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Recently funded science companies in Michigan

63 companies in Michigan closed federal SBIR/STTR awards in the last two years, newest first. The funding event is the signal — small companies grow right after the award lands.

BAKER ENGINEERING, LLC

Nunica, MI · 25 employees

Cost Effective Coatings and Materials for Enhanced Rotary Engine Corrosion Protection and Performance

Department of Defense · Phase Phase I

$215kacross 2 awardsfunded 2025-11-03Company site →

Orb Aerospace Inc

LOWELL, MI · 15 employees

Orb ARC - On Demand 5G Infrastructure

Department of Defense · Phase Phase I

$240kawardedfunded 2025-10-21Company site →

H3D INC

ANN ARBOR, MI · 48 employees

Large Volume CdZnTe Radiation Detectors

Department of Defense · Department of Energy · Phase Phase I/Phase II

$1.5Macross 3 awardsfunded 2025-09-26Company site →

KARAX LLC

EAST LANSING, MI · 3 employees

Physics-Based ML Tools for In-situ Cable Condition Monitoring through FDR

Department of Energy · Phase Phase I

$200kawardedfunded 2025-09-26Company site →

AMPHIONIC LLC

DEXTER, MI · 10 employees

Low-Energy Charged-Particle Detection via an Avalanche Silicon Detector coupled to an Amorphous Silicon Active Layer

National Aeronautics and Space Administration · Phase Phase I

$150kawardedfunded 2025-09-24

Ripple Biosciences

GROSSE POINTE PARK, MI · 2 employees

Sperm epigenetic diagnostic to inform couples time to pregnancy

Department of Health and Human Services · Phase Phase I

$307kawardedfunded 2025-09-19

EVOQ THERAPEUTICS, INC.

ANN ARBOR, MI · 6 employees

NanoDiscs for Immune Modulation in Celiac Disease

Department of Health and Human Services · Phase Phase II

$1.1Mawardedfunded 2025-09-19Company site →

IN VIVO MICROSYSTEMS TECHNOLOGIES, LLC

ANN ARBOR, MI · 2 employees · woman-owned

In-vivo study of KSP/QRH heptapeptide dimer for detection of biliary intra-epithelial neoplasia

Department of Health and Human Services · Phase Phase II

$1.0Mawardedfunded 2025-09-19

AKNA HEALTH LLC

GRAND RAPIDS, MI · 1 employee

Assay development for the assessment of pregnancy risks in early pregnancy

Department of Health and Human Services · Phase Phase II

$1.9Mawardedfunded 2025-09-18

NITRATE ELIMINATION CO INC

LAKE LINDEN, MI · 6 employees · woman-owned

SBIR Phase II: Dual Enzyme System to Prevent Food Waste Caused by Oxygen

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-09-15Company site →

THERMOANALYTICS, INC.

CALUMET, MI · 70 employees

Artificial Intelligence for Spacecraft Thermal Control Systems

Department of Defense · National Aeronautics and Space Administration · Phase Phase I

$289kacross 2 awardsfunded 2025-09-15Company site →

TSRL, INC.

ANN ARBOR, MI · 9 employees

Microneedle delivery of Trospium Chloride optimized for improved tolerance and patient outcomes in overactive bladder disease

Department of Health and Human Services · Phase Phase II

$1.1Mawardedfunded 2025-09-15

CYBERNET SYSTEMS CORPORATION

ANN ARBOR, MI · 37 employees

Autonomous Indoor/Outdoor Warehouse Operation

Department of Defense · National Aeronautics and Space Administration · Phase Phase I/Phase II

$3.3Macross 4 awardsfunded 2025-09-09Company site →

INVIA LLC

ANN ARBOR, MI · 25 employees

Development of Deep Learning Tools for Widely-Available, Inexpensive Diagnosis of Coronary Microvascular and Vasomotor Dysfunction

Department of Health and Human Services · Phase Phase II

$1.1Mawardedfunded 2025-09-05

DORNERWORKS, LLC

GRAND RAPIDS, MI · 96 employees

Assured Isolation of AI (AI^2) for HPSC Platforms

Department of Defense · National Aeronautics and Space Administration · Phase Phase I/Phase II

$4.1Macross 7 awardsfunded 2025-09-03Company site →

NOBLE GAS SYSTEMS INC.

NOVI, MI · 9 employees

Commercialization for Conformable Hydrogen Storage for Military Applications

Department of Defense · Phase Phase II

$1.9Mawardedfunded 2025-09-03Company site →

SAFERDRIVE AI LLC

Ypsilanti, MI · 2 employees

SBIR FastTrack: Generative AI-Driven Simulation to Address the Long-Tail Problem in Autonomous Vehicle Safety Validation

National Science Foundation · Phase Phase I/Phase II

$1.6Macross 2 awardsfunded 2025-09-01Company site →

GreenMark Biomedical Inc.

East Lansing, MI · 5 employees

Restoration of non-cavitated carious lesions in enamel using nano-fluorapatite particles

Department of Health and Human Services · Phase Phase I

$565kacross 2 awardsfunded 2025-09-01Company site →

H-BAR INSTRUMENTS, LLC

ANN ARBOR, MI · 3 employees

SBIR Phase II: Liquid Helium Transmission Electron Microscopy (TEM) Sample Holder for Atomic Imaging of Next-Generation Materials

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-09-01Company site →

DARKFLITE INC.

BRIGHTON, MI · 6 employees

Accelerating Frontline Survival: A Next-Generation Drone for Rapid Military Medical Emergency Response

Department of Defense · Phase Phase II

$1.2Mawardedfunded 2025-08-28Company site →

Umapav Corporation

GRAND RAPIDS, MI · 5 employees

GD3D - Generative AI for Tactical 3D ISR

Department of Defense · Phase Phase I

$259kacross 2 awardsfunded 2025-08-28Company site →

COMPETING VALUES, LLC

ANN ARBOR, MI · 8 employees

Avengers Assemble: Rapidly Teaming the Right Talent to Solve Emergent Threats

Department of Defense · Phase Phase I

$150kawardedfunded 2025-08-28Company site →

AIRSPACE EXPERIENCE TECHNOLOGIES, INC.

DETROIT, MI · 12 employees

Traffic Management Solution for JADC5

Department of Defense · Phase Phase I/Phase II

$1.9Macross 2 awardsfunded 2025-08-27Company site →

MICHIGAN ENGINEERING SERVICES LLC

ANN ARBOR, MI · 8 employees · woman-owned

Intelligent Assistant for Ship Design

Department of Defense · Department of Homeland Security · Phase Phase II

$2.0Macross 2 awardsfunded 2025-08-26Company site →

TARN BIOSCIENCES, INC.

East Lansing, MI · 0 employees

Development of nitroreductase-activated inhibitors to treat mycobacterial infections

Department of Health and Human Services · Phase Phase I

$299kawardedfunded 2025-08-21

Nusenics, LLC

Okemos, MI · 4 employees

Fiber-Optic Bolometers for Fusion Plasma Diagnostics

Department of Energy · Phase Phase II

$1.1Mawardedfunded 2025-08-21Company site →

CAREEVOLUTION LLC

ANN ARBOR, MI · 115 employees

Advancing Techquity: Optimization of the FAITH! App for Dissemination to Promote Cardiovascular Health among African Americans

Department of Health and Human Services · Phase Phase I

$499kawardedfunded 2025-08-15Company site →

MOTMOT, INC.

DETROIT, MI · 0 employees

SBIR Fast-Track: PIPELINE - Precision Inspection of Pressurized Environments using Long-term, Intelligent Navigation and Evaluation

National Science Foundation · Phase Phase I/Phase II

$1.6Macross 2 awardsfunded 2025-08-15

LITTLE ROOM INNOVATIONS LLC

ANN ARBOR, MI · 2 employees

A Novel Prosthetic Ankle Joint with Swing Phase Dorsiflexion and Terrain Adaptation

Department of Health and Human Services · Phase Phase I

$929kacross 2 awardsfunded 2025-08-01

Advanced Materials Design LLC

ANN ARBOR, MI · 1 employee

Real Time Strain Imaging Tool for Additive Manufacturing

Department of Commerce · Phase Phase I

$100kawardedfunded 2025-08-01

ASKO THERAPEUTICS, INC.

Ann Arbor, MI · 3 employees · woman-owned

Novel injectable implants for long-term local controlled release of therapeutic monoclonal antibodies

Department of Health and Human Services · Phase Phase I

$700kacross 2 awardsfunded 2025-08-01

AnchorChem LLC

Grosse Pointe Park, MI · 1 employee

AnchorChem LLC: Pioneering Solutions to Create a Stable Supply Chain of Cyanopeptides and Cyanotoxins to Address Global Health Threats

Department of Health and Human Services · Phase Phase I

$307kawardedfunded 2025-07-19

BHAWIN LLC

ANN ARBOR, MI · 1 employee · woman-owned

Lithium Niobate Fabrication and Processing

Department of Defense · Phase Phase I

$140kawardedfunded 2025-07-16Company site →

CUTCATH LLC

BLOOMFIELD HILLS, MI · 1 employee

Aortic dissection flap division by novel electrosurgical catheter facilitates aortic endograft landing zones

Department of Health and Human Services · Phase Phase I

$395kawardedfunded 2025-07-15

RYDBERG TECHNOLOGIES INC

ANN ARBOR, MI · 11 employees

Low power integrated photonics laser package for optical clocks

Department of Defense · Phase Phase I/Phase II

$3.8Macross 2 awardsfunded 2025-07-15Company site →

INTEGRAL & OPEN SYSTEMS, INC

YPSILANTI, MI · 6 employees

S.O.A.R.: Suicide Observation and Risk Assessment for Veterans

Department of Defense · Phase Phase I

$245kawardedfunded 2025-07-14Company site →

TEMPER INC

CEDAR SPRINGS, MI · 7 employees · woman-owned

Rapid consolidation of thermoplastic composite components

Department of Defense · Phase Phase II

$1.4Mawardedfunded 2025-07-11Company site →

ALELOPHARMA INC.

BLOOMFIELD HILLS, MI · 2 employees

Ultra-precision diagnostics for ALK+ non-small cell lung cancer

Department of Health and Human Services · Phase Phase I

$399kawardedfunded 2025-07-09Company site →

LINK MEDICAL LLC

CHELSEA, MI · 1 employee

Novel Device for Treating Mitral Regurgitation

Department of Health and Human Services · Phase Phase I

$298kawardedfunded 2025-07-01

ADVERTENT BIOTHERAPEUTICS, INC.

EAST LANSING, MI · 1 employee

A novel agent for preventing fatty degeneration of muscles in LGMD2B

Department of Health and Human Services · Phase Phase II

$1.3Mawardedfunded 2025-07-01Company site →

SYNERGY ADDITIVE MANUFACTURING L.L.C.

CLINTON TOWNSHIP, MI · 5 employees

Extremely High Speed Laser Application(EHLA) for Titanium Cylinder Bores using Mirror Assisted Fiber Optic Relay (MAFOR) System

Department of Defense · Phase Phase I

$140kawardedfunded 2025-06-23Company site →

GS ENGINEERING INC

HOUGHTON, MI · 92 employees

Data Converter Cabinet for AEGIS Weapon System MK99 Fire Control System

Department of Defense · Phase Phase I

$140kawardedfunded 2025-06-16Company site →

HYFI LLC

ANN ARBOR, MI · 7 employees

SBIR Phase II: Ubiquitous Flood Forecasting using Sensors and Analytics

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-06-13Company site →

VIRTUAL EM INC.

ANN ARBOR, MI · 5 employees

Reconfigurable Conformal Antennas for Unmanned Aerial Vehicles (UAVs) utilizing Carbon Nanotubes (CNTs)

Department of Defense · Phase Phase I

$137kawardedfunded 2025-06-10Company site →

MTRI INC, dba Balto Innovations

ANN ARBOR, MI · 9 employees

3D ATR plus Motion

Department of Defense · Phase Phase I

$140kawardedfunded 2025-06-04Company site →

SPIKE NEURO LLC

ANN ARBOR, MI · 7 employees

The development of a flexible carbon fiber penetrating nerve cuff and cortical array for neural recording, stimulation, and neurochemical de

Department of Health and Human Services · Phase Phase I

$234kawardedfunded 2025-06-01Company site →

WAVE LUMINA LLC

WILLIAMSBURG, MI · 3 employees

SBIR Phase I: Development of a Portable Contaminant Field Screening Device for Rapid Measurement of PFAS in Water.

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-05-15Company site →

SEALANDAIRE TECHNOLOGIES, INC.

JACKSON, MI · 45 employees

Mid-Frequency Active Sonobuoy Development

Department of Defense · Phase Phase II

$1.9Macross 2 awardsfunded 2025-05-12Company site →

ENERGY STORAGE SAFETY PRODUCTS INTERNATIONAL LLC

DETROIT, MI · 5 employees

Battery Logistics Integrated Safety System (BLISS)

Department of Transportation · Phase Phase II

$995kawardedfunded 2025-05-05Company site →

AIRFLOW SCIENCES CORP

LIVONIA, MI · 31 employees

Geothermal Flow Rate and Liquid/Vapor Fraction Measurement System

Department of Energy · Phase Phase II

$1.1Mawardedfunded 2025-04-14Company site →

CAYMAN CHEMICAL COMPANY, INCORPORATED

ANN ARBOR, MI · 435 employees

Epigenetic Compounds Stimulating Dental Bone Repair

Department of Health and Human Services · Phase Phase I

$307kawardedfunded 2025-04-08Company site →

Rainbow Hospitality LLC dba Curry Fresh

ann arbor, MI · 10 employees · woman-owned

SBIR Phase I: Turmeric Assisted Pressure Sterilization

National Science Foundation · Phase Phase I

$303kawardedfunded 2025-03-26Company site →

PILOT SYSTEMS INTERNATIONAL LLC

FARMINGTON HILLS, MI · 11 employees

HEPPS - Electro-Mechanical Controllable Pitch Propeller/Fan/Turbine

Department of Defense · Phase Phase I

$245kawardedfunded 2025-03-05Company site →

COBRA AERO LLC

HILLSDALE, MI · 5 employees

An Optimal HEPPS For Ground, Air, Surface, And Subsurface Operations

Department of Defense · Phase Phase I

$249kawardedfunded 2025-03-04Company site →

MAGSORBEO BIOMEDICAL CORP

DETROIT, MI · 3 employees · woman-owned

STTR Phase I: Bioabsorbable Magnesium with a Tailorable Absorption Profile for Maxillofacial Fixation

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-03-01Company site →

Neuronexus Technologies, Inc.

Ann Arbor, MI · 30 employees

Advanced culture and recording system for long-term electrophysiological profiling in human brain organoids

Department of Health and Human Services · Phase Phase I

$449kawardedfunded 2025-03-01

EMAG TECHNOLOGIES INC.

ANN ARBOR, MI · 12 employees

Continuous Communications Through Plasma During Hypersonic Flight

Department of Defense · Phase Phase II

$2.0Mawardedfunded 2025-02-28Company site →

ARBOR BATTERIES, INC.

Ann Arbor, MI · 6 employees

Enabling Safer Li-ion Batteries with Less Flammable Electrolytes using 3-D Electrode Architectures

Department of Defense · Phase Phase I

$250kawardedfunded 2025-02-19Company site →

Aethero Space Inc.

NORTHVILLE, MI · 10 employees

Imaging Satellite Edge Computing

Department of Defense · Phase Phase I

$110kawardedfunded 2025-01-15Company site →

OLEANDR SCIENTIFIC LLC

ROCHESTER HILLS, MI · 7 employees · woman-owned

Tunable Magnetic Metamaterial Based On Array Of Nanowires With Magnetic Shape Anisotropy For Ultracompact Planar Antennas

Department of Defense · Phase Phase I

$204kawardedfunded 2024-12-16

REGENDODENT, INC.

ANN ARBOR, MI · 2 employees

RegendoGEL for guided pulp and dentin regeneration

Department of Health and Human Services · Phase Phase I

$399kawardedfunded 2024-12-01

SEAVIEW SYSTEMS INC

DEXTER, MI · 6 employees

Directional Wave Spectra Sensing Module for Autonomous Underwater Vehicle Gliders

Department of Defense · Phase Phase I

$130kawardedfunded 2024-11-15Company site →

FOURTH STATE LLC

ANN ARBOR, MI · 3 employees

Plasma-driven Destruction of PFAS in Complex Water Matrices: Pilot-scale Demonstration

Environmental Protection Agency · Phase Phase II

$400kawardedfunded 2024-10-16

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