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Recently funded science companies in Minnesota

46 companies in Minnesota closed federal SBIR/STTR awards in the last two years, newest first. The funding event is the signal — small companies grow right after the award lands.

SMART INFORMATION FLOW TECHNOLOGIES LLC

MINNEAPOLIS, MN · 38 employees

BRAVADO: Binary Rapid Automatic Vulnerability Attack and Defense Operations

Department of Defense · Phase Phase I/Phase II

$3.8Macross 5 awardsfunded 2025-10-06Company site →

LEONINE TECHNOLOGIES INC

MINNEAPOLIS, MN · 2 employees

STTR Phase I: Intelligent Control System for Polymer Injection Molding

National Science Foundation · Phase Phase I

$305kawardedfunded 2025-10-01Company site →

PARTICLE4X, INC.

Eden Prairie, MN · 5 employees · woman-owned

SBIR Phase I: Inline Monitoring of Particulate Matter and Sterility for Continuous Manufacturing

Department of Energy · National Science Foundation · Phase Phase I

$561kacross 2 awardsfunded 2025-10-01Company site →

Elire LLC

Minneapolis, MN · 120 employees

Elire LLC_D2P2_USSF Human Capital Management Modernization

Department of Defense · Phase Phase II

$1.9Mawardedfunded 2025-09-30Company site →

ARCHITECTURE TECHNOLOGY INC

EDEN PRAIRIE, MN · 42 employees

Foreign Object Retrieval System (FORS)

Department of Defense · Phase Phase I/Phase II

$6.6Macross 7 awardsfunded 2025-09-30Company site →

Kommodo Holdings Corp.

Shoreview, MN · 0 employees

Engineered Memory T cells as a Platform to Treat Enzymopathies

Department of Health and Human Services · Phase Phase I

$305kawardedfunded 2025-09-26

OSEMI INC

RED WING, MN · 6 employees

Cubic BN Diodes and Transistors

National Aeronautics and Space Administration · Phase Phase II

$900kawardedfunded 2025-09-25Company site →

MYOGENICA INC.

SAINT PAUL, MN · 3 employees

Systemic Transplantation of MyoPAXon: IND Enabling Studies for the Treatment of DMD

Department of Health and Human Services · Phase Phase II

$1.3Mawardedfunded 2025-09-24

INNOVATIVE DESIGN LABS INC

MINNEAPOLIS, MN · 9 employees

Addressing Challenges in Peripheral Intravenous Catheter Education

Department of Defense · Department of Health and Human Services · Phase Phase I/Phase II

$4.4Macross 6 awardsfunded 2025-09-23Company site →

APPLIED UNIVERSAL DYNAMICS, CORP

LORETTO, MN · 5 employees

System to Allow Off Site Monitoring of Pressure Ulcers for Patients in a Rural Long-Term Care Facility

Department of Health and Human Services · Phase Phase I/Phase II

$1.6Macross 3 awardsfunded 2025-09-20

BISCHOFF HOLDINGS INC

INVER GROVE HEIGHTS, MN · 4 employees

Early detection and monitoring of Alzheimers Disease and Related Dementias using non-semantic linguistic and acoustic features of speech der

Department of Health and Human Services · Phase Phase II

$927kawardedfunded 2025-09-15Company site →

ASTER LABS, INC.

SAINT PAUL, MN · 12 employees

Precise Wearable System for Accurate Continuous Gait Monitoring to Indicate Health Decline in Black Adults with Alzheimer's Disease and Rela

Department of Health and Human Services · Phase Phase I

$500kawardedfunded 2025-09-15Company site →

Koronis Biomedical Technologies Corp.

Minneapolis, MN · 6 employees

Kidney Support in Pediatric Patients using an Ultrafiltration Device

Department of Health and Human Services · Phase Phase I/Phase II

$1.5Macross 2 awardsfunded 2025-09-15

Minnesota HealthSolutions Corporation

Minneapolis, MN · 12 employees · woman-owned

Novel Bladder Catheterization Device

Department of Health and Human Services · Phase Phase I

$977kacross 3 awardsfunded 2025-09-15

REMASTERED SLEEP LLC

EAGAN, MN · 6 employees

Novel Myofunctional Nipple to Prevent Obstructive Sleep Apnea in Infants

Department of Health and Human Services · Phase Phase I

$317kawardedfunded 2025-09-15Company site →

Objective Biotechnology, INC.

Minneapolis, MN · 7 employees

High performance miniaturized microscopes for through skull cortex-wide imaging in freely behaving mice

Department of Health and Human Services · Phase Phase I

$417kawardedfunded 2025-09-15Company site →

NORTHSTAR GENOMICS, LLC

EAGAN, MN · 2 employees

Novel approaches to humanized skeletal muscle in pig

Department of Health and Human Services · Phase Phase I

$566kacross 2 awardsfunded 2025-09-10Company site →

Fillmore.AI LLC

Minnetonka, MN · 5 employees · woman-owned

Delivering Superpower Training Capabilities for Our Nation's Warfighters

Department of Defense · Phase Phase I

$147kawardedfunded 2025-09-09Company site →

GAVIA BIO, LLC

MINNEAPOLIS, MN · 2 employees

Treating drug-resistant infections of burn wounds with an optimized antimicrobial peptide

Department of Health and Human Services · Phase Phase I

$314kawardedfunded 2025-09-05Company site →

OPTIMAL MOBILITY LLC

MINNETONKA, MN · 1 employee · woman-owned

Kids Standing Up: Promoting Independent Mobility in Children with Neuromuscular Conditions with a Standing Wheelchair

Department of Health and Human Services · Phase Phase II

$739kawardedfunded 2025-09-05Company site →

Trekka Therapeutics, LLC

Saint Paul, MN · 2 employees

Nanodroplet Infused Analgesic-Wafer for Transmucosal Opioid-free Treatment of Subacute Oral Pain

Department of Health and Human Services · Phase Phase I

$413kawardedfunded 2025-09-04

OralMR, LLC

Minneapolis, MN · 6 employees · woman-owned

Redefining Dental Imaging: Low-Cost MRI with Relaxed Field Requirements

Department of Health and Human Services · Phase Phase I

$342kawardedfunded 2025-09-04

APLOS MEDICAL INC

EDEN PRAIRIE, MN · 1 employee

Readying the commercialization of Omega device as an improved safe and efficacious treatment for drug-failed GERD patients

Department of Health and Human Services · Phase Phase II

$571kawardedfunded 2025-09-02Company site →

Q-rounds Inc.

PLYMOUTH, MN · 7 employees

Q-rounds: Making Multi-Disciplinary Family Centered Rounds and Achievable Standard of Care through Novel Virtual Rounding Features

Department of Health and Human Services · Phase Phase II

$1.0Mawardedfunded 2025-09-01Company site →

LUMINARY THERAPEUTICS, INC.

MINNEAPOLIS, MN · 7 employees

Allogeneic BAFF Ligand Based CAR T Cells as a Novel Therapy for B Cell Malignancies

Department of Health and Human Services · Phase Phase II

$1.5Mawardedfunded 2025-09-01

HABITAWARE, INC.

MINNEAPOLIS, MN · 4 employees

Developing an Integrated Wearable and Patch System to Address Skin Picking Disorder

Department of Health and Human Services · Phase Phase I

$423kawardedfunded 2025-09-01Company site →

Resuscitation Innovations, LLC dba AdvancedCPR Solutions

Minneapolis, MN · 2 employees

Commercialization of the Head Up CPR System for Improving Survival after Cardiac Arrest

Department of Health and Human Services · Phase Phase I/Phase II

$895kacross 2 awardsfunded 2025-09-01

Quench Medical Inc.

Saint Paul, MN · 1 employee

Preparing IND filing for novel lung cancer therapeutic

Department of Health and Human Services · Phase Phase II

$250kawardedfunded 2025-09-01Company site →

COLLABORATION.AI, LLC

MINNEAPOLIS, MN · 54 employees

Collaboration.Ai IMPACT (Intelligent Matching of Personnel, Agents, and Capabilities for Technology)

Department of Defense · Phase Phase I

$150kawardedfunded 2025-08-28Company site →

ANNO.AI, INC.

Duluth, MN · 60 employees

EchoDome - Passive Acoustic Early Warning Threat Detection

Department of Defense · Phase Phase I/Phase II

$1.3Macross 2 awardsfunded 2025-08-28Company site →

QRONA TECHNOLOGIES LLC

EDEN PRAIRIE, MN · 3 employees

High-efficiency and high-resolution x-ray and gamma-ray imaging detectors for space science

Department of Energy · National Aeronautics and Space Administration · Phase Phase I

$600kacross 3 awardsfunded 2025-08-21Company site →

Avisure International Inc

NORTHFIELD, MN · 24 employees

Aircraft-Wildlife Collision Mitigation: A Predictive Wildlife Hazard Forecast Tool for Enhanced Aviation Safety

National Aeronautics and Space Administration · Phase Phase II

$900kawardedfunded 2025-08-06Company site →

LifEngine Animal Health Laboratories Incorporated

Eagan, MN · 4 employees

c-MYB overexpression for exhaustion resistant CAR-T cell therapies

Department of Health and Human Services · Phase Phase I

$400kawardedfunded 2025-08-04Company site →

Glimpse Diagnostics, Inc.

Minneapolis, MN · 1 employee · woman-owned

Deep learning image classification model for pediatric ear disease

Department of Health and Human Services · Phase Phase II

$1.5Mawardedfunded 2025-08-01

SUPERIOR NANO LLC

TWO HARBORS, MN · 3 employees

SBIR Phase II: Dense Nanolipid Fluids (DNLFs) for Delivery of Drugs with Poor Bioavailability: Synthesis, Manufacture, and Drug Properties

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-07-15Company site →

PRODUCT DEVELOPMENT ASSOCIATES, INC.

BURNSVILLE, MN · 178 employees

Configurable Power Control Module (PCM)

Department of Defense · Phase Phase I

$140kawardedfunded 2025-06-10Company site →

ADIALANTE L.L.C.

MINNEAPOLIS, MN

SBIR Phase II: The Development of an Affordable, Compact, and Silent Head-Only MRI Scanner

National Science Foundation · Phase Phase II

$1.2Mawardedfunded 2025-06-05

NEXGEN CANCER DETECTION LLC

LINO LAKES, MN · 5 employees

SBIR Phase II: Enrichment of Cancer DNA for Improved Cancer Diagnostics from Blood

National Science Foundation · Phase Phase II

$1.3Mawardedfunded 2025-06-05

Dragonase LLC

Minneapolis, MN · 2 employees

Fully autonomous robotic wet lab for stem cell culture media optimization

Department of Health and Human Services · Phase Phase I

$350kawardedfunded 2025-06-01

PELVA HEALTH CORPORATION

Saint Paul, MN · 2 employees · woman-owned

Novel Hydrogel Film to Reduce Pain Experienced during Sexual Intercourse for Women with Vulvodynia

Department of Health and Human Services · Phase Phase I

$328kawardedfunded 2025-05-20Company site →

Priogen Corp

SAINT PAUL, MN · 3 employees

Microfluidic device for detection of infectious prion proteins

Department of Health and Human Services · Phase Phase I

$314kawardedfunded 2025-05-15Company site →

ENVERDE LLC

MINNEAPOLIS, MN · 6 employees

Providing Energy Resilience: The Ability of eVp™ to Fuel or Power Bases and Aircraft Using Catalytically Driven Flash Volatilization of Carb

Department of Defense · Phase Phase I

$110kawardedfunded 2025-03-03Company site →

QEN LABS INC.

Eden Prairie, MN · 4 employees

CleanNode - Automatic containerization for secure, and efficient sanitization of compute nodes in HPC systems

Department of Energy · Phase Phase I

$200kawardedfunded 2025-02-18Company site →

Exergi Predictive LLC

Hugo, MN · 3 employees

Modern Diesel Engine Conversion (MDEC) Technology for JP-8 Operability

Department of Defense · Phase Phase I

$224kawardedfunded 2025-02-05Company site →

FEMTOFLUIDICS INCORPORATED

EXCELSIOR, MN · 3 employees

SBIR Phase I: Drug Discovery meets Moore's Law: Synthesizing DNA-Encoded Libraries with Electronics

National Science Foundation · Phase Phase I

$275kawardedfunded 2024-12-03Company site →

Arcnano, Inc.

WHITE BEAR LAKE, MN · 32 employees · woman-owned

MEMS Scale Ion Energy Analyzer

Department of Defense · Phase Phase II

$1.2Mawardedfunded 2024-11-15Company site →

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