Postdoctoral Fellow

About the role

The Neuro-Oncology Branch (NOB) at the National Cancer Institute’s Center for Cancer Research (CCR) is a specialized program dedicated to advancing the study and treatment of brain and central nervous system (CNS) tumors. We are seeking an exceptional candidate to join our Molecular and Cell Biology (MCB) Program. This position focuses on investigating DNA repair pathways in brain tumors, with an emphasis on identifying and characterizing critical epigenetic targets through genetic and biochemical approaches. Mechanistic insights will be validated using in vitro and in vivo models, as well as patient-derived specimens. In addition, experimental therapeutics will be developed based on preliminary findings. These discoveries are expected to provide a strong foundation for future clinical translation and therapeutic applications. Position Highlights: Outstanding Training: Combine basic mechanistic research with disease-relevant preclinical research. Advanced Models: Utilize both mouse models, patient-derived xenografts (PDXs), and human specimens to develop next-generation therapeutics. Collaborative Medicinal Research: Work in a dynamic, collaborative, and interdisciplinary research team. State-of-the-Art Resources: Access state-of-the-art research facilities and resources, including equipment, computational tools, and reagents. Exciting Research Environment: Benefit from well-equipped in-house core facilities and intense collaborations among laboratories. Expert Mentorship: Receive guidance from renowned scientists and clinicians, gaining invaluable knowledge in the field. The ideal candidate should be able to: Interested and motivated to investigate fundamental questions in cancer biology, epigenetics, and functional genomics. Leverage a background in biochemistry and molecular biology, emphasizing epigenetic profiling, chromosomal biology, and next generation sequencing. Collaborate with the Principal Investigator (PI) for hypothesis development, experimental design, and execution. Participate in data processing, analysis, discussion, reporting, presenting findings at conferences, and manuscript drafting. Work effectively within an interdisciplinary team. Stay informed of developments in the field to maintain and enhance professional expertise. Perform lab maintenance, including equipment upkeep and supply ordering. Teach techniques to, train, and mentor junior research staff. Demonstrate excellent communication skills and fluency in both spoken and written English. Qualifications: Ph.D. in biochemistry, molecular biology, genetics, or a related field, or nearing completion of degree requirements. No more than five years of postdoctoral research experience. Please email curriculum vitae, statement of research interests, and three letters of reference to the attention of:  Chunzhang Yang, Ph.D., Neuro-Oncology Branch, National Cancer Institute, 37 Convent Drive, Room 1142E, Bethesda, MD 20892 at yangc2@nih.gov Candidates may be U.S. citizens, resident aliens, or nonresident aliens.  DHHS, NIH, the NCI and the NINDS are Equal Employment Opportunity and Affirmative Action employers and are dedicated to building a diverse community in its training and employment programs and encourages the application and nomination of qualified women, minorities, and individuals with disabilities.

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