Recently funded science companies in North Carolina
95 companies in North Carolina closed federal SBIR/STTR awards in the last two years, newest first. The funding event is the signal — small companies grow right after the award lands.
Corvid ATEA, LLC
Mooresville, NC · 16 employees
“Innovations in Heater Technologies for Optimized Heating during Welding”
Department of Defense · Phase Phase I/Phase II
UNITED PROTECTIVE TECHNOLOGIES, LLC
LOCUST, NC · 93 employees
“Solid High-performance Innovative Engine Lubrication for Durability (SHIELD)”
Department of Defense · Phase Phase I/Phase II
INGENIA SERVICES INC
WAKE FOREST, NC · 13 employees
“Social-Cyber Modeling and Simulation”
Department of Defense · Phase Phase I
AXNANO LLC
GREENSBORO, NC · 7 employees
“Sustainable, Non-Incineration-based Destruction of Air Force Hazardous Waste Stockpiles : TACFI”
Department of Defense · Environmental Protection Agency · Phase Phase I/Phase II
Vulcan Elements Inc.
Durham, NC · 8 employees
“Establishing a Domestic, Rare-Earth Metal Manufacturing Supply Chain to Support Critical Department of Air Force Needs”
Department of Defense · Phase Phase I/Phase II
NCX CORPORATION
RALEIGH, NC · 8 employees
“VANTAGE: Versatile Array Nanotube Tomography for Advanced Ground Exploitation”
Department of Defense · Phase Phase I/Phase II
JMS SOUTHEAST INC.
Statesville, NC · 83 employees
“Testing Requirements to Complete R&D for Source Approval, NSN 4710015077949”
Department of Defense · Phase Phase I
Gateway Bio, Inc.
Durham, NC · 5 employees
“Next Generation Stealth Lipid for the Delivery of mRNA”
Department of Health and Human Services · Phase Phase I
CAREYAYA HEALTH TECHNOLOGIES INC
RALEIGH, NC · 5 employees
“YayaGuide: AI-Enabled Personalized Training for Caregivers of Older Adults with ADRD”
Department of Health and Human Services · Phase Phase I
PERSISTENCE THERAPEUTICS, INC.
CHAPEL HILL, NC · 1 employee
“The SynthNode Paradigm: Reimagining CAR T Cell Therapy for Improved Patient Outcomes”
Department of Health and Human Services · Phase Phase I
ARTIAM BIO INC.
Cary, NC · 2 employees
“Validation of APT101 for the Treatment of Systemic Sclerosis-Associated Interstitial Lung Disease (SSc-ILD) in an Aging Murine Model”
Department of Health and Human Services · Phase Phase I
Synvest Imaging Inc.
Chapel Hill, NC · 0 employees
“Scalable cGMP production of SV2A PET tracers using photoredox chemistry for applications in clinical trials and early AD diagnosis”
Department of Health and Human Services · Phase Phase I
EPICYPHER, INC.
DURHAM, NC · 55 employees
“Development of novel epigenetic biomarkers and detection reagents for aging”
Department of Health and Human Services · Phase Phase II
CALLAHAN-YOUNG LLC
RALEIGH, NC · 2 employees · woman-owned
“Evaluating the Health Benefits of Jigsawdio: A Novel Multisensory Jigsaw Puzzle-based Intervention for Alzheimer's Disease and Related Demen”
Department of Health and Human Services · Phase Phase II
Bedrock Therapeutics, Inc.
Raleigh, NC · 4 employees
“Intramuscular Administration of AAV Vectors Encoding soluble PD-L1 for Rheumatoid Arthritis Treatment”
Department of Health and Human Services · Phase Phase I
INTRA THERAPEUTICS, LLC
CARY, NC · 2 employees
“Development of Localized Triple-Negative Breast Cancer Immunotherapy”
Department of Health and Human Services · Phase Phase I
PERFUSIO CORP.
GREENVILLE, NC · 8 employees
“Project MATCH: Multi-spectral AI/ML powered Burn and Wound Evaluation Technology using a Cost-Effective Handheld Device.”
Department of Health and Human Services · Phase Phase I
BIOMOJO LLC
CARY, NC · 8 employees · woman-owned
“nXcomms: Intelligent Patient Simulation”
Department of Defense · Phase Phase II
MUCOMMUNE, LLC
CARRBORO, NC · 4 employees
“SBIR: In vivo engineering of multifaceted B7H3.CAR-T cells for cellular immunotherapy of pancreatic ductal adenocarcinoma”
Department of Health and Human Services · Phase Phase I/Phase II
NEUROGT INC
DURHAM, NC · 2 employees · woman-owned
“Trans-BBB AAV9 gene therapy targeting CNS neuropathy of MPS I”
Department of Health and Human Services · Phase Phase I/Phase II
CORVID TECHNOLOGIES, LLC
MOORESVILLE, NC · 416 employees
“Surrogate Model for High-Fidelity Physics-Based Post Intercept Debris Generation”
Department of Defense · Department of Energy · National Aeronautics and Space Administration · Phase Phase I/Phase II
FORESIGHTCARES INC.
MATTHEWS, NC · 2 employees · woman-owned
“SBIR Phase II: AI-based Accessible Visual-Assessment App for Active Healthy Aging of Older Adults”
National Science Foundation · Phase Phase II
ATSENA THERAPEUTICS, INC.
DURHAM, NC · 16 employees
“Manufacturing Development and Commercial Readiness of an Adeno-Associated Virus-Based Gene Therapy for the Treatment of Leber Congenital Ama”
Department of Health and Human Services · Phase Phase II
FREESCALE LLC
CARY, NC · 3 employees · woman-owned
“SBIR Phase II: Development and Analysis of Functional NanoInks for Printed Neuromorphic Electronics and Smart Sensors”
National Science Foundation · Phase Phase II
Cypress BioPharma
Cary, NC · 10 employees
“Leveraging the Highly Active Metabolite of Pioglitazone as a Scaffold for a Novel Non-Immunosuppressive Therapy for Childhood Nephrotic Synd”
Department of Health and Human Services · Phase Phase I
ELDEC PHARMACEUTICALS INC.
CHAPEL HILL, NC · 3 employees
“Novel peptide therapeutics to treat cystic fibrosis-related diabetes”
Department of Health and Human Services · Phase Phase I
OXFORD DEFENSE NORTH CAROLINA LLC
Youngsville, NC · 2 employees
“Scalable Beamed Energy Laser Concentrator”
National Aeronautics and Space Administration · Phase Phase I
BAEBIES, INC.
DURHAM, NC · 50 employees
“A Rapid, Point-of-Care Diagnostic to Identify Viable Sexually Transmitted Infections, Reduce Overtreatment, and Prevent Emerging Antibiotic ”
Department of Defense · Department of Health and Human Services · Phase Phase I/Phase II
Luxbiome Inc
Cary, NC · 2 employees
“Arsenic Removal from the Body Through Mechanism-Guided Gut Microbiome Modulation”
Department of Health and Human Services · Phase Phase I
VAST THERAPEUTICS
MORRISVILLE, NC · 7 employees
“Nebulized ALX1 as a Treatment for Difficult Non-tuberculous Mycobacterial Lung Infections”
Department of Health and Human Services · Phase Phase II
Innovation Research And Training, Inc.
DURHAM, NC · 26 employees · woman-owned
“Fundamental Training for Formal and Informal STEM Mentors”
Department of Health and Human Services · Phase Phase II
DATA DRIVEN BIOSCIENCE INC
DURHAM, NC · 4 employees
“Validation of Duoseq as a Genomic Swiss Army Knife for the Diagnosis of Lymphomas”
Department of Health and Human Services · Phase Phase I/Phase II
GRADIENT MEDICAL, INC.
CARY, NC · 1 employee
“Commercialization of Algorithmic Non-thermal Ablation Technology for the Treatment of Inoperable Tumors”
Department of Health and Human Services · Phase Phase II
RAMONA OPTICS INC
DURHAM, NC · 30 employees
“Rapid inter-procedural 3D scanning of fine-needle aspiration cytology slides with a parallelized microscope”
Department of Health and Human Services · Phase Phase I
GLYCO DISCOVERIES, INC
Raleigh, NC · 10 employees
“Development of synthetic heparin to protect liver graft from ischemia reperfusion injury during transplantation”
Department of Health and Human Services · Phase Phase II
CAROLINA INSTRUMENTS LLC.
CHAPEL HILL, NC · 4 employees
“A novel system for tracking arousal-related dynamics in freely moving animals”
Department of Health and Human Services · Phase Phase I
Reselute, Inc.
DURHAM, NC · 5 employees · woman-owned
“Local and Sustained Release of Antibiotics in the Surgical Treatment of Diabetic Charcot Foot”
Department of Health and Human Services · Phase Phase I
CLEARSENS, INC.
RALEIGH, NC · 3 employees
“Compact Wearable Ultrasonic Monitoring System for In-Suit Venous Gas Emboli Detection”
National Aeronautics and Space Administration · Phase Phase I
Deep Creek Pharma, LLC
Winston-Salem, NC · 4 employees
“Modified Thrombin Binding Aptamer Treatment of CRC Metastasis”
Department of Health and Human Services · Phase Phase I
Oraliva, Inc.
DURHAM, NC · 1 employee
“Point of care diagnostic to improve access to gynecological screening in low-resource settings”
Department of Health and Human Services · National Science Foundation · Phase Phase I/Phase II
INHALON BIOPHARMA, INC.
Morrisville, NC · 0 employees
“Development of IN-003PI as passive immunization against human metapneumovirus infection”
Department of Health and Human Services · Phase Phase II
Sidetrack Ventures, LLC
Durham, NC · 1 employee · woman-owned
“Development of an innovative tool to improve mTBI patient-provider communication of visual impairment symptoms”
Department of Health and Human Services · Phase Phase I
Round Table Research, Inc.
HILLSBOROUGH, NC · 2 employees
“Advancing Extracellular Vesicle Therapy for Brain Cancer”
Department of Health and Human Services · Phase Phase I
VORTANT TECHNOLOGIES LLC
WEAVERVILLE, NC · 3 employees
“Spatially transparent binaural beamforming for noise reduction in cochlear implant processors”
Department of Health and Human Services · Phase Phase I
VIGILANT CYBER SYSTEMS, INC.
MOUNT AIRY, NC · 22 employees
“Automatic Virtual Target Generator”
Department of Defense · Phase Phase II
CYMANTIX, INC.
PITTSBORO, NC · 9 employees
“DiscoverOS: Transforming Cyber Threat Intelligence with GenAI”
Department of Defense · Phase Phase I
SECMATION LLC
CARY, NC · 12 employees
“Interoperability and Usability Enhancements for the Anneal Embedded Hypervisor”
Department of Defense · Phase Phase I/Phase II
PRYON INCORPORATED
RALEIGH, NC · 100 employees
“Pryon RAG Suite : Building Blocks for DoD AI Applications”
Department of Defense · Phase Phase I/Phase II
ANTIXERO
RALEIGH, NC · 0 employees
“AntiXero: An extended duration solution for cancer-associated dry mouth.”
Department of Health and Human Services · Phase Phase I
eXclaim IP, LLC
Cornelius, NC · 6 employees
“Operational Dominance Through Resilient UAS: Passive Thermal and EMP Protection for Mission-Critical Drone Systems”
Department of Defense · Phase Phase I/Phase II
CYBERMEDICS LLC
N TOPSAIL BEACH, NC · 2 employees
“Virtual Medical Twin and Adaptive Medical View Technologies for Predictive Simulation of Injury Progression”
Department of Defense · Phase Phase I
PHAXTEC, INC.
WAKE FOREST, NC · 1 employee
“SBIR Phase II: Production of Biopolymer Coatings for Paper Used in Foodservice Packaging”
National Science Foundation · Phase Phase II
NABGEN INC
DURHAM, NC · 3 employees
“Novel strategy to block AAV neutralizing antibody activity”
Department of Health and Human Services · Phase Phase II
Parion Sciences, Inc.
Durham, NC · 19 employees
“A Novel ENaC Blocker/Osmolyte Inhalation Solution for the Treatment of Muco-Obstructive Lung Diseases”
Department of Health and Human Services · Phase Phase II
ADROIT MATERIALS, INC.
APEX, NC · 8 employees
“Solar blind UVC detectors for efficient plume detection”
Department of Defense · Phase Phase I/Phase II
Vulcan Ventura LLC
Concord, NC · 2 employees
“AF241-0004: Context-Aware RF Electromagnetic Surveying for Exploiting Signals of Opportunity”
Department of Defense · Phase Phase II
SWIFT UNIVERSAL OPTICAL SYSTEMS LLC
SPRING LAKE, NC · 15 employees
“Thermal Barrier Minimal Deflection Handguard”
Department of Defense · Phase Phase I/Phase II
ATTAGENE, INC.
MORRISVILLE, NC
“A Two-Tier Effect-Based Water Bioactivity Surveillance System.”
Department of Health and Human Services · Phase Phase II
VADUM INC
RALEIGH, NC · 45 employees
“Context Aware Machine Learning Signal System”
Department of Defense · Phase Phase II
REGENNOVA, INC.
DURHAM, NC · 3 employees
“Arginine-Polyamine Pathway Inhibitor for Treatment of ADPKD”
Department of Health and Human Services · Phase Phase II
AMERICAN DROID, LLC
NEW BERN, NC · 4 employees
“Robotic End-Effector Direct Drive Motor Design”
Department of Defense · Phase Phase I/Phase II
ATMOSPHERIC PLASMA SOLUTIONS, INC.
CARY, NC · 20 employees
“Integrated Cobot and Atmospheric Plasma Surface Preparation System to Enhance Operational Activities”
Department of Defense · Phase Phase I
DRIVE THERAPEUTICS, L.L.C.
CHAPEL HILL, NC · 3 employees
“SBIR Phase II: Optimizing Manufacturing Efficiency of Bispecific Aptamer Therapeutics”
National Science Foundation · Phase Phase II
POLARONYX INC
CHAPEL HILL, NC · 10 employees
“Biomimetic Zero CTE Lightweight Optical Structures”
National Aeronautics and Space Administration · Phase Phase II
SimplusDx, Inc.
Durham, NC · 4 employees
“A rapid point-of-care test for therapeutic drug monitoring of tacrolimus”
Department of Health and Human Services · Phase Phase I
CERULEAN SCIENTIFIC INC
DURHAM, NC · 7 employees
“Slippery, Omniphobic Coating to Prevent Thrombosis and Biofilm Formation on Peripheral Vascular Grafts”
Department of Health and Human Services · Phase Phase II
CALLA HEALTH FOUNDATION
Durham, NC · 3 employees · woman-owned
“Development and validation of patient-ready Callascope for cervical imaging”
Department of Health and Human Services · Phase Phase I
Piximune, Inc.
Durham, NC · 3 employees
“Antibody-based gene-agnostic treatment for inherited retinal degeneration”
Department of Health and Human Services · Phase Phase I
SOELECT INC
GREENSBORO, NC · 22 employees
“Rapid and Facile Manufacturing of All Dry Electrode Solid State Batteries for High Temperature and Voltage Applications”
Department of Defense · Phase Phase II
Altis Biosystems, Inc.
Durham, NC · 23 employees
“Mucus and ALI Models of the Human Intestine”
Department of Health and Human Services · Phase Phase II
AURA TECHNOLOGIES, LLC
Durham, NC · 31 employees
“MVDC Fault DLI Relay”
Department of Defense · Phase Phase I
Oncotab, Inc.
WAXHAW, NC · 1 employee
“Optimized targeted radiotherapy of pancreatic cancer”
Department of Health and Human Services · Phase Phase I
INNOVAKNITS, LLC
CONOVER, NC · 5 employees
“Continued design, development, optimization, and testing of seamless garments created using State-of-the-Art Stoll and Shima Seiki knitting ”
Department of Defense · Phase Phase II
THIRD FLOOR MATERIALS, INC.
DURHAM, NC · 3 employees
“Compressive hyperspectral imaging with free-form plasmonic filter arrays”
Department of Defense · Phase Phase I
Junipero Therapeutics, Inc.
Durham, NC · 1 employee
“SBIR Phase I: Epigenome Editing by Induced Proximity Using Oligonulcleotide-conjugates”
National Science Foundation · Phase Phase I
ScitoVation, LLC
Research Triangle Park, NC · 13 employees
“Triage of Developmental and Reproductive Toxicants using an In vitro to In Vivo Extrapolation (IVIVE)-Toxicokinetic Computational modeling A”
Department of Health and Human Services · Phase Phase II
TELESWIVEL LLC
DURHAM, NC · 1 employee
“Replacing the Pintle/Lunette: Autonomous Vehicle Towing”
Department of Defense · Phase Phase II
MIMETICS, LLC
CHAPEL HILL, NC · 3 employees
“Applying Dynamical Systems Theory to Improve Analysis of Time Series Transcriptional Data from Bioproduction Processes”
Department of Energy · Phase Phase II
OpiAID, LLC
WILMINGTON, NC · 2 employees
“Development of the OpiAID strength band platform”
Department of Health and Human Services · Phase Phase II
SOCIAL CASCADE, INC.
Cary, NC · 2 employees
“Integrating AI nowcasting models with digital communications to reduce RSV infections in rural areas”
Department of Health and Human Services · Phase Phase I
AEGIS POWER SYSTEMS INC
MURPHY, NC · 25 employees · woman-owned
“Wide Bandgap High Power High Density Inverter Ruggedization and Characterization Study”
Department of Defense · Phase Phase I
3-C INSTITUTE FOR SOCIAL DEVELOPMENT INC
Chapel Hill, NC · 25 employees · woman-owned
“A Mobile Text Approach to Measurement and Feedback for Wraparound Care Coordination”
Department of Health and Human Services · Phase Phase II
Lupine Materials and Technology, Inc.
MEBANE, NC · 4 employees
“Development of Low Microbend Loss Radiation Resistant Fiber”
Department of Energy · Phase Phase I
RESONANTIA DIAGNOSTICS, INC.
DURHAM, NC · 1 employee
“SBIR Phase I: Acoustic Sensor Based Point of Care Diagnostic Platform for Rapid Identification and Antimicrobial Susceptibility Testing”
National Science Foundation · Phase Phase I
GEOMETRIC DATA ANALYTICS INC.
DURHAM, NC · 11 employees
“AIDA: Artificial Intelligence Design Assistant”
Department of Defense · Phase Phase II
VQBiomedical
Apex, NC · 6 employees
“Development of a Portable Automated System for Intravascular Delivery of Oxygen”
Department of Defense · Phase Phase II
Raglan LLC
WILMINGTON, NC · 22 employees
“Family of Special Operations Vehicles Open Topic”
Department of Defense · Phase Phase II
SMART MATERIAL SOLUTIONS LLC
RALEIGH, NC · 4 employees
“Light-trapping features made with a scalable nanomanufacturing process”
Department of Defense · Phase Phase I
ForagR Medicines Inc
Durham, NC · 3 employees
“SBIR Phase I: High-throughput platform for small molecule, in-cell targeting of undruggable proteins via their mRNAs”
National Science Foundation · Phase Phase I
LUMEOVA INC
RALEIGH, NC · 5 employees
“Ultra-Wideband High-Power Digital Fiber Optic Transmitter Laser”
Department of Defense · Phase Phase I
mHealth Systems, Inc
Waxhaw, NC · 1 employee
“MiREA, a mHealth intervention to Reduce Health Disparities by Improving Equitable Access to Mandated College Students with Problematic Alcoh”
Department of Health and Human Services · Phase Phase I
GREENLIFETECH CORP
BANNER ELK, NC · 5 employees
“Novel Method for Produce Preservation and Sterilization in Modern Refrigerators”
Environmental Protection Agency · Phase Phase II
COLLABORATIONS PHARMACEUTICALS INC
FUQUAY VARINA, NC · 16 employees
“Pyronaridine as an oral Treatment for Ebola”
Department of Health and Human Services · Phase Phase II
Radiant Dx Inc.
Durham, NC · 1 employee
“CLARITAS: PHENOTYPIC AND MULTI-OMIC READOUTS TO INFORM RARE CANCER COMBINATION THERAPY”
Department of Health and Human Services · Phase Phase I
EydisBio, Inc.
DURHAM, NC · 3 employees
“Development of selective NS5 inhibitors for the broad-spectrum treatment of flaviviruses”
Department of Health and Human Services · Phase Phase I
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