Postdoctoral Fellow for Program in Memory & Longevity at UT Southwestern O'Donnell Brain Institute

About the role

The newly established Program for Memory Longevity (PML), led by Attila Losonczy, MD, PhD, in the  O’Donnell Brain Institute (OBI) and the Department of Neuroscience at the University of Texas Southwestern (UTSW) Medical Center in Dallas, seeks applications for multiple postdoctoral fellow positions to investigate memory mechanisms in the mammalian brain using innovative molecular, cellular, or imaging approaches in animal models and human tissue. The successful applicant will be embedded in the larger Neuroscience community at UTSW and OBI, and will benefit from a network of collaborations with research groups in the US and Europe. Potential projects include: In vitro electrophysiology and imaging: Characterizing synaptic and dendritic integration and plasticity of mouse and human hippocampal neurons using patch-clamp recording, single-cell electroporation, Patch-seq, and advanced imaging approaches. In vivo imaging: Characterizing synaptic plasticity during navigation and learning using two-photon calcium, voltage, and neurotransmitter imaging. Molecular neurobiology: Characterizing learning related plasticity in vivo and in vitro through multi-omics approaches (e.g., transcriptomics, proteomics). Education:  Ph.D. in Neuroscience, Cell Biology, Biochemistry Physics, (Electrical) Engineering, Statistics, Computer Science or a related field. Description:  This is a full-time postdoctoral fellow position in a neurobiology laboratory focusing on the synaptic and cellular/molecular mechanisms of learning and memory. Required qualifications: Candidates should have experience in one or more of the following areas: In vitro electrophysiology: Proficiency in whole-cell patch clamp recording, acute slice preparation, and/or cell culture electrophysiology, along with related data analysis methods using tools such as MATLAB or Python. In vivo imaging: Proficiency with in vivo two-photon calcium and/or voltage imaging techniques, including experimental execution and data analysis. Molecular neurobiology: Proficiency with techniques such as proteomics, transcriptomics and genomics, and related bioinformatics and statistical analysis techniques. How to Apply: Send your CV, research statements and name/contact information for three referees to : [attila.losonczy@gmail.com]. Review begins July 1, 2025.

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