Recently funded science companies in Pennsylvania

Integral Molecular Inc

2 open roles on the board

Philadelphia, PA · 100 employees · Department of Health and Human Services · Phase II · company site

“High-throughput Discovery of Antibodies against Understudied Membrane Proteins using mRNA”

SeaLion Energy Inc.

Pittsburgh, PA · 4 employees · Department of Energy · Phase I/II · woman-owned · company site

“TARDIS-J: Tunable Activation & Regeneration in Devices using In-Situ Jamming”

Goeppert LLC

Philadelphia, PA · 5 employees · Department of Defense, National Aeronautics and Space Administration · Phase I · woman-owned · company site

“Aerosolized Fentanyl Electrochemical Nano-Sensor for Field Detection”

Carley Technologies, Inc

Sewickley, PA · 8 employees · Department of Defense · Phase I · woman-owned · company site

“GHOSTFIELD: A realistic integrated cyber information warfare simulation for joint live, virtual constructive exercises”

Edge Case Research Inc

Pittsburgh, PA · 53 employees · Department of Defense · Phase II · company site

“Autonomous Internal Exploration and Inspection of Confined Spaces”

Advanced Cooling Technologies Inc

Lancaster, PA · 373 employees · Department of Commerce, Department of Defense, Department of Energy, Department of Health and Human Services, National Aeronautics and Space Administration · Phase I/II · company site

“DOD Navy SBIR  Icephobic Coating for Air Cycle Machine”

Hydropore Technologies LLC

Philadelphia, PA · 3 employees · National Science Foundation · Phase I

“STTR Phase I: Zinc-Assisted Two-Step Electrolyzer for Clean Hydrogen Production Using Low Purity Water”

Myexposome Inc

Philadelphia, PA · 2 employees · Department of Commerce · Phase II · company site

“Using Silicone Wristbands as Personal Monitors of PFAS Exposures”

Quantumbio Inc

State College, PA · Department of Health and Human Services · Phase I

“Addressing Structural Disorder and Conformational Heterogeneity in Modern Therapeutic Modalities: A Unified X-ray/Cryo-EM QM/MM Ensemble Ref”

Nokomis Inc

Charleroi, PA · 44 employees · Department of Defense · Phase I/II · company site

““Left of Launch” Indications and Warning for Enhanced Battle Management”

Forallsecure. Inc.

Pittsburgh, PA · 31 employees · Department of Defense · Phase II · company site

“Automated Descriptive Vulnerability Illumination in Software for Operation Readiness (ADVISOR)”

Combustion Research & Flow Technology Inc

Pipersville, PA · 22 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site

“Efficient Models for Film Condensation in Cryogenic Tank Applications”

Environmental and Metallurgical Consultancy, LLC.

Malvern, PA · 1 employee · Department of Energy · Phase I

“Production of Zr Metal by Molten Salt Electrolysis of ZrCl4”

Visimo LLC

Pittsburgh, PA · 3 employees · Department of Defense, Department of Energy, National Aeronautics and Space Administration · Phase I · company site

“GRIDview: AI-Driven Visualization Platform for Dynamic Uncertainty Quantification and Risk-Informed Grid Decision-Making”

Hamr Industries LLC

Clinton, PA · 6 employees · Department of Defense, National Aeronautics and Space Administration · Phase I · company site

“Solid-State Cold Spray Additive Manufacturing (CSAM) of GRX-810”

Prodigy Biotech Inc.

West Chester, PA · 1 employee · Department of Health and Human Services · Phase I · company site

“Investigation of Novel IgY Technology for Fungal Targets in Alcohol-associated Hepatitis”

Cytoagents, Inc.

Pittsburgh, PA · 1 employee · Department of Health and Human Services · Phase II · company site

“CTO1681 to prevent and mitigate cytokine release syndrome in multiple myeloma patients receiving CAR T-cell therapy”

Materials Research & Design Inc

Wayne, PA · 22 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site

“3D Reinforced Composites for Improved Impact Resistance in Spacesuits”

X-Hab 3d, Inc.

State College, PA · 9 employees · National Aeronautics and Space Administration · Phase I · company site

“Lunar Construction Site Mapping for Exploitation of Geotechnical Features”

Remcom Inc

State College, PA · 41 employees · National Aeronautics and Space Administration · Phase I · company site

“Wireless Channel Simulation for Antennas Mounted on Spacesuits and Lunar Vehicles”

Vesteck, Inc

West Chester, PA · 7 employees · Department of Health and Human Services · Phase II · company site

“Endovascular Suturing Device for Augmentation of Endograft Fixation During Endovascular Repair of Abdominal Aortic Aneurysm to Reduce Reinte”

Respair, Inc

Pittsburgh, PA · 2 employees · Department of Health and Human Services · Phase I

“AssuranceET: a novel endotracheal tube sealing mechanism to protect pediatric patients from airway trauma and collapse while empowering clin”

Ship of Theseus LLC

Eagleville, PA · 1 employee · Department of Health and Human Services · Phase I/II · company site

“Preclinical development of a tandem CART / HSC transplantation platform for hematologic malignancies”

InnSight Technology, Inc

Pittsburgh, PA · 5 employees · Department of Defense · Phase II · woman-owned · company site

“Novel, handheld biosensor for real time detection of full-thickness corneal injuries in civilian and military personnel”

Astrobotic Technology Inc

Pittsburgh, PA · 225 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site

“LaserNav – LiDAR-Based Dark Navigation for Safe and Precise Lunar Landing”

Equa Health, Inc.

Pittsburgh, PA · 8 employees · Department of Health and Human Services · Phase II · company site

“Mindfulness Meditation and Respiration Biosignal Feedback”

Starship Health Technologies LLC

Fort Washington, PA · 7 employees · Department of Health and Human Services · Phase I · company site

“Maternal Health Navigator intervention to reduce disparities in severe maternal morbidity and mortality”

Airalux Medical, Inc.

Philadelphia, PA · 5 employees · Department of Health and Human Services · Phase I

“DIGITAL INCENTIVE SPIROMETRY EXERCISER TO IMPROVE PATIENT ADHERENCE AND CLINICAL WORKFLOWS”

The Ultran Group, Inc.

State College, PA · 6 employees · Department of Defense · Phase I · company site

“Inspection of Bonded Composite Structures Through Fairing Materials using Ultrasound”

Nous Biosciences Inc

Doylestown, PA · 1 employee · Department of Health and Human Services · Phase I · company site

“Combination of formulated dolcanatide, a guanylate cyclase-C agonist, with formulated atiprimod, a JAK-STAT inhibitor, for treatment of muri”

Renerva, Inc.

Pittsburgh, PA · 10 employees · Department of Health and Human Services · Phase I · company site

“PNM-CAP: A novel nerve cap to prevent painful neuroma formation in peripheral nerve injuries and amputations”

Titan Robotics Inc

Coraopolis, PA · 70 employees · Department of Defense · Phase I/II · company site

“APPcS - Autonomous Process Planning for Complex Surfaces”

Nebula Compute, Inc.

Wilkes Barre, PA · 18 employees · Department of Defense · Phase II · company site

“Real-Time Intelligence Delivery, Highly Secured Edge Compute for Hypersonic Detection”

Kef Robotics Inc

Pittsburgh, PA · 20 employees · Department of Defense · Phase I/II · company site

“Visual Navigation Advances for Low-altitude, Subsonic Flight using WOSA Design Principles”

Qortek Inc

Linden, PA · 58 employees · Department of Defense · Phase I/II · company site

“Scalable High Frequency Transmit/Receive Array for Multiple Unmanned Underwater Vehicle and Torpedo Applications”

Blade Diagnostics Corporation

Pittsburgh, PA · 9 employees · Department of Defense · Phase I/II · company site

“In-situ Inlet and 1st Fan IBR Inspection for Advanced Aircraft”

Zeroeyes, Inc.

Conshohocken, PA · 182 employees · Department of Defense · Phase II · company site

“Automated Security Threat Recognition & Alerting (ASTRA)”

Merlin Therapeutics Inc

King of Prussia, PA · 2 employees · Department of Health and Human Services · Phase II · woman-owned · company site

“AAV-mediated delivery of the inflammasome adapter protein, ASC, as a pro-apoptotic gene therapy for schwannoma”

Sage Technologies, Ltd.

Warminster, PA · 20 employees · Department of Defense · Phase II · company site

“PIVASS-Pilot IRIS enabled Visual Augmentation Safety System (PIVASS)”

Merge Plot LLC

Huntingdon Valley, PA · 6 employees · Department of Defense · Phase I · company site

“Advanced Tactical Leadership Assistance System (ATLAS) Tool”

Bucket Robotics INC

Pittsburgh, PA · 2 employees · Department of Defense · Phase I/II · company site

“Readiness Improving Inspection Software Hub for Multi Source NDI Inputs”

Briacell Therapeutics Corp

Philadelphia, PA · 12 employees · Department of Health and Human Services · Phase II

“An Off-the-Shelf tumor cell vaccine with HLA-matching alleles for personalized treatment of advanced metastatic prostate cancer.”

Harlingene Life Sciences LLC

Doylestown, PA · 0 employees · Department of Health and Human Services · Phase II

“Hepatoselective Dihydrozuinolizone (HS-DHQ) Molecules for Treatment and Prevention of Hepatitis A Virus (HAV) Infection”

Strategy Robot Inc

Pittsburgh, PA · 8 employees · Department of Defense · Phase I · company site

“Computational Game Theory AI for Army Tactical COA Generation Scenarios”

Altrumed LLC

Philadelphia, PA · 1 employee · Department of Health and Human Services · Phase I

“Device-Agnostic Hypoxia Detection Software for Overdose Prediction and Positive Reversal Monitoring”

RJA Technologies LLC

New York, PA · 3 employees · Department of Defense · Phase I/II

“Interoperability using AI/ML”

OWL Integrations, Inc.

Allentown, PA · 6 employees · Department of Defense · Phase I/II · company site

“Secure, Cost-Effective, low-SWAP Logistics Data Transfer Solution through DuckLink”

Magneton Inc

Allentown, PA · 1 employee · Department of Defense · Phase II

“High Precision Single Photon Detection System for 1030 nm Laser Ranging”

Materials Sciences LLC

Horsham, PA · 77 employees · Department of Defense · Phase I/II · company site

“Domestic, Low-Cost Pitch Carbon Fiber for High Temperature Applications - P4945”

Vest Inc.

Pittsburgh, PA · 5 employees · Department of Health and Human Services · Phase I

“Development and Feasibility Testing of PrivyPod - a modular bathroom to support aging in place”

Sindri Materials Corp

West Chester, PA · 4 employees · Department of Health and Human Services · Phase I

“Investigating Ultra-High-Quality Graphene-Based Cryo-EM Device Architecture for Higher Reproducibility, Speed, and Resolution”

Genus Research Group, LLC

Pittsburgh, PA · 4 employees · Department of Defense · Phase II · company site

“Guardian Knot: A Space Force Gamified Capstone”

Peca Labs Inc

Pittsburgh, PA · 11 employees · Department of Health and Human Services · Phase I · company site

“A Novel Fully-Polymeric, Biomimetic Prosthetic Mitral Valve Constructed from Clinically-Proven Materials to Improve Durability, Performance,”

Apollo Neuroscience, Inc

Pittsburgh, PA · 5 employees · Department of Defense · Phase I · woman-owned · company site

“Apollo: Adapted Wearable to Improve Military Working Dog Physiological Monitoring, Rehabilitation, and Recovery”

Biomotivate LLC

Pittsburgh, PA · 1 employee · Department of Health and Human Services · Phase I · company site

“PEACE Platform for Non-Invasive Narrative Neuromodulation (Personalized Evocative Audiovisual Content for Everyone)”

CadnzaMed LLC

Wayne, PA · 1 employee · Department of Health and Human Services · Phase I

“A Machine Learning Software Tool for Automatic Segmentation and Analysis of T1p MR Images of Knee Cartilage for OA Diagnosis and Treatment M”

Wavefront Research, Inc

Northampton, PA · 12 employees · Department of Defense · Phase II · company site

“Compact Midwave Infrared Hyperspectral Imager for Attritable Platforms”

AssetLink Global LLC

Jessup, PA · 12 employees · Department of Defense · Phase II · company site

“ArmorPulse: An Embedded Vehicle Monitoring Solution Using Multiple Redundant DoD-Proven Secure Data Transport Pathways to Deliver a Field-Re”

Protoinnovations, LLC

Pittsburgh, PA · 12 employees · National Aeronautics and Space Administration · Phase II · company site

“Modular Software Architecture and Algorithms for Fast and Efficient Lunar Mobility (M-SAFE)”

Iqinetics Technologies Inc.

Philadelphia, PA · 14 employees · Department of Defense · Phase II · company site

“Body-Stabilizing Propulsion For Logistics sUAS”

Daniel H Wagner Associates Inc

Exton, PA · 24 employees · Department of Defense · Phase I/II · company site

“Optimal Planning for Minefields with Advanced Capabilities (OPMAC)”

One Spot Learning, Inc.

Bryn Mawr, PA · 2 employees · National Science Foundation · Phase II · woman-owned · company site

“SBIR Phase II: Holistic System for Comprehensive Student Assessment”

Chestnut Ridge Foam, Inc.

Latrobe, PA · 115 employees · Department of Defense · Phase I · company site

“Chestnut Ridge Foam, Inc Proposal for Mattresses to Improve Sleep Quality”

Journey Robotics, Inc

Mars, PA · 8 employees · Department of Defense · Phase I

“Shipboard Technology for Engine Work, Autonomous Repair, and Diagnostics (STEWARD)”

Hebi Robotics, Inc.

Pittsburgh, PA · 15 employees · Department of Defense · Phase I · company site

“MERMAIDS - Marine Engine Robotic Maintenance and Inspection Development System”

Chemia Biosciences, Inc.

Doylestown, PA · 2 employees · Department of Energy, Department of Health and Human Services · Phase I/II

“A novel platform for nonribosomal peptide discovery”

Chromatir Technologies, LLC

State College, PA · 2 employees · National Science Foundation · Phase II · company site

“SBIR Phase II: Customized Security Films Harnessing Iridescent Structural Color from Multibounce Optical Interference”

Advanced Optronics Inc.

Pittsburgh, PA · 4 employees · Department of Health and Human Services · Phase II

“Reducing structural damage and adverse surgical events during cochlear implantation using an intraoperative sensing system”

ImCare Biotech LLC

Doylestown, PA · 3 employees · Department of Health and Human Services · Phase I · company site

“A novel multi-analyte algorithmic assay diagnostic for hepatocellular carcinoma (HCC).”

Liquid Ion Solutions LLC

Pittsburgh, PA · 4 employees · Department of Defense · Phase I · woman-owned · company site

“High-Nitrogen Containing Binders for Enhanced Performance in Solid Rocket Motor Applications”

FLX Solutions, Inc.

Bethlehem, PA · 7 employees · Department of Defense · Phase II · company site

“Collaborative Robotic System for Efficient Aircraft Confined Space Inspections”

Conifer Point Pharmaceuticals LLC

Doylestown, PA · 11 employees · Department of Health and Human Services · Phase II · company site

“An Open Web Service For Fragment-based Design of Small Molecule Inhibitors”

Atlas Biologics, LLC

State College, PA · 3 employees · Department of Health and Human Services · Phase II

“Development of Deep Mutational Scanning with Duplex Sequencing (DMS-DS) for anti-cancer drug evaluation and administration”

Power 3d, Inc

Pittsburgh, PA · 2 employees · National Science Foundation · Phase I · woman-owned

“SBIR Phase I: 3D Printed Electrodes for High Performance Microbatteries”

Near Earth Autonomy, Inc

Pittsburgh, PA · 90 employees · Department of Defense · Phase II · company site

“Improving and Modernizing Navy Shipyards Through Precise, Drone-Based Digital Twins and Autonomous Inspection”

Obeewan Technologies Inc

Glenshaw, PA · 0 employees · National Science Foundation · Phase I

“SBIR Phase I: Queen Honey Bee Location Identification”

Sea-Gal Technologies Inc.

Bethlehem, PA · 3 employees · National Science Foundation · Phase I · woman-owned · company site

“SBIR Phase I: High Data-Rate Multiple-Input Multiple-Output (MIMO) Underwater Acoustic Communications”

Progenra Inc

Malvern, PA · 17 employees · Department of Health and Human Services · Phase I · company site

“Ubiquitin pathway modulators as novel antituberculosis drugs”

Noma AI Inc.

Pittsburgh, PA · 3 employees · Department of Health and Human Services · Phase I · company site

“A Real-time, Automated Maternal Hemorrhage Risk Assessment Platform Using Artificial Intelligence”

IMPULSE TECHNOLOGY LLC DBA Xmorphe

State College, PA · 4 employees · Department of Defense · Phase II · woman-owned · company site

“Compliant Mechanisms for Self-Aligning of Prosthetics”

Mindtrace Technologies, Inc.

Pittsburgh, PA · 3 employees · National Science Foundation · Phase II

“SBIR Phase II: A Cognitive Dashboard to Support Clinical Decision Making in Neurosurgery”

Estenda Solutions, Inc.

Wayne, PA · Department of Health and Human Services · Phase II

“Hub4Smell: Advancing Human Olfactory Research through Digital Innovation and Community Engagement”

Additive Innovations LLC

Pittsburgh, PA · 2 employees · Department of Defense · Phase I · company site

“3D Printed Silicon Carbide for HEL Directed Energy”

Young Therapeutics, LLC

Philadelphia, PA · 3 employees · Department of Health and Human Services · Phase II · company site

“Minimizing myocardial damage and loss of cardiac function post myocardial infarction using Targeted PKC inhibitors 002 and 004.”

Rda Inc.

Doylestown, PA · 65 employees · Department of Defense · Phase II · company site

“F7-Wideband Acoustic Receiver and Source (F7-WARS) Sonobuoy”

Captis Diagnostics

State College, PA · 1 employee · Department of Health and Human Services · Phase II

“Magnetic Lipid Nanoprobe Platform for Rapid, Highly-Efficient, and Cost-Effective Isolation of Extracellular Vesicles from Non-Invasive Bodi”

Elk Valley Enterprises, Inc.

Girard, PA · 1 employee · Department of Energy · Phase I · company site

“Advancing Robotics for Structural Biology”

Plasma Futures LLC

Trevose, PA · 102 employees · Department of Energy · Phase I · company site

“Harnessing Plasma Directed Electron Beam (PDEB) Technology to Ensure Food Safety, Maintain Product Quality and Reduce Food Loss and Waste”

Aimilight Sensors And Intelligent Systems

Pittsburgh, PA · 3 employees · Department of Energy · Phase I · company site

“STTR: Real-Time Tritiated Gas Composition Analysis through Waveguide Enhanced Optical Spectroscopy for Fusion Fuel Cycles”

Anactisis LLC

Pittsburgh, PA · 7 employees · Department of Defense · Phase I · company site

“Functionalized Adsorbents for Highly Efficient Germanium Extraction and Separation from Coal Ash Leachates”

Spinhance LLC

Rydal, PA · 2 employees · Department of Health and Human Services · Phase I · company site

“Free-Breathing Dynamic Cardiopulmonary Function Imaging System to use with Xenon MRI”

ENSION Inc

Butler, PA · 7 employees · Department of Health and Human Services · Phase II · company site

“Bearingless flux reversal motor for neonatal and pediatric extracorporeal life support applications”

Luca AI, LLC

Gibsonia, PA · 2 employees · National Science Foundation · Phase I · company site

“SBIR Phase I: Adaptive Phonetic Analysis for Personalized Dyslexia Reading Support”

Lazul Software, Inc.

Philadelphia, PA · 2 employees · Department of Defense · Phase I · company site

“Optimizing Air Force Pilot Selection & Readiness through Neuroscience-Based Cognitive Modeling”

Advanced Parachutes, LLC

Evans City, PA · 17 employees · Department of Defense · Phase I · woman-owned

“Tethered Remote Aerial Control (TRAC)”

Rafias LLC

Philadelphia, PA · 2 employees · Department of Health and Human Services · Phase I · woman-owned

“Advancing Nr4a1 as a novel target in cocaine use disorder.”

Jaw Joint Science Institute, Inc.

Philadelphia, PA · 4 employees · Department of Defense · Phase I · company site

“Increasing the Safety Profile for the Temporal Mandibular Joint and the Base of the Temporal Lobe”

CoPilot Systems Inc

Pittsburgh, PA · 99 employees · Department of Defense · Phase I · company site

“Trainwell: One-on-One Fitness Coaching that Scales to Every Airmen and Guardian”

Lovelace AI Inc.

Pittsburgh, PA · 20 employees · Department of Defense · Phase I · company site

“Left-of-Launch Early Warning via AI-Enabled Anticipatory Tipping and Queuing”

Echogenesis Therapeutics Inc

Pittsburgh, PA · 3 employees · Department of Health and Human Services · Phase I

“Cell type-specific gene therapy approach for TOMT-linked congenital hearing loss”