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Recently funded science companies in Massachusetts

255 companies in Massachusetts closed federal SBIR/STTR awards in the last two years, newest first. The funding event is the signal — small companies grow right after the award lands.

BUSEK CO., INC.

NATICK, MA · 110 employees

Compact Stored Propellant Propulsion System for VLEO Satellites

Department of Defense · Phase Phase II

$1.7Mawardedfunded 2026-01-23Company site →

ANALOG PHOTONICS LLC

Boston, MA · 26 employees

On-Chip Wavelength Generation for DWDM Photonic Transceivers

Department of Defense · Phase Phase I

$250kawardedfunded 2025-12-22Company site →

CHARLES RIVER ANALYTICS, INC.

CAMBRIDGE, MA · 156 employees

Neural Network Enhancements for Customized Reduced Order Models to Accelerate Nuanced COA Evaluation and Reasoning (NECROMANCER)

Department of Defense · Department of Health and Human Services · Phase Phase I/Phase II

$18.2Macross 20 awardsfunded 2025-12-19Company site →

PHYSICAL SCIENCES INC.

ANDOVER, MA · 259 employees

Bio-inspired Energy Dissipating Structures for Enhanced Airdrop Capabilities

Department of Defense · Department of Energy · Department of Health and Human Services · Department of Homeland Security · Department of Transportation · National Aeronautics and Space Administration · Phase Phase I/Phase II

$64.2Macross 84 awardsfunded 2025-12-10Company site →

TRUE ENGINEERING TECHNOLOGY, LLC

LINCOLN, MA · 2 employees

Enhanced Language-oriented System for Analysis and Management of C2 and Maintenance Data

Department of Defense · Phase Phase II

$1.7Mawardedfunded 2025-11-04Company site →

Aperture Space, Inc.

Lexington, MA · 4 employees

Quad-Pol L-band Scatterometer for Ocean Surface Vector Winds in Extreme Conditions

Department of Defense · Phase Phase I/Phase II

$3.1Macross 2 awardsfunded 2025-11-03

SPECTRAL SCIENCES, INC

BURLINGTON, MA · 43 employees

Development and Demonstration of an Efficient Multiphysics Modeling Framework for Rain-Induced Damage and Aerodynamic Effects on Hypersonic

Department of Defense · National Aeronautics and Space Administration · Phase Phase I/Phase II

$11.1Macross 13 awardsfunded 2025-11-03Company site →

TRITON SYSTEMS, INC.

CHELMSFORD, MA · 126 employees

Coatings for Reliable Compact Rotary Engines

Department of Defense · Department of Energy · National Aeronautics and Space Administration · Phase Phase I/Phase II

$29.7Macross 41 awardsfunded 2025-11-03Company site →

RADIATION MONITORING DEVICES, INC.

WATERTOWN, MA · 101 employees

Transparent Conducting Oxide Based On-Chip Modulators for Applications at Cryogenic Temperatures

Department of Defense · Department of Energy · Department of Health and Human Services · National Aeronautics and Space Administration · Phase Phase I/Phase II

$7.9Macross 15 awardsfunded 2025-11-03Company site →

Gelsight, Inc.

Waltham, MA · 30 employees

GelSight Nano: Compact Tactile Fingertips for Intelligent Grasping in Industrial Environments

Department of Defense · Phase Phase II

$3.3Macross 2 awardsfunded 2025-10-23Company site →

SOLVUS GLOBAL LLC

WORCESTER, MA · 102 employees

High-Performance, No-Helium Cold Spray for Structural Repair Applications

Department of Defense · Department of Energy · Phase Phase I/Phase II

$2.9Macross 6 awardsfunded 2025-10-23Company site →

Photonic Systems, Inc.

BEDFORD, MA · 8 employees

High Performance Electro-optic Modulator Designed for Military Aircraft

Department of Defense · Phase Phase I/Phase II

$2.1Macross 3 awardsfunded 2025-10-14Company site →

MACROCYCLE TECHNOLOGIES

CAMBRIDGE, MA · 6 employees

SBIR Phase I: Low-Cost, Waste-Resilient Polyethylene Terephthalate (PET) and Polyester Upcycling Through Macrocyclic Chemistry

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-10-01Company site →

FLUENT METAL INC.

CAMBRIDGE, MA · 5 employees

SBIR Phase I: Drop-on Demand Liquid Metal Additive Manufacturing

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-10-01Company site →

MYRIAS OPTICS INC

AMHERST, MA · 0 employees

STTR Fast-Track: Advanced Manufacturing of All-inorganic Polarization Controlled Metasurfaces for Enabling Next Generation Full-Stokes Imagi

National Science Foundation · Phase Phase I/Phase II

$1.6Macross 2 awardsfunded 2025-10-01

ULTRASONIUM INC

WOBURN, MA · 13 employees

SBIR Phase I: Advancing Metal Additive Manufacturing with Novel Acoustic Molding Technology

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-10-01Company site →

APPLIED IMAGING SOLUTIONS LLC

QUINCY, MA · 2 employees

Online Short Wave Infrared Hyperspectral AI-Imaging System (SWIRhyperspectral AI-Imaging) for measuring cell culture material, process and q

Department of Commerce · Phase Phase II

$400kawardedfunded 2025-10-01Company site →

H2C Energy Inc.

Woburn, MA · 1 employee

STTR Phase I: High Throughput Discovery of Catalysts for Water Electrolysis Anion-Exchange Membranes

National Science Foundation · Phase Phase I

$302kawardedfunded 2025-10-01

CipherSonic Labs Inc

Cambridge, MA · 3 employees

SBIR Phase I: Bridging Multi-Party Computation and Fully Homomorphic Encryption for Practical Data Security Solutions

National Science Foundation · Phase Phase I

$303kawardedfunded 2025-10-01Company site →

Quantum Formatics

Cambridge, MA · 1 employee

SBIR Phase I: AI-Accelerate Superconductor Discovery for High-Field Magnets

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-10-01Company site →

VectorWave Corporation

Auburndale, MA · 6 employees

SBIR Phase I: Spectrum Coexistence Digital Twin

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-10-01Company site →

R7 Instruments, Inc.

Somerville, MA · 2 employees

SBIR Phase I: Acoustic Expander for Air-Cycle Flash Freezers and Ultra-Low Temperature Refrigerators

National Science Foundation · Phase Phase I

$304kawardedfunded 2025-10-01

LIMAX BIOSCIENCES INC

SOMERVILLE, MA · 2 employees

SBIR Phase I: Hemostatic Tough Adhesive Hydrogels for Advanced Biosurgery

Department of Health and Human Services · National Science Foundation · Phase Phase I

$769kacross 2 awardsfunded 2025-10-01Company site →

MORSECORP, INC

CAMBRIDGE, MA · 134 employees

Prophecy

Department of Defense · Phase Phase II

$3.0Macross 2 awardsfunded 2025-09-30Company site →

GINER INC

AUBURNDALE, MA · 40 employees

Multi-Purpose Flame Retardant Materials for Habitation Solutions

Department of Health and Human Services · National Aeronautics and Space Administration · Phase Phase I/Phase II

$2.4Macross 4 awardsfunded 2025-09-30Company site →

EMERGINGDX INC

Lowell, MA · 1 employee

Autonomous Soft Robot for Locomotion in Granular Seabed Media

Department of Defense · Phase Phase I/Phase II

$4.1Macross 5 awardsfunded 2025-09-30Company site →

WAFER, LLC

BEVERLY, MA · 145 employees

Securely Interfacing with SDA’s Proliferated Warfighter Space Architecture (PWSA)

Department of Defense · Phase Phase I

$180kawardedfunded 2025-09-30

REVBIO, INC.

LOWELL, MA · 12 employees

Improved Treatment Options for Vertebral Compression Fractures in Elderly Patients Using Minimally Invasive, Image-Guided Delivery of a Rege

Department of Health and Human Services · Phase Phase II

$2.0Mawardedfunded 2025-09-30Company site →

WILDSTAR LLC

BEVERLY, MA · 183 employees

NEXUS: Interconnecting with SDA’s Proliferated Warfighter Space Architecture (PWSA) Transport Layer

Department of Defense · Phase Phase I/Phase II

$4.0Macross 3 awardsfunded 2025-09-30

BLUEBIRD PHOTONICS, INC

WAYLAND, MA · 5 employees

Novel light source development for robust multi-MHz retinal OCT

Department of Health and Human Services · Phase Phase I

$306kawardedfunded 2025-09-30

Orama Technologies Inc

Boston, MA · 4 employees

Orama Mixed Reality Combat Simulator: AI-Driven Mixed Reality Combat Simulator for Adaptive Near-Peer Threat Training

Department of Defense · Phase Phase I/Phase II

$1.4Macross 2 awardsfunded 2025-09-29

CAPESYM INC

NATICK, MA · 15 employees

Low-Cost High-Efficiency X-ray Imaging Panels for Field Radiography

Department of Defense · Department of Energy · Department of Health and Human Services · Phase Phase I/Phase II

$2.1Macross 3 awardsfunded 2025-09-26Company site →

CPS TECHNOLOGIES CORP.

NORTON, MA · 110 employees

30b Foam-Lattice Composite Impact Limiter

Department of Defense · Department of Energy · Phase Phase I/Phase II

$2.2Macross 6 awardsfunded 2025-09-26Company site →

MATERIAL ANSWERS, LLC

WESTON, MA · 1 employee

Polybenzoxazine Aerogels for Insulation in 38% Oxygen Environments

National Aeronautics and Space Administration · Phase Phase I

$150kawardedfunded 2025-09-25Company site →

PENDAR TECHNOLOGIES LLC

CAMBRIDGE, MA · 65 employees

Heterogeneous integration of infrared single mode lasers with photonic integrated circuits

Department of Defense · Department of Homeland Security · National Aeronautics and Space Administration · Phase Phase I/Phase II

$1.6Macross 5 awardsfunded 2025-09-24Company site →

Lybra Bio

Cambridge, MA · 2 employees

Microneedle-mediated expansion of skin-resident regulatory T cells for management of autoimmune skin diseases

Department of Health and Human Services · National Science Foundation · Phase Phase I

$611kacross 2 awardsfunded 2025-09-24

EMMUNE INC

CAMBRIDGE, MA · 5 employees

Process development for manufacturing eCD4-Ig

Department of Health and Human Services · Phase Phase I/Phase II

$1.3Macross 2 awardsfunded 2025-09-23Company site →

RealNose Inc

ARLINGTON, MA · 1 employee

Embedded Machine Olfaction for Multi-Modal Sensing

Department of Defense · Phase Phase I

$209kawardedfunded 2025-09-23

MICROBIOTIX, INC.

Worcester, MA

Novel Benzyl-Piperidine antifungal agents to treat intractable Mucorales infections

Department of Health and Human Services · Phase Phase I/Phase II

$1.6Macross 3 awardsfunded 2025-09-22

RENDEVER, INC.

SOMERVILLE, MA · 30 employees

Improving Mental Health and Social Connectivity for Older Adults through Virtual Reality-Based Social Interventions

Department of Health and Human Services · Phase Phase I/Phase II

$1.7Macross 2 awardsfunded 2025-09-22Company site →

ExQor Technologies Inc

Boston, MA · 2 employees

New Nanoprobes for MR Imaging of TrkB in Alzheimer's Disease

Department of Health and Human Services · Phase Phase I

$500kawardedfunded 2025-09-22Company site →

PASCALL Systems, Incorporated

Boston, MA · 12 employees

Developing an Elderly Patient-Specific, Accurate, Intuitive and Highly Interpretable System for Unconsciousness Management in General Anesth

Department of Health and Human Services · Phase Phase II

$6.8Macross 5 awardsfunded 2025-09-20Company site →

GLIAL THERAPEUTICS, LLC

BOSTON, MA · 4 employees

Targeting aVb8 integrin to restore astrocyte-microglia crosstalk to treat Alzheimer's disease

Department of Health and Human Services · Phase Phase I

$255kawardedfunded 2025-09-20

Tauvision

Concord, MA · 1 employee

An Eyedrop Diagnostic Test for Alzheimer's Disease

Department of Health and Human Services · Phase Phase I

$493kawardedfunded 2025-09-20

General Biologics, Inc.

Cambridge, MA · 2 employees

Development of a tissue-targeted non-thrombotic EPO derivative

Department of Health and Human Services · Phase Phase I

$307kawardedfunded 2025-09-20

Navigation Sciences, Inc.

Brookline, MA · 1 employee

Targeted Localization and Optimized Surgical Resection for Lung Cancer

Department of Health and Human Services · Phase Phase I

$225kawardedfunded 2025-09-19

BODKIN DESIGN & ENGINEERING LLC

NEWTON, MA · 8 employees

Multi-Sensor Prototype for Non-Destructive Corrosion Evaluation and Characterization

Department of Defense · Phase Phase II

$3.0Macross 2 awardsfunded 2025-09-19Company site →

PROTEAN BIO INC

Lexington, MA · 3 employees

IND-enabling studies of D6PV- a novel ApoC-II peptide mimetic therapeutic

Department of Health and Human Services · Phase Phase II

$1000kawardedfunded 2025-09-19

International Fabric Machines

Cambridge, MA · 2 employees

Imperceptible Fabric-Integrated Wireless Batteryfree Fiber Temperature Sensor System (fID-T) for Remote Frostbite Detection and Prevention

Department of Defense · Phase Phase II

$1.3Mawardedfunded 2025-09-19Company site →

MAGLEV AERO INC.

Boston, MA · 14 employees

HYDRATE: A Zero-Emission Direct Drive Parallel Hybrid Turbofan for Personal Jets

Department of Defense · National Aeronautics and Space Administration · Phase Phase I

$223kacross 2 awardsfunded 2025-09-19Company site →

GVD CORP

CAMBRIDGE, MA · 12 employees

Conformal coatings to enhance biocarriers for rapid-startup of biofilm reactors

Department of Defense · National Aeronautics and Space Administration · Phase Phase I/Phase II

$1.9Macross 2 awardsfunded 2025-09-18Company site →

PopCom Health

Medford, MA · 4 employees

Project GAME ON!: Empowering urban children to engage in healthy behaviors to reduce obesity risk through an interactive digital comic tool

Department of Health and Human Services · Phase Phase I

$397kawardedfunded 2025-09-18

EMBIOSYS INC.

North Andover, MA · 5 employees

CuRrEnT: Capecitabine in RCB2/3 with a wearable induced Electric field device in Triple Negative Breast Cancer

Department of Health and Human Services · Phase Phase II

$1.4Mawardedfunded 2025-09-17Company site →

Raiz Diagnostics Inc.

Boston, MA · 3 employees

Scaling Lymphoma Diagnosis: A Cost-Effective Gene Expression Assay for Broad Implementation

Department of Health and Human Services · Phase Phase II

$1.8Mawardedfunded 2025-09-17Company site →

Microvascular Tissues, Inc.

JAMAICA PLAIN, MA · 6 employees

Evaluating the Effect of a Local Microvascular Tissue Graft Treatment in Rat Models of Diabetic Peripheral Neuropathy

Department of Health and Human Services · Phase Phase I

$350kawardedfunded 2025-09-17Company site →

Absco Therapeutics, Inc.

BROOKLINE, MA · 3 employees

Enhancing Solid Tumor lmmunotherapy with Targeted siRNA Delivery

Department of Health and Human Services · National Science Foundation · Phase Phase I

$712kacross 2 awardsfunded 2025-09-17Company site →

SAFEBVM CORP.

BOSTON, MA · 11 employees

Integration of Sotair with Capnography for Standardizing Manual Ventilation Technique and Improving Patient Outcomes

Department of Health and Human Services · Phase Phase II

$500kawardedfunded 2025-09-17Company site →

SYNTIS BIO INC

Boston, MA · 12 employees

Development of an Oral Methionine-Gamma-Lyase Enzyme for the Treatment of Homocystinuria

Department of Health and Human Services · Phase Phase I/Phase II

$3.2Macross 5 awardsfunded 2025-09-17Company site →

GUARDION INC

BURLINGTON, MA · 4 employees

Portable Major and Trace Constituent Gas Analyzer for Habitable Environments

Department of Defense · National Aeronautics and Space Administration · Phase Phase I

$375kacross 3 awardsfunded 2025-09-16Company site →

MIZAR THERAPEUTICS INC.

WOODS HOLE, MA · 4 employees

Mizar S/TAR High-Throughput Platform for Identification of Senescence Altering Therapeutics

National Aeronautics and Space Administration · Phase Phase II

$900kawardedfunded 2025-09-16

XGENOMES CORP.

CAMBRIDGE, MA · 6 employees

Achieving ultra-high-density, ultra-high-precision single molecule localization microscopy with whole-video deep learning architectures

Department of Health and Human Services · Phase Phase I

$1.1Macross 3 awardsfunded 2025-09-15Company site →

POLY ORTH INTERNATIONAL

SHARON, MA

3D-printed Skin and Bone Integrated Pylon (SBIP-3D) for Direct Skeletal Attachment of Limb Prostheses.

Department of Health and Human Services · Phase Phase II

$594kawardedfunded 2025-09-15

ZEEST BIO INC

WATERTOWN, MA · 5 employees

Development of a novel liver-specific positron emission tomography tracer

Department of Health and Human Services · Phase Phase I

$400kawardedfunded 2025-09-15

TATUM ROBOTICS LLC

HUDSON, MA · 1 employee

SBIR Phase II: Robotic system outputting multimodal methods to aid in communication

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-09-15

NEUROFIELDZ INC

NEWTON CENTER, MA · 3 employees · woman-owned

Objective Mobile diagnostics for Optic Neuropathies

Department of Health and Human Services · Phase Phase I

$376kawardedfunded 2025-09-15Company site →

OASIS PHARMACEUTICALS, LLC

LEXINGTON, MA · 5 employees

Development of PAR2 Pepducins for the Treatment of COPD

Department of Health and Human Services · Phase Phase I

$468kawardedfunded 2025-09-15

KEPHERA DIAGNOSTICS LLC

FRAMINGHAM, MA · 13 employees

Peptide-based ELISA for laboratory diagnosis of sarcoidosis

Department of Health and Human Services · Phase Phase I/Phase II

$1.3Macross 2 awardsfunded 2025-09-15Company site →

ROBIGO, INC

CAMBRIDGE, MA · 5 employees · woman-owned

SBIR Phase II: Engineering the Plant Microbiome to Reduce Disease in Crops

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-09-15

SIGNABLOK, INC.

WORCESTER, MA · 2 employees

TREM-1 therapy for the treatment of empyema

Department of Health and Human Services · Phase Phase I/Phase II

$1.3Macross 2 awardsfunded 2025-09-15Company site →

INTELON OPTICS, INC.

WOBURN, MA · 19 employees

Next-generation Brillouin ocular scanner

Department of Health and Human Services · Phase Phase II

$566kawardedfunded 2025-09-15Company site →

EARTH XYZ, Inc.

CAMBRIDGE, MA · 8 employees

Ultra Low Reflectance Black Silicon for Visible to IR Light Absorption

Department of Defense · National Aeronautics and Space Administration · Phase Phase I/Phase II

$1.4Macross 2 awardsfunded 2025-09-12Company site →

LINGUISTIC INC

Cambridge, MA · 7 employees · woman-owned

Personalized and Context-relevant English lessons with AI (Pace AI) to Advance Adult Learners in Integrated Education and Training (IET) Wor

Department of Education · Phase Phase II

$1.0Mawardedfunded 2025-09-12Company site →

EDIFII, INC

CAMBRIDGE, MA · 2 employees

AI and Neuroscience-powered chatbot to provide students individualized guidance that complements the support they receive from school counse

Department of Education · Phase Phase II

$1.0Mawardedfunded 2025-09-12

FGC Plasma Solutions, Inc.

Cambridge, MA · 10 employees

High Mach Airbreathing Target (HMAT)

Department of Defense · Phase Phase II

$5.0Macross 2 awardsfunded 2025-09-11Company site →

ADEPTRIX CORP

DORCHESTER, MA · 5 employees

TauTrace™: An ultrasensitive immunoassay for neurodegenerative protein biomarkers

Department of Health and Human Services · Phase Phase I

$500kawardedfunded 2025-09-11Company site →

MYCSOLOGY FOODS INC.

MEDFORD, MA · 1 employee · woman-owned

A discovery platform to optimize the production of nutrient rich food via solid state fermentation of feedstocks relevant to spaceflight.

National Aeronautics and Space Administration · Phase Phase I

$156kawardedfunded 2025-09-10Company site →

VERAMORPH LLC

NORWOOD, MA · 3 employees

Preclinical validation of an effective oral fulvestrant product as the future standard of care endocrine therapy for ER+ metastatic breast c

Department of Health and Human Services · Phase Phase I

$400kawardedfunded 2025-09-10Company site →

TIBA BIOTECH LLC

CAMBRIDGE, MA · 4 employees

Targeted Delivery of Tumor Antigen esaRNA to the Spleen for Cancer Immunotherapy

Department of Health and Human Services · Phase Phase I

$399kawardedfunded 2025-09-10Company site →

THINK THERAPEUTICS, INC.

NEWTON, MA · 1 employee

Brilliant epitopes for improved cancer vaccines

Department of Health and Human Services · Phase Phase I

$406kawardedfunded 2025-09-08Company site →

BESSOR PHARMA, LLC

FRAMINGHAM, MA · 9 employees

Development of a novel renalase agonist for the treatment of acute pancreatitis

Department of Health and Human Services · Phase Phase II

$904kawardedfunded 2025-09-04

VELUM INC

CAMBRIDGE, MA · 5 employees

Peptide YY triagonist weight loss drugs

Department of Health and Human Services · Phase Phase I

$315kawardedfunded 2025-09-01

BIOSENSICS LLC

NEWTON, MA · 20 employees

A Wearable Sensor Platform for Remote Monitoring of Motor Impairment in Huntingtons Disease and Prodromal Huntingtons Disease

Department of Health and Human Services · Phase Phase II

$3.3Macross 3 awardsfunded 2025-09-01Company site →

ACPHARIS

HOLLISTON, MA · 2 employees

Software for increased accuracy prediction of antibody-antigen complexes

Department of Health and Human Services · Phase Phase I

$202kawardedfunded 2025-09-01Company site →

Kano Therapeutics Inc.

Cambridge, MA · 6 employees

Active non-viral nuclear delivery of DNA templates independent of mitosis

Department of Health and Human Services · Phase Phase I

$350kawardedfunded 2025-09-01

Xheme Inc.

NEWTON, MA · 0 employees

STTR Phase II: A Completely Non-Toxic Blood Bag That Keeps Blood Healthier, Longer

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-09-01Company site →

IMAGINE SCIENTIFIC INC

NORWOOD, MA · 1 employee

Transforming Mammography With STARLIGHT, Imagine Scientific's Monochromatic X-Ray Imaging System

Department of Health and Human Services · Phase Phase II

$780kawardedfunded 2025-09-01Company site →

Aphios Corporation

North Reading, MA · 12 employees

Botanical Drug for Chemotherapy Induced Nausea and Vomiting

Department of Health and Human Services · Phase Phase I

$416kawardedfunded 2025-09-01Company site →

OUTCOME REFERRALS INC

FRAMINGHAM, MA · 16 employees

Consumer-Therapist-Connector: Increasing Access to Quality Behavioral Healthcare

Department of Health and Human Services · Phase Phase II

$1.1Mawardedfunded 2025-09-01Company site →

BIOMEMBRETICS, INC.

SCITUATE, MA · 1 employee

Manufacturable Biomimetic Microfluidic Oxygenator for Safer, Simpler Treatment of Respiratory Failure

Department of Health and Human Services · Phase Phase II

$2.9Mawardedfunded 2025-09-01

ACCURE HEALTH INC

CAMBRIDGE, MA · 4 employees

AI-powered engineering and analysis of cyanobacterium vesicles targeting gastrointestinal cancer

Department of Health and Human Services · Phase Phase I

$400kawardedfunded 2025-09-01

Galibra Neuroscience, Inc.

CHESTNUT HILL, MA · 2 employees

Developing Brain Penetrable AAV Gene Therapy for Succinic Semialdehyde Dehydrogenase Deficiency (SSADHD)

Department of Health and Human Services · Phase Phase I

$500kawardedfunded 2025-09-01

OPTIC FRINGE CORP.

Billerica, MA

SBIR Phase II: AI-Driven Part Identification that Converts Standard Coordinate Measuring Machines into Autonomous Systems for Automated Part

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-09-01

BOSTON AI LLC

MEDFIELD, MA · 3 employees · woman-owned

An AI Enabled Training Tool for Complex Surgical Suturing Skills

Department of Health and Human Services · Phase Phase I

$327kawardedfunded 2025-09-01

MYOLEX, INC.

BROOKLINE, MA · 8 employees

Electrical impedance myography (EIM) to detect and track cancer cachexia

Department of Health and Human Services · Phase Phase I

$263kawardedfunded 2025-09-01Company site →

Aperture Bio Inc.

Allston, MA · 7 employees · woman-owned

Rapid, Single Cell Proteomic Profiling for Biomarker Development in Precision Oncology

Department of Health and Human Services · Phase Phase I/Phase II

$1.3Macross 2 awardsfunded 2025-09-01

FORWARD PHOTONICS LLC

WOBURN, MA · 11 employees

Laser Magazine for Direct Diode Directed Energy Weapons

Department of Defense · Phase Phase II

$1000kawardedfunded 2025-08-28Company site →

INTERACTIVE APTITUDE LLC

Tyngsboro, MA · 9 employees

ORCHESTRA-AI: Operational Rhythm Coordination & Handoff Engine for Strategic Tasking & Real-time Adaptation

Department of Defense · Phase Phase I/Phase II

$3.2Macross 9 awardsfunded 2025-08-28Company site →

UFA, INC.

WOBURN, MA · 130 employees

Objective. Measurable. Mission-Ready: Advanced Evaluation Capabilities for ATC Readiness

Department of Defense · Phase Phase I/Phase II

$3.1Macross 3 awardsfunded 2025-08-28Company site →

Delta Learning, Inc.

Sandwich, MA · 3 employees

Delta AI - Artificial Intelligence (AI) Role-Players for Scenario Based Training

Department of Defense · Phase Phase I

$150kawardedfunded 2025-08-28

APTIMA INC

WOBURN, MA · 140 employees

PROACTIVE

Department of Defense · Phase Phase I/Phase II

$9.9Macross 12 awardsfunded 2025-08-28Company site →

Software Velocity Corp.

Fairhaven, MA · 2 employees

Software Velocity Corp - TestGPT - Autonomous AI-assisted Test Generation platform

Department of Defense · Phase Phase I

$149kawardedfunded 2025-08-28

AUTONODYNE LLC

BOSTON, MA · 33 employees

Adaptive Weapons-to-Targets Optimization for Counter UAS Applications

Department of Defense · Phase Phase I/Phase II

$1.6Macross 2 awardsfunded 2025-08-27Company site →

STRAND THERAPEUTICS INC.

BOSTON, MA · 8 employees

STX-005: A Next-Generation Therapy for Autoimmune Disease to Sustain Force Readiness

Department of Defense · Phase Phase II

$1.2Mawardedfunded 2025-08-27

MAYFLOWER COMMUNICATIONS COMPANY, INC.

BEDFORD, MA · 48 employees

Low Size, Weight and Power and Cost (SWAP-C) Advanced CRPA (Controlled Radiation Pattern Antenna) GPS L1 and L2 Anti-Jam System with compara

Department of Defense · Phase Phase II

$1.7Mawardedfunded 2025-08-26Company site →

USMAT INC

NATICK, MA · 5 employees

Sonobuoy Vector Sensor

Department of Defense · Phase Phase I

$1.0Macross 5 awardsfunded 2025-08-26Company site →

VIA SCIENCE INC

SOMERVILLE, MA · 70 employees

FA442723R1002 eJARVIS Project (MacDill and JBMDL) Solicitation

Department of Defense · Phase Phase I/Phase II

$4.0Macross 2 awardsfunded 2025-08-25Company site →

SUNFLOWER THERAPEUTICS PBC

MEDFORD, MA · 13 employees · woman-owned

Pioneering continuous cell disruption for efficient commercial scale virus-like particle (VLP) biomanufacturing

Department of Health and Human Services · Phase Phase I

$306kawardedfunded 2025-08-21Company site →

SPACERAKE, INC.

CAMBRIDGE, MA · 6 employees

SDA-interoperable transPortable Laser Ground Terminals

Department of Defense · Phase Phase II

$3.1Macross 2 awardsfunded 2025-08-21Company site →

HIGHLAND INSTRUMENTS INC

BRAINTREE, MA · 4 employees

CRP: Noninvasive brain stimulation for chronic pain treatment

Department of Health and Human Services · Phase Phase II

$2.1Mawardedfunded 2025-08-20

EPOCH BIOTECH, LLC

DOVER, MA · 2 employees

Preclinical efficacy of an APOE targeted antibody for Alzheimer's disease

Department of Health and Human Services · Phase Phase I

$499kawardedfunded 2025-08-20

ZKXKZ LLC

LEXINGTON, MA · 5 employees

3D-Printed vs Injection Molded Vortex Modular Roundabout Components for a New Turbo Configuration

Department of Transportation · Phase Phase I

$206kawardedfunded 2025-08-18Company site →

GentiBio

Cambridge, MA · 51 employees

Development of Tissue Engineered Tregs as a Treatment for Acute Ischemic Stroke

Department of Health and Human Services · Phase Phase II

$1.2Mawardedfunded 2025-08-15Company site →

SOLID MATERIAL SOLUTIONS LLC

NORTH CHELMSFORD, MA · 7 employees

Superconducting coil operating at temperatures above 15K for ADR instruments

National Aeronautics and Space Administration · Phase Phase II

$850kawardedfunded 2025-08-14

INFRASENSE, INC.

WOBURN, MA · 35 employees

Enhanced GPR system for Rapid Assessment of Chloride Content in Concrete Bridge Decks

Department of Transportation · Phase Phase II

$1.3Mawardedfunded 2025-08-13Company site →

FTL LABS CORPORATION

AMHERST, MA · 13 employees

TRAIDMA (Transit Reliability and AI Driven Maintenance Architecture)

Department of Defense · Department of Transportation · Phase Phase I/Phase II

$2.7Macross 4 awardsfunded 2025-08-13Company site →

InnoTech Precision Medicine, Inc

JAMAICA PLAIN, MA · 2 employees · woman-owned

Point of Care Detection of HPV and P16 in Saliva

Department of Health and Human Services · National Science Foundation · Phase Phase I/Phase II

$1.7Macross 2 awardsfunded 2025-08-08

MAGNOLIA OPTICAL TECHNOLOGIES, INC.

WOBURN, MA · 4 employees

High-Sensitivity UV Solid-State Photon-Counting Devices and Arrays

Department of Defense · National Aeronautics and Space Administration · Phase Phase II

$2.2Macross 2 awardsfunded 2025-08-07Company site →

INOVIANT INC

LINCOLN, MA · 5 employees

AI for Airworthiness Certification

Department of Defense · Phase Phase I

$149kawardedfunded 2025-08-06Company site →

BRIGHTLIGHT PHOTONICS, INC

Cambridge, MA · 3 employees

Space-Ready Chip-Integrated Titanium:Sapphire Lasers

National Aeronautics and Space Administration · National Science Foundation · Phase Phase I/Phase II

$1.2Macross 2 awardsfunded 2025-08-05Company site →

LLG Associates

Natick, MA · 3 employees

Ferrimagnetic Shocklines for a Solid-State High-Power Microwave System

Department of Defense · Phase Phase II

$1.3Mawardedfunded 2025-08-04

EIKONIZO THERAPEUTICS, INC.

CAMBRIDGE, MA · 8 employees

Next-Generation CNS-Penetrant HDAC6 Inhibitors: Proof-of-Principle in Parkinson's Disease

Department of Health and Human Services · Phase Phase I

$500kawardedfunded 2025-08-01

CILA THERAPEUTICS INC.

JAMAICA PLAIN, MA · 3 employees · woman-owned

Development of CIL-0X: A Platform to Enhance Delivery of Inhaled RNA Therapeutics to Lung Cells

Department of Health and Human Services · Phase Phase I

$380kawardedfunded 2025-08-01Company site →

VENOVA TECHNOLOGIES INC

CAMBRIDGE, MA · 2 employees · woman-owned

Development of a novel, non-hormonal female contraceptive device to submit IDE

Department of Health and Human Services · Phase Phase II

$1.1Mawardedfunded 2025-08-01Company site →

VIGOROUS MIND INC

NEWTON, MA · 1 employee

Demonstrating feasibility of using a robot to deliver a multicomponent intervention to reduce delirium in hospitalized elderly patients liv

Department of Health and Human Services · Phase Phase I

$500kawardedfunded 2025-08-01Company site →

ARSENAL MEDICAL INC

Waltham, MA · 18 employees

Engineering a Middle Meningeal Artery Embolization Model with Hydrophilicity and Hydraulic Resistance

Department of Health and Human Services · Phase Phase I

$314kawardedfunded 2025-08-01Company site →

Epoulosis Therapeutics, Inc.

Newton, MA · 2 employees

Metrifonate local application for DFU treatment

Department of Health and Human Services · Phase Phase II

$1.0Mawardedfunded 2025-08-01Company site →

GREENSIGHT INC.

CHARLESTOWN, MA · 46 employees

OsmoInverter

Department of Defense · Phase Phase I/Phase II

$8.9Macross 9 awardsfunded 2025-07-30Company site →

BLUERISC INC

AMHERST, MA · 16 employees

Large Language Models for System Security Engineering Analysis

Department of Defense · Phase Phase I/Phase II

$2.1Macross 3 awardsfunded 2025-07-30Company site →

A10 Systems Inc. d/b/a AiRANACULUS

LOWELL, MA · 18 employees

Future Lunar surface comms using Cognitive 3gpp Radio Access Networks for Ubiquitous Mission success (FULCRUM)

Department of Defense · National Aeronautics and Space Administration · Phase Phase I/Phase II

$4.4Macross 5 awardsfunded 2025-07-28Company site →

DIVERSIFIED TECHNOLOGIES, INC.

BEDFORD, MA · 123 employees

High Power Mechanically-Phased Helix Array

Department of Defense · Department of Energy · Phase Phase I/Phase II

$5.2Macross 5 awardsfunded 2025-07-25Company site →

VISHWA ROBOTICS AND AUTOMATION LLC

CAMBRIDGE, MA · 2 employees

DROP IN REPLACEMENT OF TOROIDAL PROPELLERS FOR TORPEDO AND UUV (UNMANNED UNDERSEA VEHICLES)

Department of Defense · Phase Phase I

$140kawardedfunded 2025-07-23Company site →

WINDOW THERAPEUTICS, INC.

BOSTON, MA · 5 employees

SBIR Phase II: Antibody-Drug Conjugates (ADCs) with High Drug-Antibody Ratios (DAR) and Molecularly Targeted Payloads

National Science Foundation · Phase Phase II

$1.0Mawardedfunded 2025-07-15

Fourth Power, Inc.

CAMBRIDGE, MA · 16 employees

SBIR Phase II: Advanced Thermal Battery Systems for Grid-Scale Energy Storage: Further Optimization of an Innovative Thermal Cycle Test Rig

National Science Foundation · Phase Phase II

$1.1Mawardedfunded 2025-07-15Company site →

MESPILUS INC

WORCESTER, MA · 1 employee

STTR Phase II: Nano Functionalized Capacitive Deionization For Water Purification

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-07-15Company site →

IIAM CORPORATION

Boston, MA

SBIR Phase II: NLP Driven Automation for Optimizing New Patient Referral Pathways

National Science Foundation · Phase Phase II

$1.3Mawardedfunded 2025-07-15

AUTOIVF, INC.

Natick, MA · 7 employees

OvaReady: An automated microfluidic oocyte retrieval and denudation device

Department of Health and Human Services · Phase Phase II

$997kawardedfunded 2025-07-15Company site →

Giwotech Inc.

Boston, MA · 1 employee

STTR Phase I: Accelerating Molecular Dynamics using Coarse-Grained Neural Network Potentials

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-07-15Company site →

Tycho AI Inc.

Boston, MA · 30 employees

Cognitive Terrain Flight Assistance

Department of Defense · Phase Phase I

$229kawardedfunded 2025-07-14Company site →

SENTENAI INC

CAMBRIDGE, MA · 8 employees

Multi-source target localization and state estimation for passive sonar arrays

Department of Defense · Phase Phase I

$140kawardedfunded 2025-07-10Company site →

BOSTON ENGINEERING CORPORATION

WALTHAM, MA · 75 employees

Robotic Manipulation Learning for Repair of Marine Diesel Engines

Department of Defense · Phase Phase I/Phase II

$7.9Macross 8 awardsfunded 2025-07-07Company site →

Infibertech, Corp,

Sharon, MA · 4 employees

Miniature High-Performance Integrated Photonics Inertial Measurement Unit

Department of Defense · National Aeronautics and Space Administration · Phase Phase I/Phase II

$1.1Macross 2 awardsfunded 2025-07-07

ZEUS AI, INC.

ARLINGTON, MA · 4 employees

Observation Driven Multi-Scale Medium Range ML Weather Forecasts

Department of Defense · Department of Energy · Phase Phase I/Phase II

$1.8Macross 2 awardsfunded 2025-07-07Company site →

SCIENTIFIC SYSTEMS COMPANY, INC.

Burlington, MA · 83 employees

ASTAR-ASP: ADS-B Signal Transmission Authenticity Reckoner with Advanced Signal Processing

Department of Defense · Phase Phase I/Phase II

$3.9Macross 7 awardsfunded 2025-07-07Company site →

Harris Miller Miller & Hanson Inc.

Burlington, MA · 50 employees · woman-owned

Proposal Response for Non-Wearable and Off-Engine Jet Noise Reduction

Department of Defense · Phase Phase I

$140kawardedfunded 2025-07-07Company site →

STOA TECH, INC.

SCITUATE, MA · 4 employees · woman-owned

Profiling the boundary layers of the atmosphere and ocean from the surface outward

Department of Defense · Phase Phase I

$140kawardedfunded 2025-07-07

METIS DESIGN CORPORATION

BOSTON, MA · 8 employees

Aerial Refueling Latch Indicator

Department of Defense · Phase Phase I

$215kacross 2 awardsfunded 2025-07-07Company site →

QUERA COMPUTING INCORPORATED

BOSTON, MA · 60 employees

Advanced Quantum Testbeds for Atomic Technologies (AQUA)

Department of Defense · Phase Phase II

$3.6Mawardedfunded 2025-07-02Company site →

CLEARVIEW OPTICS LLC

CHESTNUT HILL, MA · 2 employees

STTR Phase I: Novel Bioactive Hydrogel Dressings with Porous Surface for Burn Wound Treatment

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-07-01

KINEOLABS, INC.

BILLERICA, MA · 3 employees

Line Scan Swept Source OCT (LS-SS-OCT)

Department of Health and Human Services · Phase Phase I

$300kawardedfunded 2025-07-01Company site →

HARVEST MOON AUTOMATION INC

WINCHESTER, MA · 2 employees · woman-owned

SBIR Phase II: Precision Weeder

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-07-01

OPTOWARES INC

WOBURN, MA · 75 employees

Ambient Pressure-Dried Ormosil Hybrid Aerogel Composite Blankets for Advanced Space Suit Insulation

Department of Defense · National Aeronautics and Space Administration · Phase Phase I/Phase II

$990kacross 2 awardsfunded 2025-06-27

APPLIED NANOFEMTO TECHNOLOGIES LLC

LOWELL, MA · 3 employees

Ultra-compact, Color Visible and Shortwave Infrared (SWIR) Dual-band Camera

Department of Defense · Phase Phase I

$549kacross 3 awardsfunded 2025-06-25

Epicore Biosystems, Inc.

CAMBRIDGE, MA · 24 employees

LOW COST AND RUGGEDIZED SMART WEARABLE MICROFLUIDIC PLATFORM FOR REAL-TIME HYDRATION MANAGEMENT

Department of Defense · Phase Phase II

$1.2Mawardedfunded 2025-06-24Company site →

NEURABLE INC.

BOSTON, MA · 16 employees

PRISM (Persistent Readiness Insight & Sensing for Mission optimization) – Brain-sensing wearable technology for enhancing cognitive readines

Department of Defense · Phase Phase II

$1.2Mawardedfunded 2025-06-18Company site →

GEL4MED INC

NEWTONVILLE, MA · 6 employees

Novel dermal templates for prevention and treatment of biofilms in cutaneous wounds

Department of Health and Human Services · Phase Phase II

$1.1Mawardedfunded 2025-06-17

Aquinnah Pharmaceuticals Inc.

Newton, MA · 2 employees

Development of a novel oral brain penetrant therapeutic for ALS disease

Department of Health and Human Services · Phase Phase II

$1.5Mawardedfunded 2025-06-15

X-SIGHT INCORPORATED

CAMBRIDGE, MA · 4 employees

SBIR Phase II: Compact Multi X-ray Source Imaging Modules for Point-Of-Care Medical Screening

National Science Foundation · Phase Phase II

$1.3Mawardedfunded 2025-06-13Company site →

POLYMERIX TECHNOLOGIES LLC

ALLSTON, MA · 2 employees

A universal underwater curing adhesive with acoustic transparency

Department of Defense · Phase Phase I

$140kawardedfunded 2025-06-12

ASTROCYTE PHARMACEUTICALS INC.

CAMBRIDGE, MA · 4 employees

Preclinical Efficacy and Safety Evaluation of Oral AST-004 for Moderate Traumatic Brain Injury (TBI)

Department of Health and Human Services · Phase Phase II

$1.5Mawardedfunded 2025-06-12Company site →

PISON TECHNOLOGY INC

BOSTON, MA · 8 employees

A Digital Biomarker for ALS - Pison Neural Biosensor

Department of Health and Human Services · Phase Phase I

$459kawardedfunded 2025-06-12Company site →

MAGIQ TECHNOLOGIES, INC.

SOMERVILLE, MA · 18 employees

Photonic-Based Miniature Electric Field Sensing for Underwater Applications

Department of Defense · Department of Energy · Phase Phase I

$340kacross 2 awardsfunded 2025-06-09Company site →

ZAIPUT FLOW TECHNOLOGIES LLC

WALTHAM, MA · 10 employees · woman-owned

SBIR Phase II: Continuous, Scalable Crystallizer for Pharmaceutical Manufacturing

National Science Foundation · Phase Phase II

$1.3Mawardedfunded 2025-06-05Company site →

AKITA INNOVATIONS LLC

NORTH BILLERICA, MA · 7 employees

Permanent Elastomeric Radar Array Cover

Department of Defense · Phase Phase I/Phase II

$898kacross 2 awardsfunded 2025-06-03Company site →

White River Technologies Inc

Newton, MA

Magnetometer Data Processing for Subsea Noise Mitigation and Object Detection

Department of Defense · Phase Phase I

$140kawardedfunded 2025-06-02

Tissuevision Inc

Cambridge, MA · 10 employees

The Development of Tabletop Brain-Mapping Platform

Department of Health and Human Services · Phase Phase II

$1.3Mawardedfunded 2025-06-01

Guided Clinical Solutions Inc.

BROOKLINE, MA · 4 employees · woman-owned

GuidedOR: A Real-Time Medication Safety Software Platform for the Operating Room

Department of Health and Human Services · Phase Phase I

$314kawardedfunded 2025-06-01Company site →

CG SCIENTIFIC INC

WORCESTER, MA · 2 employees

Low-Cost Platform Technology for Rapid Isolation of Peripheral Blood Mononuclear Cells

Department of Health and Human Services · Phase Phase II

$833kawardedfunded 2025-06-01

D-2 Inc

Bourne, MA · 14 employees

Extended Performance Petroleum Expeditionary Analysis Kit, (E-PEAK)

Department of Defense · Phase Phase II

$1.4Mawardedfunded 2025-05-28Company site →

HIGH CALIBER SOLUTIONS, LLC

NORFOLK, MA · 1 employee

BEACON (Bluetooth-Enabled Adaptive Combat Operational Notifier)

Department of Defense · Phase Phase II

$1.8Mawardedfunded 2025-05-23Company site →

WayFinder Genetics, LLC

WHITINSVILLE, MA · 15 employees

Instant Infection Detection to Keep Warfighters in the Fight

Department of Defense · Phase Phase II

$1.8Mawardedfunded 2025-05-23

Lumia Health, Inc.

Allston, MA · 30 employees

The future of Cockpit Safety-- Validating Lumia in-ear wearable for hypoxia monitoring at high altitudes

Department of Defense · Phase Phase II

$2.5Macross 2 awardsfunded 2025-05-22Company site →

RedPoint Oncology, Inc

Holden, MA · 2 employees

SBIR Phase I: Developing Next-Generation Payloads for Targeted Therapies

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-05-22

Crgo Inc

Burlington, MA · 3 employees

Long Range Autonomous Unmanned Logistics UAS

Department of Defense · Phase Phase II

$1.2Mawardedfunded 2025-05-20Company site →

QUIVER BIOSCIENCE INC.

CAMBRIDGE, MA · 22 employees

Safe-OPTION: Optical Physiology To Interrogate Oligonucleotide Neurotoxicity

Department of Health and Human Services · Phase Phase II

$862kawardedfunded 2025-05-20Company site →

Lightsynq Technologies Inc.

Boston, MA · 18 employees

Low-loss, cryogenically compatible optical fiber-to-chip interfaces for quantum and advanced classical photonic technologies

Department of Defense · Phase Phase II

$1.2Mawardedfunded 2025-05-19Company site →

SKYLINE NAV AI INC

CAMBRIDGE, MA · 5 employees

Fused 2D and 3D Computer Vision Aided Navigation in GPS-Denied Environments for Combat Aircraft Take-Off, Landing and Flight Operations

Department of Defense · Phase Phase II

$1.3Mawardedfunded 2025-05-19Company site →

Code Metal, Inc.

Boston, MA · 41 employees

STRATEGIC Engine: Strategic Training and Robust AI for Transferable and Effective - PHASE II

Department of Defense · Phase Phase II

$1.8Mawardedfunded 2025-05-15Company site →

APEIRON LABS, INC.

CAMBRIDGE, MA · 10 employees

NEXUS - Naval Expeditionary/Expendable Undersea Sensing at Scale

Department of Defense · Phase Phase II

$584kawardedfunded 2025-05-13Company site →

CAMX Power LLC

Lexington, MA · 40 employees

High Performance Rechargeable Battery for Edge Environments

Department of Defense · Phase Phase II

$2.0Mawardedfunded 2025-05-07Company site →

SafeFlights Inc. /d/b/a 14bis Supply Tracking

Brookline, MA · 3 employees · woman-owned

RSP PACKOPS Advanced Compute: Seamless 3D Visualization and Packing with Edge Computing, Reducing Time and Environmental Footprint

Department of Defense · Phase Phase II

$1.8Mawardedfunded 2025-05-02Company site →

Boston Interactome LLC

Mansfield, MA · 3 employees

Developing high-precision epigenetic therapeutics for opioid use disorder

Department of Health and Human Services · Phase Phase I

$398kawardedfunded 2025-05-01

SEE YOURSELF HEALTH LLC

BEVERLY, MA · 1 employee · woman-owned

Mirame Salud: Immersive Diabetes Self-Management Training for Latino Americans

Department of Health and Human Services · Phase Phase I

$386kawardedfunded 2025-04-29Company site →

KOPIN TARGETING CORPORATION

WESTBOROUGH, MA · 150 employees

Kopin Off the Visor Heads Up Display A244-011-0119

Department of Defense · Phase Phase II

$2.0Mawardedfunded 2025-04-24Company site →

UNMUTE ENTERPRISE INC

CHELSEA, MA · 2 employees · woman-owned

Unmute's CARE framework: A Novel Approach to Strengthen the Therapeutic Alliance and Reduce Treatment Disparities

Department of Health and Human Services · Phase Phase I

$462kawardedfunded 2025-04-22Company site →

LIFTWAVE INC

SOMERVILLE, MA · 19 employees

RISE Robotics Advanced Lifting Solutions: Collapsible Lightweight Cranes

Department of Defense · Phase Phase I

$250kawardedfunded 2025-04-22Company site →

CANETIA ANALYTICS, INC.

SOMERVILLE, MA · 2 employees

SBIR Phase II: Development of an AI-based, IoT Enabled System for Structural Health Monitoring

National Science Foundation · Phase Phase II

$992kawardedfunded 2025-04-15

BIODEVEK INC

ALLSTON, MA · 2 employees

SBIR Phase II: Sprayable Hydrogel Sealant for Gastrointestinal Wound Protection

National Science Foundation · Phase Phase II

$1.3Mawardedfunded 2025-04-15Company site →

BOSTON FUSION CORP

LEXINGTON, MA · 20 employees · woman-owned

SIGMA: Strategic Intelligence for Grey-zone Modeling and Analysis

Department of Defense · Phase Phase I/Phase II

$4.1Macross 3 awardsfunded 2025-04-14Company site →

SENSORQ TECHNOLOGIES INC.

Somerville, MA · 9 employees

Information Rich Sampling via Adaptive Modal Imaging for Quantum-Limited Resolution (IRIS)

Department of Defense · Phase Phase II

$1.5Mawardedfunded 2025-04-10Company site →

Linton Lifesciences

Milton, MA · 2 employees

SBIR Phase I: Microfluidic 3D Bioprinting of Dacron-Recombinant Human Collagen Double-Network Crosslinked Biomimetic Vascular Conduits

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-04-10

CORCORAN ENGINEERING, INC.

WALTHAM, MA · 1 employee

Compact High-Power Direct Diode Laser with Diffraction-Limited Output

Department of Defense · Phase Phase I

$150kawardedfunded 2025-04-07

SENSORIUM THERAPEUTICS INC

BOSTON, MA · 16 employees

A Drug Discovery Platform to Prioritize Development of Natural Product Neuromodulators for Treating Cognitive Impairment

Department of Health and Human Services · Phase Phase II

$1.5Mawardedfunded 2025-04-05

CERETYPE NEUROMEDICINE IN

CAMBRIDGE, MA · 5 employees · woman-owned

Design and Development of an Advanced Functional MRI Software as Medical Device (SaMD) forClinical Trials and Therapeutic Applications in Ne

Department of Health and Human Services · Phase Phase I

$380kawardedfunded 2025-04-03

SAFI BIOTHERAPEUTICS INC

CAMBRIDGE, MA · 13 employees

Manufacturing Process Intensification for Pluripotent Stem Cell-Derived Rare Red Cell Production

Department of Health and Human Services · Phase Phase I

$568kawardedfunded 2025-04-01Company site →

SANGTERA INC

LEXINGTON, MA · 1 employee

STTR Phase II: Miniature Precision Stage for High Throughput Hybrid Bonding

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-04-01

DELINEATE INC

MEDFORD, MA · 2 employees · woman-owned

DelineateQSP: Accelerating Quantitative Systems Pharmacology Model Building and Repurposing

Department of Health and Human Services · Phase Phase I

$314kawardedfunded 2025-04-01

LAUNCHBAY LLC

N BILLERICA, MA · 3 employees

Breathable, Non-Fluorinated Chemical Barrier Materials

Department of Defense · Phase Phase II

$658kawardedfunded 2025-04-01Company site →

PLATELET BIOGENESIS, INC

WATERTOWN, MA · 10 employees

Scale-up and Manufacturing of STLR-201, an off-the-shelf regenerative therapeutic for Sjogren's syndrome-related dry eye disease

Department of Health and Human Services · Phase Phase I

$356kawardedfunded 2025-04-01Company site →

Fleet Robotics

Somerville, MA · 12 employees

Optimizing Naval Asset Management: Next-Gen Autonomous Hull Maintenance Robots

Department of Defense · Phase Phase I

$74kawardedfunded 2025-03-31Company site →

NOVOWI LLC

BROOKLINE, MA · 3 employees

O244-P002-0090 Sentinel: xApps for Detecting, Characterizing, and Mitigating Malicious Signaling Attacks and Interference against 5G

Department of Defense · Phase Phase I

$295kawardedfunded 2025-03-28Company site →

ZTOUCH NETWORKS INC.

NEWTON CENTER, MA · 6 employees

O244-P002-0078 ZTAI: Zero-Trust Artificial Intelligence for secure-by-design O-RAN control and inference

Department of Defense · Phase Phase I

$295kawardedfunded 2025-03-28Company site →

BEACON INTERACTIVE SYSTEMS LLC

WALTHAM, MA · 30 employees · woman-owned

Maintenance, Sustainment, and Operations of Land Based Test Facilities

Department of Defense · Phase Phase II

$4.7Mawardedfunded 2025-03-13Company site →

Mantacus

Auburndale, MA · 1 employee

DELCOF - DETECT LONG CONCEAL IN FOLIAGE

Department of Defense · Phase Phase I

$204kawardedfunded 2025-03-06Company site →

EIC LABORATORIES, INC.

NORWOOD, MA · 65 employees

High Pulse Power and Safe LFP Li-Ion Battery Technologies

Department of Defense · Phase Phase I

$250kawardedfunded 2025-03-05Company site →

Palena Therapeutics, Inc.

WORCESTER, MA · 2 employees · woman-owned

SBIR Phase I: Novel Peptide Immunomodulators for Treatment of Autoimmune and Inflammatory Disorders

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-02-26Company site →

NOVAURUM BIOSCIENCES INCORPORATED

SOMERVILLE, MA · 1 employee

SBIR Phase I: Development of a Novel Mammalian Cell-Based Nano-Biological Coating for Implantable Medical Devices.

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-02-26

Boston Immune Technologies And Therapeutics Inc.

Winchester, MA · 3 employees · woman-owned

Advancing BITT-101 a novel dominant CD40 antagonist for use in treatment of Sjogren Syndrome.

Department of Health and Human Services · Phase Phase II

$927kawardedfunded 2025-02-25Company site →

IRRADIANT TECHNOLOGIES INC.

CAMBRIDGE, MA · 4 employees

Nano-Scaffolding Assembly of Materials for Next Generation Uncooled Thermal Optics

Department of Defense · Phase Phase I

$250kawardedfunded 2025-02-24Company site →

Daqus Energy, Inc.

Woburn, MA · 7 employees

Temperature-Tolerant, Critical Metal-Free, Lithium-ion Batteries using Organic Cathodes

Department of Defense · Phase Phase I

$250kawardedfunded 2025-02-24Company site →

INCOM, INC.

CHARLTON, MA · 175 employees

EPPD: Particle Detector for the LHCb-ECAL Upgrade 2 Featuring ~10 Picosecond Timing

Department of Energy · Phase Phase I

$200kawardedfunded 2025-02-18Company site →

Dayhoff Labs

Cambridge, MA · 7 employees

Horizyn: advanced deep learning for enzyme discovery and annotation

Department of Energy · Phase Phase I

$248kawardedfunded 2025-02-18Company site →

BRIDGE 12 TECHNOLOGIES, INC.

NATICK, MA · 16 employees

A 350 GHz, 0.25 MW Robust Gyrotron Optimized for High Volume Production for Net Electric Fusion Reactors

Department of Energy · Phase Phase I

$200kawardedfunded 2025-02-18Company site →

nOhm devices, Inc

CAMBRIDGE, MA · 2 employees

C59-27(c) Low-noise deep-cryogenic amplifier based on hydrodynamic charge transport in GaAs/AlGaAs

Department of Energy · Phase Phase I

$206kawardedfunded 2025-02-18Company site →

MULTISCALE SYSTEMS, INC.

WORCESTER, MA · 15 employees

Optimized Alloy Composites Using Wire-fed Direct Energy Deposition

Department of Energy · Phase Phase I

$200kawardedfunded 2025-02-18Company site →

2WITECH SOLUTIONS LLC

ANDOVER, MA · 3 employees

Efficient Red Micro-LEDs with Pixel Size <5 Microns for Next-Generation Displays

Department of Defense · Phase Phase I

$210kawardedfunded 2025-02-12Company site →

AUTONOMUS MEDICAL TECHNOLOGIES, INC.

Cambridge, MA · 14 employees

Handheld Robotic Medical Device for Semi-automated Nerve Block Administration in Austere Environments

Department of Defense · Phase Phase I/Phase II

$1.3Macross 2 awardsfunded 2025-02-10Company site →

General Biophysics LLC

WAYLAND, MA · 4 employees

Xenon gas inhalation as a novel treatment for opioid withdrawal syndrome

Department of Health and Human Services · Phase Phase I

$400kawardedfunded 2025-02-01Company site →

MESODYNE INC

SOMERVILLE, MA · 10 employees

LightCell Power Generation for Autonomous Long-Range Group 2 eVTOL Systems

Department of Defense · Phase Phase II

$1.9Mawardedfunded 2025-01-29Company site →

BOSTON GEOSPATIAL, INC.

BOSTON, MA · 4 employees

Enhanced Soil State Monitoring in Arctic Environments

Department of Defense · Phase Phase II

$2.1Mawardedfunded 2025-01-29Company site →

Tactical Edge Systems Inc

North Billerica, MA · 7 employees

Tactical Fuel Production System for ACE Support Systems

Department of Defense · Phase Phase II

$1.8Mawardedfunded 2025-01-23Company site →

LASE INNOVATION INC

WOBURN, MA · 11 employees

DNA-optical barcoding technology for spatiotemporal single-cell analysis

Department of Health and Human Services · Phase Phase II

$900kawardedfunded 2025-01-20Company site →

YB Numerics, Inc.

Sharon, MA · 2 employees

IGA Mid-Processing Modeling Tools for FSI in Vehicle Mobility Applications

Department of Defense · Phase Phase I

$204kawardedfunded 2025-01-17

RAS LABS, INC.

BOSTON, MA · 3 employees · woman-owned

Sensitive and Robust Touch Sensing Systems for Robotic Humanoid Hands and Other Mission Driven Applications

Department of Defense · Phase Phase I

$73kawardedfunded 2025-01-17Company site →

FREYJA HEALTHCARE, LLC

NORTH ANDOVER, MA · 4 employees

Deployable Abdominal Imaging: Real-Time Diagnostics for Combat Zones

Department of Defense · Phase Phase I

$75kawardedfunded 2025-01-17

CERANOVA CORP

MARLBOROUGH, MA · 7 employees

Conformal IR Windows for Hypersonic Vehicles and Weapons Systems

Department of Defense · Phase Phase I

$110kawardedfunded 2025-01-15Company site →

RT MicroDx Inc.

BROOKLINE, MA · 4 employees · woman-owned

SBIR Phase I: Development of a Molecular Diagnostic Platform for Use at Home without an Expensive Table-top Device

National Science Foundation · Phase Phase I

$274kawardedfunded 2025-01-14Company site →

ROGUE WOLF ADVANCED RESEARCH LLC

COHASSET, MA · 1 employee

Drone Assault and Rehearsal Kit (DARK)

Department of Defense · Phase Phase I

$106kawardedfunded 2025-01-14Company site →

TRANSCEND AIR CORPORATION

CARLISLE, MA · 9 employees

Slayer - A Counter-UAS Cost Win for Affordably Scalable Air Defense

Department of Defense · Phase Phase I

$75kawardedfunded 2025-01-14Company site →

AM BATTERIES INC

Billerica, MA · 45 employees

A Revolutionary Manufacturing Technology to Secure the DAF’s Battery Supply Chain

Department of Defense · Phase Phase I

$75kawardedfunded 2025-01-14Company site →

ANVIL DIAGNOSTICS INC.

CAMBRIDGE, MA · 2 employees

SBIR Phase I: Ultra-Sensitive and Multiplexed Pathogen Profiling for Neonatal Sepsis Detection

National Science Foundation · Phase Phase I

$299kawardedfunded 2025-01-14Company site →

Collect'd, Inc.

Lincoln, MA · 2 employees

Comprehensive Document Management System for Enhanced Warfighter Readiness

Department of Defense · Phase Phase I

$109kawardedfunded 2025-01-14Company site →

Stitch3D Inc.

CAMBRIDGE, MA · 7 employees

3D Point Cloud Registration and Change Detection for Large-Scale Topographic Assessment

Department of Defense · Phase Phase I

$110kawardedfunded 2025-01-14Company site →

T33 Dental, Inc.

CAMBRIDGE, MA · 2 employees

SBIR Phase I: A Platform for Penetrative Drug Delivery to Teeth

National Science Foundation · Phase Phase I

$275kawardedfunded 2025-01-13

TELAZTEC LLC

BURLINGTON, MA · 12 employees

RAR Nano-Texturing For High Performance Super-Hydrophobic Beam Director Head Windows

Department of Defense · Phase Phase II

$500kawardedfunded 2025-01-13Company site →

ENCLEAR THERAPIES, INC.

Newburyport, MA · 0 employees

Targeted Cerebral Spinal Fluid (CSF) Drug Delivery - Enclear Precision System

Department of Health and Human Services · Phase Phase II

$3.0Mawardedfunded 2025-01-01

TeraDar, Inc.

Boston, MA · 48 employees

Low-Probability-of-Intercept Terahertz Communications for Air Force Applications

Department of Defense · Phase Phase II

$1.2Mawardedfunded 2024-12-18Company site →

Prospect Growth, Inc.

Newton, MA · 3 employees

Field-Scale Production of Nanoparticle Phosphorus Fertilizers: Advancing to Multi-Acre Trials

Environmental Protection Agency · Phase Phase I

$100kawardedfunded 2024-12-16Company site →

PHAGEPRO, INC.

MANSFIELD, MA · 2 employees · woman-owned

Manufacturing and Formulation Process Development for a Prophylactic Cholera Phage Cocktail

Department of Health and Human Services · Phase Phase II

$1.0Mawardedfunded 2024-12-16

NONA TECHNOLOGIES

CAMBRIDGE, MA · 6 employees

Disaster-Ready Portable/Standalone Universal Water Purifier based on CER-ICP technology.

Department of Health and Human Services · Phase Phase I

$298kawardedfunded 2024-12-05Company site →

SURMET CORP

BURLINGTON, MA · 30 employees

Develop and Demonstrate Improved Transparent Armor for Army Systems

Department of Defense · Phase Phase II

$1000kawardedfunded 2024-12-04Company site →

WILD MICROBES CO

CAMBRIDGE, MA · 5 employees

SBIR Phase I: Developing new bacterial hosts for productive secretion of difficult-to-express proteins by precision fermentation

National Science Foundation · Phase Phase I

$275kawardedfunded 2024-12-03Company site →

PHOTONWARES CORP

WOBURN, MA · 65 employees

Handheld Instruments for Multimode CWDM Optical Interconnects

Department of Defense · Phase Phase I

$140kawardedfunded 2024-11-27

BioNet Sonar

Newton, MA · 6 employees

Hydronet: An Open, Modular, and Programmable Underwater Modem

Department of Defense · Phase Phase I/Phase II

$3.3Macross 2 awardsfunded 2024-11-21Company site →

ARMADA MARINE ROBOTICS INC

East Falmouth, MA · 4 employees

Passive Ballasted Floats for Observing Interior Ocean Flows and More

Department of Defense · Phase Phase I

$296kacross 2 awardsfunded 2024-11-15Company site →

BLUEFUSION INC.

Natick, MA · 2 employees

Event-Based Cameras with GigE-Vision: Enabling Low-Latency Data Transfer with 10G Interface and GenICam Software Interface

Department of Defense · Phase Phase I

$240kawardedfunded 2024-11-15Company site →

LINTRINSIC SEMICONDUCTORS INC.

SOMERVILLE, MA · 3 employees

Semiconductor switches Providing Linearity And Speed at High-power (SPLASH)

Department of Defense · Phase Phase I

$240kawardedfunded 2024-11-15Company site →

2PI INC

NEWTON, MA · 6 employees

Wide Field-of-View, Ultra-compact, Broadband Compound Metalenses

Department of Defense · Phase Phase I

$140kawardedfunded 2024-10-31

TRANALYTICS, LLC

BEDFORD, MA · 4 employees

Complete Pavement Markings for Safe and Complete Streets

Department of Transportation · Phase Phase I

$200kawardedfunded 2024-10-28

STATE OF PLACE INC

NATICK, MA · 5 employees · woman-owned

AI for Complete, Equitable Streets (ACES): Using Computer Vision and Machine Learning to Deliver Data-Driven Guidance for Complete Streets

Department of Transportation · Phase Phase I

$200kawardedfunded 2024-10-28Company site →

SI2 TECHNOLOGIES, INC

NORTH BILLERICA, MA · 54 employees

Affordable Wideband Scalable Front-End Electronics Supporting Multi-Function Seekers (PROP.SI2T.RADR.03)

Department of Defense · Phase Phase II

$1.8Mawardedfunded 2024-10-22Company site →

VALIS INSIGHTS, INC.

WORCESTER, MA · 4 employees

Enhanced Efficiency of UBC Recycling Powered by Artificial Intelligence

Environmental Protection Agency · Phase Phase II

$400kawardedfunded 2024-10-16Company site →

Merlin Labs

Boston, MA · 150 employees

Enhancing Reduced-Crew Flight Operations with NLP-Driven Real-Time Dynamic Replanning

Department of Defense · Phase Phase II

$2.0Mawardedfunded 2024-10-08Company site →

PATHCISION MEDICINE, INC.

WATERTOWN, MA · 3 employees · woman-owned

SBIR CONCEPT AWARD FOR A NOVEL DELIVERY APPROACH TO TRANSFORM METASTATIC PANCREATIC CANCER TREATMENT AND PREVENTION

Department of Health and Human Services · Phase Phase I

$355kawardedCompany site →

KidvoKit Inc.

Newton Lower Falls, MA · 2 employees · woman-owned

AI Progress Monitor for Dyslexic Students on IEPs.

Department of Health and Human Services · Phase Phase I

$100kawardedCompany site →

AERODYNE RESEARCH INC

BILLERICA, MA · 68 employees

Autonomous Method to Quantify and Localize Hydrogen Facility Emissions

Department of Energy · National Aeronautics and Space Administration · Phase Phase I/Phase II

$3.0Macross 5 awardsaward starts 2026-12-20Company site →

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