255 companies · SBIR/STTR awards, last two years
255 companies in Massachusetts closed federal SBIR/STTR awards in the last two years. 3 of them have open roles on our board and come first; the rest follow, newest award first. The funding event is the signal — small companies grow right after the award lands.
A weekly alert for new science jobs in Massachusetts.
Open roles near Massachusetts
Cambridge, MA · 134 employees · Department of Defense · Phase II · company site
“Prophecy”
Boston, MA · 150 employees · Department of Defense · Phase II · company site
“Enhancing Reduced-Crew Flight Operations with NLP-Driven Real-Time Dynamic Replanning”
Boston, MA · 8 employees · Department of Defense · Phase II
“STX-005: A Next-Generation Therapy for Autoimmune Disease to Sustain Force Readiness”
Natick, MA · 110 employees · Department of Defense · Phase II · company site
“Compact Stored Propellant Propulsion System for VLEO Satellites”
Boston, MA · 26 employees · Department of Defense · Phase I · company site
“On-Chip Wavelength Generation for DWDM Photonic Transceivers”
Cambridge, MA · 156 employees · Department of Defense, Department of Health and Human Services · Phase I/II · company site
“Neural Network Enhancements for Customized Reduced Order Models to Accelerate Nuanced COA Evaluation and Reasoning (NECROMANCER)”
Andover, MA · 259 employees · Department of Defense, Department of Energy, Department of Health and Human Services, Department of Homeland Security, Department of Transportation, National Aeronautics and Space Administration · Phase I/II · company site
“Bio-inspired Energy Dissipating Structures for Enhanced Airdrop Capabilities”
Lincoln, MA · 2 employees · Department of Defense · Phase II · company site
“Enhanced Language-oriented System for Analysis and Management of C2 and Maintenance Data”
Lexington, MA · 4 employees · Department of Defense · Phase I/II
“Quad-Pol L-band Scatterometer for Ocean Surface Vector Winds in Extreme Conditions”
Burlington, MA · 43 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site
“Development and Demonstration of an Efficient Multiphysics Modeling Framework for Rain-Induced Damage and Aerodynamic Effects on Hypersonic ”
Chelmsford, MA · 126 employees · Department of Defense, Department of Energy, National Aeronautics and Space Administration · Phase I/II · company site
“Coatings for Reliable Compact Rotary Engines”
Watertown, MA · 101 employees · Department of Defense, Department of Energy, Department of Health and Human Services, National Aeronautics and Space Administration · Phase I/II · company site
“Transparent Conducting Oxide Based On-Chip Modulators for Applications at Cryogenic Temperatures”
Waltham, MA · 30 employees · Department of Defense · Phase II · company site
“GelSight Nano: Compact Tactile Fingertips for Intelligent Grasping in Industrial Environments”
Worcester, MA · 102 employees · Department of Defense, Department of Energy · Phase I/II · company site
“High-Performance, No-Helium Cold Spray for Structural Repair Applications”
Bedford, MA · 8 employees · Department of Defense · Phase I/II · company site
“High Performance Electro-optic Modulator Designed for Military Aircraft”
Cambridge, MA · 6 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Low-Cost, Waste-Resilient Polyethylene Terephthalate (PET) and Polyester Upcycling Through Macrocyclic Chemistry”
Cambridge, MA · 5 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Drop-on Demand Liquid Metal Additive Manufacturing”
Amherst, MA · 0 employees · National Science Foundation · Phase I/II
“STTR Fast-Track: Advanced Manufacturing of All-inorganic Polarization Controlled Metasurfaces for Enabling Next Generation Full-Stokes Imagi”
Woburn, MA · 13 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Advancing Metal Additive Manufacturing with Novel Acoustic Molding Technology”
Quincy, MA · 2 employees · Department of Commerce · Phase II · company site
“Online Short Wave Infrared Hyperspectral AI-Imaging System (SWIRhyperspectral AI-Imaging) for measuring cell culture material, process and q”
Woburn, MA · 1 employee · National Science Foundation · Phase I
“STTR Phase I: High Throughput Discovery of Catalysts for Water Electrolysis Anion-Exchange Membranes”
Cambridge, MA · 3 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Bridging Multi-Party Computation and Fully Homomorphic Encryption for Practical Data Security Solutions”
Cambridge, MA · 1 employee · National Science Foundation · Phase I · company site
“SBIR Phase I: AI-Accelerate Superconductor Discovery for High-Field Magnets”
Auburndale, MA · 6 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Spectrum Coexistence Digital Twin”
Somerville, MA · 2 employees · National Science Foundation · Phase I
“SBIR Phase I: Acoustic Expander for Air-Cycle Flash Freezers and Ultra-Low Temperature Refrigerators”
Somerville, MA · 2 employees · Department of Health and Human Services, National Science Foundation · Phase I · company site
“SBIR Phase I: Hemostatic Tough Adhesive Hydrogels for Advanced Biosurgery”
Auburndale, MA · 40 employees · Department of Health and Human Services, National Aeronautics and Space Administration · Phase I/II · company site
“Multi-Purpose Flame Retardant Materials for Habitation Solutions”
Lowell, MA · 1 employee · Department of Defense · Phase I/II · company site
“Autonomous Soft Robot for Locomotion in Granular Seabed Media”
Beverly, MA · 145 employees · Department of Defense · Phase I
“Securely Interfacing with SDA’s Proliferated Warfighter Space Architecture (PWSA)”
Lowell, MA · 12 employees · Department of Health and Human Services · Phase II · company site
“Improved Treatment Options for Vertebral Compression Fractures in Elderly Patients Using Minimally Invasive, Image-Guided Delivery of a Rege”
Beverly, MA · 183 employees · Department of Defense · Phase I/II
“NEXUS: Interconnecting with SDA’s Proliferated Warfighter Space Architecture (PWSA) Transport Layer”
Wayland, MA · 5 employees · Department of Health and Human Services · Phase I
“Novel light source development for robust multi-MHz retinal OCT”
Boston, MA · 4 employees · Department of Defense · Phase I/II
“Orama Mixed Reality Combat Simulator: AI-Driven Mixed Reality Combat Simulator for Adaptive Near-Peer Threat Training”
Natick, MA · 15 employees · Department of Defense, Department of Energy, Department of Health and Human Services · Phase I/II · company site
“Low-Cost High-Efficiency X-ray Imaging Panels for Field Radiography”
Norton, MA · 110 employees · Department of Defense, Department of Energy · Phase I/II · company site
“30b Foam-Lattice Composite Impact Limiter”
Weston, MA · 1 employee · National Aeronautics and Space Administration · Phase I · company site
“Polybenzoxazine Aerogels for Insulation in 38% Oxygen Environments”
Cambridge, MA · 65 employees · Department of Defense, Department of Homeland Security, National Aeronautics and Space Administration · Phase I/II · company site
“Heterogeneous integration of infrared single mode lasers with photonic integrated circuits”
Cambridge, MA · 2 employees · Department of Health and Human Services, National Science Foundation · Phase I
“Microneedle-mediated expansion of skin-resident regulatory T cells for management of autoimmune skin diseases”
Cambridge, MA · 5 employees · Department of Health and Human Services · Phase I/II · company site
“Process development for manufacturing eCD4-Ig”
Arlington, MA · 1 employee · Department of Defense · Phase I
“Embedded Machine Olfaction for Multi-Modal Sensing”
Worcester, MA · Department of Health and Human Services · Phase I/II
“Novel Benzyl-Piperidine antifungal agents to treat intractable Mucorales infections”
Somerville, MA · 30 employees · Department of Health and Human Services · Phase I/II · company site
“Improving Mental Health and Social Connectivity for Older Adults through Virtual Reality-Based Social Interventions”
Boston, MA · 2 employees · Department of Health and Human Services · Phase I · company site
“New Nanoprobes for MR Imaging of TrkB in Alzheimer's Disease”
Boston, MA · 12 employees · Department of Health and Human Services · Phase II · company site
“Developing an Elderly Patient-Specific, Accurate, Intuitive and Highly Interpretable System for Unconsciousness Management in General Anesth”
Boston, MA · 4 employees · Department of Health and Human Services · Phase I
“Targeting aVb8 integrin to restore astrocyte-microglia crosstalk to treat Alzheimer's disease”
Concord, MA · 1 employee · Department of Health and Human Services · Phase I
“An Eyedrop Diagnostic Test for Alzheimer's Disease”
Cambridge, MA · 2 employees · Department of Health and Human Services · Phase I
“Development of a tissue-targeted non-thrombotic EPO derivative”
Brookline, MA · 1 employee · Department of Health and Human Services · Phase I
“Targeted Localization and Optimized Surgical Resection for Lung Cancer”
Newton, MA · 8 employees · Department of Defense · Phase II · company site
“Multi-Sensor Prototype for Non-Destructive Corrosion Evaluation and Characterization”
Lexington, MA · 3 employees · Department of Health and Human Services · Phase II
“IND-enabling studies of D6PV- a novel ApoC-II peptide mimetic therapeutic”
Cambridge, MA · 2 employees · Department of Defense · Phase II · company site
“Imperceptible Fabric-Integrated Wireless Batteryfree Fiber Temperature Sensor System (fID-T) for Remote Frostbite Detection and Prevention”
Boston, MA · 14 employees · Department of Defense, National Aeronautics and Space Administration · Phase I · company site
“HYDRATE: A Zero-Emission Direct Drive Parallel Hybrid Turbofan for Personal Jets”
Cambridge, MA · 12 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site
“Conformal coatings to enhance biocarriers for rapid-startup of biofilm reactors”
Medford, MA · 4 employees · Department of Health and Human Services · Phase I
“Project GAME ON!: Empowering urban children to engage in healthy behaviors to reduce obesity risk through an interactive digital comic tool”
North Andover, MA · 5 employees · Department of Health and Human Services · Phase II · company site
“CuRrEnT: Capecitabine in RCB2/3 with a wearable induced Electric field device in Triple Negative Breast Cancer”
Boston, MA · 3 employees · Department of Health and Human Services · Phase II · company site
“Scaling Lymphoma Diagnosis: A Cost-Effective Gene Expression Assay for Broad Implementation”
Jamaica Plain, MA · 6 employees · Department of Health and Human Services · Phase I · company site
“Evaluating the Effect of a Local Microvascular Tissue Graft Treatment in Rat Models of Diabetic Peripheral Neuropathy”
Brookline, MA · 3 employees · Department of Health and Human Services, National Science Foundation · Phase I · company site
“Enhancing Solid Tumor lmmunotherapy with Targeted siRNA Delivery”
Boston, MA · 11 employees · Department of Health and Human Services · Phase II · company site
“Integration of Sotair with Capnography for Standardizing Manual Ventilation Technique and Improving Patient Outcomes”
Boston, MA · 12 employees · Department of Health and Human Services · Phase I/II · company site
“Development of an Oral Methionine-Gamma-Lyase Enzyme for the Treatment of Homocystinuria”
Burlington, MA · 4 employees · Department of Defense, National Aeronautics and Space Administration · Phase I · company site
“Portable Major and Trace Constituent Gas Analyzer for Habitable Environments”
Woods Hole, MA · 4 employees · National Aeronautics and Space Administration · Phase II
“Mizar S/TAR High-Throughput Platform for Identification of Senescence Altering Therapeutics”
Cambridge, MA · 6 employees · Department of Health and Human Services · Phase I · company site
“Achieving ultra-high-density, ultra-high-precision single molecule localization microscopy with whole-video deep learning architectures”
Sharon, MA · Department of Health and Human Services · Phase II
“3D-printed Skin and Bone Integrated Pylon (SBIP-3D) for Direct Skeletal Attachment of Limb Prostheses.”
Watertown, MA · 5 employees · Department of Health and Human Services · Phase I
“Development of a novel liver-specific positron emission tomography tracer”
Hudson, MA · 1 employee · National Science Foundation · Phase II
“SBIR Phase II: Robotic system outputting multimodal methods to aid in communication”
Newton Center, MA · 3 employees · Department of Health and Human Services · Phase I · woman-owned · company site
“Objective Mobile diagnostics for Optic Neuropathies”
Lexington, MA · 5 employees · Department of Health and Human Services · Phase I
“Development of PAR2 Pepducins for the Treatment of COPD”
Framingham, MA · 13 employees · Department of Health and Human Services · Phase I/II · company site
“Peptide-based ELISA for laboratory diagnosis of sarcoidosis”
Cambridge, MA · 5 employees · National Science Foundation · Phase II · woman-owned
“SBIR Phase II: Engineering the Plant Microbiome to Reduce Disease in Crops”
Worcester, MA · 2 employees · Department of Health and Human Services · Phase I/II · company site
“TREM-1 therapy for the treatment of empyema”
Woburn, MA · 19 employees · Department of Health and Human Services · Phase II · company site
“Next-generation Brillouin ocular scanner”
Cambridge, MA · 8 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site
“Ultra Low Reflectance Black Silicon for Visible to IR Light Absorption”
Cambridge, MA · 7 employees · Department of Education · Phase II · woman-owned · company site
“Personalized and Context-relevant English lessons with AI (Pace AI) to Advance Adult Learners in Integrated Education and Training (IET) Wor”
Cambridge, MA · 2 employees · Department of Education · Phase II
“AI and Neuroscience-powered chatbot to provide students individualized guidance that complements the support they receive from school counse”
Cambridge, MA · 10 employees · Department of Defense · Phase II · company site
“High Mach Airbreathing Target (HMAT)”
Dorchester, MA · 5 employees · Department of Health and Human Services · Phase I · company site
“TauTrace™: An ultrasensitive immunoassay for neurodegenerative protein biomarkers”
Medford, MA · 1 employee · National Aeronautics and Space Administration · Phase I · woman-owned · company site
“A discovery platform to optimize the production of nutrient rich food via solid state fermentation of feedstocks relevant to spaceflight.”
Norwood, MA · 3 employees · Department of Health and Human Services · Phase I · company site
“Preclinical validation of an effective oral fulvestrant product as the future standard of care endocrine therapy for ER+ metastatic breast c”
Cambridge, MA · 4 employees · Department of Health and Human Services · Phase I · company site
“Targeted Delivery of Tumor Antigen esaRNA to the Spleen for Cancer Immunotherapy”
Newton, MA · 1 employee · Department of Health and Human Services · Phase I · company site
“Brilliant epitopes for improved cancer vaccines”
Framingham, MA · 9 employees · Department of Health and Human Services · Phase II
“Development of a novel renalase agonist for the treatment of acute pancreatitis”
Cambridge, MA · 5 employees · Department of Health and Human Services · Phase I
“Peptide YY triagonist weight loss drugs”
Newton, MA · 20 employees · Department of Health and Human Services · Phase II · company site
“A Wearable Sensor Platform for Remote Monitoring of Motor Impairment in Huntingtons Disease and Prodromal Huntingtons Disease”
Holliston, MA · 2 employees · Department of Health and Human Services · Phase I · company site
“Software for increased accuracy prediction of antibody-antigen complexes”
Cambridge, MA · 6 employees · Department of Health and Human Services · Phase I
“Active non-viral nuclear delivery of DNA templates independent of mitosis”
Newton, MA · 0 employees · National Science Foundation · Phase II · company site
“STTR Phase II: A Completely Non-Toxic Blood Bag That Keeps Blood Healthier, Longer”
Norwood, MA · 1 employee · Department of Health and Human Services · Phase II · company site
“Transforming Mammography With STARLIGHT, Imagine Scientific's Monochromatic X-Ray Imaging System”
North Reading, MA · 12 employees · Department of Health and Human Services · Phase I · company site
“Botanical Drug for Chemotherapy Induced Nausea and Vomiting”
Framingham, MA · 16 employees · Department of Health and Human Services · Phase II · company site
“Consumer-Therapist-Connector: Increasing Access to Quality Behavioral Healthcare”
Scituate, MA · 1 employee · Department of Health and Human Services · Phase II
“Manufacturable Biomimetic Microfluidic Oxygenator for Safer, Simpler Treatment of Respiratory Failure”
Cambridge, MA · 4 employees · Department of Health and Human Services · Phase I
“AI-powered engineering and analysis of cyanobacterium vesicles targeting gastrointestinal cancer”
Chestnut Hill, MA · 2 employees · Department of Health and Human Services · Phase I
“Developing Brain Penetrable AAV Gene Therapy for Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD)”
Billerica, MA · National Science Foundation · Phase II
“SBIR Phase II: AI-Driven Part Identification that Converts Standard Coordinate Measuring Machines into Autonomous Systems for Automated Part”
Medfield, MA · 3 employees · Department of Health and Human Services · Phase I · woman-owned
“An AI Enabled Training Tool for Complex Surgical Suturing Skills”
Brookline, MA · 8 employees · Department of Health and Human Services · Phase I · company site
“Electrical impedance myography (EIM) to detect and track cancer cachexia”
Allston, MA · 7 employees · Department of Health and Human Services · Phase I/II · woman-owned
“Rapid, Single Cell Proteomic Profiling for Biomarker Development in Precision Oncology”
Woburn, MA · 11 employees · Department of Defense · Phase II · company site
“Laser Magazine for Direct Diode Directed Energy Weapons”
Tyngsboro, MA · 9 employees · Department of Defense · Phase I/II · company site
“ORCHESTRA-AI: Operational Rhythm Coordination & Handoff Engine for Strategic Tasking & Real-time Adaptation”
Woburn, MA · 130 employees · Department of Defense · Phase I/II · company site
“Objective. Measurable. Mission-Ready: Advanced Evaluation Capabilities for ATC Readiness”
Showing 100 of 255. See all 255 companies in Massachusetts
Source: public SBIR/STTR award record. Company-level facts only. Open roles are live listings on our board.