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Recently funded science companies in South Dakota

4 companies in South Dakota closed federal SBIR/STTR awards in the last two years, newest first. The funding event is the signal — small companies grow right after the award lands.

ENRECTEC LLC

SIOUX FALLS, SD · 4 employees · woman-owned

Neurotrophic Drug Development for Alzheimer's Disease

Department of Health and Human Services · Phase Phase I

$475kawardedfunded 2025-09-22

AEROFLY LLC

BROOKINGS, SD · 22 employees

Integrated Regolith Excavation and Water Extraction Using Auger-Dryer Systems

National Aeronautics and Space Administration · Phase Phase I/Phase II

$1.0Macross 2 awardsfunded 2025-09-10Company site →

RTutor LLC

Sioux Falls, SD · 7 employees

Commercializing iDEP, an interactive and reproducible tool for analyzing RNA-Seq data

Department of Defense · Department of Health and Human Services · Phase Phase I

$545kacross 2 awardsfunded 2025-09-04Company site →

VRC Metal Systems, LLC

BOX ELDER, SD · 77 employees

Non-Helium Cold Spray System for Nuclear Component Repair and Retrofit

Department of Defense · Department of Energy · Phase Phase I/Phase II

$2.1Macross 3 awardsfunded 2025-04-14Company site →

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