110 companies · SBIR/STTR awards, last two years
Every company in Pennsylvania that closed a federal SBIR/STTR award in the last two years: those with open roles on our board first, then newest award first. Back to the Pennsylvania page
Philadelphia, PA · 100 employees · Department of Health and Human Services · Phase II · company site
“High-throughput Discovery of Antibodies against Understudied Membrane Proteins using mRNA”
Pittsburgh, PA · 4 employees · Department of Energy · Phase I/II · woman-owned · company site
“TARDIS-J: Tunable Activation & Regeneration in Devices using In-Situ Jamming”
Philadelphia, PA · 5 employees · Department of Defense, National Aeronautics and Space Administration · Phase I · woman-owned · company site
“Aerosolized Fentanyl Electrochemical Nano-Sensor for Field Detection”
Sewickley, PA · 8 employees · Department of Defense · Phase I · woman-owned · company site
“GHOSTFIELD: A realistic integrated cyber information warfare simulation for joint live, virtual constructive exercises”
Pittsburgh, PA · 53 employees · Department of Defense · Phase II · company site
“Autonomous Internal Exploration and Inspection of Confined Spaces”
Lancaster, PA · 373 employees · Department of Commerce, Department of Defense, Department of Energy, Department of Health and Human Services, National Aeronautics and Space Administration · Phase I/II · company site
“DOD Navy SBIR Icephobic Coating for Air Cycle Machine”
Philadelphia, PA · 3 employees · National Science Foundation · Phase I
“STTR Phase I: Zinc-Assisted Two-Step Electrolyzer for Clean Hydrogen Production Using Low Purity Water”
Philadelphia, PA · 2 employees · Department of Commerce · Phase II · company site
“Using Silicone Wristbands as Personal Monitors of PFAS Exposures”
State College, PA · Department of Health and Human Services · Phase I
“Addressing Structural Disorder and Conformational Heterogeneity in Modern Therapeutic Modalities: A Unified X-ray/Cryo-EM QM/MM Ensemble Ref”
Charleroi, PA · 44 employees · Department of Defense · Phase I/II · company site
““Left of Launch” Indications and Warning for Enhanced Battle Management”
Pittsburgh, PA · 31 employees · Department of Defense · Phase II · company site
“Automated Descriptive Vulnerability Illumination in Software for Operation Readiness (ADVISOR)”
Pipersville, PA · 22 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site
“Efficient Models for Film Condensation in Cryogenic Tank Applications”
Malvern, PA · 1 employee · Department of Energy · Phase I
“Production of Zr Metal by Molten Salt Electrolysis of ZrCl4”
Pittsburgh, PA · 3 employees · Department of Defense, Department of Energy, National Aeronautics and Space Administration · Phase I · company site
“GRIDview: AI-Driven Visualization Platform for Dynamic Uncertainty Quantification and Risk-Informed Grid Decision-Making”
Clinton, PA · 6 employees · Department of Defense, National Aeronautics and Space Administration · Phase I · company site
“Solid-State Cold Spray Additive Manufacturing (CSAM) of GRX-810”
West Chester, PA · 1 employee · Department of Health and Human Services · Phase I · company site
“Investigation of Novel IgY Technology for Fungal Targets in Alcohol-associated Hepatitis”
Pittsburgh, PA · 1 employee · Department of Health and Human Services · Phase II · company site
“CTO1681 to prevent and mitigate cytokine release syndrome in multiple myeloma patients receiving CAR T-cell therapy”
Wayne, PA · 22 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site
“3D Reinforced Composites for Improved Impact Resistance in Spacesuits”
State College, PA · 9 employees · National Aeronautics and Space Administration · Phase I · company site
“Lunar Construction Site Mapping for Exploitation of Geotechnical Features”
State College, PA · 41 employees · National Aeronautics and Space Administration · Phase I · company site
“Wireless Channel Simulation for Antennas Mounted on Spacesuits and Lunar Vehicles”
West Chester, PA · 7 employees · Department of Health and Human Services · Phase II · company site
“Endovascular Suturing Device for Augmentation of Endograft Fixation During Endovascular Repair of Abdominal Aortic Aneurysm to Reduce Reinte”
Pittsburgh, PA · 2 employees · Department of Health and Human Services · Phase I
“AssuranceET: a novel endotracheal tube sealing mechanism to protect pediatric patients from airway trauma and collapse while empowering clin”
Eagleville, PA · 1 employee · Department of Health and Human Services · Phase I/II · company site
“Preclinical development of a tandem CART / HSC transplantation platform for hematologic malignancies”
Pittsburgh, PA · 5 employees · Department of Defense · Phase II · woman-owned · company site
“Novel, handheld biosensor for real time detection of full-thickness corneal injuries in civilian and military personnel”
Pittsburgh, PA · 225 employees · Department of Defense, National Aeronautics and Space Administration · Phase I/II · company site
“LaserNav – LiDAR-Based Dark Navigation for Safe and Precise Lunar Landing”
Pittsburgh, PA · 8 employees · Department of Health and Human Services · Phase II · company site
“Mindfulness Meditation and Respiration Biosignal Feedback”
Fort Washington, PA · 7 employees · Department of Health and Human Services · Phase I · company site
“Maternal Health Navigator intervention to reduce disparities in severe maternal morbidity and mortality”
Philadelphia, PA · 5 employees · Department of Health and Human Services · Phase I
“DIGITAL INCENTIVE SPIROMETRY EXERCISER TO IMPROVE PATIENT ADHERENCE AND CLINICAL WORKFLOWS”
State College, PA · 6 employees · Department of Defense · Phase I · company site
“Inspection of Bonded Composite Structures Through Fairing Materials using Ultrasound”
Doylestown, PA · 1 employee · Department of Health and Human Services · Phase I · company site
“Combination of formulated dolcanatide, a guanylate cyclase-C agonist, with formulated atiprimod, a JAK-STAT inhibitor, for treatment of muri”
Pittsburgh, PA · 10 employees · Department of Health and Human Services · Phase I · company site
“PNM-CAP: A novel nerve cap to prevent painful neuroma formation in peripheral nerve injuries and amputations”
Coraopolis, PA · 70 employees · Department of Defense · Phase I/II · company site
“APPcS - Autonomous Process Planning for Complex Surfaces”
Wilkes Barre, PA · 18 employees · Department of Defense · Phase II · company site
“Real-Time Intelligence Delivery, Highly Secured Edge Compute for Hypersonic Detection”
Pittsburgh, PA · 20 employees · Department of Defense · Phase I/II · company site
“Visual Navigation Advances for Low-altitude, Subsonic Flight using WOSA Design Principles”
Linden, PA · 58 employees · Department of Defense · Phase I/II · company site
“Scalable High Frequency Transmit/Receive Array for Multiple Unmanned Underwater Vehicle and Torpedo Applications”
Pittsburgh, PA · 9 employees · Department of Defense · Phase I/II · company site
“In-situ Inlet and 1st Fan IBR Inspection for Advanced Aircraft”
Conshohocken, PA · 182 employees · Department of Defense · Phase II · company site
“Automated Security Threat Recognition & Alerting (ASTRA)”
King of Prussia, PA · 2 employees · Department of Health and Human Services · Phase II · woman-owned · company site
“AAV-mediated delivery of the inflammasome adapter protein, ASC, as a pro-apoptotic gene therapy for schwannoma”
Warminster, PA · 20 employees · Department of Defense · Phase II · company site
“PIVASS-Pilot IRIS enabled Visual Augmentation Safety System (PIVASS)”
Huntingdon Valley, PA · 6 employees · Department of Defense · Phase I · company site
“Advanced Tactical Leadership Assistance System (ATLAS) Tool”
Pittsburgh, PA · 2 employees · Department of Defense · Phase I/II · company site
“Readiness Improving Inspection Software Hub for Multi Source NDI Inputs”
Philadelphia, PA · 12 employees · Department of Health and Human Services · Phase II
“An Off-the-Shelf tumor cell vaccine with HLA-matching alleles for personalized treatment of advanced metastatic prostate cancer.”
Doylestown, PA · 0 employees · Department of Health and Human Services · Phase II
“Hepatoselective Dihydrozuinolizone (HS-DHQ) Molecules for Treatment and Prevention of Hepatitis A Virus (HAV) Infection”
Pittsburgh, PA · 8 employees · Department of Defense · Phase I · company site
“Computational Game Theory AI for Army Tactical COA Generation Scenarios”
Philadelphia, PA · 1 employee · Department of Health and Human Services · Phase I
“Device-Agnostic Hypoxia Detection Software for Overdose Prediction and Positive Reversal Monitoring”
New York, PA · 3 employees · Department of Defense · Phase I/II
“Interoperability using AI/ML”
Allentown, PA · 6 employees · Department of Defense · Phase I/II · company site
“Secure, Cost-Effective, low-SWAP Logistics Data Transfer Solution through DuckLink”
Allentown, PA · 1 employee · Department of Defense · Phase II
“High Precision Single Photon Detection System for 1030 nm Laser Ranging”
Horsham, PA · 77 employees · Department of Defense · Phase I/II · company site
“Domestic, Low-Cost Pitch Carbon Fiber for High Temperature Applications - P4945”
Pittsburgh, PA · 5 employees · Department of Health and Human Services · Phase I
“Development and Feasibility Testing of PrivyPod - a modular bathroom to support aging in place”
West Chester, PA · 4 employees · Department of Health and Human Services · Phase I
“Investigating Ultra-High-Quality Graphene-Based Cryo-EM Device Architecture for Higher Reproducibility, Speed, and Resolution”
Pittsburgh, PA · 4 employees · Department of Defense · Phase II · company site
“Guardian Knot: A Space Force Gamified Capstone”
Pittsburgh, PA · 11 employees · Department of Health and Human Services · Phase I · company site
“A Novel Fully-Polymeric, Biomimetic Prosthetic Mitral Valve Constructed from Clinically-Proven Materials to Improve Durability, Performance,”
Pittsburgh, PA · 5 employees · Department of Defense · Phase I · woman-owned · company site
“Apollo: Adapted Wearable to Improve Military Working Dog Physiological Monitoring, Rehabilitation, and Recovery”
Pittsburgh, PA · 1 employee · Department of Health and Human Services · Phase I · company site
“PEACE Platform for Non-Invasive Narrative Neuromodulation (Personalized Evocative Audiovisual Content for Everyone)”
Wayne, PA · 1 employee · Department of Health and Human Services · Phase I
“A Machine Learning Software Tool for Automatic Segmentation and Analysis of T1p MR Images of Knee Cartilage for OA Diagnosis and Treatment M”
Northampton, PA · 12 employees · Department of Defense · Phase II · company site
“Compact Midwave Infrared Hyperspectral Imager for Attritable Platforms”
Jessup, PA · 12 employees · Department of Defense · Phase II · company site
“ArmorPulse: An Embedded Vehicle Monitoring Solution Using Multiple Redundant DoD-Proven Secure Data Transport Pathways to Deliver a Field-Re”
Pittsburgh, PA · 12 employees · National Aeronautics and Space Administration · Phase II · company site
“Modular Software Architecture and Algorithms for Fast and Efficient Lunar Mobility (M-SAFE)”
Philadelphia, PA · 14 employees · Department of Defense · Phase II · company site
“Body-Stabilizing Propulsion For Logistics sUAS”
Exton, PA · 24 employees · Department of Defense · Phase I/II · company site
“Optimal Planning for Minefields with Advanced Capabilities (OPMAC)”
Bryn Mawr, PA · 2 employees · National Science Foundation · Phase II · woman-owned · company site
“SBIR Phase II: Holistic System for Comprehensive Student Assessment”
Latrobe, PA · 115 employees · Department of Defense · Phase I · company site
“Chestnut Ridge Foam, Inc Proposal for Mattresses to Improve Sleep Quality”
Mars, PA · 8 employees · Department of Defense · Phase I
“Shipboard Technology for Engine Work, Autonomous Repair, and Diagnostics (STEWARD)”
Pittsburgh, PA · 15 employees · Department of Defense · Phase I · company site
“MERMAIDS - Marine Engine Robotic Maintenance and Inspection Development System”
Doylestown, PA · 2 employees · Department of Energy, Department of Health and Human Services · Phase I/II
“A novel platform for nonribosomal peptide discovery”
State College, PA · 2 employees · National Science Foundation · Phase II · company site
“SBIR Phase II: Customized Security Films Harnessing Iridescent Structural Color from Multibounce Optical Interference”
Pittsburgh, PA · 4 employees · Department of Health and Human Services · Phase II
“Reducing structural damage and adverse surgical events during cochlear implantation using an intraoperative sensing system”
Doylestown, PA · 3 employees · Department of Health and Human Services · Phase I · company site
“A novel multi-analyte algorithmic assay diagnostic for hepatocellular carcinoma (HCC).”
Pittsburgh, PA · 4 employees · Department of Defense · Phase I · woman-owned · company site
“High-Nitrogen Containing Binders for Enhanced Performance in Solid Rocket Motor Applications”
Bethlehem, PA · 7 employees · Department of Defense · Phase II · company site
“Collaborative Robotic System for Efficient Aircraft Confined Space Inspections”
Doylestown, PA · 11 employees · Department of Health and Human Services · Phase II · company site
“An Open Web Service For Fragment-based Design of Small Molecule Inhibitors”
State College, PA · 3 employees · Department of Health and Human Services · Phase II
“Development of Deep Mutational Scanning with Duplex Sequencing (DMS-DS) for anti-cancer drug evaluation and administration”
Pittsburgh, PA · 2 employees · National Science Foundation · Phase I · woman-owned
“SBIR Phase I: 3D Printed Electrodes for High Performance Microbatteries”
Pittsburgh, PA · 90 employees · Department of Defense · Phase II · company site
“Improving and Modernizing Navy Shipyards Through Precise, Drone-Based Digital Twins and Autonomous Inspection”
Glenshaw, PA · 0 employees · National Science Foundation · Phase I
“SBIR Phase I: Queen Honey Bee Location Identification”
Bethlehem, PA · 3 employees · National Science Foundation · Phase I · woman-owned · company site
“SBIR Phase I: High Data-Rate Multiple-Input Multiple-Output (MIMO) Underwater Acoustic Communications”
Malvern, PA · 17 employees · Department of Health and Human Services · Phase I · company site
“Ubiquitin pathway modulators as novel antituberculosis drugs”
Pittsburgh, PA · 3 employees · Department of Health and Human Services · Phase I · company site
“A Real-time, Automated Maternal Hemorrhage Risk Assessment Platform Using Artificial Intelligence”
State College, PA · 4 employees · Department of Defense · Phase II · woman-owned · company site
“Compliant Mechanisms for Self-Aligning of Prosthetics”
Pittsburgh, PA · 3 employees · National Science Foundation · Phase II
“SBIR Phase II: A Cognitive Dashboard to Support Clinical Decision Making in Neurosurgery”
Wayne, PA · Department of Health and Human Services · Phase II
“Hub4Smell: Advancing Human Olfactory Research through Digital Innovation and Community Engagement”
Pittsburgh, PA · 2 employees · Department of Defense · Phase I · company site
“3D Printed Silicon Carbide for HEL Directed Energy”
Philadelphia, PA · 3 employees · Department of Health and Human Services · Phase II · company site
“Minimizing myocardial damage and loss of cardiac function post myocardial infarction using Targeted PKC inhibitors 002 and 004.”
Doylestown, PA · 65 employees · Department of Defense · Phase II · company site
“F7-Wideband Acoustic Receiver and Source (F7-WARS) Sonobuoy”
State College, PA · 1 employee · Department of Health and Human Services · Phase II
“Magnetic Lipid Nanoprobe Platform for Rapid, Highly-Efficient, and Cost-Effective Isolation of Extracellular Vesicles from Non-Invasive Bodi”
Girard, PA · 1 employee · Department of Energy · Phase I · company site
“Advancing Robotics for Structural Biology”
Trevose, PA · 102 employees · Department of Energy · Phase I · company site
“Harnessing Plasma Directed Electron Beam (PDEB) Technology to Ensure Food Safety, Maintain Product Quality and Reduce Food Loss and Waste”
Pittsburgh, PA · 3 employees · Department of Energy · Phase I · company site
“STTR: Real-Time Tritiated Gas Composition Analysis through Waveguide Enhanced Optical Spectroscopy for Fusion Fuel Cycles”
Pittsburgh, PA · 7 employees · Department of Defense · Phase I · company site
“Functionalized Adsorbents for Highly Efficient Germanium Extraction and Separation from Coal Ash Leachates”
Rydal, PA · 2 employees · Department of Health and Human Services · Phase I · company site
“Free-Breathing Dynamic Cardiopulmonary Function Imaging System to use with Xenon MRI”
Butler, PA · 7 employees · Department of Health and Human Services · Phase II · company site
“Bearingless flux reversal motor for neonatal and pediatric extracorporeal life support applications”
Gibsonia, PA · 2 employees · National Science Foundation · Phase I · company site
“SBIR Phase I: Adaptive Phonetic Analysis for Personalized Dyslexia Reading Support”
Philadelphia, PA · 2 employees · Department of Defense · Phase I · company site
“Optimizing Air Force Pilot Selection & Readiness through Neuroscience-Based Cognitive Modeling”
Evans City, PA · 17 employees · Department of Defense · Phase I · woman-owned
“Tethered Remote Aerial Control (TRAC)”
Philadelphia, PA · 2 employees · Department of Health and Human Services · Phase I · woman-owned
“Advancing Nr4a1 as a novel target in cocaine use disorder.”
Philadelphia, PA · 4 employees · Department of Defense · Phase I · company site
“Increasing the Safety Profile for the Temporal Mandibular Joint and the Base of the Temporal Lobe”
Pittsburgh, PA · 99 employees · Department of Defense · Phase I · company site
“Trainwell: One-on-One Fitness Coaching that Scales to Every Airmen and Guardian”
Pittsburgh, PA · 20 employees · Department of Defense · Phase I · company site
“Left-of-Launch Early Warning via AI-Enabled Anticipatory Tipping and Queuing”
Pittsburgh, PA · 3 employees · Department of Health and Human Services · Phase I
“Cell type-specific gene therapy approach for TOMT-linked congenital hearing loss”
Pittsburgh, PA · 2 employees · Department of Health and Human Services · Phase I · company site
“Combinatorial pipeline for discovery of anti-GPCR Nanobodies”
Pittsburgh, PA · 2 employees · National Science Foundation · Phase II · company site
“SBIR Phase II: Programmable Three-Dimensional (3D) Light Curtains for Enhanced Human-Robot Collaboration”
Pittsburgh, PA · 3 employees · Department of Defense · Phase I · company site
“Omni-Materials: PFAS-Free Biomaterial for Army Textiles”
State College, PA · 24 employees · Environmental Protection Agency · Phase I · company site
“Phosphorus Control in Soils with Legacy Phosphorus Using RhizoSorb® Technology”
Ambler, PA · 4 employees · Department of Health and Human Services · Phase II · woman-owned · company site
“Wearable Wireless Respiratory Monitoring System that Detects and Predicts Opioid Induced Respiratory Depression”
Pittsburgh, PA · 4 employees · Department of Transportation · Phase I · company site
“Informing infrastructure interventions via novel near-miss data collection”
Wexford, PA · 1 employee · Department of Health and Human Services · Phase I · company site
“Emotional Intelligence Training Tools Helping People with Autism Spectrum Disorder (ASD) Build Emotional Intelligence Skills on Social Media”
Philadelphia, PA · 3 employees · Department of Health and Human Services · Phase I · woman-owned · company site
“SBIR FY25 CONCEPT AWARD, TARGETING PLOD2 IN UNDIFFERENTIATED PLEOMORPHIC SARCOMA”
Doylestown, PA · 4 employees · Department of Health and Human Services · Phase I · company site
“SBIR FY25 CONCEPT AWARD, DEVELOPMENT OF AN IMMUNOTHERAPY FOR EWING SARCOMA USING A NOVEL MURINE MODEL”
Doylestown, PA · 29 employees · Department of Health and Human Services · Phase I · company site
“Combinations of Oral Antibiotics to Treat Syphilis”
Source: public SBIR/STTR award record. Company-level facts only. Open roles are live listings on our board.