefensePhase IIcompany site

“Classified AI Weather Forecasting for USAF Operations”

$2.9M

Exergy Systems, Inc.

Irvine, CA8 employeesDepartment of DefensePhase Iwoman-ownedcompany site

“Lightweight Portable Water Purification Systems for Military Field Operations”

$250k

Farad Power Inc

Hillsborough, CA2 employeesDepartment of DefensePhase I/IIcompany site

“Synthetic Graphite from Biomass as Anode Material for 6T Batteries”

$1.4M3 awards

Schemata Inc.

San Francisco, CA12 employeesDepartment of DefensePhase I/IIcompany site

“Traverse3D Unlocking Scalable Immersive Training for Enhanced Readiness”

$2.1M2 awards

Quantum Ventura Inc

San Jose, CA10 employeesDepartment of Defense, Department of EnergyPhase Icompany site

“Advanced Mechanical Metamaterials & High-Entropy Alloys for hypersonics”

$340k2 awards

Rimark Technology Inc

Sebastopol, CA1 employeeDepartment of DefensePhase Icompany site

“Solstice Smart Contract Supply Chain Platform”

$139k

Pacific Science & Engineering Group, Inc.

San Diego, CA60 employeesDepartment of DefensePhase IIcompany site

“FormAID: A general purpose, receiver-centric, Artificial Intelligence (AI)-assisted system for effective naval reporting”

$3.0M2 awards

Innsightful Inc

Sunnyvale, CA7 employeesDepartment of DefensePhase I/IIcompany site

“An AI-Powered Co-Pilot for Suicide Detection and Inclusive Mental Health Support”

$1.5M2 awards

Perceptra Technologies, Inc.

Oakland, CA3 employeesDepartment of Defense, Department of Homeland SecurityPhase Icompany site

“High-throughput micro-Raman Aerosol Analyzer”

$373k2 awards

BluumBio

Albany, CA7 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“Reducing PFAS Exposure Through In-situ Microbial Remediation of PFAS Impacted Matrixes”

$188k

D&g Analytics Inc.

Sunnyvale, CA16 employeesDepartment of DefensePhase IIcompany site

“Expanding Software Integrity Platform (SIP) Coverage Beyond Basic Windows Software Applications”

$3.0M2 awards

Kapha Bio

Benicia, CA2 employeesNational Science FoundationPhase Iwoman-ownedcompany site

“STTR Phase I: A Platform of Biomimetic Mucins for Addressing Recurrent Infections”

$305k

Arkham Technology Limited

Irvine, CA15 employeesDepartment of DefensePhase IIwoman-ownedcompany site

“Efficient Automated Key Management for pLEO Operations”

$3.7M2 awards

Knoubis Bio Inc

La Jolla, CA1 employeeDepartment of Health and Human ServicesPhase I

“Bispecific biologic for rheumatoid arthritis therapy”

$312k

Ali Far

Saratoga, CANational Science FoundationPhase II

“SBIR Phase II: Preventative Maintenance AI Chip: Software-Configurable, Tiny, Low-Latency, Always-On, Ultra-Low-Power, Near-Sensor-AI, No C”

$1.3M

Hypercomp Inc

Thousand Oaks, CA15 employeesDepartment of DefensePhase Iwoman-ownedcompany site

“Modeling the Performance of VLF Antennas designed to interact with the Magnetized Plasma in Earth’s Magnetosphere”

$180k

NovaTech Innovations LLC

San Diego, CA3 employeesNational Science FoundationPhase Iwoman-ownedcompany site

“STTR Phase I: Cutting-Edge Nitride Based Distributed Bragg IR-Reflectors”

$304k

Kinetic River Corp.

Mountain View, CA5 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Compensation-Free Flow Cytometer with Expanded Reagent Choices and Reduced Manufacturing Costs”

$1000k

Cognicom Inc

San Diego, CA11 employeesDepartment of DefensePhase I/IIcompany site

“Neptune Radio Improvement for Logistics in a Contested Environment”

$1.1M2 awards

DittoLive Incorporated

Berkeley, CA60 employeesDepartment of DefensePhase IIcompany site

“DITTO STRATEGIC FUNDING INCREASE: UNIFIED EDGE SYNC PLATFORM”

$12.7M

SimInsights, Inc.

Irvine,, CA6 employeesDepartment of DefensePhase Icompany site

“FIATSim: Flexible Immersive Adaptive Training Simulations”

$140k

Iperformx LLC

Newport Beach, CA40 employeesDepartment of DefensePhase Icompany site

“Multi-Disciplinary Enhancement of Adaptive Naval Aviation Training”

$140k

Ao Technologies, LLC

Glendale, CA2 employeesDepartment of Health and Human ServicesPhase I

“Development of a high performance reduced cost OCT Otoscope”

$306k

Calnetix Technologies LLC

Cypress, CA171 employeesDepartment of DefensePhase IIcompany site

“Bi-directional Export Power Inverter for Ground Vehicles”

$2.0M

Imagize, LLC

Berkeley, CA8 employeesDepartment of DefensePhase IIcompany site

“Digital Multisensory Augmented Reality for Special Warfare (DMARS)”

$1.4M

Lairson Bruce

Ventura, CA1 employeeNational Aeronautics and Space AdministrationPhase IIcompany site

“Large Silicon Carbide Grids for X-Ray Microcalorimeter Blocking Filters”

$850k

Hedral Inc.

San Francisco, CA18 employeesDepartment of DefensePhase I/II

“AI for Adaptive 3D Infrastructure Design in Navy Engineering”

$674k2 awards

Hj Science & Technology Inc

San Leandro, CA5 employeesDepartment of DefensePhase IIcompany site

“Rapid portable detection technology for wastewater and solidwaste”

$600k

Scientific Applications & Research Associates, Inc.

Cypress, CA295 employeesDepartment of DefensePhase I/IIcompany site

“Persistent Airbrn CUAS Surveil (PANCAS)”

$1.9M4 awards

Stratin LLC

Hawthorne, CA21 employeesDepartment of DefensePhase I/IIcompany site

“Coordinated High-efficiency Autonomous Recharge and Generation of Energy for Drones (CHARGED)”

$1.9M3 awards

Solid State Battery Incorporated

Fullerton, CA5 employeesDepartment of DefensePhase Icompany site

“Composite Solid Polymer Electrolyte (CPSE) Solid State Battery for UAS”

$140k

Engineering And Software System Solutions, Inc.

San Diego, CA205 employeesDepartment of DefensePhase I/IIwoman-ownedcompany site

“Removable Smart Tooling for High Temperature Composite Fabrication”

$3.1M5 awards

Tanner Research, Inc.

Duarte, CA15 employeesDepartment of DefensePhase I/IIwoman-owned

“Retrofittable Probe Latching Detection Concepts for Unmanned Aerial Refueling”

$2.1M4 awards

ODMR Technologies, Inc

El Cerrito, CA3 employeesDepartment of Health and Human ServicesPhase II

“Diamond NMR spectrometer for microfluidic metabolite profiling”

$1.0M

Adtech Photonics, Inc.

City Of Industry, CA25 employeesDepartment of DefensePhase IIwoman-owned

“Single-Mode Continuous-Wave InP-Based Photonic Crystal Surface Emitting Lasers at 2 µm”

$1.4M

Cmsoft, Inc.

Palo Alto, CA4 employeesDepartment of DefensePhase Icompany site

“High-Performance Partitioned Analysis Procedures for Fluid-Thermal-Structural Interactions in Hypersonic Air-Breathing Systems”

$140k

Mentia Dtx ,inc.

Novato, CA2 employeesDepartment of Health and Human ServicesPhase I

“An AI-based empathic virtual companion to track changing health states in persons living with dementia”

$506k

Invvax Inc

Cypress, CA3 employeesNational Science FoundationPhase IIcompany site

“SBIR Phase II: Stable Prophylactic Antibodies”

$997k

Cari Health Inc

San Diego, CA6 employeesDepartment of Health and Human ServicesPhase II

“Methadone Dosing System (MDS)”

$1.4M

Vivreon Biosciences LLC

San Diego, CA4 employeesDepartment of Health and Human ServicesPhase II

“Preclinical Characterization of CRAC Channel Inhibitors for the Treatment of Alzheimer's Disease”

$2.0M

Vortex Medical Inc.

Woodside, CA4 employeesDepartment of Health and Human ServicesPhase II

“Developing a novel vesico-amniotic shunt to treat fetal lower urinary tract obstruction”

$804k

Cortechs Labs, Inc.

San Diego, CA19 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Quantification of ARIA During the Treatment of Alzheimer's Patients”

$933k

Cache DNA, Inc.

San Carlos, CA6 employeesNational Science FoundationPhase II

“SBIR Phase II: Rapid Ambient Preservation using Thermosets for Optimized Protection of Biomolecules”

$1.2M

Analatom Incorporated

Santa Clara, CA7 employeesDepartment of DefensePhase Icompany site

“Physics-Informed Synthetic Sonar Data Generation using Deep Diffusion Models”

$140k

Interlog Corporation

Anaheim, CA25 employeesDepartment of DefensePhase Icompany site

“C-VIS: Color Vision Integrated SWIR for Multi-Spectral Imaging and Navigation”

$140k

Surface Optics Corporation

San Diego, CA36 employeesDepartment of DefensePhase Icompany site

“Dual-Band, Color Visible (VIS) and Short-Wave Infrared (SWIR) Camera”

$280k2 awards

Critical Innovations LLC

Lawndale, CA31 employeesDepartment of DefensePhase I/IIcompany site

“Aid-Tex Wearable e-Textile System for Control of Junctional and Extremity”

$1.6M2 awards

Terra Quantum Falcon Inc.

San Francisco, CA20 employeesDepartment of DefensePhase II

“Ultra-Secure, Post-Quantum Communications and Encryptions (US-PQC/E)”

$1.2M

Astro Mechanica Corp

San Francisco, CA17 employeesDepartment of DefensePhase II

“Revolutionizing Air Dominance: The Duality Engine's Role in Future Combat Aircraft”

$1.2M

Beacon AI Inc

San Carlos, CA14 employeesDepartment of DefensePhase IIcompany site

“AI-Enhanced Adaptive Risk Analytics and Automated Briefing Product for Military and Commercial Aviation”

$3.2M2 awards

Quasar Federal Systems, Inc.

San Diego, CA12 employeesDepartment of DefensePhase Icompany site

“Compact Underwater Electromagnetic Sensor System (CUES) with Internal Data Logging”

$573k4 awards

Verne Inc

San Francisco, CA19 employeesDepartment of DefensePhase IIcompany site

“Delivered power with containerized cryo-compressed hydrogen systems”

$1.9M

Exploration Laboratories LLC

Long Beach, CA10 employeesDepartment of DefensePhase II

“Space Exploration Resource Vehicle for in-space Servicing, Assembly and Manufacturing (SERVSAM)”

$1.9M

Across AI, Inc

San Francisco, CA0 employeesNational Science FoundationPhase I

“SBIR Phase I: Revolutionizing Enterprise Processes with Automated Logical Reasoning Across Unstructured Data”

$305k

Xsite LLC

San Diego, CA34 employeesDepartment of DefensePhase Icompany site

“XSITE - N251-004 - Kill Web Conceptual Modeling for Wargaming”

$140k

Inertialwave Inc

Torrance, CA5 employeesDepartment of DefensePhase Icompany site

“An Application-Specific DTDSM ADC Using State-of-The-Art Circuit Techniques for Magnetic and Electropotential Sensors”

$140k

Syncanica Bio, Inc.

Sacramento, CA2 employeesDepartment of Health and Human ServicesPhase Icompany site

“Pseudocannabinoids for mitigation of substance use disorder”

$334k

Third Element Bio Inc.

San Diego, CA5 employeesDepartment of Health and Human ServicesPhase I

“Development of a RUNX1 modulator to slow cognitive decline in Alzheimer's disease”

$392k

Biolinq Incorporated

San Diego, CA110 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Wearable Metabolic Sensor for Monitoring of Lactate and Glucose for People with Diabetes”

$854k

Albireo Technologies LLC

Porter Ranch, CA2 employeesDepartment of DefensePhase II

“Multi-Modal X-ray Inspection System”

$1.5M

Gbl Systems Corporation

Camarillo, CA61 employeesDepartment of DefensePhase IIcompany site

“Next Generation Open Mission System (NOMS) Weapon Integration Support”

$388k

Electronic Biosciences, Inc.

San Diego, CA12 employeesDepartment of Health and Human ServicesPhase Icompany site

“SpinSeq”

$1.5M4 awards

Protein Fluidics Inc

Redwood City, CA3 employeesDepartment of DefensePhase Icompany site

“High-throughput Organoid Screening Platform for Investigating Novel Traumatic Brain Injury Therapeutics”

$250k

Space Foundry Inc

San Jose, CA3 employeesDepartment of DefensePhase Icompany site

“Plasma Jet Printing of Lead-salt based MWIR Photoconductive Detectors”

$204k

SPZ Technologie, LLC

Los Angeles, CA3 employeesDepartment of DefensePhase I

“Platelet Contractility Imaging Analyzer (PCIA)”

$249k

Lumina Medical LLC

Culver City, CA1 employeeDepartment of Health and Human ServicesPhase Icompany site

“Motorized Girth Adjustable Dilator with Dilation and Pressure Measurement for Anorectal Disorders, Designed to Improve Patient Adherence to ”

$710k2 awards

Vellum Biotechology, Inc.

Palo Alto, CA8 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Developing a New Nucleic Acid Extraction Technology to Enable High Quality DNA Sequencing for Formalin Fixed Paraffin Embedded Tissue Sample”

$1.0M

Artyc Pbc

Fremont, CA7 employeesNational Science FoundationPhase Icompany site

“STTR Phase I: A Novel Magnetocaloric Cooling System for the Cold Chain”

$305k

Spatial Genomics, Inc.

Pasadena, CA9 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Next generation spatial genomics tools for the human brain”

$1.2M

Stress Therapeutics, Inc.

San Diego, CA2 employeesDepartment of Health and Human ServicesPhase I

“Lead Optimization of a Therapeutic Candidate for Alzheimer’s Disease”

$1.3M2 awards

Tetac Inc.

Monterey, CA4 employeesDepartment of DefensePhase IIcompany site

“APOBS Modernization”

$858k

Atomnaut Inc.

San Francisco, CA1 employeeNational Science FoundationPhase Icompany site

“SBIR Phase I: In situ vitrification to unlock routine atomic-scale imaging of biomolecule structure and chemistry in three dimensions”

$305k

3vo Medical, Inc

Los Angeles, CA3 employeesNational Science FoundationPhase Icompany site

“SBIR Phase I: Feasibility of a Novel Minimally Invasive Labor Augmentation System for Stage I Labor”

$304k

Nanodesk, LLC

Fremont, CA3 employeesNational Science FoundationPhase Icompany site

“SBIR Phase I: Software for Collaborative End-to-End Development of DNA Nanostructures”

$305k

Bridge Platform Holdings, INC.

Woodside, CA50 employeesDepartment of DefensePhase IIcompany site

“Optimizing Remote Pre-Accession Training for AFSPECWAR using BridgeAthletic with Garmin Integration”

$1.8M

Xcelerium Inc

Irvine, CA20 employeesDepartment of DefensePhase IIcompany site

“A Low-Power, Dynamically Reconfigurable Scalable Array Processor (DRSAP) for Software-Defined Universal Terminals with Integrated RF”

$1.2M

Rhoman Aerospace Corporation

Marina Del Rey, CA5 employeesDepartment of DefensePhase I/IIcompany site

“Software Deployable GPS-Denied UAV Autonomy: Alt-PNT via Software Upload, No-Emit, No Pre-Loaded Terrain Maps, Scalable Across UAV Platforms”

$2.3M3 awards

Freedom Flight Works, Inc.

San Diego, CA10 employeesDepartment of DefensePhase II

“Powered Parafoil - Self Propelled Charging System (PP-SPCS)”

$1.2M

Oorjahvaan

vacaville, CA1 employeeDepartment of DefensePhase II

“Revitalizing the US Innovation Triangle digitally using Omtrium”

$1.2M

DeepSat

North Hollywood, CA3 employeesDepartment of DefensePhase II

“DeepSat - DAF X25.5 CSO Air Force Direct-to-Phase II (D2P2)”

$1.2M

Kyte Dynamics, Inc.

Los Angeles, CA3 employeesDepartment of DefensePhase II

“Low-signature, Dual-stage UAS for Precision Resupply and ISR in Contested, GPS-Denied Environments”

$1.3M

Grid Aero, Inc.

San Leandro, CA20 employeesDepartment of DefensePhase IIcompany site

“Mission Automation of Low Cost Group 5 UAS for Contested Logistics”

$1.2M

Trabus

San Diego, CA35 employeesDepartment of DefensePhase I/IIcompany site

“SEPP Networks - Waveform Agility using Spectrally Efficient Peer-to-Peer Communications Technology”

$1.3M2 awards

Array Labs, Inc.

Palo Alto, CA25 employeesDepartment of DefensePhase IIcompany site

“Development of Robust All-Weather 3D RADAR Algorithms with Immediate Warfighter Benefit”

$2.5M2 awards

Neurofit, Inc.

Mountain View, CA6 employeesDepartment of DefensePhase IIcompany site

“Brain Health Monitoring Platform”

$1.2M

BeeSafe Labs, LLC

San Diego, CA1 employeeNational Science FoundationPhase I

“SBIR Phase I: Counteracting Social Engineering Attacks with Honeypot LLM Chatbots”

$305k

Flyby Robotics

Los Angeles, CA10 employeesDepartment of DefensePhase IIcompany site

“Non-Emitting Autonomous ISR Mission Capability With AI Object Identification Onboard Unmanned Aerial System”

$1.2M

Rattan Life Science Inc

Sunnyvale, CA4 employeesNational Science FoundationPhase IIwoman-ownedcompany site

“SBIR Phase II: Engineered Induced Thymic Epithelial Cells for Novel T Cell Immunotherapies”

$1.3M

Additive Space Technologies, Inc.

Berkeley, CA2 employeesDepartment of DefensePhase II

“Single Pallet Additive Manufacturing Cell for Rapid Deployment and Part Manufacturing”

$1.2M

Auriga Space, Inc

Garden Grove, CA11 employeesDepartment of DefensePhase I/IIwoman-ownedcompany site

“Auriga’s Electromagnetic Testbed for Hypersonic Experimentation and Rapid development (AETHER)”

$1.3M2 awards

Composabl, Inc

Martinez, CA5 employeesDepartment of DefensePhase IIcompany site

“AI-Driven Wargaming for Strategic Decision-Making at Air University”

$1.2M

Spiro Robotics, Inc

Hayward, CA12 employeesDepartment of DefensePhase I/IIcompany site

“Handheld Robotic Device for Difficult Tracheal Intubation”

$1.9M2 awards

Osel, Inc.

Mountain View, CADepartment of Health and Human ServicesPhase I

“Novel Antimicrobial Approach to Treat Chemoradiation Resistant Cervical Cancer by Selectively Inhibiting Lactobacillus iners”

$296k

Rescan Inc

Menlo Park, CA12 employeesDepartment of DefensePhase IIcompany site

“REVOLUTIONIZING AIR FORCE INFRASTRUCTURE WITH AI-POWERED 3D DIGITAL TWINS”

$1.2M

Hedgefog Research Inc.

San Pedro, CA10 employeesDepartment of DefensePhase I/IIcompany site

“Contact Lens Integrated Physiological Sensors”

$1.9M2 awards

Reflect Orbital Inc.

Hawthorne, CA70 employeesDepartment of DefensePhase IIcompany site

“Satellite Technology Delivering On-Demand Lighting for Military Operations and Uninterrupted Solar Power for Energy Production”

$1.2M

Information Systems Laboratories Inc

Poway, CA72 employeesDepartment of DefensePhase IIcompany site

“Threat Emitter Omniscience Suite (THEOS)”

$5.0M4 awards

Cofactor Systems Inc.

Santa Barbara, CA30 employeesDepartment of DefensePhase IIcompany site

“Shiftwave: A Deployable Solution for Rapid Recovery, Stress Reduction, and Enhanced Human Performance for Air Force Operational Support Team”

$1.8M

Pleiogenix Inc

Carlsbad, CA2 employeesDepartment of Health and Human ServicesPhase II

“An innovative, non-thiazolidinedione pan-PPAR agonist therapeutic for alcoholic hepatitis: IND-enabling safety and toxicological evaluation”

$1.0M

Hepatx Corporation

Palo Alto, CA4 employeesDepartment of Health and Human ServicesPhase Icompany site

“Development of a proteomic assay for monitoring transplanted cells and tissues”

$176k

Iotai Inc

Fremont, CA20 employeesDepartment of DefensePhase IIcompany site

“All Domain Tracking Kits”

$5.4M4 awards

3dt Holdings, LLC

San Diego, CA8 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Software-guided Operative Planning of MitraClip Placement”

$1.1M

Dfusion Inc.

Scotts Valley, CA8 employeesDepartment of Health and Human ServicesPhase I/IIwoman-ownedcompany site

“Simulation for Environmental Exposure Education (S3E): A Serious Game Platform for Environmental Health Literacy”

$1.4M3 awards

Endura Therapeutics, Inc.

South San Francisco, CA3 employeesNational Science FoundationPhase Icompany site

“SBIR Phase I: Multiplexed High Throughput Discovery of Functional RNA-Targeting Small Molecules Via Next-Generation Sequencing”

$303k

Syntopa Inc.

El Sobrante, CA6 employeesNational Science FoundationPhase Icompany site

“SBIR Phase I: Enhanced Rock Weathering through Gene Editing of Soil Microorganisms”

$305k

Castle Global, Inc

San Francisco, CA250 employeesDepartment of Homeland SecurityPhase Icompany site

“Enhancing Video Conferencing Security To Prevent Digital Injection Attacks”

$175k

Nanotech Energy Inc

Chico, CA45 employeesDepartment of DefensePhase II

“Next Generation 21700 Battery Cells for 6T Batteries”

$2.0M

Rincell Corporation

Sunnyvale, CA10 employeesDepartment of DefensePhase IIcompany site

“Strengthening Army Capabilities: Ultra-High Energy 18650 Batteries for Tactical Power Needs”

$2.0M

Aaiit LLC

San Diego, CA3 employeesDepartment of Health and Human ServicesPhase I

“Protein display drug ANDI reduces asthmatic airway hyperreactivity”

$321k

Mantis Composites Inc

San Luis Obispo, CA10 employeesDepartment of DefensePhase IIcompany site

“3D Printed Continuous Fiber Ablative Propulsion Elements”

$2.0M

Jacaranda Biosciences, Inc.

San Francisco, CA2 employeesDepartment of Health and Human ServicesPhase IIcompany site

“eiF2B Activators to Treat Noise-Induced Hearing Loss”

$1.6M

Submarine Scientific LLC

San Francisco, CA3 employeesNational Science FoundationPhase Iwoman-owned

“SBIR Phase I: Automatically Configurable Graphical Processing Unit Optimized Ocean Carbon Modeling Platform”

$295k

Hill Engineering LLC

Rancho Cordova, CA22 employeesDepartment of DefensePhase IIcompany site

“Nondestructive Evaluation for Assessing Cold Worked Countersunk and/or Filled Fastener Holes in Titanium and Steel Aerospace Alloys”

$1.4M

Venator Solutions, LLC

San Diego, CA17 employeesDepartment of DefensePhase IIcompany site

“Next Generation Autonomous Tracking”

$1.4M

Alkemix Corporation

Laguna Hills, CA6 employeesDepartment of DefensePhase IIcompany site

“TPS for Hypersonic Applications”

$3.9M2 awards

Sensydia Corporation

Los Angeles, CA9 employeesDepartment of Health and Human ServicesPhase II

“A non-invasive, automated platform for hemodynamic assessment of patients at risk of heart failure or pulmonary hypertension”

$1.6M

Utopiacompression,corporation

Los Angeles, CA18 employeesDepartment of DefensePhase IIcompany site

“Intelligent Visual System for Maritime Applications”

$694k

Nextgenjane Inc

Oakland, CA6 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Performance evaluation of a non-invasive menstrual test for endometriosis in infertility patients”

$760k

VDF Industries Inc

Burlingame, CA1 employeeDepartment of Health and Human ServicesPhase I

“Phonocath - An endovascular medical device to objectively evaluate Pulsatile Tinnitus”

$305k

Aerosol Dynamics Inc

Berkeley, CA7 employeesDepartment of EnergyPhase IIcompany site

“Coupled Aerodynamic and Optical Sizing for Coarse Particles”

$1.2M

Xia LLC

Oakland, CA16 employeesDepartment of EnergyPhase IIcompany site

“Improved electronics for BeEST sterile neutrino search”

$1.1M

Sigray, Inc.

Concord, CA85 employeesDepartment of EnergyPhase IIcompany site

“Development of Advanced X-ray Emission Spectrometer”

$1.6M

Q-Flex Inc

Santa Ana, CA26 employeesDepartment of EnergyPhase IIwoman-ownedcompany site

“Development of Super Conducting Low Radioactivity flexible cables and circuitry (ULB-SSC)”

$600k

SiLi-ion Inc.

Yorba Linda, CA2 employeesDepartment of EnergyPhase IIcompany site

“A Plasma-Enabled Approach to Next-Generation Energy Storage Materials”

$1.1M

Somewear Labs, Inc.

San Francisco, CA31 employeesDepartment of DefensePhase IIcompany site

“Somewear Labs Non-Attributable Mobile Mesh and Satcom Network Devices”

$2.0M

Mobilio Co.

San Francisco, CA10 employeesDepartment of DefensePhase I/IIcompany site

“Autonomous Component Replacement Engine for Army Equipment Sustainment”

$1.6M2 awards

Attollo Engineering, LLC

Camarillo, CA60 employeesDepartment of DefensePhase I/IIcompany site

“Optical Proximity Sensor for APKWS”

$2.9M3 awards

Inspird Inc.

Mission Viejo, CA12 employeesDepartment of DefensePhase Icompany site

“Toolkit for Practical, Accurate, Secure, and Reliable RAG”

$500k2 awards

Endomet Biosciences, Inc

Irvine, CA6 employeesDepartment of Health and Human ServicesPhase IIwoman-owned

“Novel, Non-hormonal Therapeutic for Endometriosis”

$2.0M

Cellecho Inc.

Irvine, CA0 employeesNational Science FoundationPhase Icompany site

“SBIR Phase I: A Microprocessor for Complex, Multidimensional Cell Reprogramming: Acoustic-Electric Micro-Vortices Technology for Precise, Se”

$305k

Lewiz Communications, Inc.

Sunnyvale, CA10 employeesDepartment of DefensePhase IIcompany site

“Fast, Self-Recovery, Fully Rad-Hard FPGA Chip”

$900k

Invizyne Technologies Inc

Monrovia, CA13 employeesDepartment of Health and Human ServicesPhase I

“Bio-Click: A cell-free high-throughput platform for the engineering of enzymatic group transfer reactions”

$284k

Trestle Optics LLC

Irvine, CA6 employeesDepartment of Health and Human ServicesPhase I

“In vitro metabolite profiling with vibrational phase-contrast imaging”

$330k

Partillion Bioscience Corp

Los Angeles, CA12 employeesDepartment of Health and Human ServicesPhase II

“Scaling function-first antibody discovery leveraging memory B cells”

$1M

Nuravax, Inc.

Irvine, CA9 employeesDepartment of Health and Human ServicesPhase Icompany site

“Evaluate the Safety, Tolerability, and Immunogenicity of Adjuvanted Preventive Dual Aβ/tau Vaccine, Duvax in Healthy Volunteers”

$500k

Lebrun Labs LLC

Anaheim, CA5 employeesDepartment of Health and Human ServicesPhase IIcompany site

“An In Chemico Test to Identify Dermal Corrosives”

$669k

Se-Ran L.L.C.

Cupertino, CA5 employeesDepartment of DefensePhase I

“O244-P002-0117 Extending the Open-RAN for 5G and Beyond Autonomous Fault and Security Posture Management”

$295k

Julia Jean, LLC

Irvine, CA4 employeesNational Science FoundationPhase Iwoman-ownedcompany site

“SBIR Phase I: Novel Cold Cathode E-Beam Sources for Advancing Semiconductor Manufacturing”

$305k

Core Biotherapeutics, Inc

Ladera Ranch, CA2 employeesNational Science FoundationPhase Icompany site

“SBIR Phase I: Determination of the Mechanisms Driving Diseases at the Molecular Network Level to Develop Disruptive Drug Candidates”

$304k

Synthefy, Inc.

San Diego, CA3 employeesDepartment of DefensePhase IIcompany site

“Synthefy: Multi-Modal Diffusion Models for Synthetic RF Time Series”

$1.0M

Luna Manufacturing LLC

San Francisco, CA1 employeeDepartment of DefensePhase I

“Additive Manufacturing High Density Materials with Locally Controllable Deformation Properties”

$250k

Survey Genomics, Inc.

Berkeley, CA6 employeesDepartment of Health and Human ServicesPhase II

“Pioneering assays for spatially-resolved single-cell multiomics”

$1.1M

Dark Fission Space Systems, Inc.

Huntington Beach, CA3 employeesDepartment of DefensePhase IIcompany site

“DARKFORCE - A Fast Orbital Transfer Vehicle for Dynamic Space Operations”

$1.9M

Evidation Health, Inc.

San Mateo, CA96 employeesDepartment of Health and Human ServicesPhase Icompany site

“Research and Engagement on Substance use Harnessing Awareness and Personalized Education (RESHAPE)”

$304k

ChemRegen Inc

San Diego, CA5 employeesDepartment of Health and Human ServicesPhase Icompany site

“iPSC-derived human neurons and OUD medications development”

$400k

Ali Innovation Inc

Lake Forest, CA1 employeeDepartment of DefensePhase I

“Reentry Event Detection and Prediction using Deep Learning-based Satellite Constellation Analysis”

$108k

Wilson Eagle LP

San Clemente, CA4 employeesDepartment of DefensePhase IIcompany site

“Integrating the Advanced Correlator-Navy (ACOR-N) Data Fusion Processor into the Command and Control Experimentation (C2X) Capability to Enh”

$2.0M

PETcoil, Inc.

Sunnyvale, CA4 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Commercialization Readiness for a Portable PET Insert System for Simultaneous TOF-PET and MR Brain Imaging”

$1.6M

Nu-Trek, Inc.

San Diego, CA9 employeesDepartment of DefensePhase I/IIwoman-ownedcompany site

“Low SWAP Thermal ROIC in an Advanced Node”

$2.0M2 awards

Artium Technologies, Inc.

Sunnyvale, CA13 employeesDepartment of DefensePhase IIcompany site

“High-Efficiency High-Resolution Characterization of Flow Velocity, Median Volume Diameter, and Liquid Water Content Uniformity in Simulated ”

$1.4M

Dirac Solutions, Inc.

Pleasanton, CA9 employeesDepartment of DefensePhase IIcompany site

“Secure UWB Communications for Aircrew Physiological Monitoring”

$767k

Rc Integrated Systems LLC

Torrance, CA5 employeesDepartment of DefensePhase IIwoman-ownedcompany site

“Hybrid Integrated Slipring Capsule”

$1.2M

Gentiam Consulting LLC

Oakland, CA3 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase Icompany site

“Universal Hybrid Powertrain Controller for Integrated Hybrid and Electric Powertrains”

$407k2 awards

Scaled Power Inc

San Francisco, CA6 employeesDepartment of DefensePhase Icompany site

“Lightweight Turbogenerator for Hybrid-Electric Propulsion Systems”

$250k

Intrinsic Power, Inc.

Los Angeles, CA5 employeesDepartment of DefensePhase Icompany site

“The Ruggedized Power export Module (RPeM) for Holistically Supplementing Army Power Needs in Austere Environments Through EVs and Solar Gene”

$324k2 awards

Jumpcode Genomics Inc

San Diego, CA10 employeesDepartment of Health and Human ServicesPhase Icompany site

“CRISPR-based depletion method for resolving pseudogene contamination in Next Generation Sequencing (NGS) based genetic testing”

$384k

Thaero LLC

Westlake Village, CA5 employeesDepartment of DefensePhase Icompany site

“Active Materials for Protection Sustainment (AMPS)”

$136k

Elite Neuro Inc.

Pasadena, CA1 employeeNational Science FoundationPhase I

“STTR Phase I: Enhancing Cognitive Performance Through a Scalable Virtual Reality Platform”

$305k

Aesculatech Inc

Los Angeles, CA8 employeesDepartment of Health and Human ServicesPhase IIwoman-owned

“Humidifeye Plug for Dry Eye Disease”

$1.2M

Sonomotion Inc.

San Mateo, CA10 employeesDepartment of Health and Human ServicesPhase Icompany site

“Break Wave lithotripsy to fragment large kidney stones”

$278k

Confidencial Inc

Menlo Park, CA20 employeesDepartment of DefensePhase Icompany site

“Confidencial for Advanced Data Integrity and Control Methods”

$94k

GIANT BioSystems Inc.

Pasadena, CA6 employeesNational Science FoundationPhase Iwoman-ownedcompany site

“SBIR Phase I: High-Throughput AST Using Gradient-Based Microfluidic”

$305k

Ziva Corporation

San Diego, CA7 employeesDepartment of DefensePhase IIcompany site

“Precision Indirect Fire Navigation (ODIN)”

$3.3M2 awards

Nexus Photonics Inc

Goleta, CA15 employeesNational Aeronautics and Space AdministrationPhase IIcompany site

“Application specific PICs operating around 780 nm towards MPWs”

$849k

Redondo Optics, Inc.

Redondo Beach, CA6 employeesDepartment of Defense, Department of EnergyPhase Icompany site

“Low Cost, High-Throughput, Dense-Fiber Channel Optical Interrogator Based Photonic Integrated Circuits (PIC) Microchip Technology”

$446k2 awards

Brechtel Manufacturing, Inc.

Hayward, CA17 employeesDepartment of EnergyPhase Icompany site

“Aerosol Size Distribution Measurements for Marine Platforms”

$256k

IBP USA Group Inc.

San Pedro, CA1 employeeDepartment of EnergyPhase I

“30 nm thick silicon photodiodes with 100% internal quantum efficiency for VUV spectroscopy of tokamak plasmas”

$182k

Rochester Scientific LLC

El Cerrito, CA2 employeesDepartment of EnergyPhase Icompany site

“Improvements in optical metrology for high-performance variable-line-spacing x-ray gratings”

$200k

Partow Technologies LLC

Carlsbad, CA3 employeesDepartment of EnergyPhase Icompany site

“Fiber-optic electro-optic sensors for non-destructive electron beam diagnostics”

$200k

Controlx, Inc.

Santa Clara, CA5 employeesDepartment of DefensePhase Icompany site

“Resilient Robotic Automation: Enhancing Efficiency and Safety in Aircraft Servicing”

$75k

Stellar Engiine

Los Altos, CA2 employeesNational Science FoundationPhase I

“SBIR Phase I: Advanced PEALD Processing Technology using Nanosecond Pulse Power”

$305k

Apex Technology, Inc.

Los Angeles, CA164 employeesDepartment of DefensePhase IIcompany site

“APEX STRATFI Proposal”

$30M

Archetype AI Inc

San Diego, CA7 employeesDepartment of DefensePhase I

“Artificial Intelligence Pipeline for Infrared Thermography, Ultrasonic, Visual and other Unconventional Data for Non-Destructive Inspection ”

$46k

Formalloy Technologies Inc

Spring Valley, CA21 employeesDepartment of DefensePhase Iwoman-ownedcompany site

“Advanced Robotic Automation for Repair, Metal Forming, and Welding via Directed Energy Deposition (DED)”

$175k

Altex Technologies Corporation

San Jose, CA15 employeesDepartment of DefensePhase Icompany site

“Desulfurizer for JP-8 Fueled Tier 4 Engines (JP8T4)”

$140k

Quantum Applied Science & Research Inc

San Diego, CA13 employeesDepartment of DefensePhase IIcompany site

“Cognitive Health Impact and Physiological Sensors (CHIPS) Helmet, Phase II”

$1.3M

Rekovar Inc

Laguna Niguel, CA9 employeesDepartment of Health and Human ServicesPhase Icompany site

“Wireless Wearable with AI Analytics for Monitoring Neonatal Abstinence Syndrome (NAS)”

$412k

Argosmd, Inc.

Studio City, CA1 employeeDepartment of Health and Human ServicesPhase Icompany site

“Mini-reflectance confocal microscope (Mini-RCM) for aiding skin cancer diagnosis and treatment”

$400k

Xcellassay, Inc

San Francisco, CA4 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“Meeting the cost and privacy demands for detecting Anabolic Androgenic Steroid doping in youth athletics with rationally designed nuclear re”

$307k

Out of the Fog Research LLC

Mountain View, CA9 employeesDepartment of DefensePhase IIcompany site

“CRES for HF”

$2.0M

Collaborative Robotics Inc.

Santa Clara, CA59 employeesDepartment of DefensePhase Icompany site

“Development and Certification of Explosion-Proof Collaborative Robots: A Pathway for Modernizing the Army’s Energetic Industrial Base”

$249k

Krtkl Inc.

San Francisco, CA10 employeesDepartment of DefensePhase IIcompany site

“Spectral Awareness for Autonomous and Remotely Operated Systems”

$1.9M

Doodle Labs LLC

Marina Del Rey, CA10 employeesDepartment of DefensePhase IIcompany site

“Adaptive Ultra-Wideband SDRH for Tactical Communications”

$2.0M

Hunted Labs LLC

Long Beach, CA3 employeesDepartment of DefensePhase IIwoman-ownedcompany site

“Hunted Labs - ACE software supply chain security data analytics to improve resiliency”

$1.8M

Northwood Space Corp.

Torrance, CA45 employeesDepartment of DefensePhase Icompany site

“Ultra-wideband Arrays for Proliferated Satellite Communications”

$279k2 awards

Aerocharge Inc.

Los Angeles, CA6 employeesDepartment of DefensePhase Icompany site

“Scalable UAS Persistence using Enhanced RF power Beaming (SUPERB)”

$75k

Femtosense, Inc.

San Bruno, CA25 employeesDepartment of DefensePhase Icompany site

“Low-Power Sparse AI Processing for Enhanced ISR Communications with Femtosense’s SPU-001 Chip”

$75k

MonuMedical LLC

Penryn, CA5 employeesDepartment of DefensePhase Icompany site

“Prolonged Field Care with the MiniFuser Infusion Device”

$75k

Celeris Systems, Inc.

Anaheim, CA60 employeesDepartment of DefensePhase Icompany site

“Predictive Analytics to Maintain Program Development Speed and Reduce Risk on Test Resources”

$72k

Ubiquity Robotics, Inc.

San Jose, CA40 employeesDepartment of DefensePhase Icompany site

“MAGNI ROBOT: Mobile Autonomous Ground Navigation Integrated Robot for Optimizing Base Operational Tasks”

$75k

Kyndi Inc

San Mateo, CA19 employeesDepartment of DefensePhase Icompany site

“Empowering Air Force with Large Language Model-powered Agentic RAG”

$73k

Sophia Space, Inc.

Pasadena, CA15 employeesDepartment of DefensePhase I

“Large Scale Data Centers in Space”

$75k

Re:orbital Inc.

Los Angeles, CA1 employeeDepartment of DefensePhase Icompany site

“Bodyguard - Deployable System for ASAT Defense”

$75k

Eclipse Bioinnovations, Inc.

San Diego, CA10 employeesDepartment of Health and Human ServicesPhase IIcompany site

“eMOA: A Multi-Omic Service for Mechanism of Action Determination in Drug Screening”

$1.1M

Swirlabs Corp

La Canada Flintridge, CA3 employeesDepartment of DefensePhase Icompany site

“Development of Analog Mixed Signal IP Library ? for IR FPA ROIC Sensors?”

$250k

Customweather, Inc.

Mill Valley, CA5 employeesDepartment of DefensePhase Icompany site

“Tactical Weather Modeling System (TEMS)”

$102k

Atomic Semi, Inc

Palo Alto, CA25 employeesDepartment of DefensePhase Icompany site

“Domestic Semiconductor Fab for Fast, Agile, and Inexpensive Chipset Production”

$75k

Dtp Thermoelectrics LLC

Pasadena, CA4 employeesDepartment of DefensePhase Icompany site

“Advancing Distributed Transport Properties Thermoelectrics for Solid-State Cryo-Cooling for Air Force IR Sensors and Optical Packages”

$74k

Kitt Bio, Inc

Los Angeles, CA17 employeesDepartment of DefensePhase Icompany site

“FlyKitt: Jet Lag Elimination”

$75k

Zeroavia, Inc

Hollister, CA120 employeesDepartment of DefensePhase Icompany site

“Feasibility Study for Integrating Hydrogen Propulsion and Aircraft Automation in a Cessna Caravan”

$75k

Waveye, Inc.

Palo Alto, CA5 employeesDepartment of DefensePhase Icompany site

“Multi-Agent Robotic System In Dynamic Environments With AI-Driven Networked 4D Imaging Radars Based Perception System”

$110k

Corellian Energy, LLC

Sacramento, CA15 employeesDepartment of DefensePhase I

“Battle-Ready Data: Miniaturizing Cloud Power for Tactical Superiority”

$109k

Selas Energy, LLC

Sacramento, CA15 employeesDepartment of DefensePhase I

“EnergyOS: Transforming Legacy Energy into Smart, Resilient Grids”

$74k

Knightscope, Inc.

Mountain View, CA30 employeesDepartment of DefensePhase Icompany site

“Autonomous Public Safety Solutions for U.S. Air Force Installation Security Needs”

$73k

Terraferma Foods, Inc.

San Francisco, CA2 employeesNational Science FoundationPhase Iwoman-owned

“SBIR Phase I: A novel platform for accelerated strain development for precision fermentation”

$275k

Digibeam Corporation

San Juan Capistrano, CA9 employeesDepartment of DefensePhase Icompany site

“Surface Anti-material Weapon”

$75k

Tonic AI, Inc.

San Francisco, CA69 employeesDepartment of DefensePhase Icompany site

“Deidentifying Personally Identifiable Information (PII) for LLM Ingestion and RAG Applications”

$74k

Traverse Aero Corporation

Richmond, CA5 employeesDepartment of DefensePhase Icompany site

“Orca - Hybrid-electric eVTOL cargo drone”

$75k

Starlight Cardiovascular Inc

San Diego, CA6 employeesDepartment of Health and Human ServicesPhase II

“DUCTUS ARTERIOSUS STENT TO IMPROVE CONGENITAL HEART DEFECT MORTALITY”

$1000k

Osem Fluidics Inc

Alhambra, CA4 employeesDepartment of Health and Human ServicesPhase I

“Three-Dimensional Spatio-Temporal Control of Lipid Nanoparticle Manufacturing for Improved Nucleic Acid Delivery”

$350k

Slingshot Aerospace Inc

El Segundo, CA148 employeesDepartment of DefensePhase IIcompany site

“Slingshot RAPTOR”

$1.5M

Xtelligent Inc

Los Angeles, CA21 employeesDepartment of DefensePhase Icompany site

“Enhancing Base Security and Efficiency with an Advanced Intelligent Traffic Management System”

$180k

A.t.e. Solutions, Inc.

El Segundo, CA3 employeesDepartment of DefensePhase Icompany site

“AI-Assisted TPS Development and Sustainment”

$250k

Deep Media, Inc

Oakland, CA20 employeesDepartment of DefensePhase IIcompany site

“Advanced Machine Translation System for Low-Resource Languages with ATAK Integration”

$1.5M

Turion Space Corp

Irvine, CA120 employeesDepartment of DefensePhase IIcompany site

“Enhancing Battlespace Awareness Utilizing Multi-Payload SDA Satellites and Real-Time Command & Control”

$28.0M

Dare Bioscience, Inc.

San Diego, CA24 employeesDepartment of Health and Human ServicesPhase IIcompany site

“A first-in-class product for the clearance of high-risk human papillomaviruses”

$1M

Antaris, Inc.

Los Altos, CA12 employeesDepartment of DefensePhase Icompany site

“Antaris TrueTwin: A Cognitive Digital Twin solution for Autonomous Target Discrimination”

$150k

Symmetry Wood, PBC

Los Angeles, CA2 employeesEnvironmental Protection AgencyPhase Icompany site

“Upcycling Food Waste into Bacterial nanocellulose to Create High-Performance Dimensional Wood”

$100k

Pacific Reclaimed Lumber & Supply, Spc

Sebastopol, CA0 employeesEnvironmental Protection AgencyPhase Iwoman-ownedcompany site

“Scaling Reclaimed Lumber Sales & Procurement Through Web and App-Based Technology”

$100k

Agtec Innovations, Inc.

Los Altos, CA3 employeesEnvironmental Protection AgencyPhase Icompany site

“SMARTP Fertilizer - The Environment-Friendly Phosphate Alternative”

$100k

Synvivia, Inc.

Emeryville, CA3 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Platform for Optimizing Yield and Quality of Therapeutic AAV Vector Manufacturing via Synthetic Helper Genes”

$1.6M

Episys Science Inc

Poway, CA86 employeesDepartment of DefensePhase IIcompany site

“STRATFI SBIR Sequential Phase II”

$12.4M

Carbon Technology Inc

San Clemente, CA3 employeesDepartment of DefensePhase Icompany site

“10x Threat Detection Sensitivity Deployed in Battlefield Systems”

$210k

Design West Technologies, Inc.

Tustin, CA200 employeesDepartment of DefensePhase Icompany site

“Algorithms for Modular Remote Expendable Sensor Array”

$237k

Brainchip, Inc

Laguna Hills, CA76 employeesDepartment of DefensePhase IIcompany site

“Low C-SWAP Neuromorphic Radar Classification”

$1.8M

Mayachitra, Inc.

Santa Barbara, CA10 employeesDepartment of DefensePhase Icompany site

“GUARDIAN: Generating Understanding and Accountability in Robust Detection with Directed Energy Insights and Analysis of Neural Collapse”

$180k

Launchpoint Electric Propulsion Solutions, Inc.

Goleta, CA31 employeesDepartment of DefensePhase Icompany site

“Advancing Rotorcraft Design Through Innovative Electric Motor and Thermal Management Technologies”

$250k

Senoguard Inc

Seal Beach, CA4 employeesNational Science FoundationPhase IIwoman-owned

“SBIR Phase II: Cryogenic probe development and testing for post-lumpectomy margin ablation treatment”

$1000k

Trans Astronautica Corporation

Pacoima, CA23 employeesDepartment of DefensePhase IIcompany site

“Trans Astronautica’s Sutter Turn Key Observatory”

$1.8M

BioDynamik

lake forest, CA5 employeesNational Science FoundationPhase Icompany site

“SBIR Phase I: Innovative actuating smart implant device of Transverse Tibial Transport technology for the treatment of Diabetic Foot Ulcers”

$275k

Inneos LLC

Pleasanton, CA30 employeesDepartment of DefensePhase Icompany site

“High Power VCSEL Design for Ruggedized 50 Gbps Transmitter Optical Subassembly”

$140k

Elve Inc

Davis, CA46 employeesDepartment of DefensePhase IIcompany site

“Millimeter-wave amplifiers for space communications”

$1.8M

Roam Robotics, Inc

San Francisco, CA13 employeesDepartment of DefensePhase IIcompany site

“Powered Knee Exoskeleton for Airfield Operations”

$1.8M

Hyperkelp Inc

Encinitas, CA6 employeesDepartment of DefensePhase IIcompany site

“HyperKelp Covert Ocean Monitoring Buoy System (COMBS)”

$2.8M2 awards

Genesis Codes Incorporated

Menlo Park, CA6 employeesDepartment of DefensePhase I

“Feasibility Study of Genesis Codes’ Data Transport Solution On Tactical Radio to Improve Speed, Security and Resilience”

$250k

Om Therapeutics Inc.

San Diego, CA3 employeesNational Science FoundationPhase Icompany site

“SBIR Phase I: Massive, empirical, scalable generation of small molecule and protein interaction data to enable the discovery of medicines at”

$275k

Geooptics, Inc.

Pasadena, CA5 employeesDepartment of DefensePhase IIcompany site

“Swarm Radar Surveyor for Space Based Environmental Monitoring”

$3.0M

Swr Technology Inc.

Fremont, CA4 employeesDepartment of DefensePhase I

“Combining Sound and Magnetic fields to transfer power through Seawater and Metals (CoSoMaSaM)”

$140k

Acree Technologies Incorporated

Concord, CA15 employeesDepartment of DefensePhase Icompany site

“Anti-Corrosion Coating for Gas Turbine Compressor Components Operating in Marine Environments”

$140k

Electromagnetic Systems, Inc.

El Segundo, CA23 employeesDepartment of DefensePhase Icompany site

“All-Aspect Maritime Automatic Target Recognition”

$140k

Brelyon Inc.

Redwood City, CA33 employeesDepartment of DefensePhase Icompany site

“Ultra Reality Extend: Enhanced Situational Awareness via Amplified Indirect Vision”

$217k

Gsi Technology, Inc.

Sunnyvale, CA168 employeesDepartment of DefensePhase I

“AI Accelerator for Edge Computing”

$247k

Hydroplane Ltd

Sherman Oaks, CA15 employeesDepartment of DefensePhase Iwoman-ownedcompany site

“Hydroplane Fuel Cell Powerplant for Mobile Energy Generation, Storage, and Electric Propulsion”

$250k

Starnav LLC

Riverside, CA6 employeesDepartment of DefensePhase IIcompany site

“Self-Contained Signal of Opportunity-Based PNT”

$2.0M

Ansync Inc.

El Dorado Hills, CA36 employeesDepartment of DefensePhase I

“Modular Open Architecture for Small Form Factor Technology (MOAST)”

$140k

Antara Teknik LLC

Granite Bay, CA17 employeesDepartment of DefensePhase Icompany site

“Standardized, Modular and Scalable Wideband Multifunction Radio Frequency Payloads”

$240k

K2 Space Corporation

Torrance, CA195 employeesDepartment of DefensePhase IIcompany site

“K2 Space Mega Class Satellite”

$18M

Water Illumination Inc

Lake Forest, CA4 employeesEnvironmental Protection AgencyPhase IIwoman-owned

“Demonstration of a Chemical-free Short-wavelength UV Based PFAS Destruction Technology for Saline Wastewater Treatment”

$400k

E-Skin Displays, Inc.

Pleasanton, CA1 employeeDepartment of DefensePhase Icompany site

“Lightweight Longwave Bolometer Sensor Components”

$250k

Edlore Inc.

Laguna Hills, CA6 employeesDepartment of DefensePhase IIwoman-ownedcompany site

“Edlore AI/ML Maintenance On-Prem Platform”

$1.7M

Advanced Life Technologies, LLC

Santa Barbara, CA3 employeesDepartment of DefensePhase Icompany site

“RoboMedic”

$250k

Mavericks Photonics, Inc.

San Francisco, CA1 employeeDepartment of DefensePhase Icompany site

“PRISM: PRecise Interferometers as Stratospheric Microphones”

$180k

Teraspatial Inc

Palo Alto, CA12 employeesDepartment of DefensePhase II

“Ultra-Wideband, Low-Voltage, Low-power, Low Phase Noise CMOS Voltage Controlled Oscillator”

$1.3M

Avantgen Inc

San Diego, CADepartment of Health and Human ServicesPhase II

“DEVELOPMENT OF RABBIT MONOCLONAL ANTIBODIES FOR FERRET BIOMARKERS.”

$1.5M

Gencyte Therapeutics Inc

San Carlos, CA1 employeeDepartment of Health and Human ServicesPhase I

“PHASE I SBIR CONCEPT AWARD FOR LOGIC GATED MOLECULAR ADAPTOR SYSTEM FOR JMML TREATMENT”

$500k

TippingPoint Biosciences, Inc.

Los Altos, CA3 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“SBIR FY25 CONCEPT AWARD: TARGETING DYSFUNCTIONAL CHROMATIN NETWORKS IN DIPG”

$355k

Adelphi Technology Inc

Redwood City, CA20 employeesDepartment of Health and Human ServicesPhase Icompany site

“A COMPACT SOURCE FOR NEUTRON CAPTURE THERAPY FOR PONTINE GLIOMA.”

$500k

ASO Therapeutics Inc.

San Rafael, CA2 employeesDepartment of Health and Human ServicesPhase I

“FY2025 SBIR CONCEPT CLEARANCE AWARD OR TOPIC DEVELOPMENT OF THERAPEUTIC OR PREVENTATIVE TECHNOLOGIES FOR TREATMENT OR PREVENTION OF PEDIATRI”

$355k

Big Eye Diagnostics Inc

San Diego, CA8 employeesDepartment of Health and Human ServicesPhase Icompany site

“An Antigen-Based Rapid Test to detect L. loa infections, Aimed at Supporting Onchocerciasis Elimination Programs”

$300k

Qoolabs Inc

Carlsbad, CA12 employeesDepartment of Health and Human ServicesPhase IIwoman-ownedcompany site

“AFFINITY REAGENTS FOR THE IMMUNE SYSTEM OF GUINEA PIGS IL1B, IL2, IL4, IL6, IL8, IL10, IL12, AND IL13.”

$1.5M

Marwell Bio Inc

South San Francisco, CA2 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“NEXT GENERATION DUAL TARGETING ADCS FOR SCLC EMPOWERED BY GENERATIVE AI.”

$355k

Source: public SBIR/STTR award record. Company-level facts only. Open roles are live listings on our board.