255 companies · SBIR/STTR awards, last two years
Every company in Massachusetts that closed a federal SBIR/STTR award in the last two years: those with open roles on our board first, then newest award first. Back to the Massachusetts page
Cambridge, MA · 134 employees · Department of Defense · Phase II · company site
“Prophecy”
Boston, MA · 150 employees · Department of Defense · Phase II · company site
“Enhancing Reduced-Crew Flight Operations with NLP-Driven Real-Time Dynamic Replanning”
Boston, MA · 8 employees · Department of Defense · Phase II
“STX-005: A Next-Generation Therapy for Autoimmune Disease to Sustain Force Readiness”
Natick, MA · 110 employees · Department of Defense · Phase II · company site
“Compact Stored Propellant Propulsion System for VLEO Satellites”
Boston, MA · 26 employees · Department of Defense · Phase I · company site
“On-Chip Wavelength Generation for DWDM Photonic Transceivers”
Cambridge, MA · 156 employees · Department of Defense, Department of Health and Human Services · Phase I/II · company site
“Neural Network Enhancements for Customized Reduced Order Models to Accelerate Nuanced COA Evaluation and Reasoning (NECROMANCER)”
Andover, MA · 259 employees · Department of Defense, Department of Energy, Department of Health and Human Services, Department of Homeland Security, Department of Transportation, National Aeronautics and Space Administration · Phase I/II · company site
“Bio-inspired Energy Dissipating Structures for Enhanced Airdrop Capabilities”
Lincoln, MA · 2 employees · Department of Defense · Phase II · company site
“Enhanced Language-oriented System for Analysis and Management of C2 and Maintenance Data”
Lexington, MA · 4 employees · Department of Defense · Phase I/II
“Quad-Pol L-band Scatterometer for Ocean Surface Vector Winds in Extreme Conditions”
Burlington, MA · 43 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site
“Development and Demonstration of an Efficient Multiphysics Modeling Framework for Rain-Induced Damage and Aerodynamic Effects on Hypersonic ”
Chelmsford, MA · 126 employees · Department of Defense, Department of Energy, National Aeronautics and Space Administration · Phase I/II · company site
“Coatings for Reliable Compact Rotary Engines”
Watertown, MA · 101 employees · Department of Defense, Department of Energy, Department of Health and Human Services, National Aeronautics and Space Administration · Phase I/II · company site
“Transparent Conducting Oxide Based On-Chip Modulators for Applications at Cryogenic Temperatures”
Waltham, MA · 30 employees · Department of Defense · Phase II · company site
“GelSight Nano: Compact Tactile Fingertips for Intelligent Grasping in Industrial Environments”
Worcester, MA · 102 employees · Department of Defense, Department of Energy · Phase I/II · company site
“High-Performance, No-Helium Cold Spray for Structural Repair Applications”
Bedford, MA · 8 employees · Department of Defense · Phase I/II · company site
“High Performance Electro-optic Modulator Designed for Military Aircraft”
Cambridge, MA · 6 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Low-Cost, Waste-Resilient Polyethylene Terephthalate (PET) and Polyester Upcycling Through Macrocyclic Chemistry”
Cambridge, MA · 5 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Drop-on Demand Liquid Metal Additive Manufacturing”
Amherst, MA · 0 employees · National Science Foundation · Phase I/II
“STTR Fast-Track: Advanced Manufacturing of All-inorganic Polarization Controlled Metasurfaces for Enabling Next Generation Full-Stokes Imagi”
Woburn, MA · 13 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Advancing Metal Additive Manufacturing with Novel Acoustic Molding Technology”
Quincy, MA · 2 employees · Department of Commerce · Phase II · company site
“Online Short Wave Infrared Hyperspectral AI-Imaging System (SWIRhyperspectral AI-Imaging) for measuring cell culture material, process and q”
Woburn, MA · 1 employee · National Science Foundation · Phase I
“STTR Phase I: High Throughput Discovery of Catalysts for Water Electrolysis Anion-Exchange Membranes”
Cambridge, MA · 3 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Bridging Multi-Party Computation and Fully Homomorphic Encryption for Practical Data Security Solutions”
Cambridge, MA · 1 employee · National Science Foundation · Phase I · company site
“SBIR Phase I: AI-Accelerate Superconductor Discovery for High-Field Magnets”
Auburndale, MA · 6 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Spectrum Coexistence Digital Twin”
Somerville, MA · 2 employees · National Science Foundation · Phase I
“SBIR Phase I: Acoustic Expander for Air-Cycle Flash Freezers and Ultra-Low Temperature Refrigerators”
Somerville, MA · 2 employees · Department of Health and Human Services, National Science Foundation · Phase I · company site
“SBIR Phase I: Hemostatic Tough Adhesive Hydrogels for Advanced Biosurgery”
Auburndale, MA · 40 employees · Department of Health and Human Services, National Aeronautics and Space Administration · Phase I/II · company site
“Multi-Purpose Flame Retardant Materials for Habitation Solutions”
Lowell, MA · 1 employee · Department of Defense · Phase I/II · company site
“Autonomous Soft Robot for Locomotion in Granular Seabed Media”
Beverly, MA · 145 employees · Department of Defense · Phase I
“Securely Interfacing with SDA’s Proliferated Warfighter Space Architecture (PWSA)”
Lowell, MA · 12 employees · Department of Health and Human Services · Phase II · company site
“Improved Treatment Options for Vertebral Compression Fractures in Elderly Patients Using Minimally Invasive, Image-Guided Delivery of a Rege”
Beverly, MA · 183 employees · Department of Defense · Phase I/II
“NEXUS: Interconnecting with SDA’s Proliferated Warfighter Space Architecture (PWSA) Transport Layer”
Wayland, MA · 5 employees · Department of Health and Human Services · Phase I
“Novel light source development for robust multi-MHz retinal OCT”
Boston, MA · 4 employees · Department of Defense · Phase I/II
“Orama Mixed Reality Combat Simulator: AI-Driven Mixed Reality Combat Simulator for Adaptive Near-Peer Threat Training”
Natick, MA · 15 employees · Department of Defense, Department of Energy, Department of Health and Human Services · Phase I/II · company site
“Low-Cost High-Efficiency X-ray Imaging Panels for Field Radiography”
Norton, MA · 110 employees · Department of Defense, Department of Energy · Phase I/II · company site
“30b Foam-Lattice Composite Impact Limiter”
Weston, MA · 1 employee · National Aeronautics and Space Administration · Phase I · company site
“Polybenzoxazine Aerogels for Insulation in 38% Oxygen Environments”
Cambridge, MA · 65 employees · Department of Defense, Department of Homeland Security, National Aeronautics and Space Administration · Phase I/II · company site
“Heterogeneous integration of infrared single mode lasers with photonic integrated circuits”
Cambridge, MA · 2 employees · Department of Health and Human Services, National Science Foundation · Phase I
“Microneedle-mediated expansion of skin-resident regulatory T cells for management of autoimmune skin diseases”
Cambridge, MA · 5 employees · Department of Health and Human Services · Phase I/II · company site
“Process development for manufacturing eCD4-Ig”
Arlington, MA · 1 employee · Department of Defense · Phase I
“Embedded Machine Olfaction for Multi-Modal Sensing”
Worcester, MA · Department of Health and Human Services · Phase I/II
“Novel Benzyl-Piperidine antifungal agents to treat intractable Mucorales infections”
Somerville, MA · 30 employees · Department of Health and Human Services · Phase I/II · company site
“Improving Mental Health and Social Connectivity for Older Adults through Virtual Reality-Based Social Interventions”
Boston, MA · 2 employees · Department of Health and Human Services · Phase I · company site
“New Nanoprobes for MR Imaging of TrkB in Alzheimer's Disease”
Boston, MA · 12 employees · Department of Health and Human Services · Phase II · company site
“Developing an Elderly Patient-Specific, Accurate, Intuitive and Highly Interpretable System for Unconsciousness Management in General Anesth”
Boston, MA · 4 employees · Department of Health and Human Services · Phase I
“Targeting aVb8 integrin to restore astrocyte-microglia crosstalk to treat Alzheimer's disease”
Concord, MA · 1 employee · Department of Health and Human Services · Phase I
“An Eyedrop Diagnostic Test for Alzheimer's Disease”
Cambridge, MA · 2 employees · Department of Health and Human Services · Phase I
“Development of a tissue-targeted non-thrombotic EPO derivative”
Brookline, MA · 1 employee · Department of Health and Human Services · Phase I
“Targeted Localization and Optimized Surgical Resection for Lung Cancer”
Newton, MA · 8 employees · Department of Defense · Phase II · company site
“Multi-Sensor Prototype for Non-Destructive Corrosion Evaluation and Characterization”
Lexington, MA · 3 employees · Department of Health and Human Services · Phase II
“IND-enabling studies of D6PV- a novel ApoC-II peptide mimetic therapeutic”
Cambridge, MA · 2 employees · Department of Defense · Phase II · company site
“Imperceptible Fabric-Integrated Wireless Batteryfree Fiber Temperature Sensor System (fID-T) for Remote Frostbite Detection and Prevention”
Boston, MA · 14 employees · Department of Defense, National Aeronautics and Space Administration · Phase I · company site
“HYDRATE: A Zero-Emission Direct Drive Parallel Hybrid Turbofan for Personal Jets”
Cambridge, MA · 12 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site
“Conformal coatings to enhance biocarriers for rapid-startup of biofilm reactors”
Medford, MA · 4 employees · Department of Health and Human Services · Phase I
“Project GAME ON!: Empowering urban children to engage in healthy behaviors to reduce obesity risk through an interactive digital comic tool”
North Andover, MA · 5 employees · Department of Health and Human Services · Phase II · company site
“CuRrEnT: Capecitabine in RCB2/3 with a wearable induced Electric field device in Triple Negative Breast Cancer”
Boston, MA · 3 employees · Department of Health and Human Services · Phase II · company site
“Scaling Lymphoma Diagnosis: A Cost-Effective Gene Expression Assay for Broad Implementation”
Jamaica Plain, MA · 6 employees · Department of Health and Human Services · Phase I · company site
“Evaluating the Effect of a Local Microvascular Tissue Graft Treatment in Rat Models of Diabetic Peripheral Neuropathy”
Brookline, MA · 3 employees · Department of Health and Human Services, National Science Foundation · Phase I · company site
“Enhancing Solid Tumor lmmunotherapy with Targeted siRNA Delivery”
Boston, MA · 11 employees · Department of Health and Human Services · Phase II · company site
“Integration of Sotair with Capnography for Standardizing Manual Ventilation Technique and Improving Patient Outcomes”
Boston, MA · 12 employees · Department of Health and Human Services · Phase I/II · company site
“Development of an Oral Methionine-Gamma-Lyase Enzyme for the Treatment of Homocystinuria”
Burlington, MA · 4 employees · Department of Defense, National Aeronautics and Space Administration · Phase I · company site
“Portable Major and Trace Constituent Gas Analyzer for Habitable Environments”
Woods Hole, MA · 4 employees · National Aeronautics and Space Administration · Phase II
“Mizar S/TAR High-Throughput Platform for Identification of Senescence Altering Therapeutics”
Cambridge, MA · 6 employees · Department of Health and Human Services · Phase I · company site
“Achieving ultra-high-density, ultra-high-precision single molecule localization microscopy with whole-video deep learning architectures”
Sharon, MA · Department of Health and Human Services · Phase II
“3D-printed Skin and Bone Integrated Pylon (SBIP-3D) for Direct Skeletal Attachment of Limb Prostheses.”
Watertown, MA · 5 employees · Department of Health and Human Services · Phase I
“Development of a novel liver-specific positron emission tomography tracer”
Hudson, MA · 1 employee · National Science Foundation · Phase II
“SBIR Phase II: Robotic system outputting multimodal methods to aid in communication”
Newton Center, MA · 3 employees · Department of Health and Human Services · Phase I · woman-owned · company site
“Objective Mobile diagnostics for Optic Neuropathies”
Lexington, MA · 5 employees · Department of Health and Human Services · Phase I
“Development of PAR2 Pepducins for the Treatment of COPD”
Framingham, MA · 13 employees · Department of Health and Human Services · Phase I/II · company site
“Peptide-based ELISA for laboratory diagnosis of sarcoidosis”
Cambridge, MA · 5 employees · National Science Foundation · Phase II · woman-owned
“SBIR Phase II: Engineering the Plant Microbiome to Reduce Disease in Crops”
Worcester, MA · 2 employees · Department of Health and Human Services · Phase I/II · company site
“TREM-1 therapy for the treatment of empyema”
Woburn, MA · 19 employees · Department of Health and Human Services · Phase II · company site
“Next-generation Brillouin ocular scanner”
Cambridge, MA · 8 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site
“Ultra Low Reflectance Black Silicon for Visible to IR Light Absorption”
Cambridge, MA · 7 employees · Department of Education · Phase II · woman-owned · company site
“Personalized and Context-relevant English lessons with AI (Pace AI) to Advance Adult Learners in Integrated Education and Training (IET) Wor”
Cambridge, MA · 2 employees · Department of Education · Phase II
“AI and Neuroscience-powered chatbot to provide students individualized guidance that complements the support they receive from school counse”
Cambridge, MA · 10 employees · Department of Defense · Phase II · company site
“High Mach Airbreathing Target (HMAT)”
Dorchester, MA · 5 employees · Department of Health and Human Services · Phase I · company site
“TauTrace™: An ultrasensitive immunoassay for neurodegenerative protein biomarkers”
Medford, MA · 1 employee · National Aeronautics and Space Administration · Phase I · woman-owned · company site
“A discovery platform to optimize the production of nutrient rich food via solid state fermentation of feedstocks relevant to spaceflight.”
Norwood, MA · 3 employees · Department of Health and Human Services · Phase I · company site
“Preclinical validation of an effective oral fulvestrant product as the future standard of care endocrine therapy for ER+ metastatic breast c”
Cambridge, MA · 4 employees · Department of Health and Human Services · Phase I · company site
“Targeted Delivery of Tumor Antigen esaRNA to the Spleen for Cancer Immunotherapy”
Newton, MA · 1 employee · Department of Health and Human Services · Phase I · company site
“Brilliant epitopes for improved cancer vaccines”
Framingham, MA · 9 employees · Department of Health and Human Services · Phase II
“Development of a novel renalase agonist for the treatment of acute pancreatitis”
Cambridge, MA · 5 employees · Department of Health and Human Services · Phase I
“Peptide YY triagonist weight loss drugs”
Newton, MA · 20 employees · Department of Health and Human Services · Phase II · company site
“A Wearable Sensor Platform for Remote Monitoring of Motor Impairment in Huntingtons Disease and Prodromal Huntingtons Disease”
Holliston, MA · 2 employees · Department of Health and Human Services · Phase I · company site
“Software for increased accuracy prediction of antibody-antigen complexes”
Cambridge, MA · 6 employees · Department of Health and Human Services · Phase I
“Active non-viral nuclear delivery of DNA templates independent of mitosis”
Newton, MA · 0 employees · National Science Foundation · Phase II · company site
“STTR Phase II: A Completely Non-Toxic Blood Bag That Keeps Blood Healthier, Longer”
Norwood, MA · 1 employee · Department of Health and Human Services · Phase II · company site
“Transforming Mammography With STARLIGHT, Imagine Scientific's Monochromatic X-Ray Imaging System”
North Reading, MA · 12 employees · Department of Health and Human Services · Phase I · company site
“Botanical Drug for Chemotherapy Induced Nausea and Vomiting”
Framingham, MA · 16 employees · Department of Health and Human Services · Phase II · company site
“Consumer-Therapist-Connector: Increasing Access to Quality Behavioral Healthcare”
Scituate, MA · 1 employee · Department of Health and Human Services · Phase II
“Manufacturable Biomimetic Microfluidic Oxygenator for Safer, Simpler Treatment of Respiratory Failure”
Cambridge, MA · 4 employees · Department of Health and Human Services · Phase I
“AI-powered engineering and analysis of cyanobacterium vesicles targeting gastrointestinal cancer”
Chestnut Hill, MA · 2 employees · Department of Health and Human Services · Phase I
“Developing Brain Penetrable AAV Gene Therapy for Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD)”
Billerica, MA · National Science Foundation · Phase II
“SBIR Phase II: AI-Driven Part Identification that Converts Standard Coordinate Measuring Machines into Autonomous Systems for Automated Part”
Medfield, MA · 3 employees · Department of Health and Human Services · Phase I · woman-owned
“An AI Enabled Training Tool for Complex Surgical Suturing Skills”
Brookline, MA · 8 employees · Department of Health and Human Services · Phase I · company site
“Electrical impedance myography (EIM) to detect and track cancer cachexia”
Allston, MA · 7 employees · Department of Health and Human Services · Phase I/II · woman-owned
“Rapid, Single Cell Proteomic Profiling for Biomarker Development in Precision Oncology”
Woburn, MA · 11 employees · Department of Defense · Phase II · company site
“Laser Magazine for Direct Diode Directed Energy Weapons”
Tyngsboro, MA · 9 employees · Department of Defense · Phase I/II · company site
“ORCHESTRA-AI: Operational Rhythm Coordination & Handoff Engine for Strategic Tasking & Real-time Adaptation”
Woburn, MA · 130 employees · Department of Defense · Phase I/II · company site
“Objective. Measurable. Mission-Ready: Advanced Evaluation Capabilities for ATC Readiness”
Sandwich, MA · 3 employees · Department of Defense · Phase I
“Delta AI - Artificial Intelligence (AI) Role-Players for Scenario Based Training”
Fairhaven, MA · 2 employees · Department of Defense · Phase I
“Software Velocity Corp - TestGPT - Autonomous AI-assisted Test Generation platform”
Boston, MA · 33 employees · Department of Defense · Phase I/II · company site
“Adaptive Weapons-to-Targets Optimization for Counter UAS Applications”
Bedford, MA · 48 employees · Department of Defense · Phase II · company site
“Low Size, Weight and Power and Cost (SWAP-C) Advanced CRPA (Controlled Radiation Pattern Antenna) GPS L1 and L2 Anti-Jam System with compara”
Natick, MA · 5 employees · Department of Defense · Phase I · company site
“Sonobuoy Vector Sensor”
Somerville, MA · 70 employees · Department of Defense · Phase I/II · company site
“FA442723R1002 eJARVIS Project (MacDill and JBMDL) Solicitation”
Medford, MA · 13 employees · Department of Health and Human Services · Phase I · woman-owned · company site
“Pioneering continuous cell disruption for efficient commercial scale virus-like particle (VLP) biomanufacturing”
Cambridge, MA · 6 employees · Department of Defense · Phase II · company site
“SDA-interoperable transPortable Laser Ground Terminals”
Braintree, MA · 4 employees · Department of Health and Human Services · Phase II
“CRP: Noninvasive brain stimulation for chronic pain treatment”
Dover, MA · 2 employees · Department of Health and Human Services · Phase I
“Preclinical efficacy of an APOE targeted antibody for Alzheimer's disease”
Lexington, MA · 5 employees · Department of Transportation · Phase I · company site
“3D-Printed vs Injection Molded Vortex Modular Roundabout Components for a New Turbo Configuration”
Cambridge, MA · 51 employees · Department of Health and Human Services · Phase II · company site
“Development of Tissue Engineered Tregs as a Treatment for Acute Ischemic Stroke”
North Chelmsford, MA · 7 employees · National Aeronautics and Space Administration · Phase II
“Superconducting coil operating at temperatures above 15K for ADR instruments”
Woburn, MA · 35 employees · Department of Transportation · Phase II · company site
“Enhanced GPR system for Rapid Assessment of Chloride Content in Concrete Bridge Decks”
Amherst, MA · 13 employees · Department of Defense, Department of Transportation · Phase I/II · company site
“TRAIDMA (Transit Reliability and AI Driven Maintenance Architecture)”
Jamaica Plain, MA · 2 employees · Department of Health and Human Services, National Science Foundation · Phase I/II · woman-owned
“Point of Care Detection of HPV and P16 in Saliva”
Woburn, MA · 4 employees · Department of Defense, National Aeronautics and Space Administration · Phase II · company site
“High-Sensitivity UV Solid-State Photon-Counting Devices and Arrays”
Lincoln, MA · 5 employees · Department of Defense · Phase I · company site
“AI for Airworthiness Certification”
Cambridge, MA · 3 employees · National Aeronautics and Space Administration, National Science Foundation · Phase I/II · company site
“Space-Ready Chip-Integrated Titanium:Sapphire Lasers”
Natick, MA · 3 employees · Department of Defense · Phase II
“Ferrimagnetic Shocklines for a Solid-State High-Power Microwave System”
Cambridge, MA · 8 employees · Department of Health and Human Services · Phase I
“Next-Generation CNS-Penetrant HDAC6 Inhibitors: Proof-of-Principle in Parkinson's Disease”
Jamaica Plain, MA · 3 employees · Department of Health and Human Services · Phase I · woman-owned · company site
“Development of CIL-0X: A Platform to Enhance Delivery of Inhaled RNA Therapeutics to Lung Cells”
Cambridge, MA · 2 employees · Department of Health and Human Services · Phase II · woman-owned · company site
“Development of a novel, non-hormonal female contraceptive device to submit IDE”
Newton, MA · 1 employee · Department of Health and Human Services · Phase I · company site
“Demonstrating feasibility of using a robot to deliver a multicomponent intervention to reduce delirium in hospitalized elderly patients liv”
Waltham, MA · 18 employees · Department of Health and Human Services · Phase I · company site
“Engineering a Middle Meningeal Artery Embolization Model with Hydrophilicity and Hydraulic Resistance”
Newton, MA · 2 employees · Department of Health and Human Services · Phase II · company site
“Metrifonate local application for DFU treatment”
Charlestown, MA · 46 employees · Department of Defense · Phase I/II · company site
“OsmoInverter”
Amherst, MA · 16 employees · Department of Defense · Phase I/II · company site
“Large Language Models for System Security Engineering Analysis”
Lowell, MA · 18 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site
“Future Lunar surface comms using Cognitive 3gpp Radio Access Networks for Ubiquitous Mission success (FULCRUM)”
Bedford, MA · 123 employees · Department of Defense, Department of Energy · Phase I/II · company site
“High Power Mechanically-Phased Helix Array”
Cambridge, MA · 2 employees · Department of Defense · Phase I · company site
“DROP IN REPLACEMENT OF TOROIDAL PROPELLERS FOR TORPEDO AND UUV (UNMANNED UNDERSEA VEHICLES)”
Boston, MA · 5 employees · National Science Foundation · Phase II
“SBIR Phase II: Antibody-Drug Conjugates (ADCs) with High Drug-Antibody Ratios (DAR) and Molecularly Targeted Payloads”
Cambridge, MA · 16 employees · National Science Foundation · Phase II · company site
“SBIR Phase II: Advanced Thermal Battery Systems for Grid-Scale Energy Storage: Further Optimization of an Innovative Thermal Cycle Test Rig ”
Worcester, MA · 1 employee · National Science Foundation · Phase II · company site
“STTR Phase II: Nano Functionalized Capacitive Deionization For Water Purification”
Boston, MA · National Science Foundation · Phase II
“SBIR Phase II: NLP Driven Automation for Optimizing New Patient Referral Pathways”
Natick, MA · 7 employees · Department of Health and Human Services · Phase II · company site
“OvaReady: An automated microfluidic oocyte retrieval and denudation device”
Boston, MA · 1 employee · National Science Foundation · Phase I · company site
“STTR Phase I: Accelerating Molecular Dynamics using Coarse-Grained Neural Network Potentials”
Boston, MA · 30 employees · Department of Defense · Phase I · company site
“Cognitive Terrain Flight Assistance”
Cambridge, MA · 8 employees · Department of Defense · Phase I · company site
“Multi-source target localization and state estimation for passive sonar arrays”
Waltham, MA · 75 employees · Department of Defense · Phase I/II · company site
“Robotic Manipulation Learning for Repair of Marine Diesel Engines”
Sharon, MA · 4 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II
“Miniature High-Performance Integrated Photonics Inertial Measurement Unit”
Arlington, MA · 4 employees · Department of Defense, Department of Energy · Phase I/II · company site
“Observation Driven Multi-Scale Medium Range ML Weather Forecasts”
Burlington, MA · 83 employees · Department of Defense · Phase I/II · company site
“ASTAR-ASP: ADS-B Signal Transmission Authenticity Reckoner with Advanced Signal Processing”
Burlington, MA · 50 employees · Department of Defense · Phase I · woman-owned · company site
“Proposal Response for Non-Wearable and Off-Engine Jet Noise Reduction”
Scituate, MA · 4 employees · Department of Defense · Phase I · woman-owned
“Profiling the boundary layers of the atmosphere and ocean from the surface outward”
Boston, MA · 8 employees · Department of Defense · Phase I · company site
“Aerial Refueling Latch Indicator”
Boston, MA · 60 employees · Department of Defense · Phase II · company site
“Advanced Quantum Testbeds for Atomic Technologies (AQUA)”
Chestnut Hill, MA · 2 employees · National Science Foundation · Phase I
“STTR Phase I: Novel Bioactive Hydrogel Dressings with Porous Surface for Burn Wound Treatment”
Billerica, MA · 3 employees · Department of Health and Human Services · Phase I · company site
“Line Scan Swept Source OCT (LS-SS-OCT)”
Winchester, MA · 2 employees · National Science Foundation · Phase II · woman-owned
“SBIR Phase II: Precision Weeder”
Woburn, MA · 75 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II
“Ambient Pressure-Dried Ormosil Hybrid Aerogel Composite Blankets for Advanced Space Suit Insulation”
Lowell, MA · 3 employees · Department of Defense · Phase I
“Ultra-compact, Color Visible and Shortwave Infrared (SWIR) Dual-band Camera”
Cambridge, MA · 24 employees · Department of Defense · Phase II · company site
“LOW COST AND RUGGEDIZED SMART WEARABLE MICROFLUIDIC PLATFORM FOR REAL-TIME HYDRATION MANAGEMENT”
Boston, MA · 16 employees · Department of Defense · Phase II · company site
“PRISM (Persistent Readiness Insight & Sensing for Mission optimization) – Brain-sensing wearable technology for enhancing cognitive readines”
Newtonville, MA · 6 employees · Department of Health and Human Services · Phase II
“Novel dermal templates for prevention and treatment of biofilms in cutaneous wounds”
Newton, MA · 2 employees · Department of Health and Human Services · Phase II
“Development of a novel oral brain penetrant therapeutic for ALS disease”
Cambridge, MA · 4 employees · National Science Foundation · Phase II · company site
“SBIR Phase II: Compact Multi X-ray Source Imaging Modules for Point-Of-Care Medical Screening”
Allston, MA · 2 employees · Department of Defense · Phase I
“A universal underwater curing adhesive with acoustic transparency”
Cambridge, MA · 4 employees · Department of Health and Human Services · Phase II · company site
“Preclinical Efficacy and Safety Evaluation of Oral AST-004 for Moderate Traumatic Brain Injury (TBI)”
Boston, MA · 8 employees · Department of Health and Human Services · Phase I · company site
“A Digital Biomarker for ALS - Pison Neural Biosensor”
Somerville, MA · 18 employees · Department of Defense, Department of Energy · Phase I · company site
“Photonic-Based Miniature Electric Field Sensing for Underwater Applications”
Waltham, MA · 10 employees · National Science Foundation · Phase II · woman-owned · company site
“SBIR Phase II: Continuous, Scalable Crystallizer for Pharmaceutical Manufacturing”
North Billerica, MA · 7 employees · Department of Defense · Phase I/II · company site
“Permanent Elastomeric Radar Array Cover”
Newton, MA · Department of Defense · Phase I
“Magnetometer Data Processing for Subsea Noise Mitigation and Object Detection”
Cambridge, MA · 10 employees · Department of Health and Human Services · Phase II
“The Development of Tabletop Brain-Mapping Platform”
Brookline, MA · 4 employees · Department of Health and Human Services · Phase I · woman-owned · company site
“GuidedOR: A Real-Time Medication Safety Software Platform for the Operating Room”
Worcester, MA · 2 employees · Department of Health and Human Services · Phase II
“Low-Cost Platform Technology for Rapid Isolation of Peripheral Blood Mononuclear Cells”
Bourne, MA · 14 employees · Department of Defense · Phase II · company site
“Extended Performance Petroleum Expeditionary Analysis Kit, (E-PEAK)”
Norfolk, MA · 1 employee · Department of Defense · Phase II · company site
“BEACON (Bluetooth-Enabled Adaptive Combat Operational Notifier)”
Whitinsville, MA · 15 employees · Department of Defense · Phase II
“Instant Infection Detection to Keep Warfighters in the Fight”
Allston, MA · 30 employees · Department of Defense · Phase II · company site
“The future of Cockpit Safety-- Validating Lumia in-ear wearable for hypoxia monitoring at high altitudes”
Holden, MA · 2 employees · National Science Foundation · Phase I
“SBIR Phase I: Developing Next-Generation Payloads for Targeted Therapies”
Burlington, MA · 3 employees · Department of Defense · Phase II · company site
“Long Range Autonomous Unmanned Logistics UAS”
Cambridge, MA · 22 employees · Department of Health and Human Services · Phase II · company site
“Safe-OPTION: Optical Physiology To Interrogate Oligonucleotide Neurotoxicity”
Boston, MA · 18 employees · Department of Defense · Phase II · company site
“Low-loss, cryogenically compatible optical fiber-to-chip interfaces for quantum and advanced classical photonic technologies”
Cambridge, MA · 5 employees · Department of Defense · Phase II · company site
“Fused 2D and 3D Computer Vision Aided Navigation in GPS-Denied Environments for Combat Aircraft Take-Off, Landing and Flight Operations”
Boston, MA · 41 employees · Department of Defense · Phase II · company site
“STRATEGIC Engine: Strategic Training and Robust AI for Transferable and Effective - PHASE II”
Cambridge, MA · 10 employees · Department of Defense · Phase II · company site
“NEXUS - Naval Expeditionary/Expendable Undersea Sensing at Scale”
Lexington, MA · 40 employees · Department of Defense · Phase II · company site
“High Performance Rechargeable Battery for Edge Environments”
Brookline, MA · 3 employees · Department of Defense · Phase II · woman-owned · company site
“RSP PACKOPS Advanced Compute: Seamless 3D Visualization and Packing with Edge Computing, Reducing Time and Environmental Footprint”
Mansfield, MA · 3 employees · Department of Health and Human Services · Phase I
“Developing high-precision epigenetic therapeutics for opioid use disorder”
Beverly, MA · 1 employee · Department of Health and Human Services · Phase I · woman-owned · company site
“Mirame Salud: Immersive Diabetes Self-Management Training for Latino Americans”
Westborough, MA · 150 employees · Department of Defense · Phase II · company site
“Kopin Off the Visor Heads Up Display A244-011-0119”
Chelsea, MA · 2 employees · Department of Health and Human Services · Phase I · woman-owned · company site
“Unmute's CARE framework: A Novel Approach to Strengthen the Therapeutic Alliance and Reduce Treatment Disparities”
Somerville, MA · 19 employees · Department of Defense · Phase I · company site
“RISE Robotics Advanced Lifting Solutions: Collapsible Lightweight Cranes”
Somerville, MA · 2 employees · National Science Foundation · Phase II
“SBIR Phase II: Development of an AI-based, IoT Enabled System for Structural Health Monitoring”
Allston, MA · 2 employees · National Science Foundation · Phase II · company site
“SBIR Phase II: Sprayable Hydrogel Sealant for Gastrointestinal Wound Protection”
Lexington, MA · 20 employees · Department of Defense · Phase I/II · woman-owned · company site
“SIGMA: Strategic Intelligence for Grey-zone Modeling and Analysis”
Somerville, MA · 9 employees · Department of Defense · Phase II · company site
“Information Rich Sampling via Adaptive Modal Imaging for Quantum-Limited Resolution (IRIS)”
Milton, MA · 2 employees · National Science Foundation · Phase I
“SBIR Phase I: Microfluidic 3D Bioprinting of Dacron-Recombinant Human Collagen Double-Network Crosslinked Biomimetic Vascular Conduits”
Waltham, MA · 1 employee · Department of Defense · Phase I
“Compact High-Power Direct Diode Laser with Diffraction-Limited Output”
Boston, MA · 16 employees · Department of Health and Human Services · Phase II
“A Drug Discovery Platform to Prioritize Development of Natural Product Neuromodulators for Treating Cognitive Impairment”
Cambridge, MA · 5 employees · Department of Health and Human Services · Phase I · woman-owned
“Design and Development of an Advanced Functional MRI Software as Medical Device (SaMD) forClinical Trials and Therapeutic Applications in Ne”
Cambridge, MA · 13 employees · Department of Health and Human Services · Phase I · company site
“Manufacturing Process Intensification for Pluripotent Stem Cell-Derived Rare Red Cell Production”
Lexington, MA · 1 employee · National Science Foundation · Phase II
“STTR Phase II: Miniature Precision Stage for High Throughput Hybrid Bonding”
Medford, MA · 2 employees · Department of Health and Human Services · Phase I · woman-owned
“DelineateQSP: Accelerating Quantitative Systems Pharmacology Model Building and Repurposing”
N Billerica, MA · 3 employees · Department of Defense · Phase II · company site
“Breathable, Non-Fluorinated Chemical Barrier Materials”
Watertown, MA · 10 employees · Department of Health and Human Services · Phase I · company site
“Scale-up and Manufacturing of STLR-201, an off-the-shelf regenerative therapeutic for Sjogren's syndrome-related dry eye disease”
Somerville, MA · 12 employees · Department of Defense · Phase I · company site
“Optimizing Naval Asset Management: Next-Gen Autonomous Hull Maintenance Robots”
Brookline, MA · 3 employees · Department of Defense · Phase I · company site
“O244-P002-0090 Sentinel: xApps for Detecting, Characterizing, and Mitigating Malicious Signaling Attacks and Interference against 5G”
Newton Center, MA · 6 employees · Department of Defense · Phase I · company site
“O244-P002-0078 ZTAI: Zero-Trust Artificial Intelligence for secure-by-design O-RAN control and inference”
Waltham, MA · 30 employees · Department of Defense · Phase II · woman-owned · company site
“Maintenance, Sustainment, and Operations of Land Based Test Facilities”
Auburndale, MA · 1 employee · Department of Defense · Phase I · company site
“DELCOF - DETECT LONG CONCEAL IN FOLIAGE”
Norwood, MA · 65 employees · Department of Defense · Phase I · company site
“High Pulse Power and Safe LFP Li-Ion Battery Technologies”
Worcester, MA · 2 employees · National Science Foundation · Phase I · woman-owned · company site
“SBIR Phase I: Novel Peptide Immunomodulators for Treatment of Autoimmune and Inflammatory Disorders”
Somerville, MA · 1 employee · National Science Foundation · Phase I
“SBIR Phase I: Development of a Novel Mammalian Cell-Based Nano-Biological Coating for Implantable Medical Devices.”
Winchester, MA · 3 employees · Department of Health and Human Services · Phase II · woman-owned · company site
“Advancing BITT-101 a novel dominant CD40 antagonist for use in treatment of Sjogren Syndrome.”
Cambridge, MA · 4 employees · Department of Defense · Phase I · company site
“Nano-Scaffolding Assembly of Materials for Next Generation Uncooled Thermal Optics”
Woburn, MA · 7 employees · Department of Defense · Phase I · company site
“Temperature-Tolerant, Critical Metal-Free, Lithium-ion Batteries using Organic Cathodes”
Charlton, MA · 175 employees · Department of Energy · Phase I · company site
“EPPD: Particle Detector for the LHCb-ECAL Upgrade 2 Featuring ~10 Picosecond Timing”
Cambridge, MA · 7 employees · Department of Energy · Phase I · company site
“Horizyn: advanced deep learning for enzyme discovery and annotation”
Natick, MA · 16 employees · Department of Energy · Phase I · company site
“A 350 GHz, 0.25 MW Robust Gyrotron Optimized for High Volume Production for Net Electric Fusion Reactors”
Cambridge, MA · 2 employees · Department of Energy · Phase I · company site
“C59-27(c) Low-noise deep-cryogenic amplifier based on hydrodynamic charge transport in GaAs/AlGaAs”
Worcester, MA · 15 employees · Department of Energy · Phase I · company site
“Optimized Alloy Composites Using Wire-fed Direct Energy Deposition”
Andover, MA · 3 employees · Department of Defense · Phase I · company site
“Efficient Red Micro-LEDs with Pixel Size <5 Microns for Next-Generation Displays”
Cambridge, MA · 14 employees · Department of Defense · Phase I/II · company site
“Handheld Robotic Medical Device for Semi-automated Nerve Block Administration in Austere Environments”
Wayland, MA · 4 employees · Department of Health and Human Services · Phase I · company site
“Xenon gas inhalation as a novel treatment for opioid withdrawal syndrome”
Somerville, MA · 10 employees · Department of Defense · Phase II · company site
“LightCell Power Generation for Autonomous Long-Range Group 2 eVTOL Systems”
Boston, MA · 4 employees · Department of Defense · Phase II · company site
“Enhanced Soil State Monitoring in Arctic Environments”
North Billerica, MA · 7 employees · Department of Defense · Phase II · company site
“Tactical Fuel Production System for ACE Support Systems”
Woburn, MA · 11 employees · Department of Health and Human Services · Phase II · company site
“DNA-optical barcoding technology for spatiotemporal single-cell analysis”
Sharon, MA · 2 employees · Department of Defense · Phase I
“IGA Mid-Processing Modeling Tools for FSI in Vehicle Mobility Applications”
Boston, MA · 3 employees · Department of Defense · Phase I · woman-owned · company site
“Sensitive and Robust Touch Sensing Systems for Robotic Humanoid Hands and Other Mission Driven Applications”
North Andover, MA · 4 employees · Department of Defense · Phase I
“Deployable Abdominal Imaging: Real-Time Diagnostics for Combat Zones”
Marlborough, MA · 7 employees · Department of Defense · Phase I · company site
“Conformal IR Windows for Hypersonic Vehicles and Weapons Systems”
Brookline, MA · 4 employees · National Science Foundation · Phase I · woman-owned · company site
“SBIR Phase I: Development of a Molecular Diagnostic Platform for Use at Home without an Expensive Table-top Device”
Cohasset, MA · 1 employee · Department of Defense · Phase I · company site
“Drone Assault and Rehearsal Kit (DARK)”
Carlisle, MA · 9 employees · Department of Defense · Phase I · company site
“Slayer - A Counter-UAS Cost Win for Affordably Scalable Air Defense”
Billerica, MA · 45 employees · Department of Defense · Phase I · company site
“A Revolutionary Manufacturing Technology to Secure the DAF’s Battery Supply Chain”
Cambridge, MA · 2 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Ultra-Sensitive and Multiplexed Pathogen Profiling for Neonatal Sepsis Detection”
Lincoln, MA · 2 employees · Department of Defense · Phase I · company site
“Comprehensive Document Management System for Enhanced Warfighter Readiness”
Cambridge, MA · 7 employees · Department of Defense · Phase I · company site
“3D Point Cloud Registration and Change Detection for Large-Scale Topographic Assessment”
Cambridge, MA · 2 employees · National Science Foundation · Phase I
“SBIR Phase I: A Platform for Penetrative Drug Delivery to Teeth”
Burlington, MA · 12 employees · Department of Defense · Phase II · company site
“RAR Nano-Texturing For High Performance Super-Hydrophobic Beam Director Head Windows”
Newburyport, MA · 0 employees · Department of Health and Human Services · Phase II
“Targeted Cerebral Spinal Fluid (CSF) Drug Delivery - Enclear Precision System”
Boston, MA · 48 employees · Department of Defense · Phase II · company site
“Low-Probability-of-Intercept Terahertz Communications for Air Force Applications”
Newton, MA · 3 employees · Environmental Protection Agency · Phase I · company site
“Field-Scale Production of Nanoparticle Phosphorus Fertilizers: Advancing to Multi-Acre Trials”
Mansfield, MA · 2 employees · Department of Health and Human Services · Phase II · woman-owned
“Manufacturing and Formulation Process Development for a Prophylactic Cholera Phage Cocktail”
Cambridge, MA · 6 employees · Department of Health and Human Services · Phase I · company site
“Disaster-Ready Portable/Standalone Universal Water Purifier based on CER-ICP technology.”
Burlington, MA · 30 employees · Department of Defense · Phase II · company site
“Develop and Demonstrate Improved Transparent Armor for Army Systems”
Cambridge, MA · 5 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Developing new bacterial hosts for productive secretion of difficult-to-express proteins by precision fermentation”
Woburn, MA · 65 employees · Department of Defense · Phase I
“Handheld Instruments for Multimode CWDM Optical Interconnects”
Newton, MA · 6 employees · Department of Defense · Phase I/II · company site
“Hydronet: An Open, Modular, and Programmable Underwater Modem”
East Falmouth, MA · 4 employees · Department of Defense · Phase I · company site
“Passive Ballasted Floats for Observing Interior Ocean Flows and More”
Natick, MA · 2 employees · Department of Defense · Phase I · company site
“Event-Based Cameras with GigE-Vision: Enabling Low-Latency Data Transfer with 10G Interface and GenICam Software Interface”
Somerville, MA · 3 employees · Department of Defense · Phase I · company site
“Semiconductor switches Providing Linearity And Speed at High-power (SPLASH)”
Newton, MA · 6 employees · Department of Defense · Phase I
“Wide Field-of-View, Ultra-compact, Broadband Compound Metalenses”
Bedford, MA · 4 employees · Department of Transportation · Phase I
“Complete Pavement Markings for Safe and Complete Streets”
Natick, MA · 5 employees · Department of Transportation · Phase I · woman-owned · company site
“AI for Complete, Equitable Streets (ACES): Using Computer Vision and Machine Learning to Deliver Data-Driven Guidance for Complete Streets”
North Billerica, MA · 54 employees · Department of Defense · Phase II · company site
“Affordable Wideband Scalable Front-End Electronics Supporting Multi-Function Seekers (PROP.SI2T.RADR.03)”
Worcester, MA · 4 employees · Environmental Protection Agency · Phase II · company site
“Enhanced Efficiency of UBC Recycling Powered by Artificial Intelligence”
Watertown, MA · 3 employees · Department of Health and Human Services · Phase I · woman-owned · company site
“SBIR CONCEPT AWARD FOR A NOVEL DELIVERY APPROACH TO TRANSFORM METASTATIC PANCREATIC CANCER TREATMENT AND PREVENTION”
Newton Lower Falls, MA · 2 employees · Department of Health and Human Services · Phase I · woman-owned · company site
“AI Progress Monitor for Dyslexic Students on IEPs.”
Billerica, MA · 68 employees · Department of Energy, National Aeronautics and Space Administration · Phase I/II · company site
“Autonomous Method to Quantify and Localize Hydrogen Facility Emissions”
Source: public SBIR/STTR award record. Company-level facts only. Open roles are live listings on our board.