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76 companies · SBIR/STTR awards, last two years

Recently funded science companies in Illinois

76 companies in Illinois closed federal SBIR/STTR awards in the last two years. Newest award first. The funding event is the signal — small companies grow right after the award lands.

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Open roles near Illinois

Memq Inc

Chicago, IL6 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase Icompany site

“Cryo-Compatible Electro-Optic Modulation Using Scalable Commercial TFLN Foundry Platform”

$303k2 awards

Digital Optics Technologies Inc

Rolling Meadows, IL6 employeesDepartment of DefensePhase I/II

“Lithium Niobate In-Phase/Quadrature Modulator for High-Bandwidth Data Transmission at Cryogenic Temperatures”

$1.9M3 awards

Epir, Inc.

Bolingbrook, IL30 employeesDepartment of DefensePhase I/II

“FEM GeniusóAI-powered Intelligent Agent for Automated Finite-Element Modeling of Aerospace Structures”

$1.9M3 awards

HIDENN-AI, Inc.

Evanston, IL6 employeesDepartment of DefensePhase I/IIcompany site

“AI-based software toolkit for finite element modeling of aerospace structures based on Convolutional Hierarchical Deep-l Learning Neural Net”

$1.3M2 awards

Sunstream Scientific Incorporated

Chicago, IL1 employeeDepartment of DefensePhase Icompany site

“Servo Throttle Strategy for Solid Fuel Ramjet”

$240k

RESDEF INC. (DBA Frontier Audio Labs)

Chicago, IL7 employeesDepartment of DefensePhase I/IIcompany site

“Machine Learning and Array Beamforming Military Boom Microphone”

$1.5M3 awards

Integrated Dynamics, Inc.

Chicago, IL3 employeesNational Science FoundationPhase I

“SBIR Phase I: High-Temperature Fermentation for Volatile Organic Chemical Production”

$245k

N'waii Inc.

Naperville, IL1 employeeDepartment of Health and Human ServicesPhase I

“First in Class Mitochondrially targeted antioxidants with transcriptional modulator capabilities and their implication in the diseases of th”

$349k

Starfire Industries, LLC

Champaign, IL44 employeesDepartment of EnergyPhase Icompany site

“PVD manufacturing process for inner protective liners enabling advanced cladding compositions to reduce fuel-cladding chemical interactions,”

$400k2 awards

Neurolux, Inc.

Northfield, IL7 employeesDepartment of Health and Human ServicesPhase Icompany site

“Development and Validation of a Compliant Reversible Actuator and Detector Leveraging Electrophysiology for Organoids (Organoid-CRADLE)”

$1.0M2 awards

Qdir, Inc.

Chicago, IL3 employeesDepartment of DefensePhase I/IIcompany site

“A Systematic Approach to High Operating Temperature (HOT) Colloidal Quantum Dot Infrared Photodetectors”

$2.1M2 awards

Zinnia Technologies Inc.

Winnetka, IL4 employeesDepartment of Health and Human ServicesPhase Icompany site

“Zinnia All Day: An application for mobile devices and connected TVs to assist care partners promote routine in activities of daily living in”

$500k

O2m Technologies LLC

Chicago, IL9 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Advanced Imaging Methods in Pulse EPR”

$1.2M

Zecoat Corporation

Granite City, IL9 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Micrometeorite Shield with Tailorable, High-Performance, Thermal/Optical Properties for Spacecraft Telescope Baffle”

$150k

Hinetics LLC

Champaign, IL20 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Health monitoring and pre-flight diagnostics for robust electrical machines”

$150k

Third Coast Dynamics, Inc.

Evanston, IL1 employeeDepartment of Health and Human ServicesPhase II

“Anatomic Imaging Derived 4D Hemodynamics using Deep Learning”

$813k

Homecare Hub US Inc

Willow Springs, IL12 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Scaling a network of small community-based care homes as a high-value alternative to institutional care”

$1.1M

Microlink Devices Inc

Niles, IL60 employeesNational Aeronautics and Space AdministrationPhase Icompany site

“Radiation Resistant Solar and Laser Power Converter for Lunar Applications”

$300k2 awards

Brightoutcome Inc

Buffalo Grove, IL7 employeesDepartment of Health and Human ServicesPhase Icompany site

“WHIM (Women's Health in Menopause): Promoting healthy aging in menopausal women”

$400k

Angiotensin Therapeutics, Inc.

Evanston, IL3 employeesDepartment of Health and Human ServicesPhase I

“AGT001 for Delayed Graft Function in Kidney Transplantation”

$610k2 awards

Laborecom Therapeutics Inc

Chicago, IL3 employeesDepartment of Health and Human ServicesPhase I

“A cell-permeable peptide therapeutic to reduce myocardial reperfusion injury”

$388k

Common Ground Publishing, LLC

Champaign, IL17 employeesDepartment of EducationPhase IIcompany site

“CGScholar AI Helper: A Generative AI Writing and Learning Assistant”

$1M

Vortex Therapeutics Inc

Lombard, IL2 employeesDepartment of Health and Human ServicesPhase II

“Development of a novel MYC inhibitor for cancer therapy”

$1.1M

QuesTek Innovations LLC

Evanston, IL42 employeesDepartment of Defense, National Aeronautics and Space AdministrationPhase Icompany site

“Multi-scale location-specific fatigue life prediction for additive propulsion components”

$693k4 awards

Regenerative Medical Solutions Inc

Park Ridge, IL7 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Development of a safer stem cell-based diabetes therapy via suicide gene-mediated ablation of proliferative cells”

$915k

Influit Energy LLC

Chicago, IL30 employeesDepartment of DefensePhase IIcompany site

“American-Made High-Energy Density Flow Battery with Neutral pH Electrolytes for Tactical and Strategic Energy Resilience”

$1.2M

MAIA Biotechnology, Inc.

Chicago, IL12 employeesDepartment of Health and Human ServicesPhase II

“Novel Telomere-Targeting Therapy for Advanced Non-Small Cell Lung Cancer”

$770k

Evoquant LLC

Chicago, IL1 employeeDepartment of Health and Human ServicesPhase I

“Leveraging Large Scale Bioinformatics and AI for Natural Product Drug Discovery and Target Selection”

$307k

Applied Material Systems Engineering, Inc

Streamwood, IL7 employeesNational Aeronautics and Space AdministrationPhase I

“Innovative Advances in Coatings for Extreme Environmental Thermal Radiators and Complex Surfaces”

$150k

PeptiForge, Inc

Chicago, IL3 employeesDepartment of Health and Human ServicesPhase Icompany site

“A platform for the rapid development of protein binders”

$307k

Docbotic Inc

Naperville, IL5 employeesDepartment of Health and Human ServicesPhase Iwoman-ownedcompany site

“Betterbot: Promoting Accessible and Inclusive Mental Health Support for Individuals with Brain Injury”

$500k

Uptake Technologies, Inc.

Chicago, IL21 employeesDepartment of DefensePhase I/IIcompany site

“Next Generation Condition-Based Maintenance Plus for USAF”

$1.3M2 awards

Villa-Tech, Inc.

Naperville, IL14 employeesDepartment of DefensePhase Icompany site

“"Revolutionizing Infrastructure/security and compliance for the warfighter using AI/NLP"”

$149k

Falex Corporation

Sugar Grove, IL36 employeesDepartment of DefensePhase IIcompany site

“Next-Gen Fuel Testing: Automating Breakpoint Detection with an Upgraded Thermal Oxidation Stability Test Equipment”

$1.2M

Lifeboat LLC

Champaign, IL9 employeesDepartment of Energy, National Aeronautics and Space AdministrationPhase I/IIcompany site

“NetCDF4 / HDF5 Format Extension Pack (NFEP): Transparently Adding More Formats to NetCDF4 and HDF5”

$1.5M3 awards

Iris Light Technologies Inc

Chicago, IL4 employeesDepartment of Defense, Department of EnergyPhase I/IIcompany site

“Low SWAP frequency combs for RF photonic chips and portable atomic clocks enabled by black phosphorus actives”

$2.1M3 awards

Impossible Objects, Inc.

Northbrook, IL24 employeesDepartment of DefensePhase I/IIcompany site

“High-Volume Low-Cost Long-range Fixed Wing UAS with near-conflict Distributed Manufacturability”

$1.5M2 awards

Rational Cyphy Inc

Champaign, IL3 employeesNational Aeronautics and Space AdministrationPhase II

“SkyAID: A Safe Autonomy Infrastructure for Disaster Response”

$850k

Sivananthan Laboratories, Inc.

Bolingbrook, IL30 employeesDepartment of DefensePhase I/II

“Metasurface-coupled HgCdTe alloys for nonreciprocal optical limiting”

$2.0M2 awards

Midgard AI, INC.

Chicago, IL3 employeesNational Aeronautics and Space AdministrationPhase IIcompany site

“Highly Photorealistic Programmable 3D Worlds”

$848k

Dupage Medical Technology, Inc.

Willowbrook, IL2 employeesDepartment of Health and Human ServicesPhase I

“A new drug to treat transplant-associated renal ischemia-reperfusion injury”

$307k

Briteseed, LLC

Chicago, IL7 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Development of a Multispectral Kerrison Rongeur for Dura and Nerve Root Detection”

$1.0M

Snc Therapeutics, Inc.

Evanston, IL2 employeesDepartment of Health and Human ServicesPhase I

“Tolerogenic Nanotherapy to Delay Type I Diabetes”

$350k

Fluid Reality Incorporated

Chicago, IL2 employeesNational Science FoundationPhase I

“SBIR Phase I: Compact Haptic Actuators Using Electroosmotic Pumps”

$305k

AI Tech Holdings Inc

Chicago, IL9 employeesDepartment of DefensePhase IIcompany site

“Integration of Physiological Alerting and Location Monitoring from WearTAK-Mil into Special Tactics Radio Data Transport Layers”

$2.5M2 awards

Mantis Tech, LLC

Oswego, IL100 employeesDepartment of DefensePhase Icompany site

“Marksmanship Analysis and Training Information System (MANTIS)”

$139k

Creative Thermal Solutions, Inc.

Urbana, IL26 employeesDepartment of DefensePhase I/IIcompany site

“Development of a Shipboard Modular Refrigeration System Using Carbon Dioxide as the Refrigerant”

$1.1M2 awards

Tango Biosciences Inc.

Chicago, IL3 employeesDepartment of Health and Human ServicesPhase I

“The Avidimer Platform - a molecular toolbox to accelerate proximity research and drug discovery”

$314k

Earnest Agriculture, Inc.

Rantoul, IL2 employeesNational Science FoundationPhase Icompany site

“STTR Phase I: Development of Seed Applied Bacterial Consortium for Soybean to Increase Yield, Nitrogen Fixation, Disease Resistance, and Aft”

$275k

Nuts Technologies Inc

Glencoe, IL4 employeesDepartment of DefensePhase Icompany site

“TALON2D: Tactical Autonomous Layer for Optimized Networking with Distributed and Decentralized Key Management”

$140k

Ingenium Technologies Corp

Rockford, IL36 employeesDepartment of DefensePhase IIcompany site

“Advanced Ceramic Electrochemical Cell for Oxygen Production”

$1.4M

Enduvo Inc

Peoria, IL19 employeesDepartment of DefensePhase IIcompany site

“Enduvo TACFI - RAISE: Rapid AI-Immersive Scalable Education”

$3.2M2 awards

Nuago Therapeutics Inc

Chicago, IL1 employeeDepartment of Health and Human ServicesPhase Icompany site

“Development of a DISE-inducing, short RNA therapeutic to treat ovarian cancer”

$400k

Opera Bioscience, Inc.

Evanston, IL3 employeesNational Science FoundationPhase IIwoman-owned

“SBIR Phase II: A Gram-Negative Bacterial Secretion Platform for Cost-Effective, High-Purity Recombinant Protein Production”

$1.2M

Inertial Technologies Inc.

Chicago, IL1 employeeNational Science FoundationPhase Icompany site

“STTR Phase I: Supersonic Inertial Separation for Carbon Capture Technologies”

$305k

A Cubed Design LLC

Aurora, IL3 employeesNational Science FoundationPhase I

“SBIR Phase I: Novel Mechanism for Refreshable Braille Device with Embedded Curriculum”

$305k

Celadyne Technologies, Inc.

Willowbrook, IL12 employeesDepartment of DefensePhase IIcompany site

“SPECTRE - Silent Propulsion, Extended Range, Covert Transport and Resupply Engine”

$1.8M

Synapticure Inc

Kenilworth, IL1 employeeDepartment of Health and Human ServicesPhase II

“3D in vitro model of genetic and sporadic FTD: accelerating novel therapeutic development”

$1.3M

American Energy Technologies Co

Glenview, IL19 employeesDepartment of DefensePhase IIwoman-ownedcompany site

“New and Improved Domestic Carbon Monofluoride for D-size lithium-primary battery cells.”

$2.0M

Kompass Diagnostics Inc

Chicago, IL2 employeesNational Science FoundationPhase I

“SBIR Phase I: Portable Blood Diagnostic Technology Enabling Care Delivery Beyond Hospital Walls”

$305k

Haas, Inc

Chicago, IL48 employeesDepartment of TransportationPhase IIcompany site

“Child Safety Using Optical and V2X Digital Alerting Technology to Bring School Buses and Students on the Vehicle Grid for Collision Preventi”

$748k

Covira Surgical

North Chicago, IL3 employeesDepartment of Health and Human ServicesPhase IIcompany site

“A novel, non-antibiotic, microbiome-directed agent to prevent post-surgical infection”

$1M

Sensewhy, Inc.

Chicago, IL4 employeesDepartment of Health and Human ServicesPhase Icompany site

“ASHES: Assessing Smoking BeHavior with ThErmal Sensing to Prevent Relapse”

$400k

Sciaky Inc

Chicago, IL54 employeesDepartment of EnergyPhase IIcompany site

“Real-Time Adaptive Control for Conduction Mode EB Welding of Niobium Cavities”

$724k

Caporus Technologies Inc

Orland Park, IL6 employeesDepartment of EnergyPhase IIcompany site

“Engineered Substrates for Radiation-Hard Sensors in High Energy Physics”

$1.1M

Tera-Print LLC

Skokie, IL7 employeesDepartment of EnergyPhase IIcompany site

“Towards Rapid and Accessible DNA Synthesis for Synthetic Biology via Beam Pen Lithography”

$1.1M

Rhaeos, Inc

Evanston, IL5 employeesDepartment of Health and Human ServicesPhase I/IIcompany site

“Lowering Economic, Infrastructure, & Physical Barriers with Noninvasive, Wireless Telemedicine Cerebrospinal Fluid Flow Sensing for Pediatri”

$1.3M2 awards

Biomesense Inc

Chicago, IL7 employeesDepartment of Health and Human ServicesPhase II

“Development of a Novel Biosensor to Accelerate Investigations of the Gut Microbiome”

$1.1M

Eden Park Illumination, Inc.

Champaign, IL25 employeesDepartment of EnergyPhase Icompany site

“Development of a Portable Microplasma Far-UVC Source for the Prevention of Surgical Site Infections”

$206k

Articulate Labs, Inc

Chicago, IL3 employeesDepartment of DefensePhase Icompany site

“Accelerated Physical Rehabilitation & Improved Military Readiness Through Movement-Synchronous Electrical Muscle Stimulation”

$109k

Kaney Aerospace, Inc.

Rockford, IL150 employeesDepartment of DefensePhase IIcompany site

“Final Development & Qualification of NSN 5996-01-419-3249 Aircraft Synchronous Amplifier”

$925k

Belay Diagnostics, LLC

Chicago, IL2 employeesDepartment of Health and Human ServicesPhase IIcompany site

“Multi-omic CSF Assay for the Diagnosis of Brain Cancers”

$844k

Novaa Ltd

Chicago, IL4 employeesDepartment of DefensePhase IIcompany site

“Pressure-Tolerant Electronically Steered Antenna for Satellite Communications on Unmanned Undersea Vehicles”

$645k

Azul 3d Inc

Skokie, IL20 employeesDepartment of DefensePhase Icompany site

“Protective Eyewear with Vision Correction Using Continuous 3D Printing”

$204k

Hy-Tek Manufacturing Co., Inc.

Sugar Grove, IL38 employeesDepartment of DefensePhase Iwoman-ownedcompany site

“Steel Laminated Armor Plate (SLAP)”

$249k

Epicwide, LLC

Chicago, IL1 employeeDepartment of Health and Human ServicesPhase I

“Home-Use Synergy-Alleviating System.”

$93k

Source: public SBIR/STTR award record. Company-level facts only. Open roles are live listings on our board.

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