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substance-use funding

41 open opportunities tagged substance-use, across federal agencies and private foundations. Sorted by deadline.

PAR-25-192 • National Institutes of Health

Alcohol Health Services Research (R34 Clinical Trial Optional)

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R34 Clinical Trial Optional mechanism focusing on alcohol health services.

3 review criteria on file
amount not statedDue 2026-09-074 days left
PAR-25-193 • National Institutes of Health

Alcohol Treatment, Pharmacotherapy, and Recovery Research (R34 Clinical Trial required)

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R34 Clinical Trial Optional mechanism focusing on alcohol health services.

3 review criteria on file
amount not statedDue 2026-09-074 days left
PA-25-163 • National Institutes of Health

Alcohol Treatment, Pharmacotherapy, and Recovery Research (R01 Clinical Trial Required)

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R01 Clinical Trial Required mechanism focusing on alcohol treatment and recovery research.

3 review criteria on file
$500,000award ceilingDue 2026-09-074 days left
PAR-25-347 • National Institutes of Health

Substance Use/Substance Use Disorder Dissertation Research Award (R36 Clinical Trials Not Allowed)

The goal of this notice of funding opportunity (NOFO) is to support doctoral candidates from a variety of academic disciplines for up to two years for the completion of the doctoral dissertation research project.gov) .

3 review criteria on file
amount not statedDue 2026-09-074 days left
PA-25-245 • National Institutes of Health

Alcohol Health Services Research (R01 Clinical Trial Optional)

The National Institute on Alcohol Abuse and Alcoholism solicits applications for an R01 Clinical Trial Optional mechanism focusing on alcohol health services.

3 review criteria on file
$500,000award ceilingDue 2026-09-074 days left
RFA-NS-25-023 • National Institutes of Health

HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed)

This notice of funding opportunity (NOFO) aims to encourage research grant applications for initial translational efforts that will enable a drug discovery program for novel, non-opioid, and non-addictive treatments for pain.

4 review criteria on file
$350,000award ceilingDue 2026-09-1714 days left
PAR-24-071 • National Institutes of Health

Alcohol Research-Related Resource Award (R24 Clinical Trial Not Allowed)

The purpose of the Resource-Related Research Projects (R24) grant is to support investigator-initiated resources designed to provide materials and services to support and advance biomedical, behavioral, and social sciences research on a national basis.

6 review criteria on file
amount not statedDue 2026-09-2522 days left
PAR-27-026 • National Institutes of Health

Avant Garde/Avenir Awards for Investigators Conducting High Risk/High Reward Research on HIV and Substance Use (or Substance Use Disorders) (DP1 Clinical Trial Optional)

The National Institute on Drug Abuse (NIDA) Avant-Garde and Avenir Awards Program for HIV Research supports exceptionally creative scientists, who propose high-impact studies that open new areas of HIV research in the context of substance use and Substance Use Disorders (SUD) and/or lead to new avenues for HIV prevention, treatment and…

7 review criteria on file
amount not statedDue 2026-09-2522 days left
PAR-25-383 • National Institutes of Health

Blueprint MedTech Translator (UG3/UH3 - Clinical Trial Optional)

This Notice of Funding Opportunity (NOFO) is to encourage applications from investigators to pursue translational activities and clinical studies to advance the development of medical devices to prevent, monitor, diagnose, and treat disorders within the missions of the participating NIH institutes and centers, as well as the NIH Brain…

3 review criteria on file
amount not statedDue 2026-09-2825 days left
RFA-DA-27-015 • National Institutes of Health

Establishing a Center for the Advancement of Substance Use Disorder (SUD) Pharmacotherapeutics through Training and Preclinical Support (U54 Clinical Trial Not Allowed)

Background Translating novel ideas from the laboratory into clinically viable commercial products presents numerous challenges.

10 review criteria on file
amount not statedDue 2026-09-3027 days left
RFA-AR-27-002 • National Institutes of Health

HEAL INITIATIVE: INTERACT Data Coordination and Integration Center (U24 Clinical Trial Not Allowed)

The goal of this announcement is to support a Data Coordination and Integration Center (DCIC) as part of the NIH HEAL Initiative’s INTERACT program. The DCIC will curate, harmonize, and integrate comprehensive clinical, -omics, and other complex datasets generated by INTERACT as well as from the larger HEAL Initiative related datasets.

7 review criteria on file
amount not statedDue 2026-10-0128 days left
RFA-DA-27-007 • National Institutes of Health

Limited Competition: Growing Great Ideas: Research Education Course in Entrepreneurship and Product Development for Researchers Studying Drug Use, Drug Misuse, and Drug Addiction (UE5 Clinical Trial Not Allowed)

Background This is a Notice of Funding Opportunity (NOFO) for a Limited Competition that will invite application(s) from eligible organization(s) to apply. Please see Section III.

9 review criteria on file
amount not statedDue 2026-10-0128 days left
PAR-26-001 • National Institutes of Health

Screening, Brief Intervention and Referral to Treatment or Prevention (SBIRT/P) for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult populations that experience health disparities (R01, Clinical Trial Required)

The Office of Disease Prevention (ODP) and participating National Institutes of Health (NIH) Institutes, Centers, and Offices (ICOs) are issuing this notice of funding opportunity (NOFO) seeking applications to test innovative approaches to implementing SBIRT/P for alcohol, tobacco, and other drugs (ATOD) use and misuse in adult…

3 review criteria on file
amount not statedDue 2026-10-05
PAR-27-057 • National Institutes of Health

Causal Hypotheses on the Oral-Systemic Health Impacts of Human Behaviors among People with Chronic Conditions (U01 Clinical Trial Not Allowed)

6 years.25 billion fewer life years for the United States population.

3 review criteria on file
$500,000award ceilingDue 2026-10-05
PAR-25-221 • National Institutes of Health

Population Approaches to Reducing Alcohol-related Cancer Risk (R01 Clinical Trial Optional)

This Notice of Funding Opportunity (NOFO) aims to support research on interdisciplinary population approaches to increasing awareness of the relationship between alcohol and cancer risk, understanding and changing social norms related to alcohol consumption, developing and/or evaluating alcohol policy approaches, and the development,…

3 review criteria on file
amount not statedDue 2026-10-05
RFA-DA-27-016 • National Institutes of Health

HEAL Initiative: Translating Addiction Epidemiology, Prevention, Treatment, and Recovery Research into Practice (R61/R33 - Clinical Trial Optional)

Background: HEAL Initiative The NIH Helping to End Addiction Long-term (HEAL) Initiative: This notice of funding opportunity (NOFO) encourages applications in support of the NIH's HEAL initiative to speed scientific solutions to the national opioid public health crisis.

3 review criteria on file
amount not statedDue 2026-10-09
PAR-25-248 • National Institutes of Health

Utilizing the PLCO Biospecimens Resource to Bridge Gaps in Cancer Etiology and Early Detection Research (U01 Clinical Trial Not Allowed)

Through this Notice of Funding Opportunity (NOFO), the National Cancer Institute (NCI) encourages the submission of applications that propose to advance research in cancer etiology and early detection biomarkers, utilizing the advantages of the unique biorepository resources of the NCI-sponsored Prostate, Lung, Colorectal, and Ovarian…

3 review criteria on file
amount not statedDue 2026-10-09
O-BJA-2026-172662 • Bureau of Justice Assistance

U.S. Department of Justice FY26 Coordinated Tribal Assistance Solicitation Notice of Funding Opportunity

The Coordinated Tribal Assistance Solicitation (CTAS) responds to tribal leaders’ requests to improve and simplify the DOJ grant-making process.

$5,600,000award ceilingDue 2026-10-15
RFA-MH-27-180 • National Institutes of Health

Advancing Research on Empirically-Supported Interventions for Older Adults Living with Serious Mental Illness (SMI) (R01 Clinical Trial Optional)

Key Definitions for this NOFO: Older adult: For the purposes of this announcement, "older adult" is defined as individuals with SMI who are 50 years of age and older.

3 review criteria on file
amount not statedDue 2026-10-15
PAR-24-297 • National Institutes of Health

Imaging - Science Track Award for Research Transition (I/START) (R03 Clinical Trial Optional)

This Notice of Funding Opportunity Announcement (NOFO) is designed to encourage and facilitate the entry of investigators to the area of brain imaging research.

3 review criteria on file
$150,000award ceilingDue 2026-10-16
PAS-25-236 • National Institutes of Health

D-START: Data Science Track Award for Research Transition (D/START) (R03-Clinical Trial Optional)

Data science is an important cross-cutting research approach in the 2022 - 2026 NIDA Strategic Plan and increasing the capacity of experts in addiction related data science is critical.

3 review criteria on file
$100,000award ceilingDue 2026-10-16
PAR-25-100 • National Institutes of Health

Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)

The purpose of this notice of funding opportunity (NOFO) encourages pilot and preliminary research in preparation for larger-scale services research effectiveness trials.

3 review criteria on file
amount not statedDue 2026-10-16
PAR-27-015 • National Institutes of Health

Community-Based Participatory Research to Advance Data and Practice Transformation (ADAPT) for Optimizing Oral Health for All (UG3/UH3 Clinical Trial Optional)

This Notice of Funding Opportunity (NOFO) solicits UG3/UH3 phased, cooperative agreement research applications to evaluate, implement, and/or test population-based interventions to policies, programs, and/or practices that promote the integration of services, systems, and/or values by leveraging cross-sector partnerships in communities.

3 review criteria on file
$300,000award ceilingDue 2026-10-16
PAR-25-159 • National Institutes of Health

Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R34 Clinical Trial Optional)

This Notice of Funding Opportunity (NOFO) for R34 planning grant applications focuses on prevention and intervention strategies for fetal alcohol spectrum disorders (FASD) throughout the lifespan.

3 review criteria on file
amount not statedDue 2026-10-16
PAS-27-028 • National Institutes of Health

Science Track Award for Research Transition (START) Program (R03, Clinical Trial Optional)

The Science Track Award for Research Transition (START) programs have been key initiatives of the National Institute on Drug Abuse (NIDA).

3 review criteria on file
amount not statedDue 2026-10-16
PAR-25-158 • National Institutes of Health

Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R61/R33 Clinical Trial Optional)

This Notice of Funding Opportunity (NOFO) focuses on prevention and intervention strategies for fetal alcohol spectrum disorders (FASD) throughout the lifespan.

3 review criteria on file
amount not statedDue 2026-10-19
RFA-DE-27-001 • National Institutes of Health

Community Engagement Evaluation and Data Coordination (CEED) Hub to Advance Data and Practice Transformation for Optimizing Oral Health for All (U01, Clinical Trial Not Allowed)

This Notice of Funding Opportunity (NOFO) seeks applications for a Community Engagement Evaluation and Data coordination hub (CEED) for the Community-Based Participatory Research (CBPR) consortium: Advancing Data and Practice Transformation (ADAPT) for Optimizing Oral Health for All.

3 review criteria on file
amount not statedDue 2026-10-19
PAR-25-446 • National Institutes of Health

Development of Interventions to Prevent and Treat Substance Use Disorders and Overdose (UG3/UH3 - Clinical Trial Optional)

The purpose of this Funding Opportunity (NOFO) is to solicit grant applications to support research on the discovery and development of interventions to prevent and/or treat substance use disorders (SUDs) and overdose, including medications and medical devices to treat co-morbid SUDs.

3 review criteria on file
$3,000,000award ceilingDue 2026-10-20
RFA-NS-27-007 • National Institutes of Health

HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional)

Background: The NIH HEAL Initiative: This NOFO encourages applications in support of the NIH's Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis.

3 review criteria on file
amount not statedDue 2026-10-21
PAR-25-378 • National Institutes of Health

Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)

The purpose of this notice of funding opportunity (NOFO) is to support planning and development, including pilot or feasibility research, to improve health in Native populations.

3 review criteria on file
amount not statedDue 2026-10-21
PAR-25-379 • National Institutes of Health

Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)

The purpose of this notice of funding opportunity (NOFO) is to support research on interventions to improve health in Native populations.

3 review criteria on file
amount not statedDue 2026-10-21
PAR-25-353 • National Institutes of Health

National Cooperative Drug/Device Discovery/Development Groups (NCDDG) for the Treatment of Mental Disorders (U19 Clinical Trial Optional)

Reissue of PAR-20-119.

7 review criteria on file
amount not statedDue 2026-10-25
PAR-24-027 • National Institutes of Health

Population Assessment of Tobacco and Health (PATH) Study Biospecimen Access (X01)

S.gov/research/nida-research-programs-activities/population-assessment-tobacco-health-path-study/data-access ).

Review criteria on file
amount not statedDue 2026-10-30
RFA-DA-26-034 • National Institutes of Health

Chemical Countermeasures Research Program (CCRP) Initiative: Basic Research on The Deleterious Effects of Acute Exposure to Ultra-Potent Synthetic (UPS) Opioids (R01 Clinical Trial Not Allowed)

, fentanyl and xylazine). This NOFO will also support research on the persistent and/or delayed pathophysiological effects after acute exposure to such agents.

3 review criteria on file
$300,000award ceilingDue 2026-11-18
RFA-DA-26-056 • National Institutes of Health

Accelerating the Pace of Substance Use Research Using Existing Data (R21 Clinical Trial Not Allowed)

The purpose of this notice of funding opportunity (NOFO) is to invite applications proposing innovative analysis of existing social science, behavioral, administrative, and neuroimaging data to study the etiology and epidemiology of substance using behaviors (defined as alcohol, tobacco, prescription, and other substances) and related…

3 review criteria on file
amount not statedDue 2026-12-03
RFA-DA-26-055 • National Institutes of Health

Accelerating the Pace of Substance Use Research Using Existing Data (R01 Clinical Trial Not Allowed)

The purpose of this notice of funding opportunity (NOFO) is to invite applications proposing innovative analysis of existing social science, behavioral, administrative, and neuroimaging data to study the etiology and epidemiology of substance using behaviors (defined as alcohol, tobacco, prescription, and other substances) and related…

3 review criteria on file
amount not statedDue 2026-12-03
RFA-DA-25-024 • National Institutes of Health

High Priority HIV and Substance Use Research (R01 Clinical Trial Optional)

The purpose of this notice of funding opportunity (NOFO) is to support high priority research at the intersection of HIV and substance use.

3 review criteria on file
amount not statedDue 2027-02-05
RFA-DA-25-060 • National Institutes of Health

High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)

The purpose of this notice of funding opportunity (NOFO) is to support high priority research at the intersection of HIV and substance use.

Review criteria on file
$1,500,000award ceilingDue 2027-02-05
PAR-24-269 • National Institutes of Health

NIDA Animal Genomics Program (U01 Clinical Trial Not Allowed)

The purpose of the NIDA Animal Genetics Program is to identify genetic, genomic, and molecular (epi)genetic variants that underlie: 1.g.

3 review criteria on file
amount not statedDue 2027-02-11
RFA-OH-22-005 • Centers for Disease Control and Prevention - ERA

Commercial Fishing Occupational Safety Research Cooperative Agreement (U01)

L.L.

Review criteria on file
$975,000award ceilingDue 2028-01-31
• Brain & Behavior Research Foundation

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$100,000award ceilingRolling

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