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Recently funded science companies in Delaware

40 companies in Delaware closed federal SBIR/STTR awards in the last two years, newest first. The funding event is the signal — small companies grow right after the award lands.

Nitro Biosciences Inc.

NEWARK, DE · 2 employees

STTR Phase I: A platform to overcome immunodominance in vaccine development

National Science Foundation · Phase Phase I

$304kawardedfunded 2025-10-01

STF TECHNOLOGIES LLC

NEWARK, DE · 3 employees

Attack deterrent and ballistic-resistant substation component protection system using STF-Armor materials

Department of Energy · National Aeronautics and Space Administration · Phase Phase I/Phase II

$1.0Macross 2 awardsfunded 2025-09-26Company site →

SPHERIC BIO INC

WILMINGTON, DE · 1 employee

emuLAAte: atraumatic patient-specific stroke prevention technology

Department of Health and Human Services · Phase Phase I

$599kawardedfunded 2025-09-25

MOONPRINT SOLUTIONS LLC

DOVER, DE · 12 employees

Flexible Lunar Robotics/Rover Dust Mitigation Covers

Department of Defense · National Aeronautics and Space Administration · Phase Phase I/Phase II

$2.9Macross 6 awardsfunded 2025-09-24Company site →

Vishenary, LLC

Hockessin, DE · 2 employees

A novel Th17-enhancing adjuvant and conserved antigen for protection against viral/bacterial co-infection

Department of Health and Human Services · Phase Phase I

$309kawardedfunded 2025-09-23

MATRISOME BIO, INC.

WILMINGTON, DE · 4 employees · woman-owned

Development of an extracellular matrix-targeted theranostic radiopharmaceutical for metastatic lung cancer

Department of Health and Human Services · Phase Phase I/Phase II

$1.6Macross 2 awardsfunded 2025-09-23

COMPOSITES AUTOMATION LLC

NEWARK, DE · 11 employees

Impact-resistant Composite Structures for Spacesuits

Department of Defense · National Aeronautics and Space Administration · Phase Phase I

$290kacross 2 awardsfunded 2025-09-22Company site →

CAREVIRTUE TECHNOLOGIES, INC.

DOVER, DE · 3 employees

A Novel, AI-Enabled Dementia Care Agent to Reduce Disparities for Rural ADRD Care Partners.

Department of Health and Human Services · Phase Phase I/Phase II

$1.5Macross 2 awardsfunded 2025-09-20

MICROPURE GENOMICS INC.

MIDDLETOWN, DE · 2 employees

A gel-less, bead-less genomic size selection approach on a rapid and inexpensive microfluidic sample preparation platform

Department of Health and Human Services · National Science Foundation · Phase Phase I/Phase II

$1.5Macross 2 awardsfunded 2025-09-17Company site →

Unco Therapeutics LLC

MIDDLETOWN, DE · 2 employees

Development of Allosteric Uncouplers as Therapeutics for Chronic Pain

Department of Health and Human Services · Phase Phase I

$350kawardedfunded 2025-09-16

SPIROMATICS, INC.

CAMDEN, DE · 4 employees

Novel Technologies for Detection and Monitoring of Lung Disease

Department of Health and Human Services · Phase Phase I

$472kawardedfunded 2025-09-16

TOIVOA, INC

Newark, DE · 23 employees

Development of an accessible Cognitive Behavioral Therapy digital therapeutic for individuals with Long COVID

Department of Health and Human Services · Phase Phase I

$383kawardedfunded 2025-09-16

WUI-GO, LLC

LEWES, DE · 5 employees · woman-owned

SBIR Phase II: Decentralized Evacuation Intelligence with Generative AI, Personalized Preparedness and Robust Real-Time Navigation

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-09-15Company site →

BALLYDEL TECHNOLOGIES INC.

WILMINGTON, DE · 11 employees

Chemical Warfare Agent Spray Detection System

Department of Defense · Phase Phase II

$658kawardedfunded 2025-09-12Company site →

FOUND ENERGY CO

WILMINGTON, DE · 9 employees

Modular, Scalable, and Cost-Effective Domestic Gallium Metal Production

Department of Defense · Phase Phase I

$99kawardedfunded 2025-09-04Company site →

Walnot, Inc.

NEWARK, DE · 4 employees · woman-owned

A precision functional neuroimaging platform to enable collection of highly-sampled data at home

Department of Health and Human Services · Phase Phase I

$449kawardedfunded 2025-09-01

RASHI TECHNOLOGIES CORP.

WILMINGTON, DE · 2 employees

Input and Data agnostic topic-evolution system for R&D insights

Department of Defense · Phase Phase I

$150kawardedfunded 2025-08-25Company site →

SANSIMEON INC

WILMINGTON, DE · 3 employees

A Uniquely Scalable Platform for Sequencing Tens of Millions of Single Cells from Complex Clinical Samples with a Streamlined Workflow

Department of Health and Human Services · Phase Phase II

$938kawardedfunded 2025-08-15

Koi Biotherapeutics Inc.

NEWARK, DE · 2 employees

Revolutionizing CAR T-cell Therapy: Enhancing Activity and Persistence of CAR T-cell by Developing a CAR-Enhancer Platform

Department of Health and Human Services · Phase Phase II

$1.3Mawardedfunded 2025-08-12

VASARYA THERAPEUTICS, INC.

CAMDEN, DE · 4 employees

Translating a Novel Therapeutic Approach to the Treatment for Idiopathic Pulmonary Fibrosis

Department of Health and Human Services · Phase Phase II

$1.1Mawardedfunded 2025-08-01

Coalesenz Inc.

REHOBOTH BEACH, DE · 1 employee · woman-owned

Point of Care Blood Coagulopathy Diagnostics

Department of Defense · Phase Phase II

$1.6Mawardedfunded 2025-07-25

FILAMENTECH, INC.

NEWARK, DE · 6 employees

MUSICO: An in silico platform for evaluating the effects of disease and drug effectiveness in HCM and DCM cardiomyopathies

Department of Health and Human Services · Phase Phase I

$298kawardedfunded 2025-07-15Company site →

Echo Mind Ai Corp

Dover, DE · 0 employees

SBIR Phase II: Artificial Intelligence (AI)-Enabled Ultrasound for Imaging and Diagnosing Musculoskeletal Injuries

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-07-15Company site →

LEAP PHOTONICS INC

Dover, DE · 1 employee

SBIR Phase I: Chip Scale Acousto-Optics Beam-Steering LiDAR

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-07-15Company site →

PHASE SENSITIVE INNOVATIONS INC

NEWARK, DE · 120 employees

Low Cost Technologies for Manufacturing of Thin Film Lithium Niobate

Department of Defense · Phase Phase I

$200kawardedfunded 2025-07-11Company site →

EINSENCA INC.

DOVER, DE · 5 employees

Phase 0 Study to Evaluate the in vivo Characteristics of a Myeloperoxidase-Targeting PET Agent in Healthy Volunteers and Early AD Patients

Department of Health and Human Services · Phase Phase I

$498kawardedfunded 2025-07-01

Instanosis, Inc.

Milford, DE · 1 employee · woman-owned

A Rapid, Sensitive and Instrument-free Oral Fluid Fentanyl Test

Department of Health and Human Services · Phase Phase II

$4.1Macross 3 awardsfunded 2025-06-15

VICTORY OVER CARBON, INC.

DOVER, DE · 1 employee

SBIR Phase II: CAS: A Novel Approach for Achieving Scale in Direct Air Carbon Capture

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-06-05

COSMYC INC

DOVER, DE · 5 employees

Therapeutic Inhibition of MYC:TRRAP Interaction in Cancer

Department of Health and Human Services · Phase Phase II

$907kawardedfunded 2025-06-01Company site →

AQUA SCIENCE LLC

NEWARK, DE · 7 employees · woman-owned

SBIR Phase II: Enzyme-linked Immunosorbent Assay for Detection of Per- and Polyfluoroalkyl Substances in Water

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-05-21Company site →

DARK MATTER THERAPEUTICS, INC.

WILMINGTON, DE · 3 employees

AI-Powered chemical-pathway-patient-directed polypharmacology for OUD therapy

Department of Health and Human Services · Phase Phase I

$399kawardedfunded 2025-05-01

Magnolia Electronics

Middletown, DE · 2 employees

SBIR Phase I: Machine-Learning Enabled Analog-to-Digital Converter

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-04-02Company site →

OAKGROVE BIO LLC

TALLEYVILLE, DE · 1 employee

SBIR Phase II: Cost-Effective Peptide Production Platform

National Science Foundation · Phase Phase II

$1.0Mawardedfunded 2025-03-13

Talos Tech LLC

New Castle, DE · 4 employees

Wild-Temperature Lithium Ion Batteries for Extreme Conditions

Department of Defense · Phase Phase I

$250kawardedfunded 2025-03-05Company site →

APPLIED DIAMOND, INC

WILMINGTON, DE · 22 employees

32e - Large area time-of-flight diamond detector for heavy-ion beam diagnostics

Department of Energy · Phase Phase I

$206kawardedfunded 2025-02-18Company site →

Apollodyne LLC

WILMINGTON, DE · 2 employees

Phase Change Material and Metal Organic Framework Fabrics for Enhanced Chemical Protection and Reduced Physiological Burden

Department of Defense · Phase Phase I

$150kawardedfunded 2025-02-11Company site →

CELLERGY PHARMA

WILMINGTON, DE · 1 employee

Bispecific antibody targeting IgE-producing B cells for treating allergic diseases

Department of Health and Human Services · Phase Phase I

$300kawardedfunded 2025-02-01

Zenith Space Technologies LLC

Wilmington, DE · 15 employees

ORBIT DETERMINATION & IMAGE PROCESSING OF NEUROMORPHIC DATA FOR SPACE DOMAIN AWARENESS (SDA)

Department of Defense · Phase Phase I

$75kawardedfunded 2025-01-15

Inkit Inc.

WILMINGTON, DE · 40 employees

PWSA Protection: Advanced Information Rights Management and Security Solutions

Department of Defense · Phase Phase I

$180kawardedfunded 2024-12-16Company site →

IVIDENCE INC

Hockessin, DE · 10 employees

Assessing Immunology Dataset Quality through Literature Mining

Department of Health and Human Services · Phase Phase I

$300kawardedCompany site →

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